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BRPI0407694A - métodos de usar células derivadas do tecido adiposo no tratamento de condições cardiovasculares - Google Patents

métodos de usar células derivadas do tecido adiposo no tratamento de condições cardiovasculares

Info

Publication number
BRPI0407694A
BRPI0407694A BRPI0407694-0A BRPI0407694A BRPI0407694A BR PI0407694 A BRPI0407694 A BR PI0407694A BR PI0407694 A BRPI0407694 A BR PI0407694A BR PI0407694 A BRPI0407694 A BR PI0407694A
Authority
BR
Brazil
Prior art keywords
methods
cardiovascular conditions
fat
treatment
derived cells
Prior art date
Application number
BRPI0407694-0A
Other languages
English (en)
Inventor
John K Fraser
Marc H Hedrick
Min Zhu
Brian M Strem
Eric Daniels
Isabella Wulur
Original Assignee
Macropore Biosurgery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32912320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0407694(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Macropore Biosurgery Inc filed Critical Macropore Biosurgery Inc
Publication of BRPI0407694A publication Critical patent/BRPI0407694A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

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  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Rheumatology (AREA)
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  • Dermatology (AREA)
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  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract

"MéTODOS DE USAR CéLULAS DERIVADAS DO TECIDO ADIPOSO NO TRATAMENTO DE CONDIçõES CARDIOVASCULARES". Células presentes em tecido lipoaspirado processado são usadas para tratar pacientes, incluindo pacientes com condições, doenças ou desordens vasculares. Métodos de tratamento de pacientes incluem processamento do tecido adiposo pára entregar uma quantidade concentrada de células-tronco obtidas do tecido adiposo a um paciente. os métodos podem ser praticados em um sistema fechado, de maneira tal que as células-tronco não fiquem expostas a um ambiente externo antes de ser administrada a um paciente. Dessa maneira, em um método preferido, células presentes em lipoaspirado processado são colocadas diretamente em um recipiente juntamente com tais aditivos necessários para promover, engendrar ou suportar um beneficio cardiovascular terapêutico.
BRPI0407694-0A 2003-02-20 2004-02-20 métodos de usar células derivadas do tecido adiposo no tratamento de condições cardiovasculares BRPI0407694A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44927903P 2003-02-20 2003-02-20
US46291103P 2003-04-15 2003-04-15
PCT/US2004/005117 WO2004074457A2 (en) 2003-02-20 2004-02-20 Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions

Publications (1)

Publication Number Publication Date
BRPI0407694A true BRPI0407694A (pt) 2006-03-01

Family

ID=32912320

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407694-0A BRPI0407694A (pt) 2003-02-20 2004-02-20 métodos de usar células derivadas do tecido adiposo no tratamento de condições cardiovasculares

Country Status (13)

