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BR9714358A - Derivatives of n- (aryl / heteroaryl) amino acid, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by using such compounds - Google Patents

Derivatives of n- (aryl / heteroaryl) amino acid, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by using such compounds

Info

Publication number
BR9714358A
BR9714358A BR9714358A BR9714358A BR9714358A BR 9714358 A BR9714358 A BR 9714358A BR 9714358 A BR9714358 A BR 9714358A BR 9714358 A BR9714358 A BR 9714358A BR 9714358 A BR9714358 A BR 9714358A
Authority
BR
Brazil
Prior art keywords
synthesis
release
methods
pharmaceutical compositions
beta
Prior art date
Application number
BR9714358A
Other languages
Portuguese (pt)
Inventor
James E Audia
Beverly K Folmer
Varghese John
Lee H Latimer
Jeffrey S Nissen
Warren J Porter
Eugene D Thorsett
Jing Wu
Original Assignee
Elan Pharm Inc
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Lilly Co Eli filed Critical Elan Pharm Inc
Publication of BR9714358A publication Critical patent/BR9714358A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE N-(ARILA/HETMPREENDENDO OS MESMOS, E MéTODOS PARA A INIBIçãO DE LIBERAçãO DE PEPTìDEO BETA-AMILóIDE E/OU SUA SìNTESE POR USO DE TAIS COMPOSTOS"<D>. Revelados são os compostos que inibem liberação de peptídeo beta-amilóide e/ou sua síntese, e, correspondentemente, têm utilidade no tratamento de doença de Alzheimer. Também revelados são composições farmacêuticas compreendendo um composto que inibe liberação de étodos para o tratamento de doença de Alzheimer tanto pofilaticamente quando terapeuticamente com tais composições farmacêuticas.Invention Patent: <B> "N- (ARILA / HETMPREENDING DERIVATIVES, AND METHODS FOR THE INHIBITION OF BETA-AMYLOID PEPTIDE RELEASE AND / OR ITS SYNTHESIS BY THE USE OF SUCH COMPOUNDS" <D>. which inhibit beta-amyloid peptide release and / or its synthesis, and, correspondingly, are useful in the treatment of Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound that inhibits the release of methods for the treatment of Alzheimer's disease both pophilatically when therapeutically with such pharmaceutical compositions.

BR9714358A 1996-11-22 1997-11-20 Derivatives of n- (aryl / heteroaryl) amino acid, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by using such compounds BR9714358A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75533496A 1996-11-22 1996-11-22
PCT/US1997/018704 WO1998022493A2 (en) 1996-11-22 1997-11-20 N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

Publications (1)

Publication Number Publication Date
BR9714358A true BR9714358A (en) 2000-03-21

Family

ID=25038718

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714358A BR9714358A (en) 1996-11-22 1997-11-20 Derivatives of n- (aryl / heteroaryl) amino acid, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by using such compounds

Country Status (13)

