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BR9714099A - Enzymatic revolution of acetic acid-benzodiazepine esters with lipase - Google Patents

Enzymatic revolution of acetic acid-benzodiazepine esters with lipase

Info

Publication number
BR9714099A
BR9714099A BR9714099A BR9714099A BR9714099A BR 9714099 A BR9714099 A BR 9714099A BR 9714099 A BR9714099 A BR 9714099A BR 9714099 A BR9714099 A BR 9714099A BR 9714099 A BR9714099 A BR 9714099A
Authority
BR
Brazil
Prior art keywords
lipase
benzodiazepine
enzymatic
revolution
esters
Prior art date
Application number
BR9714099A
Other languages
Portuguese (pt)
Inventor
Andrew Stephen Wells
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BR9714099A publication Critical patent/BR9714099A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

ODIAZEPINA COM LIPASE" A presente invenção envolveenantioméricos e métodos de preparação dos mesmos por resolução de uma mistura racêmica utilizando uma lipase.ODIAZEPINE WITH LIPASE "The present invention involves enantiomeric and methods of preparing them by resolving a racemic mixture using a lipase.

BR9714099A 1996-12-27 1997-12-23 Enzymatic revolution of acetic acid-benzodiazepine esters with lipase BR9714099A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3385396P 1996-12-27 1996-12-27
PCT/GB1997/003522 WO1998029561A1 (en) 1996-12-27 1997-12-23 Enzymatic resolution of benzodiazepine-acetic acid esters with a lipase

Publications (1)

Publication Number Publication Date
BR9714099A true BR9714099A (en) 2000-03-21

Family

ID=21872833

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714099A BR9714099A (en) 1996-12-27 1997-12-23 Enzymatic revolution of acetic acid-benzodiazepine esters with lipase

Country Status (17)

Country Link
EP (1) EP0964928A1 (en)
JP (1) JP2001507231A (en)
KR (1) KR20000069705A (en)
CN (1) CN1246157A (en)
AR (1) AR010860A1 (en)
AU (1) AU730064B2 (en)
BR (1) BR9714099A (en)
CA (1) CA2276134A1 (en)
CO (1) CO4930272A1 (en)
HU (1) HUP0002825A3 (en)
IL (1) IL130580A0 (en)
NO (1) NO993174D0 (en)
NZ (1) NZ336376A (en)
PL (1) PL334293A1 (en)
TR (1) TR199901487T2 (en)
WO (1) WO1998029561A1 (en)
ZA (1) ZA9711566B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1054996T3 (en) 1998-02-17 2004-05-24 Searle & Co Process for the enzymatic separation of lactams
KR100378741B1 (en) * 2000-06-01 2003-04-07 에스케이 주식회사 Method for preparing R- or S-form α-substituted heterocyclic carboxyl acid and counter enantiomeric form of α-substituted heterocyclic carboxyl acid ester thereto using enzyme
DE60143262D1 (en) * 2000-06-01 2010-11-25 Sk Holdings Co Ltd METHOD FOR THE OPTICAL RESOLUTION OF A RAZEMIC ALPHA-SUBSTITUTED, HETEROCYCLIC CARBOXYLIC ACID UNDER ENZYME USE
KR100379756B1 (en) * 2000-10-02 2003-04-11 한국과학기술연구원 Resolution of chiral compounds
US6828119B2 (en) * 2001-01-04 2004-12-07 Bristol Myers Squibb Company Enzymatic deprotection of amines and hydroxides
FR2853327B1 (en) 2003-04-04 2012-07-27 Solvay PROCESS FOR THE PRODUCTION OF ENANTIOPOR BETA-AMINOACID DERIVATIVES AND ENANTIOPA BETA-AMINOACIDIC DERIVATIVES
KR100650798B1 (en) * 2004-07-19 2006-11-27 (주)제이코통상 Method for preparing optically active carboxylic acid
FR2876102A1 (en) * 2004-10-04 2006-04-07 Solvay ENANTIOPUR HETEROCYCLIC COMPOUND
KR100650797B1 (en) * 2005-12-12 2006-11-27 (주)케미코월드 Method for preparing optically active cyclopropane carboxamide
FR2986804A1 (en) * 2012-02-09 2013-08-16 Servier Lab PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S) 3,4-DIMETHOXYBICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-CARBOXYLIC ACID OR ITS ESTERS, AND APPLICATION TO THE SYNTHESIS OF IVABRADIN AND IES SALTS
CN117363683A (en) * 2023-10-09 2024-01-09 江苏惠利生物科技有限公司 Enzymatic resolution method of lipase benzodiazepine-acetate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243326A (en) * 1991-06-28 1995-10-26 Smithkline Beecham Corp Benzodiazepine, benzazepine; benzothiazepine and benzoxazepine derivatives; pharmaceutical compositions
KR100318572B1 (en) * 1992-12-21 2002-04-22 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 Bicyclic fibrinogen antagonist
MA23420A1 (en) * 1994-01-07 1995-10-01 Smithkline Beecham Corp BICYCLIC FIBRINOGEN ANTAGONISTS.
US5529929A (en) * 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens

Also Published As

Publication number Publication date
HUP0002825A3 (en) 2002-09-30
AU5331498A (en) 1998-07-31
NZ336376A (en) 2000-11-24
HUP0002825A2 (en) 2000-12-28
EP0964928A1 (en) 1999-12-22
CN1246157A (en) 2000-03-01
WO1998029561A1 (en) 1998-07-09
NO993174L (en) 1999-06-25
TR199901487T2 (en) 1999-11-22
IL130580A0 (en) 2000-06-01
CO4930272A1 (en) 2000-06-27
PL334293A1 (en) 2000-02-14
JP2001507231A (en) 2001-06-05
AR010860A1 (en) 2000-07-12
NO993174D0 (en) 1999-06-25
CA2276134A1 (en) 1998-07-09
ZA9711566B (en) 1998-06-29
AU730064B2 (en) 2001-02-22
KR20000069705A (en) 2000-11-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1905 DE 10/07/2007.