BR9807020B1 - método para purificar um derivado de aspartame n-alquilado. - Google Patents

método para purificar um derivado de aspartame n-alquilado.

Info

Publication number: BR9807020B1
Authority: BR; Brazil
Prior art keywords: purifying; aspartame derivative; alkylated aspartame; alkylated; derivative
Prior art date: 1997-01-29

Application number

BRPI9807020-7A

Other languages

English (en)

Other versions

BR9807020A (pt

Inventor

Indra Prakash

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-29

Filing date

1998-01-29

Publication date

2011-04-19

1998-01-29 Application filed filed Critical

2000-03-14 Publication of BR9807020A publication Critical patent/BR9807020A/pt

2011-04-19 Publication of BR9807020B1 publication Critical patent/BR9807020B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Seasonings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Arrangements For Transmission Of Measured Signals (AREA)

BRPI9807020-7A 1997-01-29 1998-01-29 método para purificar um derivado de aspartame n-alquilado. BR9807020B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/790,113 US5728862A (en)	1997-01-29	1997-01-29	Method for preparing and purifying an N-alkylated aspartame derivative
PCT/US1998/001734 WO1998032767A1 (en)	1997-01-29	1998-01-29	Method for preparing and purifying an n-alkylated aspartame derivative

Publications (2)

Publication Number	Publication Date
BR9807020A BR9807020A (pt)	2000-03-14
BR9807020B1 true BR9807020B1 (pt)	2011-04-19

Family

ID=25149681

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9807020-7A BR9807020B1 (pt)	1997-01-29	1998-01-29	método para purificar um derivado de aspartame n-alquilado.

Country Status (29)

Country	Link
US (1)	US5728862A (pt)
EP (1)	EP0973796B1 (pt)
CN (1)	CN1136227C (pt)
AR (1)	AR011782A1 (pt)
AT (1)	ATE313555T1 (pt)
AU (1)	AU723479B2 (pt)
BG (1)	BG64562B1 (pt)
BR (1)	BR9807020B1 (pt)
CA (1)	CA2278608C (pt)
CO (1)	CO5040054A1 (pt)
CZ (1)	CZ296888B6 (pt)
DE (1)	DE69832870T2 (pt)
DK (1)	DK0973796T3 (pt)
EA (1)	EA001948B1 (pt)
EE (1)	EE03928B1 (pt)
ES (1)	ES2251765T3 (pt)
HU (1)	HU228676B1 (pt)
ID (1)	ID22966A (pt)
IL (1)	IL131140A0 (pt)
NO (1)	NO326212B1 (pt)
NZ (1)	NZ336893A (pt)
PE (1)	PE71999A1 (pt)
PL (1)	PL191750B1 (pt)
SK (1)	SK285451B6 (pt)
TR (1)	TR199901811T2 (pt)
TW (1)	TW432074B (pt)
UA (1)	UA57605C2 (pt)
UY (1)	UY24864A1 (pt)
WO (1)	WO1998032767A1 (pt)

