BR9408407A - Uso de inibidores pla2 como tratamento para doença de alzheimer - Google Patents

Uso de inibidores pla2 como tratamento para doença de alzheimer

Info

Publication number: BR9408407A
Authority: BR; Brazil
Prior art keywords: alzheimer; disease; treatment; pla2 inhibitors; pla2
Prior art date: 1993-12-23

Application number

BR9408407A

Other languages

English (en)

Inventor

James Allan Clemens

Michael Joseph Sofia

Diane Teresa Stephenson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-23

Filing date

1994-12-14

Publication date

1997-08-05

1994-12-14 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1997-08-05 Publication of BR9408407A publication Critical patent/BR9408407A/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BR9408407A 1993-12-23 1994-12-14 Uso de inibidores pla2 como tratamento para doença de alzheimer BR9408407A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/173,544 US5478857A (en)	1993-12-23	1993-12-23	Use of PLA2 inhibitors as treatment for alzheimer's disease
PCT/US1994/014504 WO1995017183A1 (en)	1993-12-23	1994-12-14	Use of pla2 inhibitors as treatment for alzheimer's disease

Publications (1)

Publication Number	Publication Date
BR9408407A true BR9408407A (pt)	1997-08-05

Family

ID=22632512

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9408407A BR9408407A (pt)	1993-12-23	1994-12-14	Uso de inibidores pla2 como tratamento para doença de alzheimer

Country Status (13)

Country	Link
US (2)	US5478857A (pt)
EP (1)	EP0735870A4 (pt)
JP (1)	JPH09507069A (pt)
CN (1)	CN1142768A (pt)
AU (1)	AU688446B2 (pt)
BR (1)	BR9408407A (pt)
CA (1)	CA2179649A1 (pt)
CZ (1)	CZ178096A3 (pt)
FI (1)	FI962557L (pt)
HU (1)	HUT75335A (pt)
NO (1)	NO962568L (pt)
WO (1)	WO1995017183A1 (pt)
ZA (1)	ZA9410041B (pt)

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KR20000069075A (ko) *	1996-11-22	2000-11-25	진 엠. 듀발	Ｎ-(아릴/헤테로아릴/알킬아세틸)아미노산 아미드, 이들을 함유하는 제약 조성물, 및 이들 화합물을 사용하여 베타-아밀로이드 펩티드의 방출 및(또는) 합성의 억제 방법
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US6635632B1 (en)	1996-12-23	2003-10-21	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6090839A (en) *	1996-12-23	2000-07-18	Merck & Co., Inc.	Antidiabetic agents
US6683075B1 (en)	1996-12-23	2004-01-27	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
AU6764798A (en) *	1997-03-21	1998-10-20	Eli Lilly And Company	Leukotriene antagonists useful for treating cystic fibrosis
EP1140791A2 (en)	1997-09-23	2001-10-10	Bristol-Myers Squibb Company	Selective cpla 2 inhibitors
US6350892B1 (en) *	1997-09-23	2002-02-26	Bristol-Myers Squibb Company	Trifluoromethyl ketone analogs as selective cPLA2 inhibitors
WO1999024033A1 (en) *	1997-11-12	1999-05-20	Shionogi & Co., Ltd.	Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
WO1999025340A1 (en) *	1997-11-14	1999-05-27	Eli Lilly And Company	Treatment for alzheimer's disease
US6254853B1 (en)	1998-05-08	2001-07-03	Vyrex Corporation	Water soluble pro-drugs of propofol
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US6509331B1 (en)	1998-06-22	2003-01-21	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) *	1998-06-22	2003-05-27	Elan Pharmaceutials, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en)	1998-06-22	2003-03-04	Elan Pharmaceuticals, Inc.	Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) *	1998-06-22	2004-08-10	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en)	1998-06-22	2005-10-25	Elan Pharmaceuticals, Inc.	Polycyclic α-amino-ε-caprolactams and related compounds
AUPP609198A0 (en) *	1998-09-22	1998-10-15	Curtin University Of Technology	Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1 (en)	1998-09-22	2005-08-23	Erik Helmerhorst	Use of non-peptidyl compounds for the treatment of insulin related ailments
US20030149000A1 (en) *	1998-11-10	2003-08-07	Shionogi & Co., Ltd.	Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds
US6924391B2 (en)	2000-05-11	2005-08-02	Bristol-Myers Squibb Company	Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors
WO2001087293A1 (en) *	2000-05-19	2001-11-22	Takeda Chemical Industries, Ltd.	-secretase inhibitors
AU2001267825A1 (en) *	2000-06-29	2002-01-08	Shionogi And Co., Ltd.	Remedies for cirrhosis
EP1300159B1 (en) *	2000-06-29	2007-10-10	Anthera Pharmaceuticals, Inc.	Remedies for cancer
JP2004513090A (ja)	2000-09-27	2004-04-30	メルク　エンド　カムパニー　インコーポレーテッド	糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体
EP1347755A2 (en)	2000-10-31	2003-10-01	Merck & Co., Inc.	Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
CN1300155C (zh) *	2000-11-07	2007-02-14	I·R·B·生物技术研究院有限公司	作为胞液型磷脂酶的调制剂的甘油磷酸肌醇衍生物
US6867320B2 (en) *	2002-02-21	2005-03-15	Asahi Kasei Pharma Corporation	Substituted phenylalkanoic acid derivatives and use thereof
US20060058225A1 (en) *	2002-05-31	2006-03-16	Mcgill University	Used of inhibitors of phospholipase a2 for the treatment, prevention or diagnosis of neural inflammatory or demyelinating disease
US20030225011A1 (en) *	2002-05-31	2003-12-04	Samuel David	Phospholipase A2 expression and activity and use thereof for diagnosis, prognostication, prevention and treatment of neural inflammatory and demyelinating disease
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1993
- 1993-12-23 US US08/173,544 patent/US5478857A/en not_active Expired - Fee Related
1994
- 1994-12-14 CN CN94195027A patent/CN1142768A/zh active Pending
- 1994-12-14 AU AU14028/95A patent/AU688446B2/en not_active Ceased
- 1994-12-14 WO PCT/US1994/014504 patent/WO1995017183A1/en not_active Ceased
- 1994-12-14 BR BR9408407A patent/BR9408407A/pt not_active Application Discontinuation
- 1994-12-14 HU HU9601741A patent/HUT75335A/hu unknown
- 1994-12-14 EP EP95905404A patent/EP0735870A4/en not_active Withdrawn
- 1994-12-14 JP JP7517514A patent/JPH09507069A/ja active Pending
- 1994-12-14 CA CA002179649A patent/CA2179649A1/en not_active Abandoned
- 1994-12-14 CZ CZ961780A patent/CZ178096A3/cs unknown
- 1994-12-14 FI FI962557A patent/FI962557L/fi unknown
- 1994-12-15 ZA ZA9410041A patent/ZA9410041B/xx unknown
1995
- 1995-06-05 US US08/464,030 patent/US5563164A/en not_active Expired - Fee Related
1996
- 1996-06-17 NO NO962568A patent/NO962568L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1995017183A1 (en)	1995-06-29
FI962557A7 (fi)	1996-08-22
NO962568L (no)	1996-08-09
HUT75335A (en)	1997-05-28
FI962557A0 (fi)	1996-06-19
NO962568D0 (no)	1996-06-17
AU688446B2 (en)	1998-03-12
ZA9410041B (en)	1996-06-18
EP0735870A1 (en)	1996-10-09
CN1142768A (zh)	1997-02-12
US5478857A (en)	1995-12-26
HU9601741D0 (en)	1996-08-28
EP0735870A4 (en)	1998-08-19
AU1402895A (en)	1995-07-10
US5563164A (en)	1996-10-08
CZ178096A3 (cs)	1998-03-18
FI962557L (fi)	1996-08-22
CA2179649A1 (en)	1995-06-29
JPH09507069A (ja)	1997-07-15

Publication	Publication Date	Title
BR9408407A (pt)	1997-08-05	Uso de inibidores pla2 como tratamento para doença de alzheimer
PT861081E (pt)	2002-06-28	Utilizacao de epinastina para o tratamento de dores
BR9612204A (pt)	1999-07-13	Composto uso do composto composição farmacêutica e processo para preparação do composto e para o tratamento de dor
FI20000720A7 (fi)	2000-03-29	Pitkitettyyn vapautumiseen perustuva tablettiformulaatio Parkisonin taudin hoitamiseksi
BR9604872A (pt)	1998-05-26	Composição para tratamento de cabelo
BR9508886A (pt)	1997-12-30	Compostos e métodos para o tratamento de câncer
FI963252L (fi)	1996-08-20	Kivun hoitoon tarkoitetut uudet opioidipeptidit ja niiden käyttö
BR9711225A (pt)	1999-08-17	Composi-{es de propentofilina transd-rmica para o tratamento do mal de alzheimer
NO20001869D0 (no)	2000-04-11	Fremgangsmõte for behandling av Alzheimerssykdom
ID21948A (id)	1999-08-12	Penggunaan 1-hidroksi-2piridon untuk pengobatan infeksi-infeksi kulit
DE69405919D1 (de)	1997-11-06	Zusammensetzungen zur Behandlung von Keratinfasern
BR9606662A (pt)	1997-10-28	O emprego de triacetato de glicerila para o tratamento de onicomicoses
DE69807466D1 (de)	2002-10-02	Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten
DE69420229D1 (de)	1999-09-30	Pharmazeutische Zusammensetzung zur Behandlung von AIDS
DE69822297D1 (de)	2004-04-15	Triptolid-derivate geeignet zur behandlung von autoimmunkrankheiten
ID21874A (id)	1999-08-05	Penggunaan 1-hidroksi-2-piridon untuk pengobatan infeksi urap kulit
FI952953A7 (fi)	1995-12-18	Aineita metabolisten luustosairauksien hoitamiseen
PT804199E (pt)	2002-09-30	Uso de penciclovir para o tratamento de nevralgias pos-herpeticas
BR9507732A (pt)	1997-08-19	Composição farmacêutica para o tratamento de glaucoma
FI974609A7 (fi)	1998-01-14	Uusia heterosyklisiä yhdisteitä kivun hoitoon ja niiden käyttö
ATE204167T1 (de)	2001-09-15	Antikonvulsive derivate zur behandlung von psoriasis
ID24439A (id)	2000-07-20	Penggunaan tiazolidindion untuk pengobatan hiperglikemia
NO970127D0 (no)	1997-01-10	Topiske sammensetninger for behandling av hudsykdom
ITPD950011A0 (it)	1995-01-18	Strumenti per il trattamento chirurgico di flebectomie
ID24521A (id)	2000-07-20	Penggunaan tiazolidindion untuk pengobatan hiperglikemia

Legal Events

Date	Code	Title
1999-04-13	EG	Technical examination (opinion): publication of technical examination (opinion)
1999-08-31	FC	Decision: refusal
2000-03-08	FC	Decision: refusal