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BE1014089A4 - Nouvelles metalloproteases possedant des domaines thrombospondine et compositions d'acides nucleiques les codant. - Google Patents

Nouvelles metalloproteases possedant des domaines thrombospondine et compositions d'acides nucleiques les codant. Download PDF

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Publication number
BE1014089A4
BE1014089A4 BE2001/0104A BE200100104A BE1014089A4 BE 1014089 A4 BE1014089 A4 BE 1014089A4 BE 2001/0104 A BE2001/0104 A BE 2001/0104A BE 200100104 A BE200100104 A BE 200100104A BE 1014089 A4 BE1014089 A4 BE 1014089A4
Authority
BE
Belgium
Prior art keywords
nucleic acid
mpts
activity
metalloprotease
antagonist
Prior art date
Application number
BE2001/0104A
Other languages
English (en)
Inventor
Renu Anand Heller
Paul Klonowski
Fengrong Zuo
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of BE1014089A4 publication Critical patent/BE1014089A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouvelles métalloprotéases possédant un ou des domaines thromboqpodine (protéines MPTS) et des polypeptides qui leur sont liés, ainsi que des compositions d'acides nucléiques codant pour ces protéines. les compositions de polypeptides et d'acides nucléiques de l'invention trouvent une utilisation dans toutes sortes d'applications, notamment des applications disgnostiques, des applications de sélection d'agents thérapeutiques, ainsi que des applications thérapeutiques pour toutes sortes de maladies différentes. L'invention a également trait à des procédés pour traiter des maladies associées à l'activité agrécanase, par exemple des pathologies caractérisées par la présence de produits de clivage de l'agrécane, telles que la polyarthrite rhumatoïde et l'arthose.
BE2001/0104A 2000-02-18 2001-02-15 Nouvelles metalloproteases possedant des domaines thrombospondine et compositions d'acides nucleiques les codant. BE1014089A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18415200P 2000-02-18 2000-02-18

Publications (1)

Publication Number Publication Date
BE1014089A4 true BE1014089A4 (fr) 2003-04-01

Family

ID=22675774

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2001/0104A BE1014089A4 (fr) 2000-02-18 2001-02-15 Nouvelles metalloproteases possedant des domaines thrombospondine et compositions d'acides nucleiques les codant.

Country Status (4)

Country Link
BE (1) BE1014089A4 (fr)
CA (1) CA2332533A1 (fr)
IE (1) IE20010121A1 (fr)
NL (2) NL1017393C2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005291A2 (fr) * 1997-07-25 1999-02-04 Du Pont Pharmaceuticals Company Metalloproteases decomposant l'aggrecan
WO2001042468A1 (fr) * 1999-12-09 2001-06-14 Lexicon Genetics Incorporated Nouvelles protéases humaines et polynucléotides codant pour ces protéases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
AU2002253883A1 (en) * 2001-01-31 2002-08-12 Incyte Genomics, Inc. Protein modification and maintenance molecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005291A2 (fr) * 1997-07-25 1999-02-04 Du Pont Pharmaceuticals Company Metalloproteases decomposant l'aggrecan
WO2001042468A1 (fr) * 1999-12-09 2001-06-14 Lexicon Genetics Incorporated Nouvelles protéases humaines et polynucléotides codant pour ces protéases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HURSKAINEN TIINA L ET AL: "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases: General features and genomic distribution of the Adam-TS family", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 36, 3 September 1999 (1999-09-03), pages 25555 - 25563, XP002158991, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2332533A1 (fr) 2001-08-18
NL1017393C2 (nl) 2003-01-09
NL1022252A1 (nl) 2003-01-23
NL1022252C2 (nl) 2003-11-18
IE20010121A1 (en) 2002-12-11
NL1017393A1 (nl) 2001-08-22

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Effective date: 20040228