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BR9702231B8 - Pharmaceutical composition, compound and process for stabilizing a carbapenem - Google Patents

Pharmaceutical composition, compound and process for stabilizing a carbapenem

Info

Publication number
BR9702231B8
BR9702231B8 BRPI9702231A BR9702231A BR9702231B8 BR 9702231 B8 BR9702231 B8 BR 9702231B8 BR PI9702231 A BRPI9702231 A BR PI9702231A BR 9702231 A BR9702231 A BR 9702231A BR 9702231 B8 BR9702231 B8 BR 9702231B8
Authority
BR
Brazil
Prior art keywords
compound
carbapenem
stabilizing
pharmaceutical composition
pharmaceutical
Prior art date
Application number
BRPI9702231A
Other languages
Portuguese (pt)
Other versions
BR9702231A (en
BR9702231B1 (en
Inventor
R Sidler Daniel
C Dubost David
A Zimmerman Jeffrey
M Williams John
M Dimichele Lisa
J Kaufman Michael
A Bergquist Paul
A Hunke William
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10795438&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9702231(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority claimed from PCT/US1997/008831 external-priority patent/WO1997045430A1/en
Publication of BR9702231A publication Critical patent/BR9702231A/en
Publication of BR9702231B1 publication Critical patent/BR9702231B1/en
Publication of BR9702231B8 publication Critical patent/BR9702231B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/887—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero atom or a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"composição farmacêutico composto e processo para estabilizar um carbapenem". uma composição farmacêutica é descrita que contém um composto de fórmula (i) ou um sal farmaceuticamente aceitável, prodroga ou hidrato do mesmo, na forma estabilizada e/ou em combinação com uma fonte de dióxido de carbono."Pharmaceutical compound composition and process for stabilizing a carbapenem". a pharmaceutical composition is described which contains a compound of formula (I) or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in stabilized form and/or in combination with a source of carbon dioxide.

BRPI9702231A 1996-05-28 1997-05-23 Pharmaceutical composition, compound and process for stabilizing a carbapenem BR9702231B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1851896P 1996-05-28 1996-05-28
GBGB9612668.5A GB9612668D0 (en) 1996-06-18 1996-06-18 Carbapenem antibiotic composition and method of preparation
PCT/US1997/008831 WO1997045430A1 (en) 1996-05-28 1997-05-23 Carbapenem antibiotic, composition and method of preparation

Publications (3)

Publication Number Publication Date
BR9702231A BR9702231A (en) 1999-02-23
BR9702231B1 BR9702231B1 (en) 2019-03-12
BR9702231B8 true BR9702231B8 (en) 2022-01-18

Family

ID=10795438

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9702231A BR9702231B8 (en) 1996-05-28 1997-05-23 Pharmaceutical composition, compound and process for stabilizing a carbapenem

Country Status (4)

Country Link
AR (1) AR006284A1 (en)
BR (1) BR9702231B8 (en)
GB (1) GB9612668D0 (en)
MY (1) MY116202A (en)

Also Published As

Publication number Publication date
AR006284A1 (en) 1999-08-25
BR9702231A (en) 1999-02-23
GB9612668D0 (en) 1996-08-21
BR9702231B1 (en) 2019-03-12
MY116202A (en) 2003-11-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE ATRVES DE EXAME DO ULTIMO QUADRO REIVINDICATOTIO APRESENTADO ART. 8O, 11 E 13 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B15W Others matters related to applications: legal action concerning application

Free format text: INPI-52400.002406/2013-41 ORIGEM: JUIZO DA 009A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0037360-77.2012.4.02.5101 ACAO ORDINARIA COM PEDIDO DE LIMINAR AUTOR:MERCK SHARP AND DOHME CORP. REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI E AGENCIA NACIONAL DE VIGILANCIA SANITARIA - ANVISA.

