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BR0116010A - Kit imunoterapêutico para o tratamento de tumores - Google Patents

Kit imunoterapêutico para o tratamento de tumores

Info

Publication number
BR0116010A
BR0116010A BR0116010-9A BR0116010A BR0116010A BR 0116010 A BR0116010 A BR 0116010A BR 0116010 A BR0116010 A BR 0116010A BR 0116010 A BR0116010 A BR 0116010A
Authority
BR
Brazil
Prior art keywords
tyrosine kinase
receptor
kinase activity
kit
tumors
Prior art date
Application number
BR0116010-9A
Other languages
English (en)
Inventor
Rolando Perez Rodriguez
Gisela Maria Gonzale Marinello
Tania Crombet Ramos
Irene Beausoleil Delgado
Original Assignee
Centro Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Inmunologia Molecular filed Critical Centro Inmunologia Molecular
Publication of BR0116010A publication Critical patent/BR0116010A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001104—Epidermal growth factor receptors [EGFR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A61K39/001131—Epidermal growth factor [EGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A61K39/001134—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"KIT IMUNOTERAPêUTICO PARA O TRATAMENTO DE TUMORES". A presente invenção relaciona-se com o campo da imunologia e, mais especificamente, com a imunoterapia do câncer, particularmente com um kit imunoterapêutico para impedir o crescimento de células de tumor e/ou eliminar referidas células. O kit da invenção é útil para o tratamento de tumores, que tem efeito sobre células cujo crescimento é dependente do sistema de receptores com atividadede tirosina quinase, caracterizado pelo fato de que compreende os componentes A, B, C e D que são usados simultaneamente ou seq³encialmente nas combinações de A+C; ou A+D; ou B+C; ou 8+D; ou C+D, em que A, B, C e D são:A. um anticorpo contra um receptor de atividade de tirosina quinase;B. um anticorpo contra o(s) ligando(s) do receptor de atividade de tirosina quinase; C.-uma vacina cujo princípio ativo é um receptor de atividade de tirosina quinase, que induz anticorpos contra referido receptor de atividade de tirosina quinase; D.-uma vacina cujo princípio é o(s) ligando(s) de um receptor de atividade de tirosina quinase, que induz anticorpos contra referidos ligando(s) do receptor de atividade de tirosina quinase. O kit proporciona o meio de realizar combinação terapêutica de imunoterapia passiva e ativa. Os procedimentos referenciados podem ser aplicados em diferentes estágios clinicos com tumores de origem epitelial que sobre-expressam esses receptores. A combinação de terapia passiva e ativa pode ser simultânea ou seq³encial independentemente de se o procedimento terapêutico vai ser usado em pacientes com doença avançada ou como terapia adjuvante.
BR0116010-9A 2000-12-08 2001-12-06 Kit imunoterapêutico para o tratamento de tumores BR0116010A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU20000287A CU22979A1 (es) 2000-12-08 2000-12-08 Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina
PCT/CU2001/000012 WO2002045747A1 (es) 2000-12-08 2001-12-06 Combinaciones inmunoterapeuticas para el tratamiento de tumores

Publications (1)

Publication Number Publication Date
BR0116010A true BR0116010A (pt) 2004-01-06

Family

ID=40261022

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116010-9A BR0116010A (pt) 2000-12-08 2001-12-06 Kit imunoterapêutico para o tratamento de tumores

Country Status (25)

Country Link
US (2) US20020160014A1 (pt)
EP (2) EP2005996A3 (pt)
JP (2) JP2005519023A (pt)
KR (1) KR20030064416A (pt)
CN (1) CN1326566C (pt)
AR (1) AR031641A1 (pt)
AT (1) ATE403438T1 (pt)
AU (2) AU2152102A (pt)
BR (1) BR0116010A (pt)
CA (1) CA2431199C (pt)
CU (1) CU22979A1 (pt)
CY (1) CY1108474T1 (pt)
DE (1) DE60135248D1 (pt)
DK (1) DK1350521T3 (pt)
EA (1) EA007381B1 (pt)
ES (1) ES2311036T3 (pt)
MX (1) MXPA03005030A (pt)
MY (1) MY138833A (pt)
NZ (1) NZ526284A (pt)
PE (1) PE20020695A1 (pt)
PT (1) PT1350521E (pt)
SI (1) SI1350521T1 (pt)
UY (1) UY27058A1 (pt)
WO (1) WO2002045747A1 (pt)
ZA (1) ZA200304415B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507724B2 (en) * 2001-01-16 2009-03-24 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
EP1493445A1 (en) * 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of stress-induced ligand-dependent EGFR activation
CU23297A1 (es) * 2004-11-16 2008-07-24 Ct De Inmunologa A Molecular Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer
US8323644B2 (en) * 2006-01-17 2012-12-04 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US20090053221A1 (en) * 2006-01-17 2009-02-26 Cheung Nai-Kong V Immune response enhancing glucan
AU2007312367B2 (en) * 2006-10-12 2012-09-06 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-EREG antibody
CU23652A1 (es) * 2007-06-29 2011-05-27 Centro Inmunologia Molecular Composición vacunal homogénea para el tratamiento del cáncer y su método de obtención
CN102015769B (zh) 2008-01-17 2014-12-10 Irm责任有限公司 改进的抗-trkb抗体
US20120141501A1 (en) 2009-05-29 2012-06-07 Forerunner Pharma Research Co. Ltd Pharmaceutical Composition Containing Antagonist of EGF Family Ligand as Component
WO2012018260A1 (en) * 2010-08-05 2012-02-09 Universiteit Utrecht Holding B.V. Epidermal growth factor receptor targeted immune therapy
TWI593705B (zh) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
EP3583113B1 (en) * 2017-02-17 2025-08-20 George Todaro Immunotherapeutic combinaton for the treatment of tgf alpha-expressing lung cancer or tgf alpha expressing melanoma

