BR9911388A - Synthetic somatostatin immunogen for growth promotion in farm animals - Google Patents
Synthetic somatostatin immunogen for growth promotion in farm animalsInfo
- Publication number
- BR9911388A BR9911388A BR9911388-0A BR9911388A BR9911388A BR 9911388 A BR9911388 A BR 9911388A BR 9911388 A BR9911388 A BR 9911388A BR 9911388 A BR9911388 A BR 9911388A
- Authority
- BR
- Brazil
- Prior art keywords
- somatostatin
- immunogen
- farm animals
- peptides
- growth promotion
- Prior art date
Links
- 102000005157 Somatostatin Human genes 0.000 title abstract 6
- 108010056088 Somatostatin Proteins 0.000 title abstract 6
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 6
- 229960000553 somatostatin Drugs 0.000 title abstract 6
- 241001465754 Metazoa Species 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"IMUNóGENO DE SOMATOSTATINA SINTéTICO PARA PROMOçãO DE CRESCIMENTO EM ANIMAIS DE FAZENDA"<D>. A invenção apresenta peptídios que compreendem a somatostatina, ou uma seq³ência homóloga à somatostatina, que são ligados covalentemente a um epítopo de célula auxiliar T e opcionalmente outras seq³ências imunoestimuladores. A presente invenção apresenta o uso de peptídios como imunógenos para resultar na produção em mamíferos de anticorpos policlonais de título elevado, os quais são específicos para a somatostatina. Os peptídios devem ser úteis na redução dos níveis da somatostatina em mamíferos, na taxa de crescimento e desse modo em uma maior eficácia na utilização dos alimentos.Invention Patent: <B> "SYNTHETIC SOMATOSTATIN IMMUNOGEN FOR PROMOTING GROWTH IN FARM ANIMALS" <D>. The invention features peptides that comprise somatostatin, or a sequence homologous to somatostatin, that are covalently linked to a T helper cell epitope and optionally other immunostimulatory sequences. The present invention features the use of peptides as immunogens to result in the production in mammals of high-tier polyclonal antibodies, which are specific for somatostatin. The peptides should be useful in reducing the levels of somatostatin in mammals, in the growth rate and thus in a greater efficiency in the use of food.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10041598A | 1998-06-20 | 1998-06-20 | |
| PCT/US1999/013923 WO1999066950A1 (en) | 1998-06-20 | 1999-06-21 | Synthetic somatostatin immunogen for growth promotion in farm animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9911388A true BR9911388A (en) | 2001-03-20 |
Family
ID=22279650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9911388-0A BR9911388A (en) | 1998-06-20 | 1999-06-21 | Synthetic somatostatin immunogen for growth promotion in farm animals |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1087784A1 (en) |
| JP (1) | JP2002518033A (en) |
| CN (1) | CN1311688A (en) |
| AU (1) | AU4826799A (en) |
| BR (1) | BR9911388A (en) |
| CA (1) | CA2329755A1 (en) |
| WO (1) | WO1999066950A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI229679B (en) * | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US7956158B2 (en) * | 2007-03-29 | 2011-06-07 | University Of Southern California | Fusion proteins with cleavable spacers and uses thereof |
| CA2728735A1 (en) * | 2008-06-25 | 2009-12-30 | Braasch Biotech Llc | Compositions and methods for enhanced somatostatin immunogenicity |
| MA40824A (en) * | 2014-10-22 | 2017-08-29 | Saiba Gmbh | MODIFIED VIRUS TYPE CMV PARTICLES |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4812554A (en) * | 1977-11-08 | 1989-03-14 | Genentech, Inc. | Somatostatin peptide conjugate |
| US5759551A (en) * | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
-
1999
- 1999-06-21 AU AU48267/99A patent/AU4826799A/en not_active Abandoned
- 1999-06-21 CA CA002329755A patent/CA2329755A1/en not_active Abandoned
- 1999-06-21 BR BR9911388-0A patent/BR9911388A/en not_active IP Right Cessation
- 1999-06-21 EP EP99931846A patent/EP1087784A1/en not_active Withdrawn
- 1999-06-21 JP JP2000555636A patent/JP2002518033A/en active Pending
- 1999-06-21 CN CN99807401A patent/CN1311688A/en active Pending
- 1999-06-21 WO PCT/US1999/013923 patent/WO1999066950A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU4826799A (en) | 2000-01-10 |
| CA2329755A1 (en) | 1999-12-29 |
| CN1311688A (en) | 2001-09-05 |
| JP2002518033A (en) | 2002-06-25 |
| EP1087784A1 (en) | 2001-04-04 |
| WO1999066950A1 (en) | 1999-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 5,6,7 E 8A ANUIDADES. |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |