[go: up one dir, main page]

BR0307010A - alanina 2,3-aminomutase - Google Patents

alanina 2,3-aminomutase

Info

Publication number
BR0307010A
BR0307010A BRPI0307010-7A BR0307010A BR0307010A BR 0307010 A BR0307010 A BR 0307010A BR 0307010 A BR0307010 A BR 0307010A BR 0307010 A BR0307010 A BR 0307010A
Authority
BR
Brazil
Prior art keywords
alanine
aminomutase
cells
methods
pantothenate
Prior art date
Application number
BRPI0307010-7A
Other languages
English (en)
Inventor
Hans H Liao
Ravy R Gokarn
Steven J Gort
Holly J Jessen
Olga Selifonova
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Publication of BR0307010A publication Critical patent/BR0307010A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/32Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"ALANINA 2,3-AMINOMUTASE". A presente invenção refere-se às seqüências de alanina 2,3aminomutase, como sendo células tendo atividade de alanina 2,3aminomutase e métodos de seleção de tais células. Os métodos para produzir a beta-alanina, pantotenato, ácido 3-hidroxipropiónico, bem como outros compostos orgânicos, são descritos.
BRPI0307010-7A 2002-01-18 2003-01-17 alanina 2,3-aminomutase BR0307010A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35072702P 2002-01-18 2002-01-18
US37578502P 2002-04-25 2002-04-25
PCT/US2003/001635 WO2003062173A2 (en) 2002-01-18 2003-01-17 Alanine 2,3- aminomutase

Publications (1)

Publication Number Publication Date
BR0307010A true BR0307010A (pt) 2006-04-11

Family

ID=27616779

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0307010-7A BR0307010A (pt) 2002-01-18 2003-01-17 alanina 2,3-aminomutase

Country Status (10)

Country Link
US (4) US7309597B2 (pt)
EP (1) EP1575881B1 (pt)
JP (1) JP4532116B2 (pt)
AT (1) ATE432338T1 (pt)
BR (1) BR0307010A (pt)
CA (1) CA2473716A1 (pt)
DE (1) DE60327804D1 (pt)
ES (1) ES2329778T3 (pt)
MX (1) MXPA04006894A (pt)
WO (1) WO2003062173A2 (pt)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1575881B1 (en) * 2002-01-18 2009-05-27 Novozymes A/S Alanine 2,3- aminomutase
WO2005118719A2 (en) 2003-12-04 2005-12-15 Cargill, Incorporated Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase
US20090031453A1 (en) * 2004-07-30 2009-01-29 Holly Jean Jessen Alanine 2, 3 aminomutases
US7790432B2 (en) * 2004-10-25 2010-09-07 Codexis, Inc. Alanine 2,3-aminomutases and related polynucleotides
DE102005048818A1 (de) * 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
US8030051B2 (en) * 2005-10-14 2011-10-04 Codexis, Inc. Alanine 2,3-aminomutases and related polynucleotides
ES2397383T3 (es) 2006-04-13 2013-03-06 Chugai Seiyaku Kabushiki Kaisha Gen transportador de taurina
DE102006039203B4 (de) 2006-08-22 2014-06-18 Evonik Degussa Gmbh Verfahren zur Herstellung von durch Kristallisation gereinigter Acrylsäure aus Hydroxypropionsäure sowie Vorrichtung dazu
US20100210017A1 (en) * 2007-01-12 2010-08-19 Gill Ryan T Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
WO2008091627A2 (en) 2007-01-22 2008-07-31 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
WO2008114673A1 (ja) 2007-03-15 2008-09-25 Chugai Seiyaku Kabushiki Kaisha ポリペプチドの製造方法
WO2008115840A2 (en) * 2007-03-16 2008-09-25 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
DE102007015583A1 (de) 2007-03-29 2008-10-02 Albert-Ludwigs-Universität Freiburg Ein Enzym zur Herstellung von Methylmalonyl-Coenzym A oder Ethylmalonyl-Coenzym A sowie dessen Verwendung
BRPI0815036B1 (pt) 2007-08-07 2022-09-20 Chugai Seiyaku Kabushiki Kaisha Métodos para produção de um polipeptídeo e para preparação de um produto farmacêutico
CA2696018A1 (en) 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of olefins and derivatives
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
JP5337043B2 (ja) * 2007-10-15 2013-11-06 中外製薬株式会社 異種タンパク質を高生産する細胞の作製方法
EP2213746B1 (en) 2007-10-24 2015-07-15 Chugai Seiyaku Kabushiki Kaisha Cell for use in the production of exogenous protein, and production process using the cell
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US7803589B2 (en) 2008-01-22 2010-09-28 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009111672A1 (en) 2008-03-05 2009-09-11 Genomatica, Inc. Primary alcohol producing organisms
WO2009151728A2 (en) 2008-03-27 2009-12-17 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
AU2009242615A1 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
WO2009155382A1 (en) 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
EP2334800B1 (en) 2008-09-10 2018-12-26 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
EP2326709A4 (en) * 2008-09-15 2013-01-23 Opx Biotechnologies Inc METHODS, SYSTEMS AND COMPOSITIONS RELATED TO REDUCED MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) IN ALDEHYDMETABOLITE
AU2009327490A1 (en) 2008-12-16 2011-07-28 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
EP2210935A1 (en) * 2009-01-19 2010-07-28 Deinove Methods for isolating bacteria
US20120149077A1 (en) * 2009-03-13 2012-06-14 Mascoma Corporation Mesophilic and Thermophilic Organisms Modified to Produce Acrylate, and Methods of Use Thereof
WO2010123014A1 (ja) 2009-04-22 2010-10-28 中外製薬株式会社 異種タンパク質を高生産する細胞の作製方法
BRPI1013505A2 (pt) 2009-04-30 2018-02-14 Genomatica Inc organismos para a produção de isopropanol, n-butanol, e isobutanol
US9017983B2 (en) 2009-04-30 2015-04-28 Genomatica, Inc. Organisms for the production of 1,3-butanediol
SI2427544T1 (sl) 2009-05-07 2019-11-29 Genomatica Inc Mikroorganizmi in metode za biosintezo adipata, heksametilendiamina in 6-aminokaprojske kisline
KR20120036851A (ko) 2009-05-15 2012-04-18 게노마티카 인코포레이티드 사이클로헥사논의 제조를 위한 유기체
CN113528417A (zh) 2009-06-04 2021-10-22 基因组股份公司 生产1,4-丁二醇的微生物和相关方法
PL3199511T3 (pl) 2009-06-04 2020-05-18 Genomatica, Inc. Sposób oddzielania składników brzeczki fermentacyjnej
US8420375B2 (en) 2009-06-10 2013-04-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol
CN102482692A (zh) 2009-07-01 2012-05-30 诺维信北美公司 用于分离和回收3-羟基丙酸的工艺
BR112012002643A2 (pt) 2009-08-05 2018-08-28 Genomatica Inc ácido tereftalático semissintético por meio de micro-organismos que produzem ácido mucônico
SG179048A1 (en) 2009-09-09 2012-04-27 Genomatica Inc Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
AU2010298004B2 (en) 2009-09-27 2016-02-25 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
KR20120083908A (ko) 2009-10-13 2012-07-26 게노마티카 인코포레이티드 1,4-부탄다이올, 4-하이드록시부탄알, 4-하이드록시부티릴-coa, 푸트레신 및 관련 화합물의 제조를 위한 미생물 및 관련 방법
BR112012009332A2 (pt) 2009-10-23 2015-09-15 Genomatica Inc micro-organismo para a produção de anilina
WO2011063363A2 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
BR112012014062A2 (pt) 2009-12-10 2017-04-04 Genomatica Inc organismo microbiano que não ocorre naturalmente e método para produzir 1,3 bdo
WO2011081658A2 (en) * 2009-12-15 2011-07-07 Qteros, Inc. Methods and compositions for producing chemical products from c. phytofermentants
PH12012501526A1 (en) 2010-01-29 2018-03-21 Genomatica Inc Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
US9410131B2 (en) 2010-02-11 2016-08-09 Yeda Research And Development Co. Ltd. Enzymatic systems for carbon fixation and methods of generating same
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
WO2011140171A2 (en) 2010-05-05 2011-11-10 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
WO2012001003A1 (en) 2010-07-02 2012-01-05 Metabolic Explorer Method for the preparation of hydroxy acids
MX2013001071A (es) 2010-07-26 2013-06-28 Genomatica Inc Microorganismos y metodos para la biosintesis de aromaticos, 2, 4-pentadienoato y 1, 3-butadieno.
CN103502432A (zh) 2010-11-22 2014-01-08 诺维信股份有限公司 用于生产3-羟基丙酸的组合物和方法
US8765426B2 (en) 2011-04-07 2014-07-01 E I Du Pont De Nemours And Company Pantothenic acid biosynthesis in zymomonas
US9169486B2 (en) 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
WO2013049073A1 (en) 2011-09-30 2013-04-04 Novozymes, Inc. Dehydrogenase variants and polynucleotides encoding same
CN111705028A (zh) 2012-06-04 2020-09-25 基因组股份公司 制造4-羟基丁酸酯、1,4-丁二醇和相关化合物的微生物和方法
KR20150040359A (ko) 2012-08-10 2015-04-14 오피엑스 바이오테크놀로지스, 인크. 지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법
JP2015536669A (ja) 2012-11-30 2015-12-24 ノボザイムス,インコーポレイティド 組換え酵母による3−ヒドロキシプロピオン酸の生産
NZ706072A (en) 2013-03-08 2018-12-21 Xyleco Inc Equipment protecting enclosures
JP2016512688A (ja) 2013-03-15 2016-05-09 カーギル・インコーポレイテッド 3−ヒドロキシプロピオン酸の回収
EP2970068B1 (en) 2013-03-15 2021-07-28 Genomatica, Inc. Process and systems for obtaining 1,4-butanediol from fermentation broths
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
CA2905602A1 (en) 2013-03-15 2014-09-18 Sarah M. Hoyt Flash evaporation for product purification and recovery
WO2014176514A2 (en) 2013-04-26 2014-10-30 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
WO2014190251A1 (en) 2013-05-24 2014-11-27 Genomatica, Inc. Microorganisms and methods for producing (3r)-hydroxybutyl (3r)-hydroxybutyrate
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
DK3027733T3 (en) 2013-07-31 2018-12-10 Novozymes As Preparation of 3-Hydroxypropionic Acid in Recombinant Yeast Expressing an Insect Aspartate-1 Decarboxylase
US10704064B2 (en) 2014-08-29 2020-07-07 Sk Innovation Co., Ltd. Recombinant yeast producing 3-hydroxypropionic acid and method for producing 3-hydroxypropionic acid using the same
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
KR101839595B1 (ko) * 2015-04-13 2018-04-26 한국과학기술원 락탐의 제조방법
EP3341475A1 (en) 2015-08-24 2018-07-04 Novozymes A/S Beta-alanine aminotransferases for the production of 3-hydroxypropionic acid
KR101828551B1 (ko) * 2016-01-11 2018-02-13 한국과학기술원 말론산 생성능을 가지는 재조합 변이미생물 및 이를 이용한 말론산의 제조방법
DE102016114555A1 (de) 2016-08-05 2018-02-08 Thyssenkrupp Ag Prozess zur Herstellung von Acrylsäure aus einer wässrigen 3-Hydroxypropanol-Lösung
EP3577227A4 (en) 2017-02-02 2020-12-30 Cargill Inc. GENETICALLY MODIFIED CELLS PRODUCING C6-C10 FATTY ACID DERIVATIVES

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643758A (en) * 1987-03-10 1997-07-01 New England Biolabs, Inc. Production and purification of a protein fused to a binding protein
AU733534B2 (en) * 1996-11-13 2001-05-17 E.I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant microorganisms
US6248874B1 (en) 1998-11-24 2001-06-19 Wisconsin Alumni Research Foundation DNA molecules encoding bacterial lysine 2,3-aminomutase
US7452701B2 (en) 1998-11-24 2008-11-18 Wisconsin Alumni Research Foundation Methods for the preparation of β-amino acids
DE19855314A1 (de) 1998-12-01 2000-06-08 Degussa Verfahren zur fermentiven Herstellung von D-Pantothensäure unter Verwendung von Stämmen der Familie Enterobacteriaceae
DE19855312A1 (de) 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien
DE60030403D1 (de) * 1999-08-30 2006-10-12 Wisconsin Alumni Res Found Herstellung von 3-hydroxypropionsäure in rekombinanten organismen
EP1214420B1 (en) * 1999-09-21 2016-03-23 Basf Se Methods and microorganisms for production of panto-compounds
CA2385257A1 (en) 1999-09-22 2001-03-29 Canbas Co., Ltd. Compositions and methods for inhibiting g2 cell cycle arrest and sensitizing cells to dna damaging agents
JP4490628B2 (ja) 2000-11-20 2010-06-30 カーギル インコーポレイテッド 3−ヒドロキシプロピオン酸および他の有機化合物
EP1575881B1 (en) 2002-01-18 2009-05-27 Novozymes A/S Alanine 2,3- aminomutase
WO2005118719A2 (en) * 2003-12-04 2005-12-15 Cargill, Incorporated Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase
US20090031453A1 (en) 2004-07-30 2009-01-29 Holly Jean Jessen Alanine 2, 3 aminomutases
US7790432B2 (en) 2004-10-25 2010-09-07 Codexis, Inc. Alanine 2,3-aminomutases and related polynucleotides
WO2007047680A2 (en) 2005-10-14 2007-04-26 Cargill, Incorporated Increasing the activity of radical s-adenosyl methionine (sam) enzymes
US8030051B2 (en) 2005-10-14 2011-10-04 Codexis, Inc. Alanine 2,3-aminomutases and related polynucleotides

Also Published As

Publication number Publication date
ATE432338T1 (de) 2009-06-15
JP4532116B2 (ja) 2010-08-25
WO2003062173A8 (en) 2005-11-03
EP1575881A2 (en) 2005-09-21
WO2003062173A3 (en) 2005-08-04
US20050221466A1 (en) 2005-10-06
US7655451B2 (en) 2010-02-02
EP1575881A4 (en) 2006-02-01
EP1575881B1 (en) 2009-05-27
US20100099167A1 (en) 2010-04-22
WO2003062173A2 (en) 2003-07-31
US20110045573A1 (en) 2011-02-24
US20080124785A1 (en) 2008-05-29
US8043841B2 (en) 2011-10-25
CA2473716A1 (en) 2003-07-31
US7846707B2 (en) 2010-12-07
JP2005525100A (ja) 2005-08-25
DE60327804D1 (de) 2009-07-09
ES2329778T3 (es) 2009-12-01
MXPA04006894A (es) 2004-10-15
US7309597B2 (en) 2007-12-18

Similar Documents

Publication Publication Date Title
BR0307010A (pt) alanina 2,3-aminomutase
BRPI0418979A (pt) 2,3-aminomutases de alanina
AR027600A1 (es) Polipeptidos que tienen actividad de alfa-amilasa alcalina y los acidos nucleicos que lo codifican
AR023229A1 (es) Polipéptidos mutantes, y su uso en composiciones detergentes.
MX2010001481A (es) Proteasas fungales acidas.
UY26841A1 (es) Sales estables de ácido o-acetilsalicílico con aminoácidos básicos
BR0312121A (pt) xinalases, ácidos nucléicos codificando-as e métodos para preparar e empregá-las
EA200401398A1 (ru) Замещённые фенилацетамиды и их применение в качестве активаторов глюкокиназы
BRPI0414598A (pt) indóis substituìdos
BRPI0416546A (pt) produção de ácido 3-hidroxipropiÈnico usando beta-alanina/piruvato aminotransferase
NO20034214L (no) Dermalt applikasjonssystem for aminolevulinsyrederivater
BR0210593A (pt) polinucleotìdeos de defensina e métodos de uso
BR0313371A (pt) Composto, uso de um composto e método de tratamento de doença
BRPI0415773A (pt) derivados de indolinona e sua aplicação no tratamento de estados de doença tais como cáncer
EA200400368A1 (ru) Новые дигидроптеридиноны, способы их получения и их применение в качестве лекарственных средств
BRPI0409276A (pt) derivados de piperazina inibidores de renina
DE60327557D1 (de) Verwendung von spongosin (2-methoxyadenosin) zur behandlung von schmerzen, insbesondere hyperalgesie
BRPI0415203A (pt) pentanóis reestruturados, um processo para sua produção e seu uso como agentes antiinflamatórios
DK1572699T3 (da) Krystallinske cefdinirsalte
DK0981631T3 (da) Polypeptider, som har aminopeptidase-aktivitet, og nukleinsyrer, som koder for samme
CR9472A (es) Derivados de aminoacidos
NO20030182L (no) Dermalt påföringssystem for aminolevulinsyre
AR036623A1 (es) Proceso para la preparacion de repaglinida
ECSP055803A (es) Ésteres de ácido carbámico con actividad anticolinérgica
AR051466A1 (es) 2,3 -aminomutasas de alanina mejoradas y polinucleotidos relacionados

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12N 1/15 , C12N 1/19 , C12N 1/21 , C12N 5/04 , C12N 5/06 , C12N5/08 , C12N 9/90 , C12N 15/52 , C12N 15/70 , C12N 15/74 , C12P 7/52 , C12P 13/06 , C07H 21/04

Ipc: C12N 1/15 (2006.01), C12N 1/19 (2006.01), C12N 1/2

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM ART. 24, ART. 10, ART. 22, ART. 25 E ART. 32 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.