BR9916041A - Compound, pharmaceutical composition, and methods to inhibit the replication of a herpes virus and to treat a patient suffering from an infection with herpes virus - Google Patents
Compound, pharmaceutical composition, and methods to inhibit the replication of a herpes virus and to treat a patient suffering from an infection with herpes virusInfo
- Publication number
- BR9916041A BR9916041A BR9916041-2A BR9916041A BR9916041A BR 9916041 A BR9916041 A BR 9916041A BR 9916041 A BR9916041 A BR 9916041A BR 9916041 A BR9916041 A BR 9916041A
- Authority
- BR
- Brazil
- Prior art keywords
- carbon atoms
- alkyl
- herpes virus
- virus
- carbon
- Prior art date
Links
- 241001529453 unidentified herpesvirus Species 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000010076 replication Effects 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 21
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 abstract 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 abstract 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 abstract 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 abstract 1
- 241000700584 Simplexvirus Species 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, MéTODOSPARA INIBIR A REPLICAçãO DE UM VìRUS DO HERPES EPARA TRATAR UM PACIENTE SOFRENDO DE UMA INFECçãOPOR VìRUS DO HERPES". Em que R~ 1~-R~ 5~ sãoindependentemente selecionados dentre hidrogênio, alquila de 1 a6 átomos de carbono, alquenila de 2 a 6 átomos de carbono,alquinila de 2 a 6 átomos de carbono, per-haloalquila de 1 a 6átomos de carbono, cicloalquila de 3 a 10 átomos de carbono,heterocicloalquila de 3 a 10 membros de carbono, arila, heteroarila,halogênio, -CN, -NO~ 2~, -CO~ 2~R~ 6~, COR~ 6~, -OR~ 6~,-SR~ 6~, -SOR~ 6~, -SO~ 2~R~ 6~, -CONR~ 7~R~ 8~, -NR~6~N (R~ 7~R~ 8~), -N(R~ 7~R~ 8~) ou W-Y-(CH~ 2~)~ n~-Z,com a condição de que pelo menos um de R~ 1~-R~ 5~ não éhidrogênio; ou R~ 2~ e R~ 3~ ou R~ 3~ e R~ 4~, tomados juntos,formam uma heterocicloalquila de 3 a 7 membros ou heteroarila de3 a 7 membros; R~ 6~ e R~ 7~ são independentementehidrogênio, alquila de 1 a 6 átomos de carbono, perhaloalquila de 1a 6 átomos de carbono, ou arila; R~ 8~ é hidrogênio, alquila de 1 a6 átomos de carbono, per-haloalquila de 1 a 6 átomos de carbono,cicloalquila de 3 a 10 átomos de carbono, heterocicloalquila de 3 a10 membros, arila ou heteroarila, ou R~ 7~ e R~ 8~, tomadosjuntos, podem formar uma heterocicloalquila de 3 a 7 membros; R~9~-R~ 12~ são independentemente hidrogênio, alquila de 1 a 4átomos de carbono, per-haloalquila de 1 a 4 átomos de carbono,halogênio, alcoxi de 1 a 4 átomos de carbono, ou ciano, ou R~ 9~e R~ 10~ ou R~ 11~, e R~ 12~ podem ser tomados juntos paraformar arila de 5 a 7 átomos de carbono; W é 0, NR~ 6~ ou estáausente; Y é -(CO)-ou -(CO~ 2~)-, ou está ausente; Z é alquila de 1a 4 átomos de carbono, -CN, -CO~ 2~R~ 6~, -COR~ 6~, CONR~7~R~ 8~, -OCOR~ 6~, -NR~ 6~COR~ 7~, -OCONR~ 6~, -OR~6~, -SOR~ 6~, -SO~ 2~ R~ 6~, SR~ 6~N(R~ 7~R~ 8~), -N (R~7~R~ 8~) ou fenila; G é alquila de 1 a 6 átomos de carbono, X éuma ligação, -NH, alquila de 1 a 6 átomos de carbono, alquenila de1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono,tioalquila de 1 a 6 átomos de carbono, alquilamino de 1 a 6 átomosde carbono, ou (CH)J; J é alquila de 1 a 6 átomos de carbono,cicloalquila de 3 a 7 átomos de carbono, fenila