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BR9816021A - Derivados de ácido alfa-(1-piperazinil) acetamido areno carboxilìco como agentes antidiabéticos - Google Patents

Derivados de ácido alfa-(1-piperazinil) acetamido areno carboxilìco como agentes antidiabéticos

Info

Publication number
BR9816021A
BR9816021A BR9816021-4A BR9816021A BR9816021A BR 9816021 A BR9816021 A BR 9816021A BR 9816021 A BR9816021 A BR 9816021A BR 9816021 A BR9816021 A BR 9816021A
Authority
BR
Brazil
Prior art keywords
alpha
acid derivatives
acetamido
piperazinyl
carboxylic acid
Prior art date
Application number
BR9816021-4A
Other languages
English (en)
Inventor
Gerard Botton
Gerard Patereau
Liliane Doare
Micheline Kergoat
Didier Mesangeau
Donald D Bierer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9816021A publication Critical patent/BR9816021A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE áCIDO ALFA -(1-PIPERAZINIL) ACETAMIDO ARENO CARBOXìLICO COMO AGENTES ANTIDIABéTICOS"<D>. A invenção refere-se a compostos de fórmula genérica (I). Estes compostos são úteis no tratamento de diabetes.
BR9816021-4A 1997-05-13 1998-06-08 Derivados de ácido alfa-(1-piperazinil) acetamido areno carboxilìco como agentes antidiabéticos BR9816021A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9705849A FR2763334A1 (fr) 1997-05-13 1997-05-13 Derives anthraniliques
PCT/EP1998/003431 WO1999064407A1 (en) 1997-05-13 1998-06-08 α-(1-PIPERAZINYL)ACETAMIDO ARENECARBOXYLIC ACID DERIVATIVES AS ANTIDIABETIC AGENTS

Publications (1)

Publication Number Publication Date
BR9816021A true BR9816021A (pt) 2001-05-15

Family

ID=26070316

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9816021-4A BR9816021A (pt) 1997-05-13 1998-06-08 Derivados de ácido alfa-(1-piperazinil) acetamido areno carboxilìco como agentes antidiabéticos

Country Status (4)

Country Link
CN (1) CN1119338C (pt)
BR (1) BR9816021A (pt)
FR (1) FR2763334A1 (pt)
WO (1) WO1999064407A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL204628B1 (pl) 1998-06-02 2010-01-29 Osi Pharmaceuticals Pochodna pirolo[2,3d]pirymidyny, jej zastosowanie i sposoby wytwarzania tej pochodnej i preparaty farmaceutyczne
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
JO2390B1 (en) 2001-04-06 2007-06-17 شركة جانسين فارماسوتيكا ان. في Diphenylcarboxamides act as lipid-lowering agents
CA2468673C (en) 2001-11-30 2011-01-25 Osi Pharmaceuticals, Inc. Compounds specific to adenosine a1 and a3 receptors and uses thereof
DE60235500D1 (de) 2001-12-20 2010-04-08 Osi Pharm Inc Selektive pyrimidin-a2b-antagonistenverbindungen, ihre synthese und verwendung
CN100448869C (zh) * 2002-11-27 2009-01-07 拜尔药品公司 用于治疗糖尿病的苯胺基吡唑衍生物
AR042067A1 (es) * 2002-11-27 2005-06-08 Bayer Pharmaceuticals Corp Derivados de anilinopirazol utiles en el tratamiento de la diabetes
GB0319124D0 (en) * 2003-08-14 2003-09-17 Smithkline Beecham Corp Chemical compounds
EP1848699A1 (en) * 2005-02-14 2007-10-31 Smithkline Beecham Corporation Anthranilic acid derivatives as hm74a receptor agonists
CN103804362A (zh) * 2012-11-12 2014-05-21 韩文毅 一类治疗糖尿病的化合物及其用途
CN112074505B (zh) 2018-03-08 2024-04-05 因赛特公司 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
EP3806661B1 (en) * 2018-08-10 2025-07-02 Firmenich Incorporated Use of antagonists of t2r54

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2346011A1 (fr) * 1976-02-02 1977-10-28 Orsymonde Acetanilido-piperazines
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
FR2693722B1 (fr) * 1992-07-16 1994-10-14 Meram Lab Dérivés de la N-cycloalkylpipérazine, procédé d'obtention et compositions pharmaceutiques les contenant.
FR2707984B1 (fr) * 1993-07-23 1995-09-01 Adir Nouvelles pipérazines substituées, leur procédé de préparation et les compositions les contenant.
AU695633B2 (en) * 1995-02-28 1998-08-20 Asubio Pharma Co., Ltd. Arylpiperidine and arylpiperazine derivatives and medicament containing the same
FR2757158B1 (fr) * 1996-12-18 1999-04-02 Lipha Nouveaux derives d'acide 4-(1-piperazinyl) benzoique, leur procede de preparation et leurs applications therapeutiques

Also Published As

Publication number Publication date
WO1999064407A1 (en) 1999-12-16
CN1119338C (zh) 2003-08-27
CN1301259A (zh) 2001-06-27
FR2763334A1 (fr) 1998-11-20

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Legal Events

Date Code Title Description
HHX Correction

Free format text: REFERENTE A RENUMERACAO PUBLICADA NA RPI 1579 DE 10/04/2001 SOB O NUMERO PI0005805-0 UMA VEZ QUE A DATA DE DEPOSITO CORRETA E 08/06/98

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7,8 E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.