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BG101894A - 4-аминотетрахидробензизоксазолови или -изотиазолови съединения - Google Patents

4-аминотетрахидробензизоксазолови или -изотиазолови съединения

Info

Publication number
BG101894A
BG101894A BG101894A BG10189497A BG101894A BG 101894 A BG101894 A BG 101894A BG 101894 A BG101894 A BG 101894A BG 10189497 A BG10189497 A BG 10189497A BG 101894 A BG101894 A BG 101894A
Authority
BG
Bulgaria
Prior art keywords
compounds
izotiazole
aminothetrohydrobenzisoxazole
muscular30
inhibitingactivity
Prior art date
Application number
BG101894A
Other languages
English (en)
Other versions
BG63258B1 (bg
Inventor
Erik Falch
Jens Perregaard
Arne Schousboe
Povl Krogsgaard-Larsen
Bente Frolund
Lenz MOLTZEN
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of BG101894A publication Critical patent/BG101894A/bg
Publication of BG63258B1 publication Critical patent/BG63258B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nozzles (AREA)

Abstract

Съединенията проявяват GABA (4-аминобутанова киселина) инхибираща активност и са предназначени за лечение на аналгезия, психоза, конвулсии, потиснатост или мускулни и двигателни смущения, по-специално на епилепсия. 4-аминотетрахидробензизоксазоловите или -изотиазолови съединения имат общи формули,в които радикалите от R1 до R6 и Х и Р имат значенията, посочени в описанието.
BG101894A 1995-02-28 1997-09-16 4-аминотетрахидробензизоксазолови или -изотиазолови съединения BG63258B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK20795 1995-02-28
PCT/DK1996/000084 WO1996026929A1 (en) 1995-02-28 1996-02-28 4-aminotetrahydrobenzisoxazole or -isothiazole compounds

Publications (2)

Publication Number Publication Date
BG101894A true BG101894A (bg) 1998-05-29
BG63258B1 BG63258B1 (bg) 2001-07-31

Family

ID=8090951

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101894A BG63258B1 (bg) 1995-02-28 1997-09-16 4-аминотетрахидробензизоксазолови или -изотиазолови съединения

Country Status (30)

Country Link
US (2) US5998613A (bg)
EP (1) EP0812318B1 (bg)
JP (1) JPH11501016A (bg)
KR (1) KR100242675B1 (bg)
CN (1) CN1087290C (bg)
AT (1) ATE317391T1 (bg)
AU (1) AU697610B2 (bg)
BG (1) BG63258B1 (bg)
BR (1) BR9607443A (bg)
CA (1) CA2213127A1 (bg)
CZ (1) CZ290837B6 (bg)
DE (1) DE69635798T2 (bg)
DK (1) DK0812318T3 (bg)
EA (1) EA000380B1 (bg)
EE (1) EE03483B1 (bg)
ES (1) ES2253748T3 (bg)
FI (1) FI973519L (bg)
HU (1) HUP9800631A3 (bg)
IL (1) IL117295A (bg)
IS (1) IS2352B (bg)
NO (1) NO309474B1 (bg)
NZ (1) NZ301653A (bg)
PL (1) PL187404B1 (bg)
RO (1) RO119545B1 (bg)
SI (1) SI0812318T1 (bg)
SK (1) SK281879B6 (bg)
TR (1) TR199700873T1 (bg)
UA (1) UA43396C2 (bg)
WO (1) WO1996026929A1 (bg)
ZA (1) ZA961591B (bg)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0934061T1 (en) 1996-07-24 2003-10-31 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
GB9622370D0 (en) * 1996-10-28 1997-01-08 Merck Sharp & Dohme Therapeutic agents
US20030166554A1 (en) * 2001-01-16 2003-09-04 Genset, S.A. Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists
US20030185754A1 (en) * 2001-01-16 2003-10-02 Genset, S.A. Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists
US7378426B2 (en) * 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
KR101354335B1 (ko) * 2009-05-05 2014-02-19 에프. 호프만-라 로슈 아게 인지 장애의 치료에 사용되는 ｇａｂａ ａ 수용체 역 작용제로서의 아이속사졸-티아졸 유도체
WO2010151711A1 (en) 2009-06-25 2010-12-29 Alkermes, Inc. Prodrugs of nh-acidic compounds
CN105758807B (zh) * 2016-02-22 2019-01-29 山东出入境检验检疫局检验检疫技术中心 一种鉴别废润滑油的方法
JP7384812B2 (ja) 2018-03-05 2023-11-21 アルカームス ファーマ アイルランド リミテッド アリピプラゾール投与戦略

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2602643C2 (de) * 1976-01-24 1984-12-20 Bayer Ag, 5090 Leverkusen 1,2-Benzisothiazolinone-3, Verfahren zu ihrer Herstellung sowie Arzneimittel
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4514414A (en) * 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
IE60267B1 (en) * 1986-12-26 1994-06-29 Sankyo Co Centrally-acting muscle relaxants
US5321037A (en) * 1986-12-26 1994-06-14 Sankyo Company, Limited Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
US5225412A (en) * 1991-04-29 1993-07-06 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides

Also Published As

Publication number Publication date
CN1087290C (zh) 2002-07-10
BR9607443A (pt) 1998-05-26
NO973948D0 (no) 1997-08-27
CZ271197A3 (cs) 1998-03-18
EA199700199A1 (ru) 1998-02-26
AU4713196A (en) 1996-09-18
EP0812318A1 (en) 1997-12-17
NO973948L (no) 1997-08-27
KR100242675B1 (ko) 2000-03-02
AU697610B2 (en) 1998-10-15
HUP9800631A3 (en) 1998-12-28
ZA961591B (en) 1996-08-28
EP0812318B1 (en) 2006-02-08
TR199700873T1 (xx) 1998-01-21
US6174909B1 (en) 2001-01-16
UA43396C2 (uk) 2001-12-17
MX9706280A (es) 1998-06-30
ES2253748T3 (es) 2006-06-01
FI973519A0 (fi) 1997-08-27
SI0812318T1 (sl) 2006-06-30
PL321956A1 (en) 1998-01-05
DE69635798T2 (de) 2006-08-17
WO1996026929A1 (en) 1996-09-06
NO309474B1 (no) 2001-02-05
SK115197A3 (en) 1998-02-04
HK1008527A1 (en) 1999-07-30
EA000380B1 (ru) 1999-06-24
BG63258B1 (bg) 2001-07-31
RO119545B1 (ro) 2004-12-30
PL187404B1 (pl) 2004-07-30
EE9700197A (et) 1998-02-16
IL117295A0 (en) 1996-06-18
SK281879B6 (sk) 2001-08-06
HUP9800631A2 (hu) 1998-08-28
IL117295A (en) 1999-11-30
CZ290837B6 (cs) 2002-10-16
DE69635798D1 (de) 2006-04-20
DK0812318T3 (da) 2006-06-06
NZ301653A (en) 1998-12-23
KR19980702546A (ko) 1998-07-15
EE03483B1 (et) 2001-08-15
US5998613A (en) 1999-12-07
CN1176638A (zh) 1998-03-18
CA2213127A1 (en) 1996-09-06
IS2352B (is) 2008-04-15
IS4542A (is) 1997-08-13
FI973519A7 (fi) 1997-08-27
ATE317391T1 (de) 2006-02-15
JPH11501016A (ja) 1999-01-26
FI973519L (fi) 1997-08-27

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