Country Link
EP (2) EP2422622B1 (pt)
JP (1) JP4971787B2 (pt)
KR (2) KR101310578B1 (pt)
AT (1) ATE524070T1 (pt)
AU (1) AU2004213858B2 (pt)
BR (1) BRPI0407694A (pt)
CA (1) CA2516510C (pt)
DK (1) DK1599575T3 (pt)
ES (1) ES2373551T3 (pt)
IL (2) IL170354A (pt)
MX (1) MXPA05009044A (pt)
RU (1) RU2372924C2 (pt)
WO (1) WO2004074457A2 (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030007954A1 (en) 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US7514075B2 (en) 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
KR101083454B1 (ko) 2001-12-07 2011-11-16 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한 시스템 및 방법
DK2348103T3 (da) * 2003-09-17 2019-09-30 Lorem Vascular Pte Ltd Fremgangsmåder til anvendelse af regenerative celler til behandling af perifer karsygdom og beslægtede sygdomme
JP2007508018A (ja) 2003-10-08 2007-04-05 べト−ステム インコーポレイテッド 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット
JP4731556B2 (ja) * 2004-07-02 2011-07-27 サイトリ セラピューティクス インコーポレイテッド 臨床的に安全な脂肪組織由来再生細胞を単離し、使用するためのシステムおよび方法
EP1838840B1 (en) * 2004-11-22 2011-03-09 Theregen, Inc. Use of cultured three-dimensional tissue for treating congestive heart failure
EP1830862B1 (en) 2004-12-30 2012-12-19 PrimeGen Biotech LLC Adipose-derived stem cells for tissue regeneration and wound healing
KR100811537B1 (ko) 2005-03-11 2008-03-20 양영일 지방조직 치료제의 조성, 이들 제조방법 및 그의 전달방법
AU2013216683B2 (en) * 2005-05-25 2016-06-23 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
DK1885382T3 (da) * 2005-05-25 2011-06-20 Cytori Therapeutics Inc Fremgangsmåder til anvendelse af adipøst vævs-afledte celler i behandlingen af cardiovaskulære tilstande
RU2355325C2 (ru) * 2006-08-01 2009-05-20 Федеральное государственное учреждение Новосибирский научно-исследовательский институт патологии кровообращения имени акад. Е.Н. Мешалкина Федерального агентства по высокотехнологичной медицинской помощи Способ лечения инфаркта миокарда
RU2010109698A (ru) * 2007-09-19 2011-09-27 Плуристем Лтд. (Il) Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях
ES2478678T3 (es) * 2007-11-30 2014-07-22 Rnl Bio Co., Ltd. Agente terapéutico celular para la incontinencia urinaria que comprende células madre originadas a partir de decidua
JP5015865B2 (ja) * 2008-06-09 2012-08-29 オリンパス株式会社 脂肪組織洗浄装置
KR20100008763A (ko) * 2008-07-16 2010-01-26 주식회사 알앤엘바이오 지방조직 유래 다분화능 줄기세포의 배양물 및 그 추출 단백질을 함유한 화장료용 조성물
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
ES2625893T3 (es) 2009-05-01 2017-07-20 Bimini Technologies Llc Sistemas, procedimientos y composiciones para optimizar injertos enriquecidos con tejido y células
JP5710885B2 (ja) * 2010-02-25 2015-04-30 オリンパス株式会社 脂肪由来細胞の賦活化方法および移植材の製造方法
WO2012018127A1 (ja) * 2010-08-06 2012-02-09 国立大学法人大阪大学 膵島と脂肪組織由来幹細胞を利用した膵島移植
CA2814657A1 (en) 2010-10-12 2012-04-19 Kevin J. Tanis Medical device
SG10201800017RA (en) * 2012-02-24 2018-02-27 Masanori Saeki Cell preparation including fat cell
KR101467481B1 (ko) * 2012-04-13 2014-12-01 라정찬 줄기세포의 파쇄 및 응집 방지 방법 및 조성물
AU2013264938B2 (en) 2012-05-22 2017-11-23 Smith & Nephew Plc Apparatuses and methods for wound therapy
DE102013209718B4 (de) * 2012-06-22 2015-09-10 Human Med Ag Vorrichtung zum Separieren von adulten Stammzellen
RU2522778C2 (ru) * 2012-10-08 2014-07-20 Федеральное государственное бюджетное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения Российской Федерации Средство для лечения ишемических поражений тканей и способ его применения
US9737649B2 (en) 2013-03-14 2017-08-22 Smith & Nephew, Inc. Systems and methods for applying reduced pressure therapy
AU2014236701B2 (en) 2013-03-14 2018-07-19 Smith & Nephew Inc. Systems and methods for applying reduced pressure therapy
US9580678B2 (en) 2013-06-21 2017-02-28 The Regents Of The University Of California Microfluidic tumor tissue dissociation device
US12133789B2 (en) 2014-07-31 2024-11-05 Smith & Nephew, Inc. Reduced pressure therapy apparatus construction and control
JP6942698B2 (ja) 2015-10-07 2021-09-29 スミス アンド ネフュー インコーポレイテッド 減圧療法を施すためのシステムおよび方法
US10722540B1 (en) 2016-02-01 2020-07-28 The Regents Of The University Of California Microfluidic device and method for shear stress-induced transformation of cells
RU2627606C1 (ru) * 2016-05-05 2017-08-09 Константин Валентинович Котенко Способ обработки липоаспирата
WO2017197357A1 (en) 2016-05-13 2017-11-16 Smith & Nephew Plc Automatic wound coupling detection in negative pressure wound therapy systems
KR102579835B1 (ko) 2016-06-08 2023-09-15 더 리전트 오브 더 유니버시티 오브 캘리포니아 조직 및 세포를 프로세싱하기 위한 방법 및 장치
US12263294B2 (en) 2016-09-28 2025-04-01 T.J.Smith And Nephew, Limited Systems and methods for operating negative pressure wound therapy devices
EP3519002B1 (en) 2016-09-29 2025-01-29 Smith & Nephew, Inc Construction and protection of components in negative pressure wound therapy systems
WO2018165049A1 (en) 2017-03-07 2018-09-13 Smith & Nephew, Inc. Reduced pressure therapy systems and methods including an antenna
US11712508B2 (en) 2017-07-10 2023-08-01 Smith & Nephew, Inc. Systems and methods for directly interacting with communications module of wound therapy apparatus
CN108277152B (zh) * 2018-04-04 2023-10-13 博品(上海)生物医药科技有限公司 细胞复苏用无菌换液装置及利用该装置进行细胞复苏换液的方法
GB201820668D0 (en) 2018-12-19 2019-01-30 Smith & Nephew Inc Systems and methods for delivering prescribed wound therapy
GB201911693D0 (en) 2019-08-15 2019-10-02 Smith & Nephew Systems and methods for monitoring essential performance of wound therapy
US20230063104A1 (en) * 2020-02-04 2023-03-02 Hierabio Inc Composition for intrapericardial injection comprising stem cells and use thereof
KR102844218B1 (ko) 2021-02-09 2025-08-11 인제대학교 산학협력단 심혈관 질환 치료를 위한 양막 유래 중간엽 줄기세포 전달체