ou benzila; e n é uminteiro de 1 a 6; ou sais 1 farmacêuticos dos mesmos, sãoutilizáveis no tratamento de doenças associadas com vírus doherpes incluindo citomegalovírus humano, vírus de herpes simplex,vírus Epstein-Barr, vírus de varicella-zoster, vírus de herpeshumano 6 e 7, e vírus de herpes de Kaposi."COMPOUND, PHARMACEUTICAL COMPOSITION, AND, METHODS TO INHIBIT THE REPLICATION OF A HERPES VIRUS AND TO TREAT A PATIENT SUFFECTING AN INFECTION BY HERPES VIRUS". Where R ~ 1 ~ -R ~ 5 ~ are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 atoms of carbon, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, -CN, -NO ~ 2 ~, -CO ~ 2 ~ R ~ 6 ~, COR ~ 6 ~, -OR ~ 6 ~, -SR ~ 6 ~, -SOR ~ 6 ~, -SO ~ 2 ~ R ~ 6 ~, -CONR ~ 7 ~ R ~ 8 ~, -NR ~ 6 ~ N (R ~ 7 ~ R ~ 8 ~), -N (R ~ 7 ~ R ~ 8 ~) or WY- (CH ~ 2 ~) ~ n ~ -Z, with the proviso that at least one of R ~ 1 ~ -R ~ 5 ~ it is not hydrogen; or R ~ 2 ~ and R ~ 3 ~ or R ~ 3 ~ and R ~ 4 ~, taken together, form a 3- to 7-membered heterocycloalkyl or 3- to 7-membered heteroaryl; R ~ 6 ~ and R ~ 7 ~ are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R ~ 8 ~ is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, 3 to 10 membered heterocycloalkyl, aryl or heteroaryl, or R ~ 7 ~ and R ~ 8 ~, taken together, can form a 3- to 7-membered heterocycloalkyl; R ~ 9 ~ -R ~ 12 ~ are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyan, or R ~ 9 ~ and R ~ 10 ~ or R ~ 11 ~, and R ~ 12 ~ can be taken together to form aryl of 5 to 7 carbon atoms; W is 0, NR ~ 6 ~ or absent; Y is - (CO) -or - (CO ~ 2 ~) -, or is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -CO ~ 2 ~ R ~ 6 ~, -COR ~ 6 ~, CONR ~ 7 ~ R ~ 8 ~, -COLOR ~ 6 ~, -NR ~ 6 ~ COLOR ~ 7 ~, -OCONR ~ 6 ~, -OR ~ 6 ~, -SOR ~ 6 ~, -SO ~ 2 ~ R ~ 6 ~, SR ~ 6 ~ N (R ~ 7 ~ R ~ 8 ~), -N (R ~ 7 ~ R ~ 8 ~) or phenyl; G is alkyl of 1 to 6 carbon atoms, X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 atoms carbon, alkylamino of 1 to 6 carbon atoms, or (CH) J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is 1 to 6; or pharmaceutical salts thereof, are usable in the treatment of diseases associated with doherpes viruses including human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, herpeshuman virus 6 and 7, and Kaposi herpes virus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20831698A | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/028844 WO2000034237A2 (en) | 1998-12-09 | 1999-12-06 | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9916041A true BR9916041A (en) | 2001-12-04 |
Family
ID=22774137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9916041-2A BR9916041A (en) | 1998-12-09 | 1999-12-06 | Compound, pharmaceutical composition, and methods to inhibit the replication of a herpes virus and to treat a patient suffering from an infection with herpes virus |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1137633A2 (en) |
| JP (1) | JP2002531544A (en) |
| KR (1) | KR20010087413A (en) |
| CN (1) | CN1333750A (en) |
| AU (1) | AU3111200A (en) |
| BR (1) | BR9916041A (en) |
| CA (1) | CA2350899A1 (en) |
| CZ (1) | CZ20012060A3 (en) |
| EA (1) | EA200100640A1 (en) |
| HU (1) | HUP0104944A3 (en) |
| IL (1) | IL143204A0 (en) |
| NO (1) | NO20012834L (en) |
| PL (1) | PL349131A1 (en) |
| WO (1) | WO2000034237A2 (en) |