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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CU22545A1 (es) * 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
JPH01221326A (ja) * 1988-02-29 1989-09-04 Toyo Jozo Co Ltd 悪性腫瘍細胞障害剤
US5705157A (en) * 1989-07-27 1998-01-06 The Trustees Of The University Of Pennsylvania Methods of treating cancerous cells with anti-receptor antibodies
DK0586002T3 (da) * 1992-08-18 2000-06-19 Centro Inmunologia Molecular Monoklonale antistoffer, som genkender epidermisvækstfaktor-receptoren, celler og fremgangsmåder heraf og præparater indeho
CA2261433A1 (en) 1993-12-09 1995-06-10 Belinda Sanchez Ramirez Composition comprising autologous epidermal growth factor
DE69434279T2 (de) * 1993-12-09 2006-04-06 Centro De Inmunologia Molecular Impfstoff, der einen menschlichen autologenen epidermalen Wachstumsfaktor enthält und dessen Verwendung
CU22615A1 (es) * 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
PT981369E (pt) * 1997-05-12 2005-03-31 Aphton Corp Composicoes imunogenicas para o receptor de cck-b/gastrina e metodos para o tratamento de tumores
US20030219380A1 (en) * 1997-11-07 2003-11-27 Annie Fong Method of determining an efficacious dose of a drug
WO1999057981A1 (en) * 1998-05-08 1999-11-18 Sloan-Kettering Institute For Cancer Research Compositions and methods for active vaccination
HK1040720A1 (zh) * 1998-05-15 2002-06-21 伊姆克罗尼系统公司 用辐射和生长因子受体酪氨酸激酶抑制剂治疗人肿瘤
US6498181B1 (en) * 1999-01-06 2002-12-24 Maxim Pharmaceuticals Synergistic tumorcidal response induced by histamine
AU2001259452A1 (en) * 2000-05-05 2001-11-20 Aphton Corporation Chimeric peptide immunogens their preparation and use
CU23077A1 (es) * 2000-12-06 2005-08-17 Centro Inmunologia Molecular Composicion vacunal que contiene factor de crecimiento transformante (tgf-alfa). su uso en la terapia de enfermedades malignas

Also Published As

Publication number Publication date
MY138833A (en) 2009-07-31
EA200300646A1 (ru) 2003-10-30
JP2010150286A (ja) 2010-07-08
EP1350521A1 (en) 2003-10-08
MXPA03005030A (es) 2004-09-10
AR031641A1 (es) 2003-09-24
CA2431199A1 (en) 2002-06-13
WO2002045747A1 (es) 2002-06-13
EP2005996A2 (en) 2008-12-24
US20060188497A1 (en) 2006-08-24
EP2005996A3 (en) 2012-01-25
CA2431199C (en) 2011-10-04
EA007381B1 (ru) 2006-10-27
PE20020695A1 (es) 2002-09-23
UY27058A1 (es) 2002-03-22
CY1108474T1 (el) 2014-04-09
ZA200304415B (en) 2004-07-07
EP1350521B1 (en) 2008-08-06
DE60135248D1 (de) 2008-09-18
AU2152102A (en) 2002-06-18
KR20030064416A (ko) 2003-07-31
CU22979A1 (es) 2004-09-09
SI1350521T1 (sl) 2008-12-31
DK1350521T3 (da) 2008-11-10
JP2005519023A (ja) 2005-06-30
PT1350521E (pt) 2008-11-14
NZ526284A (en) 2004-11-26
CN1326566C (zh) 2007-07-18
CN1592636A (zh) 2005-03-09
US20020160014A1 (en) 2002-10-31
AU2002221521B2 (en) 2007-01-04
ATE403438T1 (de) 2008-08-15
US7744871B2 (en) 2010-06-29
ES2311036T3 (es) 2009-02-01
HK1073244A1 (zh) 2005-09-30

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