BR9708343A - Anticorpo composição linhagem de células método para determinar a presença de proteína de erbB3 e kit - Google Patents
Anticorpo composição linhagem de células método para determinar a presença de proteína de erbB3 e kitInfo
- Publication number
- BR9708343A BR9708343A BR9708343A BR9708343A BR9708343A BR 9708343 A BR9708343 A BR 9708343A BR 9708343 A BR9708343 A BR 9708343A BR 9708343 A BR9708343 A BR 9708343A BR 9708343 A BR9708343 A BR 9708343A
- Authority
- BR
- Brazil
- Prior art keywords
- erbb3
- kit
- determining
- erbb3 protein
- cell line
- Prior art date
Links
- 102000056372 ErbB-3 Receptor Human genes 0.000 title abstract 3
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 title abstract 3
- 102000048238 Neuregulin-1 Human genes 0.000 abstract 3
- 108090000556 Neuregulin-1 Proteins 0.000 abstract 3
- 230000004913 activation Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62403696A | 1996-03-27 | 1996-03-27 | |
| PCT/US1997/003546 WO1997035885A1 (en) | 1996-03-27 | 1997-03-07 | ErbB3 ANTIBODIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9708343A true BR9708343A (pt) | 1999-08-03 |
Family
ID=24500380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9708343A BR9708343A (pt) | 1996-03-27 | 1997-03-07 | Anticorpo composição linhagem de células método para determinar a presença de proteína de erbB3 e kit |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP1728802A3 (pt) |
| JP (1) | JP3925943B2 (pt) |
| CN (1) | CN1214044C (pt) |
| AT (1) | ATE342283T1 (pt) |
| AU (1) | AU727082B2 (pt) |
| BR (1) | BR9708343A (pt) |
| CA (1) | CA2246429C (pt) |
| DE (1) | DE69736806T3 (pt) |
| DK (1) | DK0896586T4 (pt) |
| ES (1) | ES2274537T5 (pt) |
| IL (2) | IL126303A (pt) |
| NZ (1) | NZ331360A (pt) |
| PT (1) | PT896586E (pt) |
| WO (1) | WO1997035885A1 (pt) |
| ZA (1) | ZA972554B (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6417168B1 (en) * | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
| AUPQ105799A0 (en) * | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| US7041292B1 (en) | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
| DE60042693D1 (de) | 1999-08-27 | 2009-09-17 | Genentech Inc | Dosierung für die behandlung mit anti erbb2-antikörpern |
| AU2008200654B2 (en) * | 2001-08-09 | 2010-04-29 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Inhibitors of HER3 activity |
| EP1283053A1 (en) * | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitors of HER3 activity |
| JP4660094B2 (ja) | 2002-03-26 | 2011-03-30 | ゼンサン (シャンハイ) サイ−テク. リミテッド | 新生物を治療するためのErbB3に基づく方法および組成物 |
| BR0312534A (pt) | 2002-07-15 | 2007-03-13 | Genentech Inc | método de identificação de um tumor, método para a identificação de células de tumor, método para prever a resposta de um indivìduo diagnosticado com um tumor de her2-positivo, método para a identificação de um individuo responsivo ao tratamento com anticorpo anti-her2 e métodos de tratamento de um paciente e artigo de manufatura |
| RU2404810C9 (ru) | 2004-06-01 | 2015-06-20 | Дженентек, Инк. | Конъюгаты антитело-лекарственное средство и способы |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| WO2006034488A2 (en) | 2004-09-23 | 2006-03-30 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| AR056857A1 (es) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| CA2670522C (en) | 2006-11-28 | 2018-08-07 | U3 Pharma Gmbh | Activated her3 as a marker for predicting therapeutic efficacy |
| HRP20131113T1 (hr) * | 2007-02-16 | 2014-01-17 | Merrimack Pharmaceuticals, Inc. | Protutijela protiv erbb3 i njihova uporaba |
