BR0311332A - Método para produção de material cristalino - Google Patents
Método para produção de material cristalinoInfo
- Publication number
- BR0311332A BR0311332A BR0311332-9A BR0311332A BR0311332A BR 0311332 A BR0311332 A BR 0311332A BR 0311332 A BR0311332 A BR 0311332A BR 0311332 A BR0311332 A BR 0311332A
- Authority
- BR
- Brazil
- Prior art keywords
- ultrasound
- solution
- sup
- vessel
- crystalline material
- Prior art date
Links
- 239000002178 crystalline material Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002604 ultrasonography Methods 0.000 abstract 5
- 239000000243 solution Substances 0.000 abstract 3
- 108010011485 Aspartame Proteins 0.000 abstract 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
- 229960003438 aspartame Drugs 0.000 abstract 1
- 235000010357 aspartame Nutrition 0.000 abstract 1
- 239000000605 aspartame Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012047 saturated solution Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0063—Control or regulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0081—Use of vibrations, e.g. ultrasound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1024—Apparatus for crystallization from liquid or supercritical state
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1024—Apparatus for crystallization from liquid or supercritical state
- Y10T117/1028—Crucibleless apparatus having means providing movement of discrete droplets or solid particles to thin-film precursor [e.g., Verneuil method]
Landscapes
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Disintegrating Or Milling (AREA)
- Transducers For Ultrasonic Waves (AREA)
Abstract
"MéTODO PARA PRODUçãO DE MATERIAL CRISTALINO". Um material cristalino suficientemente puro para uso em produtos farmacêuticos pode ser feito pela formação de uma solução saturada do material, alteração da temperatura da solução de modo que ela se torne supersaturada, e sujeição da solução a irradiação por ultra-som de alta intensidade, a freq³ência do ultra-som sendo explorada sobre uma faixa de freq³ências. Por exemplo, o ultra-som pode ser variado entre 19,5 e instalação de fio metálico de guia 20,5 kHz, e esta variação pode ser senoidal. Preferentemente, o ultra-som é provido apenas brevemente, a saber, por menos que 5 s, antes de permitir que a solução se resfrie gradualmente sem ulterior irradiação. O ultra-som pode ser aplicado usando um recipiente com uma disposição de transdutores ultra-sónicos fixados em uma parede, de modo que cada transdutor irradia não mais que 3 W/cm^ 2^, ainda a dissipação de energia dentro do recipiente é entre 25 e 150 W/Iitro. Este método pode reduzir a largura de zona metaestável para menos do que 10 K. O método é aplicável, em particular, para aspartame.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0212626.6A GB0212626D0 (en) | 2002-05-31 | 2002-05-31 | Production of crystalline ingredients |
| GB0302555A GB0302555D0 (en) | 2003-02-05 | 2003-02-05 | Production of Crystalline materials |
| PCT/GB2003/002017 WO2003101578A1 (en) | 2002-05-31 | 2003-05-13 | Production of crystalline materials by using high intensity ultrasound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0311332A true BR0311332A (pt) | 2005-03-15 |
Family
ID=29713390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0311332-9A BR0311332A (pt) | 2002-05-31 | 2003-05-13 | Método para produção de material cristalino |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7357835B2 (pt) |
| EP (1) | EP1509301B1 (pt) |
| JP (1) | JP4329936B2 (pt) |
| CN (1) | CN100342939C (pt) |
| AT (1) | ATE350121T1 (pt) |
| AU (1) | AU2003230006B2 (pt) |
| BR (1) | BR0311332A (pt) |
| CA (1) | CA2485941C (pt) |
| DE (1) | DE60310923T2 (pt) |
| DK (1) | DK1509301T3 (pt) |
| ES (1) | ES2279109T3 (pt) |
| IL (1) | IL165135A (pt) |
| MX (1) | MXPA04011508A (pt) |
| NO (1) | NO20045574L (pt) |
| NZ (1) | NZ536716A (pt) |
| OA (1) | OA12826A (pt) |
| PT (1) | PT1509301E (pt) |
| WO (1) | WO2003101578A1 (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7244307B2 (en) * | 2002-05-31 | 2007-07-17 | Accentus Plc | Production of crystalline materials by using high intensity ultrasound |
| GB0405108D0 (en) * | 2004-03-06 | 2004-04-07 | Accentus Plc | Removal of sodium oxalate from a bayer liquor |
| GB0413511D0 (en) * | 2004-06-17 | 2004-07-21 | Accentus Plc | Precipitation of gibbsite from a bayer liquor |
| GB0415227D0 (en) * | 2004-07-07 | 2004-08-11 | Accentus Plc | Precipitation of silica in a Bayer process |
| GB0415237D0 (en) * | 2004-07-07 | 2004-08-11 | Accentus Plc | Formation of sugar coatings |
| GB0503193D0 (en) * | 2005-02-16 | 2005-03-23 | Accentus Plc | Ultrasonic treatment plant |
| US7597148B2 (en) * | 2005-05-13 | 2009-10-06 | Baker Hughes Incorporated | Formation and control of gas hydrates |
| EP1782797A1 (en) * | 2005-11-02 | 2007-05-09 | Pharmatex Italia Srl | Process for the preparation of sterile powdered pharmaceutical compounds. |
| GB0524823D0 (en) * | 2005-12-06 | 2006-01-11 | Accentus Plc | Removal of contaminants from a bayer liquor |
| GB0821419D0 (en) * | 2008-11-24 | 2008-12-31 | Bio Sep Ltd | Processing of biomass |
| EP2429699B1 (en) * | 2009-05-14 | 2018-01-17 | Cavitus Pty Ltd | Density modification |
| US7999135B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using ultrasound |
| EP2399658A1 (en) | 2010-06-24 | 2011-12-28 | Biosyn Arzneimittel GmbH | Method for producing pharmacologically pure crystals |
| EP2500072A1 (en) | 2011-03-15 | 2012-09-19 | LEK Pharmaceuticals d.d. | A novel process of residual solvent removal |
| WO2012142927A1 (zh) * | 2011-04-18 | 2012-10-26 | 合肥贝霓医药科技有限公司 | 一种纯化二氢吡啶类钙通道阻滞剂并制备其纳米的方法 |
| WO2015001143A1 (es) | 2013-07-03 | 2015-01-08 | Pusonics S.L. | Sistema ultrasónico para mezclar líquidos y medios multifásicos, y método |
| US10604730B2 (en) * | 2015-10-16 | 2020-03-31 | Terressentia Corporation | Alcoholic beverage maturing device |
| CN107008028B (zh) * | 2017-05-22 | 2023-09-08 | 天津晶润锐拓科技发展有限公司 | 一种通过超声波控制结晶成核过程的结晶器 |
| WO2019103667A1 (en) * | 2017-11-22 | 2019-05-31 | Aak Ab (Publ) | Process for dry fractionation of a palm oil olein |
| CN107963929A (zh) * | 2017-12-05 | 2018-04-27 | 上海永通化工有限公司 | 一种植物营养元素结晶体及其制备方法 |
| CN110354528B (zh) * | 2019-08-21 | 2021-11-19 | 贺剑 | 溶液结晶系统及促进溶液结晶的方法 |
| EP3925932A1 (en) | 2020-06-17 | 2021-12-22 | Biosyn Arzneimittel GmbH | Contained production of pharmaceutically pure crystals |
| CN113521791A (zh) * | 2021-06-23 | 2021-10-22 | 福建江夏学院 | 一种光电半导体薄膜的超声波振荡制备装置 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1347350A (en) * | 1918-02-26 | 1920-07-20 | Gen Electric | Crystal production |
| US2876083A (en) * | 1953-06-29 | 1959-03-03 | Prietl Franz | Process of producing crystals from particles of crystallizable substance distributedin a liquid |
| US3892539A (en) * | 1969-09-26 | 1975-07-01 | Merck & Co Inc | Process for production of crystals in fluidized bed crystallizers |
| DE3882011T2 (de) * | 1987-10-27 | 1993-09-30 | Fujitsu Ltd | Verfahren und Vorrichtung zur Herstellung von Biopolymer-Einkristall. |
| US5362455A (en) | 1990-05-03 | 1994-11-08 | Praxair Technology, Inc. | Draft tube, direct contact cryogenic crystallizer |
| GB2276567B (en) | 1993-04-03 | 1996-11-27 | Atomic Energy Authority Uk | Processing vessel |
| DE4431872C1 (de) | 1994-09-07 | 1996-01-11 | Santrade Ltd | Anwendung von Ultraschall bei der Verfestigung von Schmelzen oder übersättigten Lösungen auf Förderbändern oder Aufnahmetrommeln |
| WO2000033366A1 (de) * | 1998-11-30 | 2000-06-08 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur herstellung von multikristallinem halbleitermaterial |
| GB9827360D0 (en) | 1998-12-12 | 1999-02-03 | Aea Technology Plc | Process and apparatus for irradiating fluids |
| FI122018B (fi) * | 2000-01-31 | 2011-07-29 | Danisco | Menetelmä betaiinin kiteyttämiseksi |
| US6630185B2 (en) | 2000-07-18 | 2003-10-07 | Lipton, Division Of Conopco, Inc. | Crystallization process using ultrasound |
| JP5008215B2 (ja) * | 2000-09-29 | 2012-08-22 | 三菱瓦斯化学株式会社 | 晶析方法および装置 |
| US6946436B2 (en) * | 2000-11-22 | 2005-09-20 | Otsuka Pharmaceutical Co., Ltd. | O/W emulsion composition and method of preparing the same |
| CN1305460C (zh) * | 2001-04-13 | 2007-03-21 | 大塚制药株式会社 | 糖摄取的促进方法 |
| DE60210622T2 (de) | 2001-05-05 | 2007-04-05 | Accentus Plc | Bildung kleiner Kristalle |
| DE10123073A1 (de) | 2001-05-11 | 2003-03-27 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Kristallen aus in einem Lösungsmittel gelösten Feststoffen |
| AU2002367296A1 (en) * | 2001-12-28 | 2003-07-24 | Ekos Corporation | Multi-resonant ultrasonic catheter |
| US6992216B2 (en) * | 2002-01-07 | 2006-01-31 | Abbott Gmbh & Co. Kg | Crystallization of amino acids using ultrasonic agitation |
| US7063741B2 (en) * | 2002-03-27 | 2006-06-20 | General Electric Company | High pressure high temperature growth of crystalline group III metal nitrides |
-
2003
- 2003-05-13 AU AU2003230006A patent/AU2003230006B2/en not_active Ceased
- 2003-05-13 NZ NZ536716A patent/NZ536716A/en unknown
- 2003-05-13 CN CNB038121603A patent/CN100342939C/zh not_active Expired - Fee Related
- 2003-05-13 EP EP03722846A patent/EP1509301B1/en not_active Expired - Lifetime
- 2003-05-13 BR BR0311332-9A patent/BR0311332A/pt not_active Application Discontinuation
- 2003-05-13 MX MXPA04011508A patent/MXPA04011508A/es active IP Right Grant
- 2003-05-13 AT AT03722846T patent/ATE350121T1/de not_active IP Right Cessation
- 2003-05-13 OA OA1200400316A patent/OA12826A/en unknown
- 2003-05-13 DK DK03722846T patent/DK1509301T3/da active
- 2003-05-13 US US10/514,883 patent/US7357835B2/en not_active Expired - Fee Related
- 2003-05-13 ES ES03722846T patent/ES2279109T3/es not_active Expired - Lifetime
- 2003-05-13 JP JP2004508925A patent/JP4329936B2/ja not_active Expired - Fee Related
- 2003-05-13 PT PT03722846T patent/PT1509301E/pt unknown
- 2003-05-13 CA CA2485941A patent/CA2485941C/en not_active Expired - Fee Related
- 2003-05-13 DE DE60310923T patent/DE60310923T2/de not_active Expired - Lifetime
- 2003-05-13 WO PCT/GB2003/002017 patent/WO2003101578A1/en not_active Ceased
-
2004
- 2004-11-10 IL IL165135A patent/IL165135A/en not_active IP Right Cessation
- 2004-12-21 NO NO20045574A patent/NO20045574L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003101578A1 (en) | 2003-12-11 |
| MXPA04011508A (es) | 2005-08-15 |
| DE60310923T2 (de) | 2007-07-05 |
| OA12826A (en) | 2006-07-11 |
| IL165135A0 (en) | 2005-12-18 |
| EP1509301A1 (en) | 2005-03-02 |
| CN100342939C (zh) | 2007-10-17 |
| JP4329936B2 (ja) | 2009-09-09 |
| DE60310923D1 (de) | 2007-02-15 |
| DK1509301T3 (da) | 2007-03-19 |
| CN1655857A (zh) | 2005-08-17 |
| PT1509301E (pt) | 2007-01-31 |
| NZ536716A (en) | 2006-08-31 |
| ATE350121T1 (de) | 2007-01-15 |
| US20050188913A1 (en) | 2005-09-01 |
| EP1509301B1 (en) | 2007-01-03 |
| AU2003230006A1 (en) | 2003-12-19 |
| CA2485941C (en) | 2011-02-01 |
| US7357835B2 (en) | 2008-04-15 |
| NO20045574L (no) | 2004-12-21 |
| JP2005527368A (ja) | 2005-09-15 |
| CA2485941A1 (en) | 2003-12-11 |
| AU2003230006B2 (en) | 2008-06-19 |
| IL165135A (en) | 2008-11-03 |
| ES2279109T3 (es) | 2007-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: ACCENTUS PLC (GB) Free format text: ANOTADAS AS ALTERACOES DE SEDE SOLICITADAS ATRAVES DA PETICAO NO 020070184946/RJ DE 28/12/2007. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ART. 8O COMBINADO COM O ART. 13 DA LPI (LEI 9279/96). |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |