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BG64705B1 - Pde iv инхибиращи пиридинови производни - Google Patents

Pde iv инхибиращи пиридинови производни Download PDF

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Publication number
BG64705B1
BG64705B1 BG104718A BG10471800A BG64705B1 BG 64705 B1 BG64705 B1 BG 64705B1 BG 104718 A BG104718 A BG 104718A BG 10471800 A BG10471800 A BG 10471800A BG 64705 B1 BG64705 B1 BG 64705B1
Authority
BG
Bulgaria
Prior art keywords
alkyl
substituted
formula
hydrogen
compound
Prior art date
Application number
BG104718A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104718A (en
Inventor
Eddy Jean Freyne
Gaston Stanislas Marcella Diels
Maria MATESANZ-BALLESTEROS
Adolfo Diaz-Martinez
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG104718A publication Critical patent/BG104718A/xx
Publication of BG64705B1 publication Critical patent/BG64705B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
BG104718A 1998-04-01 2000-08-28 Pde iv инхибиращи пиридинови производни BG64705B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98201020 1998-04-01

Publications (2)

Publication Number Publication Date
BG104718A BG104718A (en) 2001-04-30
BG64705B1 true BG64705B1 (bg) 2005-12-30

Family

ID=8233543

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104718A BG64705B1 (bg) 1998-04-01 2000-08-28 Pde iv инхибиращи пиридинови производни

Country Status (33)

Country Link
US (1) US6656959B1 (fr)
EP (1) EP1068194B1 (fr)
JP (1) JP4778612B2 (fr)
KR (1) KR100596664B1 (fr)
CN (1) CN1172930C (fr)
AR (1) AR014972A1 (fr)
AT (1) ATE253569T1 (fr)
AU (1) AU760771B2 (fr)
BG (1) BG64705B1 (fr)
BR (1) BR9909326A (fr)
CA (1) CA2326045C (fr)
CZ (1) CZ298747B6 (fr)
DE (1) DE69912590T2 (fr)
DK (1) DK1068194T3 (fr)
EA (1) EA004207B1 (fr)
EE (1) EE04718B1 (fr)
ES (1) ES2211061T3 (fr)
HR (1) HRP20000619B1 (fr)
HU (1) HU229412B1 (fr)
ID (1) ID27207A (fr)
IL (2) IL138745A0 (fr)
MY (1) MY124696A (fr)
NO (1) NO319531B1 (fr)
NZ (1) NZ507022A (fr)
PL (1) PL196026B1 (fr)
PT (1) PT1068194E (fr)
SI (1) SI1068194T1 (fr)
SK (1) SK284468B6 (fr)
TR (1) TR200002801T2 (fr)
TW (1) TWI242558B (fr)
UA (1) UA66842C2 (fr)
WO (1) WO1999050262A1 (fr)
ZA (1) ZA200006190B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
MY123585A (en) 2000-03-23 2006-05-31 Merck Canada Inc Tri-aryl-substituted-ethane pde4 inhibitors.
DE10130397A1 (de) * 2001-06-23 2003-01-09 Bayer Cropscience Gmbh Herbizide substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbzide und Pflanzenwachstumsregulatoren
DE10318610A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
GEP20084550B (en) 2004-04-30 2008-11-25 Warner Lambert Co Substituted morpholine compounds for the treatment of central nervous system disorders
US7863446B2 (en) 2006-01-19 2011-01-04 Orchid Research Laboratories Limited Heterocycles
WO2007085357A1 (fr) 2006-01-30 2007-08-02 Euro-Celtique S.A. Composes cyclo-uree utilises en tant que bloqueurs des canaux calciques
BRPI0717596B8 (pt) 2006-10-18 2021-05-25 Pfizer Prod Inc compostos de éter biarílico uréia, seu uso e composição farmacêutica que os compreende
BRPI0912029A2 (pt) 2008-02-01 2020-06-30 Orchid Research Laboratories Limited novos heterociclos
JOP20190060A1 (ar) 2016-09-26 2019-03-26 Chugai Pharmaceutical Co Ltd مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004045A1 (fr) * 1993-07-28 1995-02-09 Rhone-Poulenc Rorer Limited Composes utilises comme inhibiteurs de pde iv et du facteur de necrose tumorale (tnf)
WO1996031485A1 (fr) * 1995-04-06 1996-10-10 Janssen Pharmaceutica N.V. Composes 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one ayant une activite anti-pde iv et anti-cytokine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876657A (en) * 1971-06-03 1975-04-08 Ashland Oil Inc Preparation of 1-substituted-2-imidazolidinones
US4600430A (en) 1985-02-22 1986-07-15 Eli Lilly And Company Pyridinylimidazolidinone compounds
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
AU3272195A (en) * 1994-08-03 1996-03-04 Gics & Vermee, L.P. Ovenable food package
TW375612B (en) 1995-04-06 1999-12-01 Janssen Pharmaceutica Nv 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same
TW424087B (en) 1995-04-06 2001-03-01 Janssen Pharmaceutica Nv 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives
AU6526896A (en) 1995-07-22 1997-02-18 Rhone-Poulenc Rorer Limited Substituted aromatic compounds and their pharmaceutical use
TR199801255T2 (xx) * 1995-12-29 1998-10-21 Smithkline Beecham Corporation Vitronektin resept�r antagonistleri.
KR100520002B1 (ko) * 1996-10-02 2005-10-13 얀센 파마슈티카 엔.브이. Ｐｄｅ ｉｖ 를 억제하는 2-시아노이미노이미다졸 유도체

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004045A1 (fr) * 1993-07-28 1995-02-09 Rhone-Poulenc Rorer Limited Composes utilises comme inhibiteurs de pde iv et du facteur de necrose tumorale (tnf)
WO1996031485A1 (fr) * 1995-04-06 1996-10-10 Janssen Pharmaceutica N.V. Composes 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one ayant une activite anti-pde iv et anti-cytokine

Also Published As

Publication number Publication date
DE69912590D1 (de) 2003-12-11
ID27207A (id) 2001-03-08
EA200001009A1 (ru) 2001-02-26
NO20004906L (no) 2000-11-28
ZA200006190B (en) 2001-10-31
PT1068194E (pt) 2004-03-31
KR100596664B1 (ko) 2006-07-06
CN1172930C (zh) 2004-10-27
HU229412B1 (en) 2013-12-30
EE04718B1 (et) 2006-10-16
IL138745A0 (en) 2001-10-31
TR200002801T2 (tr) 2000-12-21
EA004207B1 (ru) 2004-02-26
ATE253569T1 (de) 2003-11-15
EP1068194A1 (fr) 2001-01-17
AU3147499A (en) 1999-10-18
HRP20000619B1 (en) 2004-06-30
CZ298747B6 (cs) 2008-01-16
HRP20000619A2 (en) 2001-10-31
EP1068194B1 (fr) 2003-11-05
PL196026B1 (pl) 2007-11-30
DE69912590T2 (de) 2004-09-16
AU760771B2 (en) 2003-05-22
CA2326045A1 (fr) 1999-10-07
AR014972A1 (es) 2001-04-11
DK1068194T3 (da) 2004-03-15
ES2211061T3 (es) 2004-07-01
WO1999050262A1 (fr) 1999-10-07
BG104718A (en) 2001-04-30
JP2002509927A (ja) 2002-04-02
HUP0101239A2 (hu) 2002-05-29
EE200000569A (et) 2002-04-15
KR20010040681A (ko) 2001-05-15
SK284468B6 (sk) 2005-04-01
CN1295571A (zh) 2001-05-16
BR9909326A (pt) 2000-12-12
SI1068194T1 (en) 2004-04-30
NO20004906D0 (no) 2000-09-29
CZ20003338A3 (cs) 2001-02-14
HK1033579A1 (en) 2001-09-07
NO319531B1 (no) 2005-08-29
CA2326045C (fr) 2008-12-09
UA66842C2 (uk) 2004-06-15
TWI242558B (en) 2005-11-01
US6656959B1 (en) 2003-12-02
MY124696A (en) 2006-06-30
IL138745A (en) 2007-06-17
HUP0101239A3 (en) 2002-09-30
SK13872000A3 (sk) 2001-11-06
NZ507022A (en) 2002-06-28
PL343194A1 (en) 2001-07-30
JP4778612B2 (ja) 2011-09-21

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