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BR9911329A - New acyl pseudodipeptides, preparation process and pharmaceutical compositions containing the same - Google Patents

New acyl pseudodipeptides, preparation process and pharmaceutical compositions containing the same

Info

Publication number
BR9911329A
BR9911329A BR9911329-5A BR9911329A BR9911329A BR 9911329 A BR9911329 A BR 9911329A BR 9911329 A BR9911329 A BR 9911329A BR 9911329 A BR9911329 A BR 9911329A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
compositions containing
preparation process
same
new acyl
Prior art date
Application number
BR9911329-5A
Other languages
Portuguese (pt)
Inventor
Jacques Bauer
Olivier Richard Martin
Original Assignee
Om Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Om Pharma filed Critical Om Pharma
Publication of BR9911329A publication Critical patent/BR9911329A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"NOVOS PSEUDODIPEPTìDEOS DE ACILA, PROCESSO DE PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS" A invenção se refere ao campo da química e, mais especificamente, da química terapêutica. Ela se refere aos pseudodipeptídeos de N-acila correspondendo à fórmula geral (I), onde os substitutos A, B, X, Y, R~ 1~, R~2~, n, m, p e q são conforme definidos nas reivindicações. A invenção também se refere às composições farmacêuticas contendo, como princípio ativo, pelo menos um composto da fórmula geral (I) na forma de ácido ou salificada, por uma base mineral ou orgânica. Tais como compostos possuem propriedades farmacológicas interessantes que os tornam úteis como medicamentos."NEW ACYLA PSEUDODIPEPTIDS, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME" The invention refers to the field of chemistry and, more specifically, therapeutic chemistry. It refers to the N-acyl pseudodipeptides corresponding to the general formula (I), where substitutes A, B, X, Y, R ~ 1 ~, R ~ 2 ~, n, m, p and q are as defined in the claims. The invention also relates to pharmaceutical compositions containing, as an active ingredient, at least one compound of the general formula (I) in the form of acid or salified, by a mineral or organic base. Such compounds have interesting pharmacological properties that make them useful as drugs.

BR9911329-5A 1998-06-30 1999-06-23 New acyl pseudodipeptides, preparation process and pharmaceutical compositions containing the same BR9911329A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801396 1998-06-30
PCT/IB1999/001170 WO2000000462A1 (en) 1998-06-30 1999-06-23 Novel acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same

Publications (1)

Publication Number Publication Date
BR9911329A true BR9911329A (en) 2001-10-16

Family

ID=9522667

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911329-5A BR9911329A (en) 1998-06-30 1999-06-23 New acyl pseudodipeptides, preparation process and pharmaceutical compositions containing the same

Country Status (21)

Country Link
US (2) US7157092B1 (en)
EP (1) EP1091928B1 (en)
JP (1) JP4699609B2 (en)
KR (1) KR100766016B1 (en)
CN (1) CN1168702C (en)
AR (1) AR029877A1 (en)
AT (1) ATE355266T1 (en)
AU (1) AU761396B2 (en)
BR (1) BR9911329A (en)
CA (1) CA2337807C (en)
CZ (1) CZ302062B6 (en)
DE (1) DE69935330T2 (en)
DK (1) DK1091928T3 (en)
EE (1) EE04489B1 (en)
ES (1) ES2284275T3 (en)
HU (1) HUP0102475A3 (en)
PL (1) PL195764B1 (en)
RU (1) RU2223262C2 (en)
SK (1) SK287073B6 (en)
TW (1) TWI255808B (en)
WO (1) WO2000000462A1 (en)

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Also Published As

Publication number Publication date
CA2337807C (en) 2012-08-21
DE69935330D1 (en) 2007-04-12
TWI255808B (en) 2006-06-01
PL195764B1 (en) 2007-10-31
RU2223262C2 (en) 2004-02-10
CZ20004893A3 (en) 2001-05-16
SK18872000A3 (en) 2001-07-10
KR20010083078A (en) 2001-08-31
AR029877A1 (en) 2003-07-23
EE200000791A (en) 2002-02-15
HUP0102475A2 (en) 2001-11-28
KR100766016B1 (en) 2007-10-11
CN1306504A (en) 2001-08-01
EE04489B1 (en) 2005-06-15
DK1091928T3 (en) 2007-07-23
DE69935330T2 (en) 2007-10-31
CZ302062B6 (en) 2010-09-22
SK287073B6 (en) 2009-11-05
PL345040A1 (en) 2001-11-19
CA2337807A1 (en) 2000-01-06
EP1091928A1 (en) 2001-04-18
JP2002519338A (en) 2002-07-02
HUP0102475A3 (en) 2001-12-28
ES2284275T3 (en) 2007-11-01
AU761396B2 (en) 2003-06-05
ATE355266T1 (en) 2006-03-15
US20060148678A1 (en) 2006-07-06
AU4284899A (en) 2000-01-17
US7157092B1 (en) 2007-01-02
WO2000000462A1 (en) 2000-01-06
JP4699609B2 (en) 2011-06-15
CN1168702C (en) 2004-09-29
EP1091928B1 (en) 2007-02-28

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A, 9A E 10A ANUIDADE(S).

B08G Application fees: restoration [chapter 8.7 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements