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BE903169A - 7-SUBSTITUTED OXOMITOSANES - Google Patents

7-SUBSTITUTED OXOMITOSANES

Info

Publication number
BE903169A
BE903169A BE0/215535A BE215535A BE903169A BE 903169 A BE903169 A BE 903169A BE 0/215535 A BE0/215535 A BE 0/215535A BE 215535 A BE215535 A BE 215535A BE 903169 A BE903169 A BE 903169A
Authority
BE
Belgium
Prior art keywords
radical
oxomitosanes
substituted
alk1
dihydroxyethyl
Prior art date
Application number
BE0/215535A
Other languages
French (fr)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE903169A publication Critical patent/BE903169A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nouveaux analogues de la mitomycine contenant un radical disulfure de formule II ou III où notamment, Alk1 et Alk2 représentent un radical éthylène, R1 représente un atome d'hydrogène, R3 représente un radical acétylamino, acétyloxy, 1,2-dihydroxyéthyle ou carboxyle, et R4 représente un radical phényle, 4-nitrophényle, 4-méthoxyphényle, 4-aminophényle, ou 2-carboxyphényle.New mitomycin analogs containing a disulfide radical of formula II or III where, in particular, Alk1 and Alk2 represent an ethylene radical, R1 represents a hydrogen atom, R3 represents an acetylamino, acetyloxy, 1,2-dihydroxyethyl or carboxyl radical, and R4 represents a phenyl, 4-nitrophenyl, 4-methoxyphenyl, 4-aminophenyl, or 2-carboxyphenyl radical.

BE0/215535A 1984-09-04 1985-09-03 7-SUBSTITUTED OXOMITOSANES BE903169A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64688884A 1984-09-04 1984-09-04
US74457085A 1985-06-17 1985-06-17

Publications (1)

Publication Number Publication Date
BE903169A true BE903169A (en) 1986-03-03

Family

ID=27095036

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215535A BE903169A (en) 1984-09-04 1985-09-03 7-SUBSTITUTED OXOMITOSANES

Country Status (24)

Country Link
JP (1) JPS61112078A (en)
KR (2) KR900008570B1 (en)
AT (1) AT394723B (en)
AU (1) AU581673B2 (en)
BE (1) BE903169A (en)
CA (2) CA1291293C (en)
CH (2) CH667094A5 (en)
CY (2) CY1585A (en)
DE (1) DE3531453C2 (en)
DK (1) DK169478B1 (en)
ES (3) ES8702408A1 (en)
FI (1) FI80700C (en)
FR (1) FR2569696B1 (en)
GB (2) GB2164038B (en)
GR (1) GR852118B (en)
HK (2) HK22491A (en)
HU (1) HU195658B (en)
IE (1) IE58720B1 (en)
IT (1) IT1209660B (en)
LU (1) LU86062A1 (en)
NL (1) NL8502383A (en)
NO (1) NO169441C (en)
PT (1) PT81083B (en)
SE (2) SE465929B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs
IL86665A0 (en) * 1987-06-12 1988-11-30 Bristol Myers Co Mitomycin analogs
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US5023253A (en) * 1987-12-21 1991-06-11 University Patents, Inc. 6-substituted mitomycin analogs
US5175303A (en) * 1990-03-08 1992-12-29 Bristol-Myers Squibb Company Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane
US5075454A (en) * 1990-03-08 1991-12-24 Bristol-Myers Squibb Company 7-(diphenylmethyl)oxy-9a-methoxymitosane

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3306821A (en) * 1962-09-04 1967-02-28 Upjohn Co Porfiromycin derivatives and method of making same
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
DE116208T1 (en) * 1982-12-07 1985-02-28 Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo MITOMYCIN ANALOGS.
JPS59175493A (en) * 1983-03-25 1984-10-04 Kyowa Hakko Kogyo Co Ltd Mitomycin derivative and its preparation
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
KR840008362A (en) * 1983-04-11 1984-12-14 사무엘 제이. 두보프 Amino disulfate
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs

Also Published As

Publication number Publication date
GB2164038A (en) 1986-03-12
ES553549A0 (en) 1987-06-16
IE852174L (en) 1986-03-04
NO169441C (en) 1992-06-24
KR860002507A (en) 1986-04-26
NL8502383A (en) 1986-04-01
FI80700B (en) 1990-03-30
ES8702408A1 (en) 1986-12-16
DK169478B1 (en) 1994-11-07
SE465929B (en) 1991-11-18
CH667457A5 (en) 1988-10-14
ES546687A0 (en) 1986-12-16
DK401385D0 (en) 1985-09-03
SE8504093D0 (en) 1985-09-03
HUT38942A (en) 1986-07-28
GR852118B (en) 1986-01-07
GB2196006B (en) 1988-11-09
PT81083A (en) 1985-10-01
FI853338L (en) 1986-03-05
IT1209660B (en) 1989-08-30
DE3531453A1 (en) 1986-03-13
GB2196006A (en) 1988-04-20
AT394723B (en) 1992-06-10
NO169441B (en) 1992-03-16
HK22491A (en) 1991-04-04
ES8706326A1 (en) 1987-06-16
ATA258985A (en) 1991-11-15
JPH0560469B2 (en) 1993-09-02
GB8726516D0 (en) 1987-12-16
GB2164038B (en) 1988-11-09
KR900008570B1 (en) 1990-11-24
GB8521816D0 (en) 1985-10-09
HK22391A (en) 1991-04-04
SE9004157L (en) 1992-06-28
HU195658B (en) 1988-06-28
SE9004157D0 (en) 1990-12-27
CA1291293C (en) 1991-10-22
DK401385A (en) 1986-03-05
IE58720B1 (en) 1993-11-03
AU581673B2 (en) 1989-03-02
JPS61112078A (en) 1986-05-30
ES553548A0 (en) 1987-06-16
FI853338A0 (en) 1985-08-30
LU86062A1 (en) 1986-03-03
CA1254892A (en) 1989-05-30
IT8522059A0 (en) 1985-09-03
PT81083B (en) 1988-01-22
DE3531453C2 (en) 1996-07-18
KR900008840B1 (en) 1990-11-30
AU4571685A (en) 1986-03-13
CY1586A (en) 1992-04-03
NO853435L (en) 1986-03-05
FR2569696A1 (en) 1986-03-07
CY1585A (en) 1992-04-03
ES8706327A1 (en) 1987-06-16
SE8504093L (en) 1986-03-05
FI80700C (en) 1990-07-10
FR2569696B1 (en) 1991-12-20
CH667094A5 (en) 1988-09-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19960930