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US6180156B1 (en)	1997-09-11	2001-01-30	The Nutrasweet Company	Acid salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6291004B1 (en)	1997-09-11	2001-09-18	The Nutrasweet Company	Basic salts of n-[n-(3,3-dimethylbutyl)-l-α-aspartyl]-l-phenylalanine 1-methyl ester
US6146680A (en) *	1997-09-11	2000-11-14	The Nutrasweet Company	Metal complexes of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6129942A (en) *	1997-09-11	2000-10-10	The Nutrasweet Company	Sweetener salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
JPH1180108A (ja) *	1997-09-12	1999-03-26	Ajinomoto Co Inc	甘味料の精製法
JPH11130794A (ja)	1997-10-23	1999-05-18	Ajinomoto Co Inc	アスパルテーム誘導体の精製方法
JPH11171895A (ja)	1997-12-11	1999-06-29	Ajinomoto Co Inc	アスパルテームとアスパルテーム誘導体の分離精製方法
JPH11169132A (ja) *	1997-12-15	1999-06-29	Ajinomoto Co Inc	アスパルテームとアスパルテーム誘導体の混晶及びその製造方法
US6692778B2 (en)	1998-06-05	2004-02-17	Wm. Wrigley Jr. Company	Method of controlling release of N-substituted derivatives of aspartame in chewing gum
EP1083799B1 (en) *	1998-06-05	2010-09-29	Wm. Wrigley Jr. Company	Method of controlling release of n-substituted derivatives of aspartame in chewing gum and gum produced thereby
US5977415A (en) *	1998-08-20	1999-11-02	The Nutrasweet Company	Preparation of 3, 3-dimethylbutyraldehyde from a tert-butyl cation precursor, vinyl chloride and an acidic catalyst
NL1010063C2 (nl) *	1998-09-10	2000-03-13	Holland Sweetener Co	Werkwijze voor de bereiding van neotaam.
US6214402B1 (en)	1998-09-17	2001-04-10	The Nutrasweet Company	Co-crystallization of sugar and n-[n-(3,3-dimethylbutyl)-l αaspartyl]-l-phenylalanine 1-methyl ester
US5994593A (en) *	1998-09-17	1999-11-30	The Nutrasweet Company	Synthesis and purification of 3,3-dimethylbutyraldehyde via hydrolysis of 1,1-dichloro-3,3-dimethylbutane or 1-bromo-1-chloro-3,3-dimethylbutane
KR20010075419A (ko)	1998-10-30	2001-08-09	에가시라 구니오	안정성이 우수한 아스파르탐 유도체 결정의 결정 석출법
US6844465B2 (en) *	1998-10-30	2005-01-18	Ajinomoto Co., Inc.	Method for preparing highly stable crystals of aspartame derivative
US6465677B1 (en) *	1998-11-19	2002-10-15	The Nutrasweet Company	Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
US6331646B1 (en)	1998-11-20	2001-12-18	The Nutrasweet Co.	Amorphous N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
AU1832500A (en) *	1998-11-25	2000-06-19	Nutrasweet Company, The	Purification of N-(N-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester via crystallization
WO2000036933A1 (en) *	1998-12-18	2000-06-29	The Nutrasweet Company	USE OF N-NEOHEXYL-α-ASPARTYL-L-PHENYLALANINE METHYL ESTER AS A FLAVOR MODIFIER
US6077962A (en) *	1998-12-24	2000-06-20	The Nutrasweet Company	N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom
US6048999A (en) *	1999-01-25	2000-04-11	The Nutrasweet Company	N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synergistic sweetener blends
US6180157B1 (en)	1999-02-18	2001-01-30	The Nutrasweet Company	Process for preparing an N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester agglomerate
AU4449100A (en) *	1999-03-03	2000-09-21	Nutrasweet Company, The	Novel crystallization products of neotame and methods for producing same
EP1164872A1 (en)	1999-03-26	2002-01-02	The NutraSweet Company	PARTICLES OF N- N-(3,3-DIMETHYLBUTYL)-L-$g(a)-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER
US6573409B1 (en) *	1999-07-02	2003-06-03	The Nutrasweet Company	Process for the preparation of 3,3-dimethylbutanal
WO2001009168A1 (en) *	1999-07-28	2001-02-08	The Nutrasweet Company	A METHOD FOR THE PURIFICATION OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER
WO2001010241A2 (en)	1999-08-06	2001-02-15	The Nutrasweet Company	PROCESS FOR COATING N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER ONTO A CARRIER
US20040176472A1 (en) *	1999-10-07	2004-09-09	Ajinomoto Co., Inc.	Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof
AU7321900A (en) *	1999-10-07	2001-05-10	Ajinomoto Co., Inc.	Process for the production of aspartyldipeptide ester derivatives, novel intermediates therefor and process for the production of the intermediates
AU7556700A (en) *	1999-10-08	2001-04-23	Ajinomoto Co., Inc.	Process for producing aspartame derivative, crystals thereof, novel production intermediates therefor and process for producing the intermediate
US6627431B1 (en)	2000-05-12	2003-09-30	The Nutrasweet Company	Chemoenzymatic synthesis of neotame
ES2233644T3 (es) *	2000-05-18	2005-06-16	The Nutrasweet Company	Sintesis de n-(n-3,3 -dimetilbutil) -l-alfa aspartil)-l- fenilalanina 1- metil ester por utilizacion de precursores de l-alfa-aspartatil-l.-fenilalanina 1-metil ester.
US6281380B1 (en) *	2000-05-18	2001-08-28	The Nutra Sweet Company	Synthesis of N-(N-(3,3-dimethylbutyl)-L-α-aspartyl)L-phenylalanine1-methyl ester by reductive alkylation and crystallization/ isolation in aqueous methanol
US6852875B2 (en)	2000-05-19	2005-02-08	The Nutrasweet Co.	Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives
US7326430B2 (en) *	2000-07-18	2008-02-05	The Nutrasweet Company	Method of preparing liquid compositions for delivery of N-[N- (3,3-dimethylbutyl-L-α-aspartyl]-L-phenylalanine 1-methyl ester in food and beverage systems
US6225493B1 (en) *	2000-08-21	2001-05-01	The Nutrasweet Company	Metal ion assisted N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester isomer resolution
AU2001297682A1 (en) *	2000-11-06	2002-09-04	The Nutrasweet Company	Catalyst modification to enhance neotame production
US6720446B2 (en) *	2001-11-05	2004-04-13	The Nutrasweet Company	Catalyst modification to enhance neotame production
US6782048B2 (en) *	2002-06-21	2004-08-24	Pulse-Link, Inc.	Ultra-wideband communication through a wired network
CN101565451B (zh) *	2003-05-06	2013-03-27	纽特拉斯威特公司	N-[N-(3,3-二甲基丁基)-L-α-天冬氨酰基]-L-苯基丙氨酸1-甲酯
US20050196503A1 (en) *	2004-03-05	2005-09-08	Sunil Srivastava	High-intensity sweetener-polyol compositions
US20060188629A1 (en) *	2005-01-21	2006-08-24	Greg Liesen	Method for the purification of sucralose
CN101270092B (zh) *	2008-04-30	2010-12-08	厦门大学	一种合成纽甜的方法
FR3102041B1 (fr)	2019-10-22	2025-02-14	Aroma Sens	Edulcorant pour liquides de cigarette électronique
CN119954888A (zh) *	2025-01-17	2025-05-09	深圳市华加生物科技有限公司	一种新型二肽类甜味剂及其合成方法

