BRPI0411136A - composto carboxìlico e medicamento consistindo no mesmo - Google Patents
composto carboxìlico e medicamento consistindo no mesmoInfo
- Publication number
- BRPI0411136A BRPI0411136A BRPI0411136-2A BRPI0411136A BRPI0411136A BR PI0411136 A BRPI0411136 A BR PI0411136A BR PI0411136 A BRPI0411136 A BR PI0411136A BR PI0411136 A BRPI0411136 A BR PI0411136A
- Authority
- BR
- Brazil
- Prior art keywords
- same
- carboxylic compound
- diabetes
- integer
- medicament consisting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"COMPOSTO CARBOXìLICO E MEDICAMENTO CONSISTINDO NO MESMO". Um composto caracterizado pela seguinte fórmula geral (1), um de seus sais ou um de seus ésteres: em que m representa um inteiro de 0 a 4, n representa um inteiro de 5 a 9 e W representa -CH (OR) - (em que R representa átomo de hidrogênio ou um grupo protetor de grupo de hidroxil) ou -C(=O)-, que possui ações de redução de glucose no sangue, insulina de plasma e triglicerídeo e é útil para tratamento de diabetes, suas complicações, hiperlipemia e outros.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47273703P | 2003-05-23 | 2003-05-23 | |
| JP2003154372 | 2003-05-30 | ||
| PCT/JP2004/007316 WO2004103946A1 (ja) | 2003-05-23 | 2004-05-21 | カルボン酸化合物及びこれを含有する医薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0411136A true BRPI0411136A (pt) | 2006-07-18 |
Family
ID=33479004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0411136-2A BRPI0411136A (pt) | 2003-05-23 | 2004-05-21 | composto carboxìlico e medicamento consistindo no mesmo |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1627866B1 (pt) |
| KR (1) | KR20060031605A (pt) |
| AT (1) | ATE418532T1 (pt) |
| AU (1) | AU2004241224A1 (pt) |
| BR (1) | BRPI0411136A (pt) |
| CA (1) | CA2526637A1 (pt) |
| DE (1) | DE602004018634D1 (pt) |
| EA (1) | EA010020B1 (pt) |
| IL (1) | IL171993A0 (pt) |
| MX (1) | MXPA05012612A (pt) |
| MY (1) | MY132415A (pt) |
| NO (1) | NO20056135L (pt) |
| NZ (1) | NZ544155A (pt) |
| WO (1) | WO2004103946A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1752145A1 (en) * | 2004-06-01 | 2007-02-14 | Kowa Company Ltd. | Therapeutic agent for hyperlipemia and therapeutic agent for diabetes |
| WO2006118187A1 (ja) * | 2005-04-28 | 2006-11-09 | Ube Industries, Ltd. | 2,2-ジクロロ-12-(4-ハロフェニル)ドデカン酸塩及びその製造中間体の製法 |
| JPWO2007114223A1 (ja) | 2006-03-31 | 2009-08-13 | 興和株式会社 | カルボン酸化合物の製造方法 |
| WO2009038204A1 (ja) * | 2007-09-17 | 2009-03-26 | Pharma Frontier Co., Ltd. | 新規長鎖脂肪酸誘導体化合物及びそれら化合物を有効成分とするgタンパク質共役型レセプター作動剤 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4439947A1 (de) * | 1994-11-09 | 1996-05-15 | Boehringer Mannheim Gmbh | 2,2-Dichloralkancarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US20060051410A1 (en) * | 2002-01-16 | 2006-03-09 | Kobayashi Shin-Ichiro | Pharmaceutical composition containing 2,2-dichloro-12-(4-chlorophenyl)-dodecanoic acid |
-
2004
- 2004-05-21 AU AU2004241224A patent/AU2004241224A1/en not_active Abandoned
- 2004-05-21 MX MXPA05012612A patent/MXPA05012612A/es active IP Right Grant
- 2004-05-21 BR BRPI0411136-2A patent/BRPI0411136A/pt not_active IP Right Cessation
- 2004-05-21 MY MYPI20041952A patent/MY132415A/en unknown
- 2004-05-21 KR KR1020057022282A patent/KR20060031605A/ko not_active Ceased
- 2004-05-21 CA CA002526637A patent/CA2526637A1/en not_active Abandoned
- 2004-05-21 EA EA200501853A patent/EA010020B1/ru not_active IP Right Cessation
- 2004-05-21 WO PCT/JP2004/007316 patent/WO2004103946A1/ja not_active Ceased
- 2004-05-21 NZ NZ544155A patent/NZ544155A/en unknown
- 2004-05-21 AT AT04734380T patent/ATE418532T1/de not_active IP Right Cessation
- 2004-05-21 EP EP04734380A patent/EP1627866B1/en not_active Expired - Lifetime
- 2004-05-21 DE DE602004018634T patent/DE602004018634D1/de not_active Expired - Fee Related
-
2005
- 2005-11-16 IL IL171993A patent/IL171993A0/en unknown
- 2005-12-22 NO NO20056135A patent/NO20056135L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1627866B1 (en) | 2008-12-24 |
| MXPA05012612A (es) | 2006-02-22 |
| ATE418532T1 (de) | 2009-01-15 |
| NZ544155A (en) | 2008-03-28 |
| CA2526637A1 (en) | 2004-12-02 |
| IL171993A0 (en) | 2009-02-11 |
| EP1627866A4 (en) | 2006-10-04 |
| EA010020B1 (ru) | 2008-06-30 |
| EA200501853A1 (ru) | 2006-06-30 |
| EP1627866A1 (en) | 2006-02-22 |
| KR20060031605A (ko) | 2006-04-12 |
| NO20056135L (no) | 2005-12-22 |
| MY132415A (en) | 2007-10-31 |
| WO2004103946A1 (ja) | 2004-12-02 |
| DE602004018634D1 (de) | 2009-02-05 |
| AU2004241224A1 (en) | 2004-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |