BR9713690B1 - agentes melatoninérgicos benzodioxola, benzofurano, diidrobenzofurano e benzodioxano. - Google Patents
agentes melatoninérgicos benzodioxola, benzofurano, diidrobenzofurano e benzodioxano.Info
- Publication number
- BR9713690B1 BR9713690B1 BRPI9713690-5A BR9713690A BR9713690B1 BR 9713690 B1 BR9713690 B1 BR 9713690B1 BR 9713690 A BR9713690 A BR 9713690A BR 9713690 B1 BR9713690 B1 BR 9713690B1
- Authority
- BR
- Brazil
- Prior art keywords
- benzodioxane
- benzodioxole
- dihydrobenzofuran
- benzofuran
- melatoninergic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3268996P | 1996-12-10 | 1996-12-10 | |
| PCT/US1997/022627 WO1998025606A1 (en) | 1996-12-10 | 1997-12-09 | Benzodioxole, benzofuran, dihydrobenzofuran, and benzodioxane melatonergic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9713690A BR9713690A (pt) | 2000-05-02 |
| BR9713690B1 true BR9713690B1 (pt) | 2009-08-11 |
Family
ID=21866306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9713690-5A BR9713690B1 (pt) | 1996-12-10 | 1997-12-09 | agentes melatoninérgicos benzodioxola, benzofurano, diidrobenzofurano e benzodioxano. |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US5856529A (pt) |
| EP (1) | EP1027043B1 (pt) |
| JP (1) | JP4290765B2 (pt) |
| KR (1) | KR100499106B1 (pt) |
| CN (1) | CN1152679C (pt) |
| AR (1) | AR010346A1 (pt) |
| AT (1) | ATE281833T1 (pt) |
| AU (1) | AU719994B2 (pt) |
| BR (1) | BR9713690B1 (pt) |
| CA (1) | CA2274183C (pt) |
| CY (1) | CY2501B1 (pt) |
| CZ (1) | CZ297673B6 (pt) |
| DE (1) | DE69731562T2 (pt) |
| DK (1) | DK1027043T3 (pt) |
| ES (1) | ES2230626T3 (pt) |
| HU (1) | HU226524B1 (pt) |
| IL (1) | IL129999A (pt) |
| NO (1) | NO321450B1 (pt) |
| NZ (1) | NZ335910A (pt) |
| PL (1) | PL190499B1 (pt) |
| PT (1) | PT1027043E (pt) |
| RU (1) | RU2190609C2 (pt) |
| TW (1) | TW476758B (pt) |
| WO (1) | WO1998025606A1 (pt) |
| ZA (1) | ZA9711051B (pt) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9614347D0 (en) * | 1996-07-09 | 1996-09-04 | Smithkline Beecham Spa | Novel compounds |
| US6160134A (en) * | 1997-12-24 | 2000-12-12 | Bristol-Myers Squibb Co. | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
| CA2334299A1 (en) * | 1998-06-05 | 1999-12-09 | Pierre Dextraze | Heterocyclic cis cyclopropane derivatives as melatonergic agents |
| AU763963B2 (en) * | 1999-06-30 | 2003-08-07 | Bristol-Myers Squibb Company | Heterocyclic aminopyrrolidine derivatives as melatonergic agents |
| ATE327753T1 (de) | 2001-05-15 | 2006-06-15 | Hoffmann La Roche | Carbonsäure-substituierte oxazol-derivate zur verwendung als ppar-alpha und -gamma aktivatoren zur behandlung von diabetes |
| JP2005505586A (ja) * | 2001-10-04 | 2005-02-24 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体 |
| US6569894B1 (en) | 2001-10-04 | 2003-05-27 | Bristol-Myers Squibb Company | Arylalkylbenzofuran derivatives as melatonergic agents |
| US6737431B2 (en) | 2002-03-12 | 2004-05-18 | Bristol-Myers Squibb Company | Benzoxazole derivatives as novel melatonergic agents |
| RU2295520C2 (ru) * | 2002-07-03 | 2007-03-20 | Ф.Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ ОКСАЗОЛА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ СЕНСИБИЛИЗАТОРОВ ИНСУЛИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ АКТИВИРУЮЩИМ ДЕЙСТВИЕМ В ОТНОШЕНИИ PRARα И/ИЛИ PRARγ |
| EP1537091B1 (en) * | 2002-08-30 | 2010-10-06 | F. Hoffmann-La Roche AG | Novel 2-arylthiazole compounds as pparalpha and ppargamma agonists |
| JP4286782B2 (ja) * | 2002-09-12 | 2009-07-01 | エフ．ホフマン−ラ ロシュ アーゲー | 糖尿病の治療に有用な、ｐｐａｒアゴニストとしてのｎ−置換−１ｈ−インドール−５−プロピオン酸化合物 |
| RU2315767C2 (ru) * | 2002-11-25 | 2008-01-27 | Ф.Хоффманн-Ля Рош Аг | Индолилпроизводные, способ их получения, фармацевтическая композиция, способ лечения и/или профилактики заболеваний |
| US7015831B2 (en) * | 2002-12-17 | 2006-03-21 | Evolution Robotics, Inc. | Systems and methods for incrementally updating a pose of a mobile device calculated by visual simultaneous localization and mapping techniques |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| RU2445973C2 (ru) * | 2006-05-22 | 2012-03-27 | Ванда Фармасьютиклз, Инк. | Способ лечения глубокой депрессии у человека |
| MX2008014841A (es) * | 2006-05-22 | 2008-12-05 | Vanda Pharmaceuticals Inc | Tratamiento de agonista de melatonina. |
| EP2141150B1 (en) * | 2007-04-26 | 2013-12-11 | Takeda Pharmaceutical Company Limited | Bicyclic compound and pharmaceutical use thereof |
| US7964430B2 (en) * | 2007-05-23 | 2011-06-21 | Applied Materials, Inc. | Silicon layer on a laser transparent conductive oxide layer suitable for use in solar cell applications |
| US11060144B2 (en) * | 2007-09-13 | 2021-07-13 | Vanda Pharmaceuticals Inc. | Prediction of sleep parameter and response to sleep-inducing compound based on PER3 VNTR genotype |
| US20120136050A1 (en) | 2009-07-16 | 2012-05-31 | Vanda Pharmaceuticals Inc. | Use of a melatonin agonist for the treatment of sleep disorders including primary insomnia |
| EP2287159A1 (en) * | 2009-07-29 | 2011-02-23 | V.Mane Fils | New bicyclic dioxanes, their preparation and their use as organoleptic compounds |
| JP4944286B1 (ja) * | 2010-09-22 | 2012-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シクロプロパン化合物 |
| US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
| WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| EP4502609A3 (en) | 2012-01-26 | 2025-04-09 | Vanda Pharmaceuticals Inc. | Determining a circadian rhythm |
| MX2014014010A (es) * | 2012-05-18 | 2015-02-12 | Vanda Pharmaceuticals Inc | Metabolitos de (1r-trans) -n - [[2- (2,3-dihidro-4-benzofuranilo) ciclopropilo] metilo] propanamida. |
| JPWO2014010603A1 (ja) | 2012-07-10 | 2016-06-23 | アステラス製薬株式会社 | 腹圧性尿失禁又は混合型尿失禁の治療又は予防用医薬組成物、及び該医薬組成物に含有される化合物のスクリーニング方法 |
| AR091699A1 (es) | 2012-07-10 | 2015-02-25 | Astellas Pharma Inc | Derivado de indol carboxamida |
| CN110200958A (zh) | 2012-12-18 | 2019-09-06 | 万达制药公司 | 昼夜节律紊乱的治疗 |
| US9643947B2 (en) | 2013-08-28 | 2017-05-09 | Northwestern University | 7-membered fused heterocycles and methods of their synthesis |
| US9573921B2 (en) * | 2013-09-30 | 2017-02-21 | Polfarmex S.A. | Substituted N, N-dimethylaminoalkyl ethers of isoflavanone oximes as H1-receptor antagonists |