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000275A (en) * 1969-11-24 1976-12-28 Eli Lilly And Company Immunosuppressants
US4346703A (en) 1979-01-23 1982-08-31 Baxter Travenol Laboratories, Inc. Solution container for continuous ambulatory peritoneal dialysis
US5034135A (en) 1982-12-13 1991-07-23 William F. McLaughlin Blood fractionation system and method
US5372945A (en) 1985-06-06 1994-12-13 Alchas; Paul G. Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endothelial cell product
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5641622A (en) 1990-09-13 1997-06-24 Baxter International Inc. Continuous centrifugation process for the separation of biological components from heterogeneous cell populations
US5234608A (en) 1990-12-11 1993-08-10 Baxter International Inc. Systems and methods for processing cellular rich suspensions
EP0563364A4 (en) 1991-10-18 1994-08-17 Baxter Int Bone marrow kit
ZA932660B (en) * 1992-04-17 1993-10-26 Sankyo Co Derivatives of adipogenesis inhibitory factor, their preparation and their use
US5968753A (en) 1994-06-14 1999-10-19 Nexell Therapeutics, Inc. Positive and positive/negative cell selection mediated by peptide release
US6238908B1 (en) 1995-06-07 2001-05-29 Aastrom Biosciences, Inc. Apparatus and method for maintaining and growth biological cells
FR2742662B1 (fr) 1995-12-21 1998-01-23 Centre Nat Rech Scient Anticorps anti-idiotypiques du facteur de croissance endotheliale vasculaire et leur utilisation comme medicaments
US5830714A (en) 1996-04-17 1998-11-03 Molecular Biology Resources, Inc. Biologically active fragment of bacillus stearothermophilus DNA polymerase
US5869037A (en) * 1996-06-26 1999-02-09 Cornell Research Foundation, Inc. Adenoviral-mediated gene transfer to adipocytes
AU5222498A (en) 1996-11-19 1998-06-10 Boehringer Mannheim Gmbh Type i recombinant clostridium histolyticum collagenase and its use for isolating cells and cell aggregates
US5830741A (en) 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
US6451207B1 (en) 1997-06-04 2002-09-17 Dexter Magnetic Technologies, Inc. Magnetic cell separation device
WO1999011771A1 (en) 1997-09-04 1999-03-11 Science Research Laboratory, Inc. Cell separation using electric fields
US6251295B1 (en) 1998-01-08 2001-06-26 Nexell Therapeutics Inc. Method for recirculation washing of blood cells
US6001642A (en) 1998-06-29 1999-12-14 Wyle Laboratories, Inc. Life Sciences Bioreactor and cell culturing processes using the bioreactor
DE19841835C2 (de) 1998-09-12 2003-05-28 Fresenius Ag Zentrifugenkammer für einen Zellseparator
IL145002A0 (en) * 1999-03-10 2002-06-30 Univ Pittsburgh Adipose-derived stem cells and lattices
US6316247B1 (en) 1999-06-15 2001-11-13 University Of Pittsburgh System and method for refining liposuctioned adipose tissue
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
EP1361896A2 (en) * 2001-01-23 2003-11-19 Boston Scientific Corporation Localized myocardial injection method for treating ischemic myocardium
US20030054331A1 (en) * 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
KR101083454B1 (ko) * 2001-12-07 2011-11-16 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한 시스템 및 방법
US20050250202A1 (en) * 2002-03-19 2005-11-10 March Keith L Adipose stromal stem cells for tissue and vascular modification
CA2550961A1 (en) * 2003-12-25 2005-07-14 Kanazawa University Technology Licensing Organization Ltd. Induction of myocardial cell with the use of mammalian bone marrow cell or cord blood-origin cell and fat tissue

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IL214373A0 (en) 2011-09-27
JP4971787B2 (ja) 2012-07-11
HK1102085A1 (en) 2007-11-02
ES2373551T3 (es) 2012-02-06
JP2007525422A (ja) 2007-09-06
ATE524070T1 (de) 2011-09-15
DK1599575T3 (da) 2012-01-16
WO2004074457A3 (en) 2006-05-18
CA2516510C (en) 2012-07-10
AU2004213858B2 (en) 2009-01-22
KR20120038534A (ko) 2012-04-23
KR20050109941A (ko) 2005-11-22
EP1599575B9 (en) 2012-03-14
MXPA05009044A (es) 2006-03-17
WO2004074457A2 (en) 2004-09-02
KR101310578B1 (ko) 2013-09-23
EP2422622A1 (en) 2012-02-29
EP1599575A4 (en) 2007-08-08
CA2516510A1 (en) 2004-09-02
EP1599575A2 (en) 2005-11-30
EP2422622B1 (en) 2017-01-11
IL170354A (en) 2011-07-31
EP1599575B1 (en) 2011-09-14
IL214373A (en) 2014-09-30
AU2004213858A1 (en) 2004-09-02

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