B15N Others concerning applications: notification of judicial decision

Free format text: INPI-52400.002406/2013 SECAO JUDICIARIA DO RIO DE JANEIRO - 9A VARA FEDERAL PROCESSO NO 0037360-77.2012.4.02.5101 AUTOR: MERCK SHARP AND DOHME CORP REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI E AGENCIA NACIONAL DE VIGILANCIA SANITARIA ANVISA DECISAO: ASSIM SENDO, NOS MOLDES DA SUPRA, DIANTE DA EXISTENCIA DO ERRO MATERIAL APONTADO PELA EMBARGANTE AS FLS.1216, ITEM IV E LEVANDO EM CONTA O CONTIDO NO ART.1.022, III, DO CODIGO DE PROCESSO CIVIL/2015 E A TEMPESTIVIDADE DO RECURSO, CONHECO EM PARTE DOS PRESENTES EMBARGOS DE DECLARACAO E DOU PARCIAL PROVIMENTO AOS MESMOS, APENAS PARA RETIFICAR A REFERIDA INEXATIDAO MATERIAL NO NUMERO DA PATENTE DESCRITO NA SENTENCA DE FLS.1191/

B15N Others concerning applications: notification of judicial decision

Free format text: INPI-52400.002406/2013 SECAO JUDICIARIA DO RIO DE JANEIRO - 9A VARA FEDERAL PROCESSO NO 0037360-77.2012.4.02.5101 AUTOR: MERCK SHARP E DOHME CORP REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI DECISAO: ISTO POSTO: 1- JULGO EXTINTO O PROCESSO, SEM APRECIACAO DO MERITO, NOS MOLDES DO ART. 485, IV DO CODIGO DE PROCESSO CIVIL/2015, EM RELACAO A ANVISA AGENCIA NACIONAL DE VIGILANCIA SANITARIA, NA FORMA DA FUNDAMENTACAO SUPRA; 2- JULGO PROCEDENTES OS PEDIDOS FORMULADOS EM FACE DO INPI, PARA DECRETAR A NULIDADE DO ATO ADMINISTRATIVO QUE MANTEVE O INDEFERIMENTO DO REQUERIMENTO DE PATENTE DE INVENCAO PI 9702231-4 (FLS. 321 E 323), RECONHECENDO A PRESENCA DOS REQUISITOS LEGAIS DE PAT

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B19A Notification of judicial decision: notification of judicial decision
B16D Grant of patent or certificate of addition of invention cancelled
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Free format text: INPI-52400.002406/2013-41 TRIBUNAL REGIONAL FEDERAL DA 2A REGIAO PROCESSO: NO0037360-77.2012.4.02.5101 AUTOR: MERCK SHAPP AND DOHME CORP REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI E AGENCIA NACIONAL DE VIGILANCIA SANITARIA ? ANVISA DECISAO: INFORMO QUE TRANSITOU EM JULGADO EM 06/10/2018.

B09A Decision: intention to grant [chapter 9.1 patent gazette]
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/1997, OBSERVADAS AS CONDICOES LEGAIS.

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Free format text: "INPI NO 52402.006859/2020-55 ORIGEM: GABINETE 02 (TRF2) PROCESSO NO: 5000998-84.2020.4.02.0000 SUBJUDICE COM PEDIDO DE ANTECIPACAO DE TUTELA AUTOR: MERCK AND CO., INC. REU(S): INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI"

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Free format text: INPI NO 52402.006859/2020-55 NUP: 00408.007505/2020-74 (REF. 5000998-84.2020.4.02.0000) AGRAVANTE: MERCK AND CO., INC. AGRAVADO: INPI-INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL DECISAO: ACORDAO, QUE DETERMINOU O SOBRESTAMENTO DO PROCESSO ADMINISTRATIVO DE NULIDADE REFERENTE A PATENTE PI9702231-4, ATE A CONCLUSAO DO MANDADO DE SEGURANCA NO 5102942-89.2019.4.02.5101

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Free format text: PROCESSO INPI NO 52402.001947/2020-61 MANDADO DE SEGURANCA NO 5102942-89.2019.4.02.5101/RJ IMPETRANTE: MERCK AND CO., INC. IMPETRADO: LETICIA KHATER COVESI E PRESIDENTE - INPI-INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL DECISAO: NAO HA QUE SE FALAR, ASSIM, NO CASO EM QUESTAO, EM VIOLACAO A DIREITO LIQUIDO E CERTO DA IMPETRANTE NEM EM ATO ILEGAL OU ABUSIVO DE PODER DA AUTORIDADE ADMINISTRATIVA. JULGO IMPROCEDENTE O PEDIDO E DENEGO A SEGURANCA, NA FORMA DA FUNDAMENTACAO SUPRA.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/1997, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.