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AU701560B2 - 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists - Google Patents

1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists Download PDF

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AU701560B2
AU701560B2 AU46233/96A AU4623396A AU701560B2 AU 701560 B2 AU701560 B2 AU 701560B2 AU 46233/96 A AU46233/96 A AU 46233/96A AU 4623396 A AU4623396 A AU 4623396A AU 701560 B2 AU701560 B2 AU 701560B2
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lower alkyl
substituted
phenyl
unsubstituted
methyl
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AU4623396A (en
Inventor
Yves Auberson
Claudia Betschart
Marc Gerspacher
Robert Mah
Silvio Ofner
Silvio Roggo
Walter Schilling
Siem Jacob Veenstra
Andreas Von Sprecher
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Novartis AG
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Novartis AG
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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AU46233/96A 1995-02-22 1996-02-09 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists Ceased AU701560B2 (en)

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AU3149297A (en) * 1996-05-24 1997-12-09 Eli Lilly And Company Methods of treating hypertension
MY132550A (en) 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
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GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
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DK1691814T3 (da) * 2003-12-01 2012-10-29 Cambridge Entpr Ltd Antiinflammatoriske midler
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
JO2630B1 (en) * 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
GB0607532D0 (en) * 2006-04-13 2006-05-24 Novartis Ag Organic compounds
JP4983616B2 (ja) 2008-01-16 2012-07-25 ソニー株式会社 熱転写記録媒体
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
MX2016009939A (es) * 2014-02-18 2017-01-23 Daiichi Sankyo Co Ltd Derivado de aminopirazolona.
CA3091944A1 (en) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
RU2697414C1 (ru) * 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение
WO2020159797A1 (en) * 2019-01-28 2020-08-06 Mitochondria Emotion, Inc. Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof
US11575807B2 (en) 2020-01-20 2023-02-07 Monomer Software LLC Optical device field of view cleaning apparatus
WO2021180885A1 (en) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

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WO1993001169A2 (en) * 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
EP0532456A1 (de) * 1991-08-12 1993-03-17 Ciba-Geigy Ag 1-Acylpiperidinverbindungen und ihre Verwendung als Substanz P Artagonisten

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JP3219096B2 (ja) * 1990-05-10 2001-10-15 ニコメド ファーマ エイエス ｎ―グリコフロール類及びｎ―エチレングリコール類を含有する医薬製剤
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides

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WO1993001169A2 (en) * 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
EP0532456A1 (de) * 1991-08-12 1993-03-17 Ciba-Geigy Ag 1-Acylpiperidinverbindungen und ihre Verwendung als Substanz P Artagonisten

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BR9607335A (pt) 1997-11-25
CZ266297A3 (en) 1997-11-12
HU226562B1 (en) 2009-04-28
DE69602087T2 (de) 1999-09-09
CZ288345B6 (en) 2001-05-16
NO325605B1 (no) 2008-06-23
CA2213080A1 (en) 1996-08-29
IL117209A0 (en) 1996-06-18
NZ300942A (en) 1998-12-23
SK282237B6 (sk) 2001-12-03
SK113997A3 (en) 1998-02-04
US5929067A (en) 1999-07-27
PL184226B1 (pl) 2002-09-30
DE69602087D1 (de) 1999-05-20
DK0810991T3 (da) 1999-10-25
EP0810991B1 (en) 1999-04-14
EP0810991A1 (en) 1997-12-10
AU4623396A (en) 1996-09-11
HUP9800051A2 (hu) 1998-05-28
CN1175944A (zh) 1998-03-11
JPH11500436A (ja) 1999-01-12
TR199700834T1 (xx) 1998-01-21
ES2132882T3 (es) 1999-08-16
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CN1081625C (zh) 2002-03-27
ATE178886T1 (de) 1999-04-15
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MX9706394A (es) 1997-11-29
FI120304B (fi) 2009-09-15
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WO1996026183A1 (en) 1996-08-29
CA2213080C (en) 2007-11-13
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CY2198B1 (en) 2002-11-08
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