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BR9913878A - Synthases - Google Patents

Synthases

Info

Publication number
BR9913878A
BR9913878A BR9913878-6A BR9913878A BR9913878A BR 9913878 A BR9913878 A BR 9913878A BR 9913878 A BR9913878 A BR 9913878A BR 9913878 A BR9913878 A BR 9913878A
Authority
BR
Brazil
Prior art keywords
synthases
active site
synthase
epi
tobacco
Prior art date
Application number
BR9913878-6A
Other languages
Portuguese (pt)
Inventor
Joseph Chappell
Kathleen R Manna
Joseph P Noel
Courtney M Starks
Original Assignee
Univ Kentucki Res Dept
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucki Res Dept, Salk Inst For Biological Studi filed Critical Univ Kentucki Res Dept
Publication of BR9913878A publication Critical patent/BR9913878A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"SINTASES"<D>. São divulgadas aqui novas sintases e os ácidos nucléicos correspondentes que codificam tais sintases. Tais sintases possuem uma bolsa de sítio ativo que inclui resíduos de aminoácido fundamentais que são modificados para gerar intermediários e produtos de reação terpenóides desejados. As modificações de sintase são projetadas baseadas, por exemplo, nas coordenadas tridimensionais de sintase de 5-epi-aristolocheno de tabaco, com ou sem um substrato ligado ao sítio ativo.Invention Patent: <B> "SYNTHASES" <D>. New synthases and the corresponding nucleic acids encoding such synthases are disclosed here. Such synthases have an active site pocket that includes fundamental amino acid residues that are modified to generate desired intermediates and terpenoid reaction products. The synthase modifications are designed based, for example, on the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate attached to the active site.

BR9913878-6A 1998-09-18 1999-09-17 Synthases BR9913878A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10099398P 1998-09-18 1998-09-18
US13062899P 1999-04-22 1999-04-22
US15026299P 1999-08-23 1999-08-23
PCT/US1999/021419 WO2000017327A2 (en) 1998-09-18 1999-09-17 Terpene synthases

Publications (1)

Publication Number Publication Date
BR9913878A true BR9913878A (en) 2001-06-12

Family

ID=27379113

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913878-6A BR9913878A (en) 1998-09-18 1999-09-17 Synthases

Country Status (13)

Country Link
US (6) US6468772B1 (en)
EP (3) EP2363458A3 (en)
JP (3) JP2002526066A (en)
AR (1) AR022383A1 (en)
AU (2) AU776690B2 (en)
BR (1) BR9913878A (en)
CA (1) CA2342053C (en)
EA (1) EA200100365A1 (en)
IL (1) IL141948A0 (en)
MX (1) MXPA01002805A (en)
NO (1) NO20011359L (en)
PL (1) PL347308A1 (en)
WO (1) WO2000017327A2 (en)

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US7192751B2 (en) * 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
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CN101835901B (en) * 2007-06-01 2013-03-06 蓝宝石能源公司 High throughput screening of genetically modified photosynthetic organisms
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CN110551645A (en) * 2019-08-08 2019-12-10 中国农业科学院植物保护研究所 Application of terpene synthase gene GhTPS14 in synthesis of nerolidol
CN111621508B (en) * 2020-06-11 2022-07-01 云南中烟工业有限责任公司 Tobacco terpenoid synthase NtTPS7 gene and its vector and application
CN112063608B (en) * 2020-08-27 2022-06-17 浙江工业大学 A fatty acid photodecarboxylase mutant and its application in the synthesis of L-glufosinate
CN115677808B (en) * 2022-10-28 2024-09-20 北京中医药大学 Preparation method of aristolochic acid-deoxynucleoside conjugate

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Also Published As

Publication number Publication date
EP2322605A2 (en) 2011-05-18
US6569656B2 (en) 2003-05-27
WO2000017327A3 (en) 2001-05-31
US20020040488A1 (en) 2002-04-04
US6495354B2 (en) 2002-12-17
US20040053386A1 (en) 2004-03-18
NO20011359L (en) 2001-05-15
CA2342053C (en) 2014-04-22
PL347308A1 (en) 2002-03-25
JP2014000082A (en) 2014-01-09
NO20011359D0 (en) 2001-03-16
US20030087406A1 (en) 2003-05-08
MXPA01002805A (en) 2002-06-04
AU2004242423A1 (en) 2005-01-20
AU6045899A (en) 2000-04-10
US20020094557A1 (en) 2002-07-18
EP2363458A2 (en) 2011-09-07
US6559297B2 (en) 2003-05-06
EP2322605A3 (en) 2011-09-14
JP2011172576A (en) 2011-09-08
WO2000017327A9 (en) 2001-10-04
EP2363458A3 (en) 2011-12-14
JP2002526066A (en) 2002-08-20
US6645762B2 (en) 2003-11-11
WO2000017327A2 (en) 2000-03-30
US6890752B2 (en) 2005-05-10
US20020094556A1 (en) 2002-07-18
AR022383A1 (en) 2002-09-04
EA200100365A1 (en) 2001-10-22
EP1121422A2 (en) 2001-08-08
IL141948A0 (en) 2002-03-10
CA2342053A1 (en) 2000-03-30
AU776690B2 (en) 2004-09-16
US6468772B1 (en) 2002-10-22
AU2004242423B2 (en) 2007-08-09

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