BR9810881B1 - mÉtodo para produzir heparina a partir do tecido da mucosa de mamÍferos. - Google Patents

mÉtodo para produzir heparina a partir do tecido da mucosa de mamÍferos.

Info

Publication number: BR9810881B1
Authority: BR; Brazil
Prior art keywords: mucosal tissue; producing heparin; mammalian mucosal; mammalian; heparin
Prior art date: 1997-07-16

Application number

BRPI9810881-6A

Other languages

English (en)

Other versions

BR9810881A (pt

Inventor

Houdenhoven Francois Egbert Abraham Van

Adrianus Lambertus Maria Sanders

Zutphen Petrus Johannes Josephus Van

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-16

Filing date

1998-07-09

Publication date

2009-01-13

1998-07-09 Application filed filed Critical

2000-09-26 Publication of BR9810881A publication Critical patent/BR9810881A/pt

2009-01-13 Publication of BR9810881B1 publication Critical patent/BR9810881B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

BRPI9810881-6A 1997-07-16 1998-07-09 mÉtodo para produzir heparina a partir do tecido da mucosa de mamÍferos. BR9810881B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97202213		1997-07-16
PCT/EP1998/004939 WO1999003893A1 (en)	1997-07-16	1998-07-09	Process for the production of heparin

Publications (2)

Publication Number	Publication Date
BR9810881A BR9810881A (pt)	2000-09-26
BR9810881B1 true BR9810881B1 (pt)	2009-01-13

Family

ID=8228564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9810881-6A BR9810881B1 (pt)	1997-07-16	1998-07-09	mÉtodo para produzir heparina a partir do tecido da mucosa de mamÍferos.

Country Status (24)

Country	Link
US (1)	US6232093B1 (pt)
EP (1)	EP0996642B1 (pt)
JP (1)	JP4455680B2 (pt)
KR (1)	KR100515706B1 (pt)
CN (1)	CN1109048C (pt)
AR (1)	AR013223A1 (pt)
AT (1)	ATE315588T1 (pt)
AU (1)	AU739225B2 (pt)
BR (1)	BR9810881B1 (pt)
CA (1)	CA2294780C (pt)
CZ (1)	CZ299281B6 (pt)
DE (1)	DE69833205T2 (pt)
DK (1)	DK0996642T3 (pt)
ES (1)	ES2256954T3 (pt)
HR (1)	HRP980399B1 (pt)
HU (1)	HU225240B1 (pt)
IL (1)	IL133363A (pt)
NO (1)	NO320786B1 (pt)
PL (1)	PL195526B1 (pt)
TR (1)	TR200000086T2 (pt)
TW (1)	TW581814B (pt)
UY (1)	UY25097A1 (pt)
WO (1)	WO1999003893A1 (pt)
ZA (1)	ZA986289B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7575886B2 (en) *	2002-03-11	2009-08-18	Momenta Pharmaceuticals, Inc.	Analysis of sulfated polysaccharides
NZ537005A (en)	2002-06-19	2008-01-31	Can Technologies Inc	Animal feed composition comprising mucosa byproduct
US6933372B2 (en) *	2003-03-07	2005-08-23	Warner-Lambert Company	Method to produce a solid form of heparin
CN100425624C (zh) *	2006-05-11	2008-10-15	中国农业大学	一种同步提取肝素钠和猪肠粘膜抗菌肽的方法
CN100439402C (zh) *	2006-10-12	2008-12-03	孙红	采用卵磷脂液膜分离法提取肝素的方法
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
WO2010110654A1 (en) *	2009-03-24	2010-09-30	Van Hessen Bv	Method for preparation of heparin from mucosa
CN102791742B (zh) *	2010-01-19	2014-12-24	动量制药公司	评价肝素制剂
WO2012115952A1 (en)	2011-02-21	2012-08-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
KR101447123B1 (ko)	2014-02-27	2014-10-06	박상협	헤파린의 추출 방법
CN104086672A (zh) *	2014-06-10	2014-10-08	安徽申奥生物科技有限公司	一种粗品肝素钠的生产方法
TWI851587B (zh)	2018-07-11	2024-08-11	日商味之素股份有限公司	使用腸桿菌科（Ｅｎｔｅｒｏｂａｃｔｅｒｉａｃｅａｅ）之細菌使醇和胺經酶催化性磺醯化之方法
KR102180261B1 (ko) *	2019-03-19	2020-11-18	중앙대학교 산학협력단	돈육 부산물 유래 헤파린의 추출 방법
KR102104367B1 (ko)	2019-09-02	2020-04-24	팜앤바이오 주식회사	헤파린나트륨의 제조장치 및 제조방법
CN115028757A (zh) *	2022-06-29	2022-09-09	江苏麦德森制药有限公司	一种肝素钠的脱色方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH617963A5 (pt) *	1973-10-05	1980-06-30	Derivati Organici Lab
HU177887B (en) *	1979-03-21	1982-01-28	Richter Gedeon Vegyeszet	Process for preparing a raw material containing heparin
IE64121B1 (en) *	1989-10-04	1995-07-12	Akzo Nv	Sulphated glycosaminoglycuronan with antithrombotic activity
WO1994012524A1 (en) *	1992-11-30	1994-06-09	Celsus, Inc.	Protein hydrolysate derived from mucosal tissue

