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BRPI0409977A - derivados de aminopropanol como moduladores de receptores esfingosina-1-fosfato - Google Patents

derivados de aminopropanol como moduladores de receptores esfingosina-1-fosfato

Info

Publication number
BRPI0409977A
BRPI0409977A BRPI0409977-0A BRPI0409977A BRPI0409977A BR PI0409977 A BRPI0409977 A BR PI0409977A BR PI0409977 A BRPI0409977 A BR PI0409977A BR PI0409977 A BRPI0409977 A BR PI0409977A
Authority
BR
Brazil
Prior art keywords
sphingosine
receptor modulators
phosphate receptor
aminopropanol derivatives
aminopropanol
Prior art date
Application number
BRPI0409977-0A
Other languages
English (en)
Inventor
Rainer Albert
Claus Ehrhardt
Peter Ettmayer
Klaus Hinterding
Klemens Hoegenauer
Peter Nussbaumer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329494A external-priority patent/GB0329494D0/en
Priority claimed from GB0329501A external-priority patent/GB0329501D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0409977A publication Critical patent/BRPI0409977A/pt

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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Abstract

"DERIVADOS DE AMINOPROPANOL COMO MODULADORES DE RECEPTORES ESFINGOSINA-1-FOSFATO". A invenção refere-se a compostos da fórmula (I) nos quais X, a, b, R~ 1~, R~ 2~, R~ 3~, R~ 4~ e R~ 5~ são como definidos no relatório descritivo, processos para sua produção, seus usos, e composições farmacêuticas que os contêm.
BRPI0409977-0A 2003-04-30 2004-04-29 derivados de aminopropanol como moduladores de receptores esfingosina-1-fosfato BRPI0409977A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0309946 2003-04-30
GB0329494A GB0329494D0 (en) 2003-12-19 2003-12-19 Organic compounds
GB0329501A GB0329501D0 (en) 2003-12-19 2003-12-19 Organic compounds
PCT/EP2004/004572 WO2004096757A1 (en) 2003-04-30 2004-04-29 Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators

Publications (1)

Publication Number Publication Date
BRPI0409977A true BRPI0409977A (pt) 2006-05-09

Family

ID=33424536

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409977-0A BRPI0409977A (pt) 2003-04-30 2004-04-29 derivados de aminopropanol como moduladores de receptores esfingosina-1-fosfato

Country Status (10)

Country Link
US (1) US7825260B2 (pt)
EP (1) EP1622866B1 (pt)
JP (1) JP4638410B2 (pt)
CN (1) CN1809531B (pt)
AU (1) AU2004234067B2 (pt)
BR (1) BRPI0409977A (pt)
CA (1) CA2523677A1 (pt)
ES (1) ES2392167T3 (pt)
MX (1) MXPA05011597A (pt)
WO (1) WO2004096757A1 (pt)

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