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BRPI0416752A - composição farmacêutica, uso de um ou mais compostos, método para a prevenção ou tratamento de distúrbios, compostos, e, processo para a preparação de uma composição farmacêutica - Google Patents

composição farmacêutica, uso de um ou mais compostos, método para a prevenção ou tratamento de distúrbios, compostos, e, processo para a preparação de uma composição farmacêutica

Info

Publication number
BRPI0416752A
BRPI0416752A BRPI0416752-0A BRPI0416752A BRPI0416752A BR PI0416752 A BRPI0416752 A BR PI0416752A BR PI0416752 A BRPI0416752 A BR PI0416752A BR PI0416752 A BRPI0416752 A BR PI0416752A
Authority
BR
Brazil
Prior art keywords
compounds
pharmaceutical composition
prevention
disorders
treatment
Prior art date
Application number
BRPI0416752-0A
Other languages
English (en)
Inventor
Martin Bolli
Michael Scherz
Claus Mueller
Boris Mathys
Christoph Binkert
Oliver Nayler
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34639216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0416752(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0416752A publication Critical patent/BRPI0416752A/pt
Publication of BRPI0416752B1 publication Critical patent/BRPI0416752B1/pt
Publication of BRPI0416752B8 publication Critical patent/BRPI0416752B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA, USO DE UM OU MAIS COMPOSTOS, MéTODO PARA A PREVENçãO OU TRATAMENTO DE DISTúRBIOS, COMPOSTOS, E, PROCESSO PARA A PREPARAçãO DE UMA COMPOSIçãO FARMACêUTICA". A invenção refere-se a composições farmacêuticas contendo pelo menos um derivado de 5-(benz-(Z)-ilideno-tiazolidin-4-ona (I) para evitar ou tratar distúrbios associados com um sistema imune ativado. Além disso, a invenção refere-se a novos derivados de tiazolidin-4-ona, notavelmente para uso como compostos farmaceuticamente ativos. Ditos compostos atuam particularmente também como agentes imunossupressores.
BRPI0416752A 2003-11-21 2004-11-16 composição farmacêutica, uso de um ou mais compostos, e, compostos BRPI0416752B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0313072 2003-11-21
PCT/EP2004/012953 WO2005054215A1 (en) 2003-11-21 2004-11-16 5-(benz- (z) -ylidene) -thiazolidin-4-one derivatives as immunosuppressant agents

Publications (3)

Publication Number Publication Date
BRPI0416752A true BRPI0416752A (pt) 2007-02-27
BRPI0416752B1 BRPI0416752B1 (pt) 2019-11-05
BRPI0416752B8 BRPI0416752B8 (pt) 2021-05-25

Family

ID=34639216

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416752A BRPI0416752B8 (pt) 2003-11-21 2004-11-16 composição farmacêutica, uso de um ou mais compostos, e, compostos

Country Status (26)

Country Link
US (8) US7435828B2 (pt)
EP (2) EP1689726B1 (pt)
JP (2) JP4061332B2 (pt)
KR (1) KR100783835B1 (pt)
CN (1) CN100567275C (pt)
AR (1) AR047128A1 (pt)
AT (1) ATE483698T1 (pt)
AU (1) AU2004295047B2 (pt)
BR (1) BRPI0416752B8 (pt)
CA (1) CA2545582C (pt)
CY (1) CY1111087T1 (pt)
DE (1) DE602004029493D1 (pt)
DK (1) DK1689726T3 (pt)
ES (1) ES2352555T3 (pt)
HR (1) HRP20100714T1 (pt)
IL (1) IL175758A (pt)
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US8524752B2 (en) 2013-09-03
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US7435828B2 (en) 2008-10-14
JP2007511563A (ja) 2007-05-10
JP2008081504A (ja) 2008-04-10
NZ547962A (en) 2010-06-25
HRP20100714T1 (hr) 2011-01-31
IL175758A0 (en) 2006-09-05
CA2545582A1 (en) 2005-06-16
JP4129286B2 (ja) 2008-08-06
USRE45174E1 (en) 2014-09-30
USRE43728E1 (en) 2012-10-09
TWI323659B (en) 2010-04-21
PT1689726E (pt) 2010-12-09
AU2004295047A1 (en) 2005-06-16
US20080280962A1 (en) 2008-11-13
US20080146629A1 (en) 2008-06-19
CN1882555A (zh) 2006-12-20
DE602004029493D1 (de) 2010-11-18
SI1689726T1 (sl) 2011-01-31
JP4061332B2 (ja) 2008-03-19
DK1689726T3 (da) 2010-12-06
EP1689726B1 (en) 2010-10-06
MY145074A (en) 2011-12-15
NO336734B1 (no) 2015-10-26
US20090275625A1 (en) 2009-11-05
US9000018B2 (en) 2015-04-07
CN100567275C (zh) 2009-12-09
TW200528097A (en) 2005-09-01
NO20062483L (no) 2006-08-10
US7875726B2 (en) 2011-01-25
RU2379299C2 (ru) 2010-01-20
ZA200605077B (en) 2007-05-30
AU2004295047B2 (en) 2011-03-10
RU2006121651A (ru) 2008-01-10
BRPI0416752B8 (pt) 2021-05-25
US7626037B2 (en) 2009-12-01
AR047128A1 (es) 2006-01-11
US20070082933A1 (en) 2007-04-12
BRPI0416752B1 (pt) 2019-11-05
KR20060117328A (ko) 2006-11-16
US20120302612A1 (en) 2012-11-29
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US20130310432A1 (en) 2013-11-21
ATE483698T1 (de) 2010-10-15
ES2352555T3 (es) 2011-02-21
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WO2005054215A1 (en) 2005-06-16
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