1998
- 1998-07-09 JP JP50645999A patent/JP4455680B2/ja not_active Expired - Lifetime
- 1998-07-09 BR BRPI9810881-6A patent/BR9810881B1/pt not_active IP Right Cessation
- 1998-07-09 AU AU90715/98A patent/AU739225B2/en not_active Expired
- 1998-07-09 US US09/462,223 patent/US6232093B1/en not_active Expired - Lifetime
- 1998-07-09 IL IL13336398A patent/IL133363A/xx not_active IP Right Cessation
- 1998-07-09 AT AT98942666T patent/ATE315588T1/de active
- 1998-07-09 DE DE69833205T patent/DE69833205T2/de not_active Expired - Lifetime
- 1998-07-09 CA CA2294780A patent/CA2294780C/en not_active Expired - Lifetime
- 1998-07-09 WO PCT/EP1998/004939 patent/WO1999003893A1/en not_active Ceased
- 1998-07-09 DK DK98942666T patent/DK0996642T3/da active
- 1998-07-09 PL PL98338007A patent/PL195526B1/pl unknown
- 1998-07-09 ES ES98942666T patent/ES2256954T3/es not_active Expired - Lifetime
- 1998-07-09 CN CN98807195A patent/CN1109048C/zh not_active Expired - Lifetime
- 1998-07-09 TR TR2000/00086T patent/TR200000086T2/xx unknown
- 1998-07-09 HU HU0003064A patent/HU225240B1/hu unknown
- 1998-07-09 KR KR10-1999-7012554A patent/KR100515706B1/ko not_active Expired - Lifetime
- 1998-07-09 CZ CZ20000138A patent/CZ299281B6/cs not_active IP Right Cessation
- 1998-07-09 EP EP98942666A patent/EP0996642B1/en not_active Expired - Lifetime
- 1998-07-15 ZA ZA986289A patent/ZA986289B/xx unknown
- 1998-07-16 UY UY25097A patent/UY25097A1/es not_active IP Right Cessation
- 1998-07-16 TW TW087111617A patent/TW581814B/zh not_active IP Right Cessation
- 1998-07-16 HR HR980399A patent/HRP980399B1/xx not_active IP Right Cessation
- 1998-07-16 AR ARP980103468A patent/AR013223A1/es active IP Right Grant
2000
- 2000-01-14 NO NO20000189A patent/NO320786B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO20000189L (no)	2000-03-14
TR200000086T2 (tr)	2000-08-21
NO20000189D0 (no)	2000-01-14
AR013223A1 (es)	2000-12-13
PL338007A1 (en)	2000-09-25
BR9810881A (pt)	2000-09-26
DE69833205T2 (de)	2006-07-20
CZ2000138A3 (cs)	2000-07-12
HUP0003064A2 (hu)	2000-12-28
EP0996642A1 (en)	2000-05-03
CA2294780A1 (en)	1999-01-28
UY25097A1 (es)	1999-01-11
EP0996642B1 (en)	2006-01-11
AU739225B2 (en)	2001-10-04
HU225240B1 (en)	2006-08-28
ZA986289B (en)	1999-05-04
CZ299281B6 (cs)	2008-06-04
ATE315588T1 (de)	2006-02-15
TW581814B (en)	2004-04-01
JP4455680B2 (ja)	2010-04-21
HRP980399B1 (en)	2003-04-30
NO320786B1 (no)	2006-01-30
WO1999003893A1 (en)	1999-01-28
CA2294780C (en)	2008-03-04
US6232093B1 (en)	2001-05-15
CN1109048C (zh)	2003-05-21
AU9071598A (en)	1999-02-10
KR100515706B1 (ko)	2005-09-15
ES2256954T3 (es)	2006-07-16
JP2002508805A (ja)	2002-03-19
IL133363A0 (en)	2001-04-30
CN1264391A (zh)	2000-08-23
HRP980399A2 (en)	1999-04-30
PL195526B1 (pl)	2007-09-28
DK0996642T3 (da)	2006-05-08
DE69833205D1 (de)	2006-04-06
KR20010014387A (ko)	2001-02-26
IL133363A (en)	2005-08-31
HUP0003064A3 (en)	2003-01-28