| US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
| US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
| WO2015117048A1 (en) | 2014-01-31 | 2015-08-06 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| US12304896B2 (en) | 2014-12-04 | 2025-05-20 | Vanda Pharmaceuticals Inc. | Highly purified pharmaceutical grade tasimelteon |
| US10071977B2 (en) | 2014-02-12 | 2018-09-11 | Vanda Pharmaceuticals Inc. | Highly purifid pharmaceutical grade tasimelteon |
| HRP20230070T1 (hr) | 2014-09-02 | 2023-03-17 | Vanda Pharmaceuticals Inc. | Tasimelteon za liječenje smith-magenis sindroma |
| CN104327022B (zh) * | 2014-10-17 | 2015-12-02 | 苏州明锐医药科技有限公司 | 他司美琼的制备方法 |
| CN104402849B (zh) * | 2014-11-11 | 2016-11-09 | 苏州莱克施德药业有限公司 | 他司美琼中间体的新制备工艺 |
| CN106588841B (zh) * | 2015-10-19 | 2019-01-25 | 富乐马鸿凯（大连）医药有限公司 | 合成2,3-二氢-1-苯并呋喃-4-甲醛的方法 |
| KR20190008265A (ko) | 2016-05-06 | 2019-01-23 | 피지션즈 씰, 엘엘씨 | 발레리안 조성물 및 관련 방법 |
| CN105949153B (zh) * | 2016-05-10 | 2018-03-02 | 浙江工业大学 | 一种他司美琼的合成方法 |
| CN107365288A (zh) * | 2016-05-12 | 2017-11-21 | 浙江京新药业股份有限公司 | 他司美琼的晶型 |
| US9944616B2 (en) | 2016-06-08 | 2018-04-17 | Apotex Inc. | Processes for the preparation of Tasimelteon and intermediates thereof |
| CN106543119B (zh) * | 2016-09-22 | 2019-07-26 | 浙江工业大学 | 一种光学纯他司美琼的制备方法 |
| BR102016024814A2 (pt) | 2016-10-24 | 2018-05-08 | Aché Laboratórios Farmacêuticos S.A. | composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono |
| WO2018149940A1 (en) | 2017-02-17 | 2018-08-23 | Quimica Sintetica, S. A. | Process for the preparation of enantiomerically enriched dihydrobenzofurans and intermediate compounds obtained in the process |
| US20210059973A1 (en) | 2017-08-02 | 2021-03-04 | Vanda Pharmaceuticals Inc. | Treatment of Affective Disorders |
| WO2019173180A1 (en) * | 2018-03-04 | 2019-09-12 | Vanda Pharmaceuticals Inc. | Treatment of disorders with tasimelteon |
| CN113365618A (zh) * | 2018-09-12 | 2021-09-07 | 万带兰制药公司 | 改善睡眠或睡醒后表现 |
| MX2021012833A (es) | 2019-05-15 | 2021-11-25 | Eisai R&D Man Co Ltd | Metodo y compuesto utiles en la preparacion del antagonista del receptor de orexina-2 y lemborexant que tiene pocas impurezas. |
| WO2021003086A1 (en) | 2019-06-29 | 2021-01-07 | Vanda Pharmaceuticals Inc. | Tasimelteon use in treating sleep aberrations |
| MX2022006577A (es) * | 2019-12-13 | 2022-07-04 | Vanda Pharmaceuticals Inc | Formulaciones liquidas de tasimelteon y metodos para su uso. |
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| FR2667316B1 (fr) * | 1990-10-02 | 1994-09-16 | Roussel Uclaf | Nouveaux derives du benzofuranne, leur procede de preparation et leur application comme pesticides. |
| FR2674524B1 (fr) * | 1991-03-25 | 1993-05-21 | Adir | Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2680507B1 (fr) * | 1991-08-23 | 1993-10-08 | Adir Cie | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2689124A1 (fr) * | 1992-03-27 | 1993-10-01 | Adir | Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US5449683A (en) * | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