| ZA (1) | ZA200104142B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| ATE311366T1 (en) | 2000-02-29 | 2005-12-15 | Millennium Pharm Inc | BENZAMIDE AND SIMILAR FACTOR XA INHIBITORS |
| RU2005115842A (en) * | 2002-10-24 | 2006-03-10 | Мерк Патент ГмбХ (DE) | METHYLENE DERIVATIVES |
| US7220768B2 (en) * | 2003-02-11 | 2007-05-22 | Wyeth Holdings Corp. | Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus |
| WO2005014825A2 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| WO2005021488A1 (en) | 2003-08-29 | 2005-03-10 | Mitsui Chemicals, Inc. | Insecticide for agricultural or horticultural use and method of use thereof |
| JP2007528409A (en) | 2004-03-09 | 2007-10-11 | アリバ ファーマシューティカルズ， インコーポレイテッド | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitors |
| US20100093864A1 (en) * | 2006-10-13 | 2010-04-15 | Lica Pharmaceuticals | Anti-infective thiourea compounds |
| ES2550057T3 (en) | 2006-11-02 | 2015-11-04 | Millennium Pharmaceuticals, Inc. | Methods for synthesizing pharmaceutical salts of a Factor Xa inhibitor |
| CN108619123A (en) * | 2018-03-13 | 2018-10-09 | 武汉威立得生物医药有限公司 | Tenovin-1 is preparing the application in preventing nerpes vinrus hominis's infection medicine |
| WO2019193541A1 (en) * | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| CN112807294B (en) * | 2019-11-18 | 2023-09-05 | 武汉大学 | Application of an acylthiourea compound in the preparation of medicines for treating or preventing herpes simplex virus type I infection |
| WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE298741T1 (en) * | 1997-04-10 | 2005-07-15 | Pharmacia & Upjohn Co Llc | POLYAROMATIC COMPOUNDS FOR THE TREATMENT OF HERPES INFECTIONS |
-
1999
- 1999-12-06 EP EP99965132A patent/EP1137633A2/en not_active Withdrawn
- 1999-12-06 JP JP2000586685A patent/JP2002531544A/en active Pending
- 1999-12-06 BR BR9916041-2A patent/BR9916041A/en not_active Application Discontinuation
- 1999-12-06 EA EA200100640A patent/EA200100640A1/en unknown
- 1999-12-06 KR KR1020017007052A patent/KR20010087413A/en not_active Withdrawn
- 1999-12-06 CA CA002350899A patent/CA2350899A1/en not_active Abandoned
- 1999-12-06 HU HU0104944A patent/HUP0104944A3/en unknown
- 1999-12-06 AU AU31112/00A patent/AU3111200A/en not_active Abandoned
- 1999-12-06 CN CN99815640A patent/CN1333750A/en active Pending
- 1999-12-06 IL IL14320499A patent/IL143204A0/en unknown
- 1999-12-06 WO PCT/US1999/028844 patent/WO2000034237A2/en not_active Ceased
- 1999-12-06 CZ CZ20012060A patent/CZ20012060A3/en unknown
- 1999-12-06 PL PL99349131A patent/PL349131A1/en not_active Application Discontinuation
-
2001
- 2001-05-21 ZA ZA200104142A patent/ZA200104142B/en unknown
- 2001-06-08 NO NO20012834A patent/NO20012834L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002531544A (en) | 2002-09-24 |
| EA200100640A1 (en) | 2001-12-24 |
| CA2350899A1 (en) | 2000-06-15 |
| NO20012834L (en) | 2001-08-07 |
| WO2000034237A2 (en) | 2000-06-15 |
| CN1333750A (en) | 2002-01-30 |
| WO2000034237A3 (en) | 2000-11-23 |
| IL143204A0 (en) | 2002-04-21 |
| HUP0104944A3 (en) | 2003-03-28 |
| PL349131A1 (en) | 2002-07-01 |
| CZ20012060A3 (en) | 2001-11-14 |
| ZA200104142B (en) | 2002-10-25 |
| HUP0104944A2 (en) | 2002-04-29 |
| NO20012834D0 (en) | 2001-06-08 |
| AU3111200A (en) | 2000-06-26 |
| KR20010087413A (en) | 2001-09-15 |
| EP1137633A2 (en) | 2001-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |