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BRPI0417179A - gentisato de amlodipina, método de preparar o mesmo e composição farmacêutica para tratamento de doenças cardiovasculares - Google Patents

gentisato de amlodipina, método de preparar o mesmo e composição farmacêutica para tratamento de doenças cardiovasculares

Info

Publication number
BRPI0417179A
BRPI0417179A BRPI0417179-9A BRPI0417179A BRPI0417179A BR PI0417179 A BRPI0417179 A BR PI0417179A BR PI0417179 A BRPI0417179 A BR PI0417179A BR PI0417179 A BRPI0417179 A BR PI0417179A
Authority
BR
Brazil
Prior art keywords
preparation
pharmaceutical composition
cardiovascular disease
amlodipine
amlodipine gentisate
Prior art date
Application number
BRPI0417179-9A
Other languages
English (en)
Inventor
Jae-Sun Kim
Jin Young Choi
Je Ho Ryu
Nam Kyu Lee
Jeong-Soo Jang
Woo Jae Jang
Key An Um
Do Seung Kum
Original Assignee
Sk Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sk Chemicals Co Ltd filed Critical Sk Chemicals Co Ltd
Publication of BRPI0417179A publication Critical patent/BRPI0417179A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"GENTISATO DE AMLODIPINA, MéTODO DE PREPARAR O MESMO E COMPOSIçãO FARMACêUTICA PARA TRATAMENTO DE DOENçAS CARDIOVASCULARES". A presente invenção se refere a um sal de ácido de gentisato de amlodipina e a um método para sua preparação. Mais particularmente, a presente invenção se refere a um sal de ácido cristalino de gentisato de amlodipina da fórmula 1 a seguir preparado reagindo amlodipina e ácido gentísico, que é útil para o tratamento de doenças cardiovasculares e tem as vantagens de baixa toxicidade, excelente estabilidade, eficácias farmacêuticas aperfeiçoadas e concentração de longa duração no sangue.
BRPI0417179-9A 2003-12-16 2004-12-15 gentisato de amlodipina, método de preparar o mesmo e composição farmacêutica para tratamento de doenças cardiovasculares BRPI0417179A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20030092001 2003-12-16
PCT/KR2004/003309 WO2005058825A1 (en) 2003-12-16 2004-12-15 Amlodipine gentisate and a method of its preparation

Publications (1)

Publication Number Publication Date
BRPI0417179A true BRPI0417179A (pt) 2007-03-06

Family

ID=36660050

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417179-9A BRPI0417179A (pt) 2003-12-16 2004-12-15 gentisato de amlodipina, método de preparar o mesmo e composição farmacêutica para tratamento de doenças cardiovasculares

Country Status (14)

Country Link
US (1) US7442714B2 (pt)
EP (1) EP1694645B1 (pt)
JP (1) JP4740875B2 (pt)
KR (1) KR100841409B1 (pt)
CN (1) CN100591669C (pt)
AT (1) ATE491686T1 (pt)
AU (1) AU2004299412B2 (pt)
BR (1) BRPI0417179A (pt)
CA (1) CA2549832C (pt)
DE (1) DE602004030616D1 (pt)
ES (1) ES2357433T3 (pt)
MX (1) MXPA06006922A (pt)
RU (1) RU2330843C2 (pt)
WO (1) WO2005058825A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101235116B1 (ko) * 2005-10-17 2013-02-20 에스케이케미칼주식회사 광학활성 암로디핀 겐티세이트 염의 제조방법
JP2008013489A (ja) * 2006-07-06 2008-01-24 Ohara Yakuhin Kogyo Kk ベシル酸アムロジピン含有錠剤
KR100913791B1 (ko) * 2006-07-21 2009-08-26 한미약품 주식회사 (ｓ)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물
KR100830003B1 (ko) 2006-10-31 2008-05-15 씨제이제일제당 (주) 결정성 ｓ-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법
UA102502C2 (uk) * 2008-08-08 2013-07-25 Віктор Павлович Кутняк Антигіпертензивна органічна сіль
CN111194312A (zh) * 2017-10-09 2020-05-22 提瓦制药工业公司 依地普仑的新盐和固态形式
KR102178355B1 (ko) * 2018-10-19 2020-11-11 전남대학교산학협력단 심장 질환 치료용 조성물
CN110372575A (zh) * 2019-07-10 2019-10-25 复旦大学 一种二氢吡啶钙拮抗剂共晶体及其制备方法和应用
CN117024292B (zh) * 2023-08-08 2024-09-24 深圳杉海创新技术有限公司 一种龙胆酸离子盐、其制备方法及日化产品或食品或药品

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
KR950007228B1 (ko) 1987-08-05 1995-07-07 화이자 인코포레이티드 암로디핀의 베실레이트염
CN1278791A (zh) * 1997-10-10 2001-01-03 阿温蒂斯药物制品公司 制造氮杂环烷基烷酰基假四肽的方法
UA33033A (uk) * 1998-10-16 2001-02-15 Др.Редіс Леборетрис Лтд Спосіб одержання безилату амлодипіну
US20020045613A1 (en) * 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
KR100452491B1 (ko) * 2001-03-29 2004-10-12 한미약품 주식회사 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법
US20070135488A1 (en) * 2002-04-13 2007-06-14 Chung You S Amlodipine nicotinate and process for the preparation thereof
KR100517383B1 (ko) * 2003-05-23 2005-09-26 동아제약주식회사 신규한 암로디핀 젠티세이트 염, 그의 제조방법 및 그의 약제학적 조성물

Also Published As

Publication number Publication date
EP1694645B1 (en) 2010-12-15
CA2549832A1 (en) 2005-06-30
JP2007513997A (ja) 2007-05-31
KR20050061317A (ko) 2005-06-22
US20070135495A1 (en) 2007-06-14
CN100591669C (zh) 2010-02-24
AU2004299412A1 (en) 2005-06-30
WO2005058825A1 (en) 2005-06-30
RU2006122472A (ru) 2008-01-27
KR100841409B1 (ko) 2008-06-25
MXPA06006922A (es) 2006-08-23
AU2004299412B2 (en) 2011-08-18
JP4740875B2 (ja) 2011-08-03
US7442714B2 (en) 2008-10-28
CN1956956A (zh) 2007-05-02
ES2357433T3 (es) 2011-04-26
CA2549832C (en) 2010-10-05
ATE491686T1 (de) 2011-01-15
DE602004030616D1 (de) 2011-01-27
EP1694645A1 (en) 2006-08-30
RU2330843C2 (ru) 2008-08-10
EP1694645A4 (en) 2009-03-04

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2260 DE 29/04/2014

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C07D 211/90 (2006.01), A61K 31/4422 (2006.01), A61

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]