| AU2009281721A1 (en) | 2008-08-15 | 2010-02-18 | Merrimack Pharmaceuticals, Inc. | Methods and systems for predicting response of cells to a therapeutic agent |
| EP2417159A1 (en) | 2009-04-07 | 2012-02-15 | Roche Glycart AG | Bispecific anti-erbb-3/anti-c-met antibodies |
| SI3351558T1 (sl) | 2009-11-13 | 2020-07-31 | Daiichi Sankyo Europe Gmbh | Material in postopki za zdravljenje ali preprečevanje bolezni, povezanih s HER-3 |
| KR20120123299A (ko) | 2009-12-04 | 2012-11-08 | 제넨테크, 인크. | 다중특이적 항체, 항체 유사체, 조성물 및 방법 |
| US8859737B2 (en) | 2009-12-22 | 2014-10-14 | Roche Glycart Ag | Anti-HER3 antibodies and uses thereof |
| ES2535503T3 (es) | 2010-03-11 | 2015-05-12 | Merrimack Pharmaceuticals, Inc. | Uso de inhibidores de ErbB3 en el tratamiento del cáncer de mama triple negativo |
| RU2568051C2 (ru) * | 2010-04-09 | 2015-11-10 | Авео Фармасьютикалз, Инк. | АНТИТЕЛА К ErbB3 |
| CA3051311A1 (en) | 2010-05-27 | 2011-12-01 | Genmab A/S | Monoclonal antibodies against her2 |
| US9714294B2 (en) | 2010-05-27 | 2017-07-25 | Genmab A/S | Monoclonal antibodies against HER2 epitope |
| CA2803900A1 (en) | 2010-07-09 | 2012-01-12 | Exelixis, Inc. | Combinations of kinase inhibitors for the treatment of cancer |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| EP3156421B1 (en) * | 2010-11-01 | 2018-06-06 | Symphogen A/S | Pan-her antibody composition |
| EP2699602B1 (en) | 2011-04-19 | 2017-03-01 | Merrimack Pharmaceuticals, Inc. | Bispecific anti-igf-1r and anti-erbb3 antibodies |
| CA2832389A1 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| US9273143B2 (en) | 2011-09-30 | 2016-03-01 | Regeneron Pharmaceuticals, Inc. | Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody |
| ES2694153T3 (es) | 2011-09-30 | 2018-12-18 | Regeneron Pharmaceuticals, Inc. | Anticuerpos anti-ErbB3 y usos de los mismos |
| CN108753942A (zh) * | 2011-10-06 | 2018-11-06 | Aveo制药公司 | 预测肿瘤对抗erbb3抗体的应答 |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun (Shanghai)Science & Technology Limited | Compositions and methods for treating heart failure |
| AU2012335543C1 (en) * | 2011-11-09 | 2017-12-14 | Beijing Cotimes Biotech Co., Ltd., | HER3 antibodies and uses thereof |
| KR102080535B1 (ko) | 2011-11-23 | 2020-02-24 | 메디뮨 엘엘씨 | Her3에 특이적인 결합 분자 및 이의 용도 |
| UY34487A (es) * | 2011-12-05 | 2013-07-31 | Novartis Ag | Anticuerpos para receptor de factor de crecimiento epidérmico 3(her3) |
| KR20150064205A (ko) | 2012-11-08 | 2015-06-10 | 에프. 호프만-라 로슈 아게 | Her3의 베타-헤어핀에 결합하는 her3 항원 결합 단백질 |
| CA2884429A1 (en) * | 2012-11-08 | 2014-05-15 | Birgit Bossenmaier | Anti-her3/her4 antigen binding proteins binding to the beta-hairpin of her3 and the beta-hairpin of her4 |
| AR094403A1 (es) | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
| WO2015048008A2 (en) | 2013-09-24 | 2015-04-02 | Medimmune, Llc | Binding molecules specific for her3 and uses thereof |
| WO2015100459A2 (en) | 2013-12-27 | 2015-07-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
| US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
| BR112016024457A2 (pt) | 2014-05-14 | 2018-01-23 | Hoffmann La Roche | anticorpo isolado, imunoconjugado, uso do anticorpo, formulação farmacêutica, ácido nucleico isolado, célula hospedeira e método de produção de um anticorpo |
| US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
