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BRPI0418166A - compostos de bicicloeteroarilamina como ligandos de canal de ìon e usos destes - Google Patents

compostos de bicicloeteroarilamina como ligandos de canal de ìon e usos destes

Info

Publication number
BRPI0418166A
BRPI0418166A BRPI0418166-2A BRPI0418166A BRPI0418166A BR PI0418166 A BRPI0418166 A BR PI0418166A BR PI0418166 A BRPI0418166 A BR PI0418166A BR PI0418166 A BRPI0418166 A BR PI0418166A
Authority
BR
Brazil
Prior art keywords
compounds
ion channel
bicycloetheroylamine
channel ligands
ligands
Prior art date
Application number
BRPI0418166-2A
Other languages
English (en)
Inventor
Michael G Kelly
Satyanarayana Janagani
Guoxian Wu
John Kincaid
David Lonergan
Yunfeng Fang
Zhi-Liang Wei
Original Assignee
Renovis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renovis Inc filed Critical Renovis Inc
Publication of BRPI0418166A publication Critical patent/BRPI0418166A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

COMPOSTOS DE BICICLOETEROARILAMINA COMO LIGANDOS DE CANAL DE ìON E USOS DESTES. A presente invenção refere-se a compostos de amina que têm uma fórmula representada pela seguinte: Os compostos podem ser preparados como composições farmacêuticas e podem ser empregados para a prevenção e tratamento de uma veriedade de condições em mamíferos incluindo seres humanos, incluindo por meio de exemplos não limitantes,dor, inflamação, lesão traumática e outros.
BRPI0418166-2A 2003-12-24 2004-12-23 compostos de bicicloeteroarilamina como ligandos de canal de ìon e usos destes BRPI0418166A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53237103P 2003-12-24 2003-12-24
PCT/US2004/043456 WO2005066171A1 (en) 2003-12-24 2004-12-23 Bicycloheteroarylamine compounds as ion channel ligands and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0418166A true BRPI0418166A (pt) 2007-06-19

Family

ID=34748796

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418166-2A BRPI0418166A (pt) 2003-12-24 2004-12-23 compostos de bicicloeteroarilamina como ligandos de canal de ìon e usos destes

Country Status (8)

Country Link
US (1) US7414131B2 (pt)
EP (1) EP1697361A1 (pt)
JP (1) JP2007517045A (pt)
AR (1) AR051156A1 (pt)
BR (1) BRPI0418166A (pt)
CA (1) CA2550717A1 (pt)
TW (1) TW200530235A (pt)
WO (1) WO2005066171A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312330B2 (en) * 2003-12-24 2007-12-25 Renovis, Inc. Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
US20060128710A1 (en) * 2004-12-09 2006-06-15 Chih-Hung Lee Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
US7297700B2 (en) 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
EP1871748A1 (en) * 2005-04-11 2008-01-02 F. Hoffmann-Roche AG (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines
WO2006117305A1 (en) * 2005-05-04 2006-11-09 F. Hoffmann-La Roche Ag (3,4-dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amines having an activity on the 5-ht receptor
CA2630617C (en) 2005-11-23 2014-03-25 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2007109182A2 (en) * 2006-03-16 2007-09-27 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
TWI464148B (zh) * 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
WO2007115408A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US20080095720A1 (en) * 2006-10-18 2008-04-24 Conopco, Inc., D/B/A Unilever Skin Benefit Compositions with a Vanilloid Receptor Antagonist
ES2576643T3 (es) * 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos
PL2139334T3 (pl) * 2007-04-17 2013-11-29 Evotec Ag Skondensowane związki heterocykliczne 2-cyjanofenylu i ich kompozycje i zastosowania
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
CA2689429C (en) * 2007-06-15 2012-08-21 Banyu Pharmaceutical Co., Ltd. Bicycloaniline derivatives
TW200942549A (en) 2007-12-17 2009-10-16 Janssen Pharmaceutica Nv Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
MX2010011545A (es) 2008-04-21 2011-04-11 Otonomy Inc Formulaciones para tratar enfermedades y afecciones del oido.
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
EP2306975A4 (en) 2008-07-21 2012-10-31 Otonomy Inc COMPOSITIONS WITH A TAXED RELEASE FOR MODULATING THE EARM STRUCTURE AND THE BORN IMMUNE SYSTEM, AND METHODS OF TREATING EAR OR DISEASE
EP2318377B1 (en) 2008-07-31 2013-08-21 Genentech, Inc. Pyrimidine compounds, compositions and methods of use
JP5555236B2 (ja) * 2008-08-25 2014-07-23 アイアールエム・リミテッド・ライアビリティ・カンパニー ヘッジホッグ経路モジュレーター
US8759362B2 (en) * 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
BR112012011188A2 (pt) 2009-11-12 2021-06-29 F.Hoffmann - La Roche Ag ''composto,composição farmacêutica e uso de um composto"
US8828990B2 (en) 2009-11-12 2014-09-09 Genentech, Inc. N-7 substituted purine and pyrazolopyrimine compounds, compositions and methods of use
US9051311B2 (en) 2012-03-09 2015-06-09 Amgen Inc. Sulfamide sodium channel inhibitors
EP3150599B1 (en) * 2014-05-29 2018-10-24 Taiho Pharmaceutical Co., Ltd. Novel tetrahydropyridopyrimidine compound or salt thereof
US10370372B2 (en) 2015-11-27 2019-08-06 Taiho Pharmaceutical Co., Ltd. Fused pyrimidine compound or salt thereof
CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途
CA3077659A1 (en) * 2017-10-09 2019-04-18 Ramot At Tel-Aviv University Ltd. Modulators of potassium ion and trpv1 channels and uses thereof
AR118243A1 (es) 2019-03-07 2021-09-22 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
CN110256420B (zh) * 2019-05-07 2020-04-28 江西中医药大学 四氢吡啶并嘧啶衍生物及其制备方法和用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04224580A (ja) 1990-12-25 1992-08-13 Nippon Soda Co Ltd ピリミジン誘導体、その製造方法及び農園芸用殺菌剤
US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
EP1754703A3 (en) 1997-02-19 2007-02-28 Berlex, Inc. N-Heterocyclic derivatives as nos inhibitors
AU1071301A (en) 1999-11-01 2001-05-14 Eli Lilly And Company Pharmaceutical compounds
ATE346064T1 (de) 2000-09-15 2006-12-15 Vertex Pharma Pyrazolverbindungen als protein-kinasehemmer
ATE354573T1 (de) 2000-12-21 2007-03-15 Vertex Pharma ßPYRAZOLVERBINDUNGEN, DIE SICH ALS PROTEINKINASEINHIBITOREN EIGNENß
JP4031363B2 (ja) 2001-01-02 2008-01-09 エフ．ホフマン−ラ ロシュ アーゲー α−１Ａ／Ｂアドレナリン作動性受容体拮抗薬としてのキナゾロン誘導体
US7105667B2 (en) 2001-05-01 2006-09-12 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
WO2002088079A2 (en) 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
DE60236322D1 (de) 2001-12-07 2010-06-17 Vertex Pharma Verbindungen auf pyrimidin-basis als gsk-3-hemmer
JP4469179B2 (ja) 2002-01-23 2010-05-26 バイエル ファーマセチカル コーポレーション Ｒｈｏキナーゼ阻害剤としてのピリミジン誘導体
GB0206033D0 (en) 2002-03-14 2002-04-24 Pfizer Ltd Compounds useful in therapy
EP1552842A1 (en) 2002-06-07 2005-07-13 Kyowa Hakko Kogyo Co., Ltd. Bicyclic pyrimidine derivatives
US7208498B2 (en) 2002-07-15 2007-04-24 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
GB0225908D0 (en) 2002-11-06 2002-12-11 Pfizer Ltd Treatment of female sexual dysfunction
EP1608631A4 (en) 2003-03-28 2008-08-20 Scios Inc BICYCLIC PYRIMIDININHIBITORS OF TGF BETA
US7419978B2 (en) 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
MY141220A (en) 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
EP1713807A1 (en) 2004-01-23 2006-10-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments

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AR051156A1 (es) 2006-12-27
US7414131B2 (en) 2008-08-19
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