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BR9707036A - Análogos de il-10 sintéticos. - Google Patents

Análogos de il-10 sintéticos.

Info

Publication number
BR9707036A
BR9707036A BR9707036-0A BR9707036A BR9707036A BR 9707036 A BR9707036 A BR 9707036A BR 9707036 A BR9707036 A BR 9707036A BR 9707036 A BR9707036 A BR 9707036A
Authority
BR
Brazil
Prior art keywords
amino acid
peptide
acid residue
terminal amino
above formula
Prior art date
Application number
BR9707036-0A
Other languages
English (en)
Inventor
Christian Gronhoj Larsen
Original Assignee
Steeno Res Group As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steeno Res Group As filed Critical Steeno Res Group As
Publication of BR9707036A publication Critical patent/BR9707036A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: <B>"ANáLOGOS DE IL-10 SINTéTICOS"<D>. A invenção refere-se à aplicação de uma substância ou polipeptídeo de acordo com a fórmula X~ 1~-X~ 2~-X~ 3~-Thr-X~ 4~-Lys-X~ 5~-Arg-X~ 6~ (SEQ. ID. N‘.: 22), na qual X~ 1~ é Ala ou Gly, X~ 2~ é Tyr ou Phe, X~ 3~, X~ 4~ e X~ 5~ são selecionados de modo independente entre o grupo consistindo de Met, Ile, Leu e Val; e X~ 6~ é selecionado entre o grupo consistindo de Asn, Asp, Gln e Glu, opcionalmente no mínimo um entre X~ 1~,X~ 2~, X~ 3~, X~ 4~, X~ 5~ e X~ 6~ é substituído de modo independente com um aminoácido não-natural ou não habitual e/ou o peptídeo é transformado num ciclo e/ou o peptídeo é estabilizado e/ou o resíduo de aminoácido de terminal amino é acilado e/ou o resíduo de aminoácido de terminal carbóxi é aminado, e os peptidomiméticos modelados sobre a base da fórmula acima, para a preparação de uma composição farmacêutica para a redução da produção de TNF~ <244>~ e/ou para a profilaxia ou o tratamento de pancreatite e/ou para a profilaxia ou o tratamento de infecções virais tais como a síndrome da imunodeficiência adquirida (AIDS) ou a infecção cutânea por HPV. Em particular, a invenção refere-se análogos de peptídeos da fórmula acima na qual no mínimo um entre X~ 1~,X~ 2~, X~ 3~, X~ 4~, X~ 5~ e X~ 6~ é substituído de modo independente com um aminoácido não-natural ou não habitual e/ou o peptídeo é transformado num ciclo e/ou o peptídeo é estabilizado e/ou o resíduo de aminoácido de terminal amino é acilado e/ou o resíduo de aminoácido de terminal carbóxi é amidado, e os peptidomiméticos modelados sobre a base da fórmula acima.
BR9707036-0A 1996-01-18 1997-01-16 Análogos de il-10 sintéticos. BR9707036A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1996/000029 WO1997026278A1 (en) 1996-01-18 1996-01-18 Synthetic il-10 analogues
PCT/DK1997/000021 WO1997026279A1 (en) 1996-01-18 1997-01-16 Synthetic il-10 analogues

Publications (1)

Publication Number Publication Date
BR9707036A true BR9707036A (pt) 1999-08-31

Family

ID=8155499

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9707036-0A BR9707036A (pt) 1996-01-18 1997-01-16 Análogos de il-10 sintéticos.

Country Status (14)

Country Link
US (1) US6936586B1 (pt)
EP (1) EP0879245A1 (pt)
JP (1) JP2000503652A (pt)
KR (1) KR19990077344A (pt)
CN (1) CN1226899A (pt)
AP (1) AP883A (pt)
AR (1) AR006517A1 (pt)
AU (2) AU4385696A (pt)
BR (1) BR9707036A (pt)
CA (1) CA2243275A1 (pt)
PL (1) PL327928A1 (pt)
RU (1) RU2194054C2 (pt)
WO (2) WO1997026278A1 (pt)
ZA (1) ZA9784B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4385696A (en) * 1996-01-18 1997-08-11 Christian Gronhoj Larsen Synthetic il-10 analogues
WO1998010792A1 (en) * 1996-09-11 1998-03-19 Prendergast Patrick T Immune direction therapy
AU9449398A (en) * 1997-10-10 1999-05-03 Imperial College Innovations Ltd. Use of csaidtm compounds for the management of uterine contractions
DE19851675A1 (de) * 1998-11-10 2000-05-11 Bayer Ag Menschliche Interleukin-10 Mutantenproteine
CA2356010A1 (en) 1998-12-22 2000-06-29 Schering Corporation Treatment of hepatitis c virus infections with interleukin-10
AU4545301A (en) * 2000-03-14 2001-09-24 Nat Jewish Med & Res Center Method and composition for treating airway hyperresponsiveness
US20070160576A1 (en) * 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
RU2260598C2 (ru) * 2003-10-29 2005-09-20 Российский кардиологический научно-производственный комплекс Министерства здравоохранения РФ Пептид, обладающий способностью ингибировать миграцию моноцитарных клеток, стимулированную белком мср-1
GB0500643D0 (en) * 2005-01-13 2005-02-23 Renovo Ltd Medicaments
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
KR101525754B1 (ko) 2007-03-28 2015-06-09 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
AU2014201269B2 (en) * 2008-02-08 2016-09-15 Aileron Therapeutics, Inc. Therapeutic peptidomimetic macrocycles
CN104474529A (zh) * 2008-02-08 2015-04-01 爱勒让治疗公司 治疗性的拟肽大环化合物
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2014138429A2 (en) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating hif1alpha
MX2017003797A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN108368161A (zh) 2015-09-10 2018-08-03 艾瑞朗医疗公司 作为mcl-1调节剂的拟肽大环化合物
US10610104B2 (en) 2016-12-07 2020-04-07 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
CA3054156A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist
WO2020106757A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
BR102019007044A2 (pt) * 2019-04-05 2021-12-28 Universidade Federal de Uberlândia Peptídeos sintéticos com afinidade ao receptor de interleucina-10, composição farmacêutica e uso dos mesmos como imunomuduladores no tratamento de doenças autoimunes, inflamatórias ou alérgicas
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置

Family Cites Families (14)

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US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
IL94878A (en) * 1989-06-28 2003-01-12 Schering Corp Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same
US5624823A (en) * 1991-11-22 1997-04-29 The General Hospital Corporation DNA encoding procine interleukin-10
AU679908B2 (en) 1992-03-04 1997-07-17 Schering Corporation Use of interleukin-10 to suppress graft-vs.-host disease
RU2051922C1 (ru) * 1992-06-19 1996-01-10 Людмила Яковлевна Соловьева СПОСОБ ВЫДЕЛЕНИЯ РЕКОМБИНАНТНОГО ИНТЕРЛЕЙКИНА - 1β ИЗ БИОМАССЫ МИКРООРГАНИЗМОВ
CA2085291A1 (en) 1992-07-30 1994-01-31 Martin L. Breitman Novel receptor tyrosine kinase
US5328989A (en) * 1993-03-05 1994-07-12 Schering-Plough Purification of human interleukin-10 from a cell culture medium
US5446128A (en) 1993-06-18 1995-08-29 The Board Of Trustees Of The University Of Illinois Alpha-helix mimetics and methods relating thereto
KR960704041A (ko) 1993-07-26 1996-08-31 에릭 에스. 딕커 사람 인터루킨-10의 효능제 및 길항제(Agonists and antagonists of human interleukin-10)
CZ1497A3 (en) * 1994-07-05 1997-05-14 Steeno Res Group As Polypeptide, its use and pharmaceutical composition based thereon, a nucleotide sequence and antibody
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
AU4385696A (en) * 1996-01-18 1997-08-11 Christian Gronhoj Larsen Synthetic il-10 analogues

Also Published As

Publication number Publication date
CN1226899A (zh) 1999-08-25
WO1997026279A1 (en) 1997-07-24
AR006517A1 (es) 1999-09-08
JP2000503652A (ja) 2000-03-28
AP883A (en) 2000-10-25
CA2243275A1 (en) 1997-07-24
ZA9784B (en) 1997-07-17
US6936586B1 (en) 2005-08-30
PL327928A1 (en) 1999-01-04
AU4385696A (en) 1997-08-11
EP0879245A1 (en) 1998-11-25
RU2194054C2 (ru) 2002-12-10
AU718476B2 (en) 2000-04-13
WO1997026278A1 (en) 1997-07-24
AU1301197A (en) 1997-08-11
KR19990077344A (ko) 1999-10-25
AP9801295A0 (en) 1998-09-30

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]