Publication	Publication Date	Title
BR9810881B1 (pt)	2009-01-13	mÉtodo para produzir heparina a partir do tecido da mucosa de mamÍferos.
BR9910611B1 (pt)	2009-05-05	processo para produção de uma composição de catalisador.
BR9708357A (pt)	1999-08-03	Processo para produção de um polímero poroso a partir de uma mistura
BR9804504B1 (pt)	2009-01-13	isoquinolina-3-carboxamidas substituÍdas, processo para a preparaÇço das mesmas e medicamento.
DE59804095D1 (de)	2002-06-13	Verfahren zur herstellung von niedermolekularem, hochreaktivem polyisobutylen
IT1319673B1 (it)	2003-10-23	Metodo per la produzione di una membrana di collagene a partire dapelle di suino.
BR9814054B1 (pt)	2009-05-05	método para fabricar um precursor de forma de impressão, precursor de forma de impressão litográfica, método para produção de uma forma de impressão e forma de impressão litográfica.
IS4828A (is)	1998-08-19	Aðferð við að framleiða N-asetýl-D-glúkósamín
BR9711318B1 (pt)	2009-01-13	processo para preparar intermediÁrios para florfenicol.
DE69801489D1 (de)	2001-10-04	Verfahren zur herstellung von 1,1,1,3,3-pentafluorpropan
BR9911845B1 (pt)	2009-01-13	mÉtodo para produzir um produto de madeira composta.
PT858440E (pt)	2002-07-31	Processo para a preparacao de 1,1,1,3,3-pentafluoropropano
ID28489A (id)	2001-05-31	Metode untuk membuat 4-karboksiamino-2-disubstitusi 1,2,3,4-tetrahidroquinolin
FI962610L (fi)	1997-12-25	Menetelmä ksylitolin valmistamiseksi
DE69838129D1 (de)	2007-09-06	Herstellungsverfahren für gewebe
KR970001299A (ko)	1997-01-24	디아릴 카르보네이트의 제조 방법
BRPI9814894B8 (pt)	2021-07-06	processo para a preparação de ácidos 8-metóxi-quinolonocarboxìlicos.
FI955855L (fi)	1996-06-07	Menetelmä ksylitolin tuottamiseksi
BR9915100B1 (pt)	2009-05-05	processo contìnuo para a fabricação de poliamida a partir de Èmega-aminonitrila.
DK1059290T3 (da)	2003-03-31	Process for producing canthaxanthin
BR0007744B1 (pt)	2012-06-26	processo para a produção de uma união de laminado metálico.
BR9807196B1 (pt)	2009-01-13	processo para recuperar hexametilenodiamina (i) a partir de uma mistura (ii).
ID18339A (id)	1998-04-02	Proses untuk memproduksi diaril karbonat
AU2000251167A1 (en)	2001-09-12	Method for producing a bioactive substance from blood serum
AR002119A1 (es)	1998-01-07	Procedimiento para preparar n-fosfonome-tilglicinaa partir de ácido n-fosfonometili-minodiacetico

Legal Events

Date	Code	Title	Description
2006-06-06	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2007-06-12	B25A	Requested transfer of rights approved	Owner name: N.V. ORGANON (NL) Free format text: TRANSFERIDO DE: AKZO NOBEL N.V.
2007-07-03	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2008-10-28	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2009-03-10	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/03/2009, OBSERVADAS AS CONDICOES LEGAIS.
2013-04-24	B25A	Requested transfer of rights approved	Owner name: MSD OSS B.V. (NL)
2014-12-09	B25A	Requested transfer of rights approved	Owner name: ORGANON BIOSCIENCES NEDERLAND B.V. (NL)
2014-12-30	B25A	Requested transfer of rights approved	Owner name: MERCK SHARP AND DOHME B.V. (NL)
2019-08-20	B21A	Patent or certificate of addition expired [chapter 21.1 patent gazette]	Free format text: PATENTE EXTINTA EM 10.03.2019