| FR2696453B1 (fr) * | 1992-10-02 | 1994-12-23 | Adir | Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent. |
| GB9326192D0 (en) * | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
| GB9407919D0 (en) * | 1994-04-21 | 1994-06-15 | Glaxo Group Ltd | Chemical compounds |
| FR2725985B1 (fr) * | 1994-10-21 | 1996-11-15 | Adir | Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5633218A (en) * | 1995-05-24 | 1997-05-27 | E. I. Du Pont De Nemours And Company | Herbicidal benzodioxoles and benzodioxanes |
| US5596019A (en) * | 1995-06-07 | 1997-01-21 | Bristol-Myers Squibb Company | N-acyl-cycloalkylamine derivatives as melatonergics |
| CA2176854A1 (en) * | 1995-06-07 | 1996-12-08 | Daniel J. Keavy | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics |
| PT901483E (pt) * | 1996-05-14 | 2003-11-28 | Glaxo Group Ltd | Benzofuranos e benzopiranos como agentes cronobiologicos |
-
1997
- 1997-12-09 WO PCT/US1997/022627 patent/WO1998025606A1/en not_active Ceased
- 1997-12-09 PL PL97333950A patent/PL190499B1/pl unknown
- 1997-12-09 DE DE69731562T patent/DE69731562T2/de not_active Expired - Lifetime
- 1997-12-09 CA CA002274183A patent/CA2274183C/en not_active Expired - Lifetime
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- 1997-12-09 ES ES97952354T patent/ES2230626T3/es not_active Expired - Lifetime
- 1997-12-09 NZ NZ335910A patent/NZ335910A/xx not_active IP Right Cessation
- 1997-12-09 IL IL12999997A patent/IL129999A/en not_active IP Right Cessation
- 1997-12-09 TW TW086118524A patent/TW476758B/zh active
- 1997-12-09 AU AU55985/98A patent/AU719994B2/en not_active Expired
- 1997-12-09 BR BRPI9713690-5A patent/BR9713690B1/pt not_active IP Right Cessation
- 1997-12-09 ZA ZA9711051A patent/ZA9711051B/xx unknown
- 1997-12-09 RU RU99115102/04A patent/RU2190609C2/ru active
- 1997-12-09 EP EP97952354A patent/EP1027043B1/en not_active Expired - Lifetime
- 1997-12-09 CN CNB971804443A patent/CN1152679C/zh not_active Expired - Lifetime
- 1997-12-09 HU HU0000695A patent/HU226524B1/hu unknown
- 1997-12-09 AT AT97952354T patent/ATE281833T1/de active
- 1997-12-09 DK DK97952354T patent/DK1027043T3/da active
- 1997-12-09 PT PT97952354T patent/PT1027043E/pt unknown
- 1997-12-09 KR KR10-1999-7005148A patent/KR100499106B1/ko not_active Expired - Lifetime
- 1997-12-09 JP JP52692198A patent/JP4290765B2/ja not_active Expired - Lifetime
- 1997-12-09 CZ CZ0199199A patent/CZ297673B6/cs not_active IP Right Cessation
- 1997-12-10 AR ARP970105795A patent/AR010346A1/es active IP Right Grant
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1998
- 1998-10-09 US US09/169,784 patent/US5981571A/en not_active Expired - Lifetime
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1999
- 1999-06-09 NO NO19992804A patent/NO321450B1/no not_active IP Right Cessation
- 1999-07-13 US US09/352,560 patent/US6060506A/en not_active Expired - Lifetime
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2005
- 2005-01-31 CY CY0500008A patent/CY2501B1/xx unknown
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