BR9406613A - Composto éster ou amida metabolicamente lábil do mesmo processo para a preparação de um composto e composição farmacêutica - Google Patents

Composto éster ou amida metabolicamente lábil do mesmo processo para a preparação de um composto e composição farmacêutica

Info

Publication number: BR9406613A
Authority: BR; Brazil
Prior art keywords: compound; preparation; pharmaceutical composition; same process; metabolically labile
Prior art date: 1993-03-29

Application number

BR9406613A

Other languages

English (en)

Inventor

Michael Garth Wayne

Michael James Smithers

John Wall Rayner

Alan Wellington Faull

Robert James Pearce

Andrew George Brewster

Richard Eden Shute

Stuart Dennet Mills

Peter William Rodney Caulkett

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-29

Filing date

1994-03-28

Publication date

1996-02-06

1993-03-29 Priority claimed from GB939306453A external-priority patent/GB9306453D0/en

1993-12-15 Priority claimed from GB939325605A external-priority patent/GB9325605D0/en

1994-03-28 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1996-02-06 Publication of BR9406613A publication Critical patent/BR9406613A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Electroluminescent Light Sources (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Pyridine Compounds (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BR9406613A 1993-03-29 1994-03-28 Composto éster ou amida metabolicamente lábil do mesmo processo para a preparação de um composto e composição farmacêutica BR9406613A (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939306453A GB9306453D0 (en)	1993-03-29	1993-03-29	Heterocyclic derivatives
GB939325605A GB9325605D0 (en)	1993-12-15	1993-12-15	Heterocyclic derivatives
PCT/GB1994/000647 WO1994022834A1 (en)	1993-03-29	1994-03-28	Heterocyclic derivatives as platelet aggregation inhibitors

Publications (1)

Publication Number	Publication Date
BR9406613A true BR9406613A (pt)	1996-02-06

Family

ID=26302668

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9406613A BR9406613A (pt)	1993-03-29	1994-03-28	Composto éster ou amida metabolicamente lábil do mesmo processo para a preparação de um composto e composição farmacêutica

Country Status (26)

Country	Link
US (1)	US5556977A (pt)
EP (2)	EP0691959B1 (pt)
JP (1)	JPH08508291A (pt)
KR (1)	KR100231089B1 (pt)
CN (1)	CN1120334A (pt)
AT (2)	ATE202345T1 (pt)
AU (1)	AU692438B2 (pt)
BR (1)	BR9406613A (pt)
CA (1)	CA2156070A1 (pt)
CZ (1)	CZ250995A3 (pt)
DE (2)	DE69427548T2 (pt)
DK (2)	DK0691959T3 (pt)
ES (2)	ES2119184T3 (pt)
FI (1)	FI954616A7 (pt)
GB (1)	GB9406143D0 (pt)
GR (2)	GR3027751T3 (pt)
HU (2)	HUT72088A (pt)
IL (1)	IL109144A (pt)
NO (1)	NO305244B1 (pt)
NZ (1)	NZ262941A (pt)
PL (1)	PL310889A1 (pt)
PT (1)	PT825184E (pt)
SK (1)	SK120895A3 (pt)
TW (1)	TW276254B (pt)
WO (1)	WO1994022834A1 (pt)
ZW (1)	ZW4294A1 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5750754A (en) *	1993-03-29	1998-05-12	Zeneca Limited	Heterocyclic compounds
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
US5700801A (en) *	1994-12-23	1997-12-23	Karl Thomae, Gmbh	Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
PL321003A1 (en) *	1994-12-23	1997-11-24	Thomae Gmbh Dr K	Derivatives of piperasine, drugs containing them, their application and methods of obtaining them
PL318440A1 (en) *	1995-06-01	1997-06-09	Zeneca Ltd	(-)-(3r)-3-methyl-4-{4-[4-pyridyl)piperazin-1-yl]phenoxy}butyric acid as cellular adhesion inhibitor
FR2734818B1 (fr) *	1995-06-01	1998-07-10	Zeneca Ltd	Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant
DE19524765A1 (de) *	1995-07-07	1997-01-09	Boehringer Mannheim Gmbh	Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
NZ321293A (en) *	1995-11-17	2001-04-27	Warner Lambert Co	Sulfonamide inhibitors of matrix metalloproteinases
GB9525620D0 (en)	1995-12-15	1996-02-14	Glaxo Group Ltd	Chemical compounds
GB9602166D0 (en) *	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
AU1608397A (en) *	1996-02-02	1997-08-22	Zeneca Limited	Heterocyclic compounds useful as pharmaceutical agents
GB9604242D0 (en)	1996-02-28	1996-05-01	Glaxo Wellcome Inc	Chemical compounds
AU712082B2 (en) *	1996-02-28	1999-10-28	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5780480A (en) *	1996-02-28	1998-07-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
WO1997036887A1 (en) *	1996-03-29	1997-10-09	Meiji Seika Kaisha, Ltd.	Novel heterocyclic compounds having platelet aggregation inhibitory effects
US5854245A (en) *	1996-06-28	1998-12-29	Merck & Co., Inc.	Fibrinogen receptor antagonists
CA2257937A1 (en) *	1996-06-28	1998-01-08	Merck & Co., Inc.	Fibrinogen receptor antagonist prodrugs
US5932582A (en) *	1996-06-28	1999-08-03	Merck & Co., Inc.	Fibrinogen receptor antagonist prodrugs
US5990107A (en) *	1996-06-28	1999-11-23	Merck & Co., Inc.	Fibrinogen receptor antagonist prodrugs
EP0912175A4 (en) *	1996-06-28	1999-09-08	Merck & Co Inc	FIBRINOGENIC RECEPTOR ANTAGONISTS
GB9821483D0 (en)	1998-10-03	1998-11-25	Glaxo Group Ltd	Chemical compounds
UA56197C2 (uk) *	1996-11-08	2003-05-15	Зенека Лімітед	Гетероциклічні похідні
US5945545A (en) *	1996-12-13	1999-08-31	Merck & Co., Inc.	Fibrinogen receptor antagonists
AU5999798A (en)	1997-02-13	1998-09-08	Zeneca Limited	Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
EP0966460A1 (en)	1997-02-13	1999-12-29	Zeneca Limited	Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
GB9715895D0 (en)	1997-07-29	1997-10-01	Zeneca Ltd	Heterocyclic compounds
US6221902B1 (en)	1998-05-12	2001-04-24	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en)	1998-05-12	2004-03-02	Wyeth	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en)	1998-05-12	2001-05-15	American Home Products Corporation	Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en)	1998-05-12	2002-09-17	Wyeth	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) *	1998-05-12	2000-08-29	American Home Products Corporation	Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en)	1998-05-12	2000-12-26	American Home Products Corporation	Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
JP2002516305A (ja)	1998-05-12	2002-06-04	アメリカン・ホーム・プロダクツ・コーポレイション	インスリン抵抗性および高血糖症の治療に有用な２，３，５−置換ビフェニル
US6358982B1 (en)	1998-07-31	2002-03-19	Eli Lilly And Company	Heterocyclyl sulphonamide derivatives
GB9902989D0 (en)	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
EP1173408B1 (en) *	1999-04-19	2005-07-20	Coelacanth Corporation	Ppar-(gamma) agonists as agents for the treatment of type ii diabetes
US6310081B1 (en)	1999-05-10	2001-10-30	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
EP1330444B1 (en)	2000-11-01	2011-03-23	Millennium Pharmaceuticals, Inc.	Nitrogenous heterocyclic compounds and process for making them
DE202011000090U1 (de)	2011-01-14	2011-04-21	E-LEAD ELECTRONIC CO., LTD., Shengang Shiang	Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
IL273428B2 (en)	2017-09-22	2023-09-01	Jubilant Epipad LLC	Heterocyclic compounds as pad inhibitors
CN111225915B (zh)	2017-10-18	2023-03-07	朱比兰特埃皮帕德有限公司	作为pad抑制剂的咪唑并吡啶化合物
BR112020008851A2 (pt)	2017-11-06	2020-10-20	Jubilant Prodel LLC	composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas
JP7368369B2 (ja)	2017-11-24	2023-10-24	ジュビラント・エピスクライブ・エルエルシー	Ｐｒｍｔ５阻害剤としてのヘテロ環式化合物
JP7279063B6 (ja)	2018-03-13	2024-02-15	ジュビラントプローデルエルエルシー	Ｐｄ１／ｐｄ－ｌ１相互作用／活性化の阻害剤としての二環式化合物

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3875165A (en) *	1973-02-22	1975-04-01	Wyeth John & Brother Ltd	(4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines
GB1474296A (en) *	1975-01-23	1977-05-18	Wyeth John & Brother Ltd	4-aminoquinoline derivatives
JPS57183738A (en) *	1981-05-06	1982-11-12	Yamanouchi Pharmaceut Co Ltd	Aromatic carboxylic acid derivative
ZA825719B (en) *	1981-09-03	1983-06-29	Recordati Chem Pharm	Alkanoylanilides
EP0100158A3 (en) *	1982-07-28	1985-03-27	The Upjohn Company	(3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4613598A (en) *	1984-03-13	1986-09-23	Mitsubishi Chemical Industries Limited	Piperazine derivatives and their acid addition salts
AU5428686A (en) *	1985-03-12	1986-09-18	Smith Kline & French Laboratories Limited	Imidazolinone and thiazolinone derivatives
GB8603120D0 (en) *	1986-02-07	1986-03-12	Pfizer Ltd	Anti-dysrhythmia agents
GB8609630D0 (en) *	1986-04-19	1986-05-21	Pfizer Ltd	Anti-arrhythmia agents
EP0264883A3 (en) *	1986-10-21	1990-04-04	Banyu Pharmaceutical Co., Ltd.	Substituted pyridine derivatives
MY104343A (en) *	1987-11-23	1994-03-31	Janssen Pharmaceutica Nv	Novel pyridizinamine deravatives
GB8819307D0 (en) *	1988-08-13	1988-09-14	Pfizer Ltd	Antiarrhythmic agents
US5039805A (en) *	1988-12-08	1991-08-13	Hoffmann-La Roche Inc.	Novel benzoic and phenylacetic acid derivatives
US5084466A (en) *	1989-01-31	1992-01-28	Hoffmann-La Roche Inc.	Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2008116C (en) *	1989-02-23	2001-11-20	Thomas Weller	Glycine derivatives
DE4134467A1 (de) *	1991-10-18	1993-04-22	Thomae Gmbh Dr K	Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
EP0484378B1 (en) *	1989-07-25	1994-09-14	The Upjohn Company	Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides
US5051405A (en) *	1989-10-10	1991-09-24	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Anti-thrombotic peptides and pseudopeptides
CA2037153A1 (en) *	1990-03-09	1991-09-10	Leo Alig	Acetic acid derivatives
GB9007751D0 (en) *	1990-04-05	1990-06-06	Ciba Geigy Ag	Novel platelet-aggregation inhibitors
US5252735A (en) *	1990-06-29	1993-10-12	The Upjohn Company	Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5264420A (en) *	1990-09-27	1993-11-23	Merck & Co., Inc.	Fibrinogen receptor antagonists
IL99539A0 (en) *	1990-09-27	1992-08-18	Merck & Co Inc	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239846A (en) *	1990-09-27	1994-11-25	Merck & Co Inc	Sulphonamide derivatives and pharmaceutical compositions thereof
IL99537A (en) *	1990-09-27	1995-11-27	Merck & Co Inc	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239876A (en) *	1990-09-27	1993-12-23	Merck & Co Inc	Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
DE4102024A1 (de) *	1991-01-24	1992-07-30	Thomae Gmbh Dr K	Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0570507A4 (en) *	1991-02-05	1994-09-21	Smithkline Beecham Corp	Anti-aggregatory peptides containing an aromatic ester or amide
DE4107857A1 (de) *	1991-03-12	1992-09-17	Thomae Gmbh Dr K	Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RU2097378C1 (ru) *	1991-03-26	1997-11-27	Ф.Хоффманн-Ля Рош Аг	ПРОИЗВОДНЫЕ N-АЦИЛ- α -АМИНОКИСЛОТЫ ИЛИ ИХ ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, ПРОСТЫЕ ИЛИ СЛОЖНЫЕ ЭФИРЫ, АМИДЫ ИЛИ ГИДРАТЫ И КОМПОЗИЦИЯ ИНГИБИРУЮЩАЯ СВЯЗЫВАНИЕ АДГЕЗИВНЫХ ПРОТЕИНОВ С ТРОМБОЦИТАМИ И АГРЕГАЦИЮ ТРОМБОЦИТОВ
MX9201416A (es) *	1991-03-28	1992-10-01	Rhone Poulenc Rorer Int	Peptidos y pseudopeptidos antitromboticos.
AU661659B2 (en) *	1991-04-11	1995-08-03	Rhone-Poulenc Rorer International (Holdings) Inc.	Anti-thrombotic peptide and pseudopeptide derivatives
FI934894A7 (fi) *	1991-05-07	1993-11-05	Merck & Co Inc	Fibrinogeenireseptorin antagonisteja
US5321034A (en) *	1991-05-07	1994-06-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
DK0513675T3 (da) *	1991-05-13	1996-09-30	Fujisawa Pharmaceutical Co	Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf
JPH05213884A (ja) *	1991-06-14	1993-08-24	Upjohn Co:The	新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
DE4124942A1 (de) *	1991-07-27	1993-01-28	Thomae Gmbh Dr K	5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4127404A1 (de) *	1991-08-19	1993-02-25	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5294713A (en) *	1991-08-23	1994-03-15	Takeda Chemical Industries, Ltd.	2-piperazinone compounds and their use
US5239113A (en) *	1991-10-15	1993-08-24	Monsanto Company	Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
ES2191659T3 (es) *	1991-10-15	2003-09-16	Searle & Co	Derivados heterociclicos substituidos utiles como inhibidores de la agregacion plaquetaria.
US5254573A (en) *	1991-10-15	1993-10-19	Monsanto Company	Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
GB9122016D0 (en) *	1991-10-16	1991-11-27	Glaxo Group Ltd	Chemical compounds
US5250679A (en) *	1991-10-18	1993-10-05	Genentech, Inc.	Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5272158A (en) *	1991-10-29	1993-12-21	Merck & Co., Inc.	Fibrinogen receptor antagonists
AU2915892A (en) *	1991-11-14	1993-06-15	Glaxo Group Limited	Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
US5424334A (en) *	1991-12-19	1995-06-13	G. D. Searle & Co.	Peptide mimetic compounds useful as platelet aggregation inhibitors
AU3351293A (en) *	1992-01-21	1993-08-03	Glaxo Group Limited	Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
US5264457A (en) *	1992-02-14	1993-11-23	G. D. Searle & Co.	Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
US5227490A (en) *	1992-02-21	1993-07-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
HUT63609A (en) *	1992-03-10	1993-09-28	Sandoz Ag	Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
DE4212304A1 (de) *	1992-04-13	1993-10-14	Cassella Ag	Asparaginsäurederivate, ihre Herstellung und Verwendung
GB9208740D0 (en) *	1992-04-23	1992-06-10	Glaxo Group Ltd	Chemical compounds
DE4213634A1 (de) *	1992-04-24	1993-10-28	Cassella Ag	2,4-Dioxo-imidazolidin-Derivate
DE4219158A1 (de) *	1992-06-11	1993-12-16	Thomae Gmbh Dr K	Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO1994014775A1 (en) *	1992-12-29	1994-07-07	Smithkline Beecham Corporation	Platelet aggregation inhibiting compounds
TW301607B (pt) *	1993-03-09	1997-04-01	Takeda Pharm Industry Co Ltd

1994
- 1994-03-28 PL PL94310889A patent/PL310889A1/xx unknown
- 1994-03-28 DE DE69427548T patent/DE69427548T2/de not_active Expired - Fee Related
- 1994-03-28 AT AT97117909T patent/ATE202345T1/de not_active IP Right Cessation
- 1994-03-28 ZW ZW4294A patent/ZW4294A1/xx unknown
- 1994-03-28 DE DE69411900T patent/DE69411900T2/de not_active Expired - Fee Related
- 1994-03-28 KR KR1019950704314A patent/KR100231089B1/ko not_active Expired - Fee Related
- 1994-03-28 BR BR9406613A patent/BR9406613A/pt not_active Application Discontinuation
- 1994-03-28 FI FI954616A patent/FI954616A7/fi unknown
- 1994-03-28 HU HU9502290A patent/HUT72088A/hu unknown
- 1994-03-28 ES ES94910494T patent/ES2119184T3/es not_active Expired - Lifetime
- 1994-03-28 CZ CZ952509A patent/CZ250995A3/cs unknown
- 1994-03-28 AT AT94910494T patent/ATE168678T1/de not_active IP Right Cessation
- 1994-03-28 EP EP94910494A patent/EP0691959B1/en not_active Expired - Lifetime
- 1994-03-28 GB GB9406143A patent/GB9406143D0/en active Pending
- 1994-03-28 NZ NZ262941A patent/NZ262941A/en unknown
- 1994-03-28 AU AU62889/94A patent/AU692438B2/en not_active Ceased
- 1994-03-28 US US08/218,171 patent/US5556977A/en not_active Expired - Fee Related
- 1994-03-28 JP JP6521810A patent/JPH08508291A/ja active Pending
- 1994-03-28 ES ES97117909T patent/ES2159798T3/es not_active Expired - Lifetime
- 1994-03-28 DK DK94910494T patent/DK0691959T3/da active
- 1994-03-28 CN CN94191664A patent/CN1120334A/zh active Pending
- 1994-03-28 DK DK97117909T patent/DK0825184T3/da active
- 1994-03-28 TW TW083102802A patent/TW276254B/zh active
- 1994-03-28 PT PT97117909T patent/PT825184E/pt unknown
- 1994-03-28 EP EP97117909A patent/EP0825184B1/en not_active Expired - Lifetime
- 1994-03-28 WO PCT/GB1994/000647 patent/WO1994022834A1/en not_active Ceased
- 1994-03-28 SK SK1208-95A patent/SK120895A3/sk unknown
- 1994-03-28 IL IL10914494A patent/IL109144A/xx not_active IP Right Cessation
- 1994-03-28 CA CA002156070A patent/CA2156070A1/en not_active Abandoned
1995
- 1995-06-13 HU HU95P/P00193P patent/HU211336A9/hu unknown
- 1995-09-28 NO NO953837A patent/NO305244B1/no not_active IP Right Cessation
1998
- 1998-08-27 GR GR980401930T patent/GR3027751T3/el unknown
2001
- 2001-09-18 GR GR20010401498T patent/GR3036640T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL109144A0 (en)	1994-06-24
AU692438B2 (en)	1998-06-11
CN1120334A (zh)	1996-04-10
ATE202345T1 (de)	2001-07-15
ES2119184T3 (es)	1998-10-01
US5556977A (en)	1996-09-17
TW276254B (pt)	1996-05-21
SK120895A3 (en)	1996-06-05
NO305244B1 (no)	1999-04-26
ATE168678T1 (de)	1998-08-15
EP0691959B1 (en)	1998-07-22
GB9406143D0 (en)	1994-05-18
NO953837L (no)	1995-09-28
DK0691959T3 (da)	1999-04-26
CZ250995A3 (en)	1996-01-17
DK0825184T3 (da)	2001-09-10
PL310889A1 (en)	1996-01-08
DE69411900T2 (de)	1998-12-10
GR3027751T3 (en)	1998-11-30
NZ262941A (en)	1997-07-27
CA2156070A1 (en)	1994-10-13
FI954616A0 (fi)	1995-09-28
KR100231089B1 (ko)	1999-11-15
DE69427548D1 (de)	2001-07-26
HUT72088A (en)	1996-03-28
FI954616L (fi)	1995-09-28
IL109144A (en)	2000-02-29
DE69427548T2 (de)	2002-04-18
ES2159798T3 (es)	2001-10-16
HU9502290D0 (en)	1995-10-30
EP0825184A1 (en)	1998-02-25
PT825184E (pt)	2001-11-30
AU6288994A (en)	1994-10-24
GR3036640T3 (en)	2001-12-31
NO953837D0 (no)	1995-09-28
ZW4294A1 (en)	1994-12-21
WO1994022834A1 (en)	1994-10-13
EP0825184B1 (en)	2001-06-20
DE69411900D1 (de)	1998-08-27
FI954616A7 (fi)	1995-09-28
EP0691959A1 (en)	1996-01-17
JPH08508291A (ja)	1996-09-03
HU211336A9 (en)	1995-11-28

Publication	Publication Date	Title
BR9406613A (pt)	1996-02-06	Composto éster ou amida metabolicamente lábil do mesmo processo para a preparação de um composto e composição farmacêutica
RU94046149A (ru)	1996-11-27	Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат)
IL93556A0 (en)	1990-11-29	Stabilized nitric oxide-primary amine complexes useful as cardiovascular agents
DK0380063T3 (da)	1993-08-30	1,2-Cyclohexylaminoarylamider til anvendelse som analgetika
PT99445A (pt)	1992-09-30	Processo para preparacao de derivados do 1,4,7,10-tetraazaciclododecano mono-n--substituidos e de composicoes farmaceuticas que os contem
IL95917A0 (en)	1991-07-18	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
DK0414263T3 (da)	1995-01-16	Fremgangsmåde til stabilisering af et fast farmaceutisk præparat indeholdende cycliske aminosyrer
DK0495982T3 (da)	1996-07-01	Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel
NO850084L (no)	1985-07-10	N-(4-piperidinyl) bicyklisk kondenserte 2-imidazolaminderivater
NO931917L (no)	1993-11-30	Farmas!ytiske forbindelser
UA26403A (uk)	1999-08-30	Похідhі n-заміщеhого 4-феhіл-4-піперидиhкарбоксаміду та їх фармацевтичhо прийhятhі солі, що проявляють аhестезувальhу та аhальгезувальhу дію, спосіб їх одержаhhя та фармацевтичhа композиція
EP0806421A4 (en)	1998-04-15	DERIVATIVES OF CHINOLINE CARBONIC ACID
CA2296560A1 (en)	1999-01-28	Amino acid derivatives useful to treat stroke
ATE158570T1 (de)	1997-10-15	Acylharnstoffe
PT90254A (pt)	1989-11-10	Processo para a preparacao de amidas de acidos ciclometileno -1,2-dicarboxilicos com actividade terapeutica e de composicoes farmaceuticas que as contem
NO883520L (no)	1989-02-13	Fremgangsmaate for fremstilling av et injeksjonspreparat.
BR8802816A (pt)	1989-01-03	Derivados do acido(2-ciano-9-oximinoacetil)-aminico,processo para sua preparacao,composicoes praguicidas,processos para combater pragas e para a preparacao de composicoes
TW339325B (en)	1998-09-01	Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same
BR8802815A (pt)	1989-01-03	Derivados de(2-ciano-2-oximinoacetil)-aminoacidos processo para sua preparacao,composicoes praguicidas,processos para o combate a parasitas e para a preparacao de composicoes
DE3770433D1 (de)	1991-07-04	4-oxo-1,3-benzodioxan-derivat.
ATE158571T1 (de)	1997-10-15	Allophansäure derivate

Legal Events

Date	Code	Title
1996-11-12	EE	Request for examination
1999-03-30	EG	Technical examination (opinion): publication of technical examination (opinion)
1999-08-31	FC	Decision: refusal
2000-03-14	FC	Decision: refusal