Country Link
EP (1) EP0942923A2 (en)
JP (1) JP2001519769A (en)
CN (1) CN1237978A (en)
AU (1) AU5354398A (en)
BR (1) BR9714358A (en)
CA (1) CA2270876A1 (en)
HU (1) HUP0001383A3 (en)
ID (1) ID22275A (en)
IL (1) IL129477A0 (en)
NO (1) NO992426L (en)
NZ (1) NZ335157A (en)
TR (1) TR199901132T2 (en)
WO (1) WO1998022493A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ509241A (en) 1998-08-07 2003-08-29 Du Pont Pharm Co Succinoylamino lactams as inhibitors of alpha-beta protein production
US6486350B1 (en) 1998-09-30 2002-11-26 Elan Pharmaceuticals Inc. Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
AU778005B2 (en) 1998-12-24 2004-11-11 Bristol-Myers Squibb Pharma Company Succinoylamino benzodiazepines as inhibitors of Abeta protein production
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
EP1218377A1 (en) 1999-10-08 2002-07-03 Bristol-Myers Squibb Pharma Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION
CA2395862A1 (en) 2000-02-17 2001-08-23 Hong Liu Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production
CA2404023A1 (en) 2000-04-03 2001-10-11 Richard E. Olson Cyclic lactams as inhibitors of a.beta. protein production
WO2001074784A1 (en) 2000-04-03 2001-10-11 Dupont Pharmaceuticals Company CYCLIC LACTAMS AS INHIBITORS OF A-β PROTEIN PRODUCTION
WO2001077086A1 (en) 2000-04-11 2001-10-18 Dupont Pharmaceuticals Company SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION
WO2001087354A2 (en) 2000-05-17 2001-11-22 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
US6509333B2 (en) 2000-06-01 2003-01-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of Aβ protein production
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
BRPI0113470B8 (en) 2000-08-24 2021-05-25 Univ Pittsburgh amyloid binding compound, pharmaceutical composition and methods of compound synthesis, of in vivo detection of amyloid deposits in an individual and in human or animal tissue, of quantification of amyloid deposit in biopsy or postmortem tissue, and of distinguishing a brain from disease alzheimer of a normal brain
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
ATE330950T1 (en) 2000-12-13 2006-07-15 Wyeth Corp HETEROCYCLIC SULFONAMIDES AS INHIBITORS OF BETA-AMYLOID PRODUCTION
US6657070B2 (en) 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
CH698246B1 (en) * 2001-12-20 2009-06-30 Hoffmann La Roche Test to identify inhibitors of beta secretases.
DE10306202A1 (en) * 2003-02-13 2004-08-26 Grünenthal GmbH 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist
JP4875487B2 (en) * 2003-03-14 2012-02-15 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション Benzothiazole derivative compounds, compositions and uses
MXPA05010368A (en) 2003-03-31 2005-11-17 Wyeth Corp Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof.
EP1633350B1 (en) 2003-06-05 2012-10-03 Elan Pharmaceuticals, Inc. Acylated amino acid amidyl pyrazoles and related compounds
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
ATE443701T1 (en) 2004-01-16 2009-10-15 Wyeth Corp HETEROCYCLIC AZOLE-CONTAINING SULFONAMIDINE INHIBITORS OF BETA-AMYLOID PRODUCTION
WO2005085185A1 (en) 2004-03-03 2005-09-15 Smithkline Beecham Corporation Aniline derivatives as selective androgen receptor modulators
US20080194536A1 (en) * 2005-04-15 2008-08-14 Marlys Hammond Cyanoarylamines
CN100999546B (en) * 2007-01-11 2010-08-11 清华大学 Polypeptide compound with aza-containing heterocyclic modification and its application
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
CN111777571B (en) * 2020-06-28 2023-07-11 武汉药明康德新药开发有限公司 Synthesis method of chiral 2-amino-3- (1, 3-benzothiazole-2-yl) propionic acid hydrochloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2170104T3 (en) * 1993-10-01 2002-08-01 Merrell Pharma Inc INHIBITORS OF THE PRODUCTION OF BETA-AMILOID PROTEINS.
US5872101A (en) * 1995-01-06 1999-02-16 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors

Also Published As

Publication number Publication date
NO992426L (en) 1999-06-30
NO992426D0 (en) 1999-05-20
WO1998022493A2 (en) 1998-05-28
EP0942923A2 (en) 1999-09-22
HUP0001383A1 (en) 2001-05-28
JP2001519769A (en) 2001-10-23
HUP0001383A3 (en) 2001-11-28
CN1237978A (en) 1999-12-08
ID22275A (en) 1999-09-23
CA2270876A1 (en) 1998-05-28
IL129477A0 (en) 2000-02-29
AU5354398A (en) 1998-06-10
NZ335157A (en) 2001-01-26
WO1998022493A3 (en) 1998-07-23
TR199901132T2 (en) 1999-08-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1833 DE 21/02/2006.