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BR9907953A - Glycine transport inhibitors - Google Patents

Glycine transport inhibitors

Info

Publication number
BR9907953A
BR9907953A BR9907953-4A BR9907953A BR9907953A BR 9907953 A BR9907953 A BR 9907953A BR 9907953 A BR9907953 A BR 9907953A BR 9907953 A BR9907953 A BR 9907953A
Authority
BR
Brazil
Prior art keywords
transport inhibitors
glycine transport
transport
piperidinabutanamides
glycin
Prior art date
Application number
BR9907953-4A
Other languages
Portuguese (pt)
Inventor
Walter Herman Maria Lou Luyten
Frans Eduard Janssens
Ludo Edmond Josephine Kennis
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR9907953A publication Critical patent/BR9907953A/en

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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Abstract

Patente de Invenção: <B>"INIBIDORES DE TRANSPORTE DE GLICINA"<D>. A presente invenção é concernida com o emprego de <244>, <244>-difenil-1-piperidinabutanamidas de inibição de transporte de glicina para a preparação de medicamentos para tratamento de distúrbios do sistema nervoso central e periférico, em particular psicoses, dores, epilepsia, doenças neuro-degenerativas (doença de Alzheimer), acidente vascular cerebral, trauma na cabeça, esclerose múltipla e outros. A invenção ainda compreende novos compostos, suas preparações e suas formas farmacêuticas.Invention Patent: <B> "GLYCIN TRANSPORT INHIBITORS" <D>. The present invention is concerned with the use of <244>, <244> -diphenyl-1-piperidinabutanamides to inhibit glycine transport for the preparation of drugs for the treatment of disorders of the central and peripheral nervous system, in particular psychoses, pain, epilepsy, neuro-degenerative diseases (Alzheimer's disease), stroke, head trauma, multiple sclerosis and others. The invention further comprises new compounds, their preparations and their pharmaceutical forms.

BR9907953-4A 1998-03-06 1999-02-26 Glycine transport inhibitors BR9907953A (en)

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EP98200700 1998-03-06
PCT/EP1999/001308 WO1999045011A1 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors

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AR032653A1 (en) 2001-02-09 2003-11-19 Telik Inc HYPERCYCLIC INHIBITORS OF THE GLICINE TRANSPORTER 2 PHARMACEUTICAL COMPOSITIONS, USE AND METHODS.
WO2003082819A1 (en) * 2002-04-01 2003-10-09 Nippon Chemiphar Co.,Ltd. N-phenyl-n-(4-piperidinyl)amide derivative
FR2838739B1 (en) 2002-04-19 2004-05-28 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL) BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US6995168B2 (en) * 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
FR2842805A1 (en) * 2002-07-29 2004-01-30 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND APPLICATION THERAPEUTICS
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JP4368375B2 (en) * 2003-02-17 2009-11-18 エフ．ホフマン−ラ ロシュ アーゲー Piperidine-benzenesulfonamide derivatives
WO2005014563A1 (en) * 2003-08-11 2005-02-17 F. Hoffmann-La Roche Ag Piperazine with or-substituted phenyl group and their use as glyt1 inhibitors
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FR2861076B1 (en) 2003-10-17 2006-01-06 Sanofi Synthelabo N-HETEROCYCLYMETHYLBENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2861071B1 (en) * 2003-10-17 2006-01-06 Sanofi Synthelabo N- [PHENYL (ALKYLPIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
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ES2338139T3 (en) * 2004-12-15 2010-05-04 F. Hoffmann-La Roche Ag FENIL-METANONAS BI- AND TRICYCLES REPLACED AS INHIBITORS OF THE GLICINE I CARRIER (GLYT-1) FOR THE TREATMENT OF ALZHEIMER'S DISEASE.
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
BRPI0519794A2 (en) 2005-01-07 2009-03-17 Hoffmann La Roche [4- (heteroaryl) piperazin-1-yl] - (2,5-substituted phenyl) methanone derivatives as glycine 1 (glyt-1) transporter inhibitors for the treatment of neurological and neuropsychiatric disorders
AU2006207650B2 (en) 2005-01-18 2011-01-27 F. Hoffmann-La Roche Ag 2, 5-disubstituted phenyl methanone derivatives as glycine transporter 1 (GlyT-I) inhibitors for the treatment of neurological and neuropsychiatry disorders
AU2006208547B2 (en) 2005-01-26 2011-02-10 F. Hoffmann-La Roche Ag Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors
DK1848694T3 (en) 2005-02-07 2010-01-25 Hoffmann La Roche Heterocyclic substituted phenylmethanones as inhibitors of glycine transport
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NO20004432D0 (en) 2000-09-05
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AU3254499A (en) 1999-09-20
IL138227A0 (en) 2001-10-31
PL342818A1 (en) 2001-07-02
TR200002570T2 (en) 2000-12-21
EP1058684A1 (en) 2000-12-13
HUP0101281A2 (en) 2001-09-28
BG104686A (en) 2001-04-30
WO1999045011A1 (en) 1999-09-10
HUP0101281A3 (en) 2001-11-28
CN1291984A (en) 2001-04-18
KR20010032967A (en) 2001-04-25
JP2002505332A (en) 2002-02-19
CA2322136A1 (en) 1999-09-10
SK13092000A3 (en) 2001-03-12
NO20004432L (en) 2000-11-02
HRP20000524A2 (en) 2001-02-28

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