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BR9915648A - Benzo [de] substituted isoquinoline-1,3-diones - Google Patents

Benzo [de] substituted isoquinoline-1,3-diones

Info

Publication number
BR9915648A
BR9915648A BR9915648-2A BR9915648A BR9915648A BR 9915648 A BR9915648 A BR 9915648A BR 9915648 A BR9915648 A BR 9915648A BR 9915648 A BR9915648 A BR 9915648A
Authority
BR
Brazil
Prior art keywords
benzo
diones
substituted isoquinoline
substituted
isoquinoline
Prior art date
Application number
BR9915648-2A
Other languages
Portuguese (pt)
Inventor
Werner Mederski
Ralf Devant
Gerhard Barnickel
Sabine Bernotat-Danielowski
Guido Melzer
Peter Raddatz
Zhengdong Wu
Daljit Dhanoa
Richard Soll
James Rinker
Todd Graybill
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9915648A publication Critical patent/BR9915648A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"BENZO [DE] ISOQUINOLINA-1,3-DIONAS SUBSTITUìDAS"<D>. Novos compostos da fórmula I onde R, R¹ e R² têm o significado indicado, e seus sais ou solvatos como antagonistas de glicoproteína IbIX.Invention Patent: <B> "BENZO [DE] ISOQUINOLINA-1,3-DIONAS SUBSTITUTED" <D>. New compounds of formula I where R, R¹ and R² have the indicated meaning, and their salts or solvates as glycoprotein antagonists IbIX.

BR9915648-2A 1998-11-25 1999-11-09 Benzo [de] substituted isoquinoline-1,3-diones BR9915648A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19941398A 1998-11-25 1998-11-25
US39878399A 1999-09-20 1999-09-20
PCT/EP1999/008561 WO2000032577A2 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones

Publications (1)

Publication Number Publication Date
BR9915648A true BR9915648A (en) 2001-08-14

Family

ID=26894745

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915648-2A BR9915648A (en) 1998-11-25 1999-11-09 Benzo [de] substituted isoquinoline-1,3-diones

Country Status (15)

Country Link
EP (1) EP1144381A2 (en)
JP (1) JP2002537225A (en)
KR (1) KR20010080569A (en)
CN (1) CN1330638A (en)
AU (1) AU760136B2 (en)
BR (1) BR9915648A (en)
CA (1) CA2352045A1 (en)
CZ (1) CZ20011782A3 (en)
HU (1) HUP0104520A3 (en)
ID (1) ID28982A (en)
NO (1) NO20012544L (en)
PL (1) PL348204A1 (en)
SK (1) SK7022001A3 (en)
TW (1) TW473474B (en)
WO (1) WO2000032577A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007421A1 (en) * 1996-08-16 1998-02-26 Ishihara Sangyo Kaisha, Ltd. Medicinal composition
EP1088821A1 (en) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
JP4448902B2 (en) * 2001-06-08 2010-04-14 株式会社医薬分子設計研究所 Sulfonamide derivatives
US6693198B2 (en) * 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
US8097725B2 (en) 2004-12-03 2012-01-17 Roche Diagnostics Operations, Inc. Luminescent indicator dye and optical sensor
FR2915685A1 (en) * 2007-05-02 2008-11-07 Thales Sa New fluorescent compounds of solid state in water, with naphthalimide base, useful for allowing the grafting on transducer, which is a biological substance, in biosensor and security or explosive detectors, and as markers
WO2014149198A1 (en) * 2013-03-15 2014-09-25 Alumend, Llc Compositions and methods of using the compositions for plaque softening
CN107417616A (en) * 2013-05-01 2017-12-01 中央研究院 Methods and compositions for treating beta-thalassemia and sickle cell disease
CN103450176B (en) * 2013-08-15 2016-07-06 大连理工大学 A class of 2-(4-aminophenyl) benzothiazole naphthalimide compounds and applications thereof
US20170283408A1 (en) 2014-09-19 2017-10-05 Yen-Ta Lu Benzo-heterocyclic compounds and their applications
CN106905237B (en) * 2017-02-08 2019-05-14 上海师范大学 A kind of pH and weary oxygen double-bang firecracker answer the naphthalimide ratio fluorescent probe and its synthetic method of positioning tumor cell
CN110283123B (en) * 2019-07-08 2022-06-17 桂林医学院 4-p-toluenesulfonyl piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof
CN110272388B (en) * 2019-07-08 2022-06-17 桂林医学院 4-dithioformic acid piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof
CN110407865B (en) * 2019-08-02 2022-04-15 山东师范大学 The compound of formula (I) based on benzenesulfonamide structure and its preparation method and application
CN111518075B (en) * 2020-04-17 2023-03-28 西南大学 Naphthalimide piperazine triazole compound and preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2423546C2 (en) * 1974-05-15 1983-01-27 Hoechst Ag, 6000 Frankfurt Process for the preparation of 4-amino-1,8-naphthalic acid-N-arylimide compounds
ES459497A1 (en) * 1977-06-04 1978-04-16 Made Labor Sa N(Aminoalkyl)-naphthalimides and their derivatives
DE3635711A1 (en) * 1986-10-21 1988-04-28 Knoll Ag 5-NITROBENZO (DE) ISOCHINOLIN-1,3-DIONE, THEIR PRODUCTION AND USE
DE69735090T2 (en) * 1996-10-21 2006-09-14 Nps Allelix Corp., Mississauga NEUROTROPHINE ANTAGONIST FOR THE TREATMENT OF EPILEPSIA, ALZHEIMER'S DISEASE AND PAIN
AU4946697A (en) * 1996-10-28 1998-05-22 Merck Patent Gmbh Dihydrobenzoanthracenone, -pyrimidinone or dihydronaphtoquinolinone

Also Published As

Publication number Publication date
ID28982A (en) 2001-07-19
HUP0104520A2 (en) 2002-04-29
SK7022001A3 (en) 2002-09-10
HUP0104520A3 (en) 2002-10-28
KR20010080569A (en) 2001-08-22
NO20012544D0 (en) 2001-05-23
WO2000032577A3 (en) 2000-09-21
PL348204A1 (en) 2002-05-06
CZ20011782A3 (en) 2001-09-12
AU760136B2 (en) 2003-05-08
TW473474B (en) 2002-01-21
CA2352045A1 (en) 2000-06-08
CN1330638A (en) 2002-01-09
AU2660300A (en) 2000-06-19
EP1144381A2 (en) 2001-10-17
WO2000032577A2 (en) 2000-06-08
NO20012544L (en) 2001-05-23
JP2002537225A (en) 2002-11-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.