| TW202227504A (zh) * | 2020-10-15 | 2022-07-16 | 大陸商上海翰森生物醫藥科技有限公司 | 抗erbb3抗體或其抗原結合片段及其醫藥用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5183884A (en) * | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| AU662311B2 (en) * | 1991-02-05 | 1995-08-31 | Novartis Ag | Recombinant antibodies specific for a growth factor receptor |
| EP0625200B1 (en) * | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
| AU4025193A (en) * | 1992-04-08 | 1993-11-18 | Cetus Oncology Corporation | Humanized C-erbB-2 specific antibodies |
| AU6527894A (en) * | 1993-03-30 | 1994-10-24 | Trustees Of The University Of Pennsylvania, The | Prevention of tumors with monoclonal antibodies against (neu) |
| US5783186A (en) * | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
-
1997
- 1997-03-07 IL IL12630397A patent/IL126303A/en not_active IP Right Cessation
- 1997-03-07 IL IL12630397D patent/IL126303A0/xx unknown
- 1997-03-07 PT PT97908923T patent/PT896586E/pt unknown
- 1997-03-07 CA CA002246429A patent/CA2246429C/en not_active Expired - Lifetime
- 1997-03-07 AU AU20711/97A patent/AU727082B2/en not_active Expired
- 1997-03-07 NZ NZ331360A patent/NZ331360A/xx not_active IP Right Cessation
- 1997-03-07 DK DK97908923.2T patent/DK0896586T4/en active
- 1997-03-07 BR BR9708343A patent/BR9708343A/pt not_active Application Discontinuation
- 1997-03-07 WO PCT/US1997/003546 patent/WO1997035885A1/en active IP Right Grant
- 1997-03-07 ES ES97908923.2T patent/ES2274537T5/es not_active Expired - Lifetime
- 1997-03-07 CN CNB971933588A patent/CN1214044C/zh not_active Expired - Lifetime
- 1997-03-07 EP EP06014174A patent/EP1728802A3/en not_active Withdrawn
- 1997-03-07 AT AT97908923T patent/ATE342283T1/de active
- 1997-03-07 JP JP53441197A patent/JP3925943B2/ja not_active Expired - Lifetime
- 1997-03-07 DE DE69736806.8T patent/DE69736806T3/de not_active Expired - Lifetime
- 1997-03-07 EP EP97908923.2A patent/EP0896586B2/en not_active Expired - Lifetime
- 1997-03-25 ZA ZA972554A patent/ZA972554B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69736806T2 (de) | 2007-08-09 |
| AU2071197A (en) | 1997-10-17 |
| EP1728802A2 (en) | 2006-12-06 |
| AU727082B2 (en) | 2000-11-30 |
| CN1214044C (zh) | 2005-08-10 |
| CA2246429A1 (en) | 1997-10-02 |
| ES2274537T3 (es) | 2007-05-16 |
| EP1728802A3 (en) | 2006-12-13 |
| DE69736806D1 (de) | 2006-11-23 |
| DE69736806T3 (de) | 2015-10-08 |
| DK0896586T4 (en) | 2015-08-24 |
| EP0896586B2 (en) | 2015-05-20 |
| CN1214695A (zh) | 1999-04-21 |
| ZA972554B (en) | 1998-09-25 |
| EP0896586B1 (en) | 2006-10-11 |
| DK0896586T3 (da) | 2007-02-19 |
| PT896586E (pt) | 2007-01-31 |
| ATE342283T1 (de) | 2006-11-15 |
| NZ331360A (en) | 2000-03-27 |
| IL126303A (en) | 2002-05-23 |
| IL126303A0 (en) | 1999-05-09 |
| WO1997035885A1 (en) | 1997-10-02 |
| JP3925943B2 (ja) | 2007-06-06 |
| JP2000508526A (ja) | 2000-07-11 |
| EP0896586A1 (en) | 1999-02-17 |
| CA2246429C (en) | 2007-07-24 |
| ES2274537T5 (es) | 2015-09-14 |
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Legal Events
| Date | Code | Title | Description |
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: SUSPENSAO DO ANDAMENTO DO PEDIDO DE PATENTE PARA QUE SEJA COMPLEMENTADA A RETRIBUICAO EQUIVALENTE AO PEDIDO DE EXAME DE 36 (TRINTA E SEIS) REIVINDICACOES, VISTO QUE A RETRIBUICAO PAGA ATRAVES DA PETICAO N SP003288, DE 20000131, REFERE-SE A 21 (VINTE E UMA) REIVINDICACOES. |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART. 37 DA LEI 9.279/96, INDEFIRO O PRESENTE PEDIDO COM BASE NOS ARTS. 24 E 25 DA LEI NO 9.279/96 |
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| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |