BR0211565A - Derivados de diamina - Google Patents
Derivados de diaminaInfo
- Publication number
- BR0211565A BR0211565A BR0211565-4A BR0211565A BR0211565A BR 0211565 A BR0211565 A BR 0211565A BR 0211565 A BR0211565 A BR 0211565A BR 0211565 A BR0211565 A BR 0211565A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- optionally substituted
- dialkyl
- alkoxy
- alkylene
- Prior art date
Links
- 150000004985 diamines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 14
- -1 heterocyclyl diamine compounds Chemical class 0.000 abstract 11
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000002947 alkylene group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 5
- 125000002619 bicyclic group Chemical group 0.000 abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 4
- 125000001589 carboacyl group Chemical group 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- CCPHAMSKHBDMDS-UHFFFAOYSA-N Chetoseminudin B Natural products C=1NC2=CC=CC=C2C=1CC1(SC)NC(=O)C(CO)(SC)N(C)C1=O CCPHAMSKHBDMDS-UHFFFAOYSA-N 0.000 abstract 1
- 101710200938 Coagulation factor X inhibitor Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- YIKSCQDJHCMVMK-UHFFFAOYSA-N Oxamide Chemical compound NC(=O)C(N)=O YIKSCQDJHCMVMK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004945 acylaminoalkyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005256 alkoxyacyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000000676 alkoxyimino group Chemical group 0.000 abstract 1
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 abstract 1
- 125000005154 alkyl sulfonyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000005015 aryl alkynyl group Chemical group 0.000 abstract 1
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005252 haloacyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004447 heteroarylalkenyl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
"DERIVADOS DE DIAMINA". Descreve-se compostos representados pela fórmula genérica (1), seus sais, seus solvatos, ou seus N-óxidos: Q^ 1^ -Q^ 2^ -T^ 0^ -N (R^ 1^) -Q^ 3^-N (R^ 2^)-T^ 1^ -Q^ 4^ (1) onde R^ 1^ e R^ 2^ representam, cada um, hidrogênio, etc. Q^ 1^ representa hidrocarbila com 5 ou 6 membros, saturada ou insaturada, opcionalmente substituída, etc.; Q^ 2^ representa uma ligação simples, etc.; Q^ 3^ representa o seguinte grupo: onde é Q^ 5^ representa alquileno de C~ 1-8~, etc. ; e T^ 0^ e T^ 1^ representam, cada um, carbonila, etc. Estes compostos são úteis como preventivos e/ou medicamentos para infarto cerebral, embolia cerebral, infarto do miocárdio, angina, infarto pulmonar, embolia pulmonar, doença de Buerger, trombose venosa profunda, coagulação intravascular disseminada, trombose após substituição por válvula ou articulação artificial, trombose e reoclusão após reconstrução circulatória, síndrome da resposta inflamatória sistêmica (SIRS), disfunção de múltiplos órgãos (MODS), trombose em circulação extracorpórea, ou coagulação sang³ínea após coleta de sangue.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001243046 | 2001-08-09 | ||
| JP2001311808 | 2001-10-09 | ||
| JP2001398708 | 2001-12-28 | ||
| PCT/JP2002/002683 WO2003000657A1 (en) | 2001-06-20 | 2002-03-20 | Diamine derivatives |
| PCT/JP2002/006141 WO2003000680A1 (en) | 2001-06-20 | 2002-06-20 | Diamine derivatives |
| PCT/JP2002/008119 WO2003016302A1 (en) | 2001-08-09 | 2002-08-08 | Diamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0211565A true BR0211565A (pt) | 2004-06-29 |
Family
ID=32600712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0211565-4A BR0211565A (pt) | 2001-08-09 | 2002-08-08 | Derivados de diamina |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1415992B1 (pt) |
| JP (1) | JP4331595B2 (pt) |
| KR (1) | KR100908966B1 (pt) |
| CN (1) | CN100545160C (pt) |
| AT (1) | ATE556066T1 (pt) |
| AU (1) | AU2002328596B2 (pt) |
| BR (1) | BR0211565A (pt) |
| CA (1) | CA2456841A1 (pt) |
| ES (1) | ES2383749T3 (pt) |
| IL (2) | IL160204A0 (pt) |
| MX (1) | MXPA04001272A (pt) |
| NO (1) | NO327003B1 (pt) |
| PL (1) | PL368402A1 (pt) |
| RU (1) | RU2314303C2 (pt) |
| WO (1) | WO2003016302A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| IL159438A0 (en) * | 2001-06-20 | 2004-06-01 | Daiichi Seiyaku Co | Diamine derivatives |
| RU2333203C2 (ru) * | 2002-12-25 | 2008-09-10 | Дайити Фармасьютикал Ко., Лтд. | Диаминовые производные |
| US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US7378409B2 (en) | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
| HUE039135T2 (hu) | 2003-11-12 | 2018-12-28 | Daiichi Sankyo Co Ltd | Eljárás tiazolszármazék elõállítására |
| AU2004312530A1 (en) | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
| CN103214414B (zh) * | 2005-09-16 | 2016-02-17 | 第一三共株式会社 | 旋光性的二胺衍生物及其制造方法 |
| ES2566479T3 (es) | 2006-01-06 | 2016-04-13 | Sunovion Pharmaceuticals Inc. | Inhibidores de reabsorción de monoamina con base en tetralona |
| KR101294014B1 (ko) | 2006-01-06 | 2013-08-09 | 선오비온 파마슈티컬스 인코포레이티드 | 모노아민 재흡수 저해제로서의 시클로알킬아민 |
| EP2816024B8 (en) | 2006-03-31 | 2018-04-04 | Sunovion Pharmaceuticals Inc. | Chiral amines |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| WO2008026563A1 (en) | 2006-08-30 | 2008-03-06 | Shionogi & Co., Ltd. | Hydrazine amide derivative |
| US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| MX351987B (es) | 2007-03-29 | 2017-11-03 | Daiichi Sankyo Co Ltd | Composicion farmaceutica. |
| CN101686672A (zh) | 2007-05-31 | 2010-03-31 | 塞普拉柯公司 | 苯基取代的环烷胺作为一元胺再摄取抑制剂 |
| CN102317248A (zh) * | 2008-12-12 | 2012-01-11 | 第一三共株式会社 | 光学活性羧酸的生产方法 |
| MY150973A (en) * | 2008-12-17 | 2014-03-31 | Daiichi Sankyo Co Ltd | Method for producing diamine derivative |
| WO2010082531A1 (ja) | 2009-01-13 | 2010-07-22 | 第一三共株式会社 | 活性化血液凝固因子阻害剤 |
| CN102348688B (zh) | 2009-03-10 | 2014-07-09 | 第一三共株式会社 | 用于制备二胺衍生物的方法 |
| EP2407450B1 (en) | 2009-03-13 | 2015-04-22 | Daiichi Sankyo Company, Limited | Method for producing optically active diamine derivative |
| WO2010131663A1 (ja) * | 2009-05-15 | 2010-11-18 | 第一三共株式会社 | オキサミド誘導体 |
| ES2605034T3 (es) | 2009-06-18 | 2017-03-10 | Daiichi Sankyo Company, Limited | Composición farmacéutica con solubilidad mejorada |
| WO2011059080A1 (ja) * | 2009-11-16 | 2011-05-19 | 第一三共株式会社 | 同位体置換されたジアミン誘導体 |
| WO2011102505A1 (ja) | 2010-02-22 | 2011-08-25 | 第一三共株式会社 | 経口用徐放性固形製剤 |
| WO2011102506A1 (ja) | 2010-02-22 | 2011-08-25 | 第一三共株式会社 | 経口用徐放性固形製剤 |
| JP5749247B2 (ja) | 2010-02-22 | 2015-07-15 | 第一三共株式会社 | 経口用徐放性固形製剤 |
| HUE031059T2 (en) | 2010-03-19 | 2017-06-28 | Daiichi Sankyo Co Ltd | Procedure for improving anticoagulant administration |
| CA2793413C (en) | 2010-03-19 | 2015-11-24 | Daiichi Sankyo Company, Limited | Crystal form of edoxaban tosylate monohydrate and method of producing same |
| WO2011149110A1 (en) | 2010-05-28 | 2011-12-01 | Daiichi Sankyo Company, Limited | Novel composition for the prevention and/or treatment of thromboembolism |
| JP5780657B2 (ja) | 2010-07-02 | 2015-09-16 | 第一三共株式会社 | 光学活性ジアミン誘導体の塩の製造方法 |
| CA2807459C (en) | 2010-08-04 | 2015-09-08 | Daiichi Sankyo Company, Limited | Process for preparing a compound by a novel sandmeyer-like reaction using a nitroxide radical compound as a reaction catalyst |
| ES2673182T3 (es) | 2011-08-10 | 2018-06-20 | Daiichi Sankyo Company, Limited | Composición farmacéutica que contiene un derivado de diamina |
| RU2665372C2 (ru) | 2012-09-03 | 2018-08-29 | Дайити Санкио Компани, Лимитед | Пероральная фармацевтическая композиция замедленного высвобождения, содержащая гидрохлорид гидроморфона |
| TWI602803B (zh) | 2013-03-29 | 2017-10-21 | 第一三共股份有限公司 | 光學活性二胺衍生物之製造方法 |
| WO2014157612A1 (ja) | 2013-03-29 | 2014-10-02 | 第一三共株式会社 | （１ｓ，４ｓ，５ｓ）－４－ブロモ－６－オキサビシクロ［３．２．１］オクタン－７－オンの製造方法 |
| HUE052100T2 (hu) | 2014-02-18 | 2021-04-28 | Daiichi Sankyo Co Ltd | Eljárás aktivált véralvadási faktor X (FXA) inhibitorának alõállítására |
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| JP6696474B2 (ja) * | 2016-06-24 | 2020-05-20 | 宇部興産株式会社 | オキサビシクロオクタン化合物の製造方法 |
| CN106467475A (zh) * | 2016-08-29 | 2017-03-01 | 上海大学 | 邻位双叠氮化合物的制备方法 |
| CN107573256B (zh) * | 2017-09-26 | 2020-02-21 | 安徽国星生物化学有限公司 | 一种对氯苯肼盐酸盐连续化生产方法及其装置 |
| CN111138357B (zh) * | 2018-11-06 | 2022-11-04 | 天津药物研究院有限公司 | 2-氧代-1，2-二氢喹啉类衍生物、其制备方法及其在医药上的应用 |
| CN111606827B (zh) * | 2020-06-23 | 2022-10-25 | 内蒙古京东药业有限公司 | 一种制备依度沙班手性胺中间体的方法 |
| CN111763222B (zh) * | 2020-08-03 | 2021-05-25 | 珠海市海瑞德新材料科技有限公司 | 用于制备依度沙班游离碱的中间体及其制备方法和应用 |
| WO2022129535A1 (en) | 2020-12-18 | 2022-06-23 | Krka, D.D., Novo Mesto | Edoxaban formulation containing no sugar alcohols |
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| WO1986007257A2 (en) * | 1985-06-07 | 1986-12-18 | The Upjohn Company | Antiarrhythmic use for aminocycloalkylamides |
| WO1992004017A1 (en) * | 1990-09-10 | 1992-03-19 | The Upjohn Company | Cis-n-(2-aminocyclohexyl)benzamide and their enantiomers as anticonvulsants |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| US5430150A (en) * | 1992-12-16 | 1995-07-04 | American Cyanamid Company | Retroviral protease inhibitors |
| JPH09503994A (ja) * | 1993-03-03 | 1997-04-22 | イーライ・リリー・アンド・カンパニー | バラノイド |
| DE19536783A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle Nicotinamid-Chelatbildner vom Typ N¶2¶S¶2¶ für radioaktive Isotope |
| US6274715B1 (en) | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
| IT1291823B1 (it) * | 1997-04-08 | 1999-01-21 | Menarini Ricerche Spa | Composti pseudo-peptidici, loro preparazione ed uso in formulazioni farmaceutiche |
| US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US6130349A (en) | 1997-12-19 | 2000-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Catalytic compositions and methods for asymmetric allylic alkylation |
| GB9807104D0 (en) * | 1998-04-02 | 1998-06-03 | Chirotech Technology Ltd | The preparation of phosphine ligands |
| DE19814801A1 (de) * | 1998-04-02 | 1999-10-07 | Basf Ag | Verfahren zur Herstellung von 1,3,4-trisubstituierten 1,2,4-Triazoliumsalzen |
| JP4665239B2 (ja) * | 1998-04-21 | 2011-04-06 | アゲンニクス アーゲー | 抗癌剤および抗増殖性薬剤としての５−アミノインデノ［１，２−ｃ］ピラゾール−４−オン |
| CA2329770A1 (en) * | 1998-06-30 | 2000-01-06 | Ian Campbell Lennon | The preparation of arylphosphines |
| TW434207B (en) * | 1998-07-24 | 2001-05-16 | Everlight Chem Ind Corp | Chiral ligand and method for preparing cyanohydrins from aldehydes |
| US6747023B1 (en) * | 1998-08-11 | 2004-06-08 | Daiichi Pharmaceutical Co., Ltd. | Sulfonyl derivatives |
| AU2241400A (en) * | 1999-04-06 | 2000-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | Novel thiazolobenzoimidazole derivative |
| GB9909592D0 (en) * | 1999-04-26 | 1999-06-23 | Chirotech Technology Ltd | Process for the preparation of calanolide precursors |
| EP1185488A1 (fr) * | 1999-06-15 | 2002-03-13 | Rhodia Chimie | Sulfonylamides et carboxamides et leur application en catalyse asymetrique |
| US6492408B1 (en) * | 1999-07-21 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
| TWI290136B (en) * | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| US7365205B2 (en) * | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| IL159438A0 (en) * | 2001-06-20 | 2004-06-01 | Daiichi Seiyaku Co | Diamine derivatives |
| ES2329881T3 (es) * | 2001-09-21 | 2009-12-02 | Bristol-Myers Squibb Company | Compuestos que contienen lactama y derivados de los mismos como inhibidores del factor xa. |
| AU2002350217A1 (en) * | 2001-12-04 | 2003-06-17 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
| AU2003273179A1 (en) * | 2002-05-10 | 2003-12-12 | Bristol-Myers Squibb Company | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
-
2002
- 2002-08-08 ES ES02762760T patent/ES2383749T3/es not_active Expired - Lifetime
- 2002-08-08 RU RU2004106625/04A patent/RU2314303C2/ru not_active IP Right Cessation
- 2002-08-08 CN CNB02819652XA patent/CN100545160C/zh not_active Expired - Fee Related
- 2002-08-08 PL PL02368402A patent/PL368402A1/xx not_active Application Discontinuation
- 2002-08-08 EP EP02762760A patent/EP1415992B1/en not_active Expired - Lifetime
- 2002-08-08 CA CA002456841A patent/CA2456841A1/en not_active Abandoned
- 2002-08-08 WO PCT/JP2002/008119 patent/WO2003016302A1/ja not_active Ceased
- 2002-08-08 MX MXPA04001272A patent/MXPA04001272A/es active IP Right Grant
- 2002-08-08 AU AU2002328596A patent/AU2002328596B2/en not_active Ceased
- 2002-08-08 JP JP2003521226A patent/JP4331595B2/ja not_active Expired - Lifetime
- 2002-08-08 AT AT02762760T patent/ATE556066T1/de active
- 2002-08-08 IL IL16020402A patent/IL160204A0/xx unknown
- 2002-08-08 BR BR0211565-4A patent/BR0211565A/pt not_active IP Right Cessation
- 2002-08-08 KR KR1020047001827A patent/KR100908966B1/ko not_active Expired - Fee Related
-
2004
- 2004-02-04 IL IL160204A patent/IL160204A/en not_active IP Right Cessation
- 2004-02-06 NO NO20040557A patent/NO327003B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1415992A1 (en) | 2004-05-06 |
| WO2003016302A1 (en) | 2003-02-27 |
| CN1894238A (zh) | 2007-01-10 |
| JPWO2003016302A1 (ja) | 2004-12-02 |
| KR20040023720A (ko) | 2004-03-18 |
| ES2383749T3 (es) | 2012-06-26 |
| IL160204A0 (en) | 2004-07-25 |
| RU2004106625A (ru) | 2005-06-27 |
| EP1415992A4 (en) | 2006-07-26 |
| CN100545160C (zh) | 2009-09-30 |
| ATE556066T1 (de) | 2012-05-15 |
| MXPA04001272A (es) | 2004-05-27 |
| KR100908966B1 (ko) | 2009-07-22 |
| RU2314303C2 (ru) | 2008-01-10 |
| NO20040557L (no) | 2004-04-02 |
| CA2456841A1 (en) | 2003-02-27 |
| IL160204A (en) | 2010-11-30 |
| NO327003B1 (no) | 2009-04-06 |
| HK1095814A1 (zh) | 2007-05-18 |
| JP4331595B2 (ja) | 2009-09-16 |
| EP1415992B1 (en) | 2012-05-02 |
| PL368402A1 (en) | 2005-03-21 |
| AU2002328596B2 (en) | 2007-09-20 |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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