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JPS59227849A (ja) *	1983-06-08	1984-12-21	Ajinomoto Co Inc	Ｌ―α―アスパルチル―Ｌ―フェニルアラニンメチルエステル束状晶の晶析分離法
FR2697844B1 (fr) *	1992-11-12	1995-01-27	Claude Nofre	Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr) *	1994-05-09	1996-07-26	Claude Nofre	Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
US5480688A (en) *	1994-06-13	1996-01-02	The Auld Company	Shaped flexible decorative articles and method for making same
US5510805A (en) *	1994-08-08	1996-04-23	Prime View International Co.	Scanning circuit
ATE214397T1 (de) *	1995-06-30	2002-03-15	Holland Sweetener Co	Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen

1997
- 1997-01-29 US US08/790,113 patent/US5728862A/en not_active Expired - Lifetime
1998
- 1998-01-26 TW TW087101110A patent/TW432074B/zh not_active IP Right Cessation
- 1998-01-29 ID IDW990777A patent/ID22966A/id unknown
- 1998-01-29 UA UA99084829A patent/UA57605C2/uk unknown
- 1998-01-29 EA EA199900690A patent/EA001948B1/ru not_active IP Right Cessation
- 1998-01-29 PE PE1998000066A patent/PE71999A1/es not_active IP Right Cessation
- 1998-01-29 AT AT98906040T patent/ATE313555T1/de active
- 1998-01-29 DE DE69832870T patent/DE69832870T2/de not_active Expired - Lifetime
- 1998-01-29 SK SK1010-99A patent/SK285451B6/sk unknown
- 1998-01-29 BR BRPI9807020-7A patent/BR9807020B1/pt not_active IP Right Cessation
- 1998-01-29 PL PL334882A patent/PL191750B1/pl unknown
- 1998-01-29 UY UY24864A patent/UY24864A1/es not_active IP Right Cessation
- 1998-01-29 NZ NZ336893A patent/NZ336893A/en not_active IP Right Cessation
- 1998-01-29 CA CA002278608A patent/CA2278608C/en not_active Expired - Lifetime
- 1998-01-29 CN CNB988035219A patent/CN1136227C/zh not_active Expired - Lifetime
- 1998-01-29 WO PCT/US1998/001734 patent/WO1998032767A1/en not_active Ceased
- 1998-01-29 AR ARP980100388A patent/AR011782A1/es active IP Right Grant
- 1998-01-29 AU AU61375/98A patent/AU723479B2/en not_active Expired
- 1998-01-29 DK DK98906040T patent/DK0973796T3/da active
- 1998-01-29 TR TR1999/01811T patent/TR199901811T2/xx unknown
- 1998-01-29 CO CO98004324A patent/CO5040054A1/es unknown
- 1998-01-29 EE EEP199900329A patent/EE03928B1/xx unknown
- 1998-01-29 ES ES98906040T patent/ES2251765T3/es not_active Expired - Lifetime
- 1998-01-29 EP EP98906040A patent/EP0973796B1/en not_active Expired - Lifetime
- 1998-01-29 HU HU0001453A patent/HU228676B1/hu unknown
- 1998-01-29 CZ CZ0261299A patent/CZ296888B6/cs not_active IP Right Cessation
- 1998-01-29 IL IL13114098A patent/IL131140A0/xx not_active IP Right Cessation
1999
- 1999-07-28 NO NO19993676A patent/NO326212B1/no not_active IP Right Cessation
- 1999-08-27 BG BG103694A patent/BG64562B1/bg unknown

Also Published As

Publication number	Publication date
HUP0001453A2 (hu)	2000-08-28
DE69832870D1 (de)	2006-01-26
DK0973796T3 (da)	2006-04-18
EP0973796B1 (en)	2005-12-21
CZ296888B6 (cs)	2006-07-12
EE9900329A (et)	2000-02-15
UA57605C2 (uk)	2003-06-16
DE69832870T2 (de)	2006-08-10
PL334882A1 (en)	2000-03-27
IL131140A0 (en)	2001-01-28
PL191750B1 (pl)	2006-06-30
CZ261299A3 (cs)	2000-06-14
AU723479B2 (en)	2000-08-24
CA2278608C (en)	2002-03-12
ATE313555T1 (de)	2006-01-15
UY24864A1 (es)	1998-02-10
BR9807020A (pt)	2000-03-14
BG64562B1 (bg)	2005-07-29
CO5040054A1 (es)	2001-05-29
HUP0001453A3 (en)	2002-02-28
NO326212B1 (no)	2008-10-20
SK285451B6 (sk)	2007-01-04
PE71999A1 (es)	1999-08-19
TW432074B (en)	2001-05-01
NO993676D0 (no)	1999-07-28
ID22966A (id)	1999-12-23
EA199900690A1 (ru)	2000-04-24
AR011782A1 (es)	2000-09-13
EP0973796A1 (en)	2000-01-26
US5728862A (en)	1998-03-17
HU228676B1 (en)	2013-05-28
CA2278608A1 (en)	1998-07-30
ES2251765T3 (es)	2006-05-01
NO993676L (no)	1999-09-28
NZ336893A (en)	2001-04-27
CN1136227C (zh)	2004-01-28
SK101099A3 (en)	2000-06-12
CN1251107A (zh)	2000-04-19
BG103694A (en)	2000-07-31
WO1998032767A1 (en)	1998-07-30
EA001948B1 (ru)	2001-10-22
EE03928B1 (et)	2002-12-16
AU6137598A (en)	1998-08-18
TR199901811T2 (xx)	1999-12-21

Publication	Publication Date	Title
BR9807020B1 (pt)	2011-04-19	método para purificar um derivado de aspartame n-alquilado.
IT1299568B1 (it)	2000-03-16	Capote per autoveicolo
PT1113965E (pt)	2004-01-30	Acessorio para gargalo de garrafa
PT922050E (pt)	2003-12-31	Derivados de 3-descladinose-2,3-anidroeritromicina
DK0891552T4 (da)	2009-05-04	Fremgangsmåde til detektion af prionsygdomme
DE69938073D1 (de)	2008-03-20	Kraftfahrzeug-Kommunikationsverfahren, und System dafür
FI950983L (fi)	1996-09-04	Menetelmä lääkaineiden puhdistamiseksi
AR008944A1 (es)	2000-02-23	Procedimiento para la obtencion de 3-hidroxipirazoles n-sustituidos.
DE69927906D1 (de)	2005-12-01	Zündsystem
TR199800403A3 (tr)	1998-09-21	a-Bromo-laktam türevlerinin hazirlanmasi için yöntem.
TR199700729A3 (tr)	1998-05-21	Sabit arilpirol parçaciklari, bunlarin hazirlanmasi için usul.
FI950044L (fi)	1995-07-06	Menetelmä proteiini C:n hajoamisen estämiseksi
FI981242A0 (fi)	1998-06-02	Menetelmä kefalokuvien ottamiseksi
ES1038214Y (es)	1998-12-01	Cajetin de tabaco perfeccionado.
ES1033082Y (es)	1996-12-16	Cajetilla de tabaco perfeccionada.
ES1038184Y (es)	1998-12-01	Dispositivo perfeccionado para la sujecion de balaustres.
ES1035728Y (es)	1997-10-16	Nebulizador perfeccionado para fumigadoras.
FI981251A0 (fi)	1998-06-02	Menetelmä iso-tiosynnaattien valmistamiseksi
ES1028007Y (es)	1995-04-01	Bloque perfeccionado para construccion.
ITGE970034A0 (it)	1997-04-11	Metodo per la stampa.
ES1036780Y (es)	1998-04-01	Bastidor perfeccionado para somier.
ES1030509Y (es)	1996-02-01	Basculante-giratorio perfeccionado para ceramicas de lavacabezas.
ES1030613Y (es)	1996-02-16	Soporte perfeccionado para bombonas de gas.
ES1035532Y (es)	1997-10-16	Puya perfeccionada para tauromaquia.
ES1030294Y (es)	1996-02-01	Gancho perfeccionado para la sujecion de canalones.

Legal Events

Date	Code	Title	Description
2008-08-19	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2009-06-30	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2010-02-17	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2011-02-22	B25D	Requested change of name of applicant approved	Owner name: NUTRASWEET PROPERTY HOLDINGS, INC. (US) Free format text: ALTERADO DE: THE NUTRASWEET COMPANY
2011-04-19	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/04/2011, OBSERVADAS AS CONDICOES LEGAIS.
2018-11-27	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 21A ANUIDADE.
2019-03-26	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2499 DE 27-11-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.