AU677001B2 - Apparatus for determining the physical and/or chemical properties of a sample, particularly of blood - Google Patents
Apparatus for determining the physical and/or chemical properties of a sample, particularly of blood Download PDFInfo
- Publication number
- AU677001B2 AU677001B2 AU36429/93A AU3642993A AU677001B2 AU 677001 B2 AU677001 B2 AU 677001B2 AU 36429/93 A AU36429/93 A AU 36429/93A AU 3642993 A AU3642993 A AU 3642993A AU 677001 B2 AU677001 B2 AU 677001B2
- Authority
- AU
- Australia
- Prior art keywords
- sample
- currents
- parameters
- blood
- biofluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 210000004369 blood Anatomy 0.000 title claims description 46
- 239000008280 blood Substances 0.000 title claims description 46
- 239000000126 substance Substances 0.000 title description 15
- 239000000523 sample Substances 0.000 claims description 76
- 238000000034 method Methods 0.000 claims description 59
- 102000008946 Fibrinogen Human genes 0.000 claims description 31
- 108010049003 Fibrinogen Proteins 0.000 claims description 31
- 229940012952 fibrinogen Drugs 0.000 claims description 31
- 238000005259 measurement Methods 0.000 claims description 28
- 239000006185 dispersion Substances 0.000 claims description 11
- 238000004062 sedimentation Methods 0.000 claims description 11
- 238000012360 testing method Methods 0.000 claims description 11
- 238000012545 processing Methods 0.000 claims description 8
- 238000011084 recovery Methods 0.000 claims description 8
- 238000011835 investigation Methods 0.000 claims description 7
- 238000011896 sensitive detection Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 47
- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 210000003743 erythrocyte Anatomy 0.000 description 11
- 239000013078 crystal Substances 0.000 description 10
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- 230000006870 function Effects 0.000 description 4
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- 238000006243 chemical reaction Methods 0.000 description 3
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- 238000005516 engineering process Methods 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 230000002489 hematologic effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000001575 pathological effect Effects 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 230000003321 amplification Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 239000010881 fly ash Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 229910000859 α-Fe Inorganic materials 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- 101100392078 Caenorhabditis elegans cat-4 gene Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000009699 differential effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 229940021013 electrolyte solution Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 238000009652 hydrodynamic focusing Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000007620 mathematical function Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000004853 protein function Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- FESBVLZDDCQLFY-UHFFFAOYSA-N sete Chemical compound [Te]=[Se] FESBVLZDDCQLFY-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9205175A GB2260407B (en) | 1991-10-10 | 1992-03-10 | Method and devices for A.C measurement on all electromagnetically permeable matter, preferably liquid blood |
| GB9205175 | 1992-03-10 | ||
| PCT/GB1993/000475 WO1993018395A1 (fr) | 1992-03-10 | 1993-03-08 | Appareil permettant de determiner les proprietes physiques et/ou chimiques d'un echantillon et plus particulierement un echantillon de sang |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3642993A AU3642993A (en) | 1993-10-05 |
| AU677001B2 true AU677001B2 (en) | 1997-04-10 |
Family
ID=10711820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU36429/93A Ceased AU677001B2 (en) | 1992-03-10 | 1993-03-08 | Apparatus for determining the physical and/or chemical properties of a sample, particularly of blood |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0630471A1 (fr) |
| AU (1) | AU677001B2 (fr) |
| WO (1) | WO1993018395A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE507563C2 (sv) * | 1993-11-15 | 1998-06-22 | Swelab Instrument Ab | Anordning för bestämning av blodets sänkningsreaktion |
| US5583432A (en) * | 1994-04-11 | 1996-12-10 | Sci-Nostics Limited | Electrical method and apparatus for non-contact determination of physical and/or chemical properties of a sample, particularly of blood |
| US6511851B1 (en) | 1997-04-16 | 2003-01-28 | Kaiku Limited | Identifying changes in composition of liquids |
| GB2336685B (en) * | 1998-04-21 | 2002-05-15 | Christopher Barnes | A method and device for the measurement of fixed or time varying capacitance |
| WO2000052453A2 (fr) * | 1999-02-28 | 2000-09-08 | Steag Microtech Gmbh | Procede permettant de determiner les proprietes d'un agent |
| ATE547045T1 (de) * | 2001-03-06 | 2012-03-15 | Solianis Holding Ag | Vorrichtung zur bestimmung der konzentration eines stoffes in körperflüssigkeit |
| US7315767B2 (en) | 2001-03-06 | 2008-01-01 | Solianis Holding Ag | Impedance spectroscopy based systems and methods |
| GB0106250D0 (en) * | 2001-03-13 | 2001-05-02 | Hall Effect Technologies Ltd | Apparatus and method for analysing blood |
| ATE446045T1 (de) | 2002-09-04 | 2009-11-15 | Solianis Holding Ag | Verfahren und vorrichtung zur glukosemessung |
| WO2004028358A1 (fr) | 2002-09-24 | 2004-04-08 | Pendragon Medical Ltd. | Dispositif destine a mesurer des concentrations de glucose |
| GB2400669B (en) * | 2003-04-17 | 2005-12-14 | * Barnes Christopher | A method and device to obtain haematological parameters and indicators by means of harnessing the dynamics of erythrocyte and other aggregation |
| GB2414558B (en) * | 2003-10-10 | 2006-04-19 | Christopher Barnes | Apparatus and method for tracking changes in composition or concentration of a fluid or one or more component parts thereof |
| WO2005053523A1 (fr) | 2003-12-02 | 2005-06-16 | Solianis Holding Ag | Dispositif et procede de mesure d'une propriete de tissus vivants |
| EP1768545B1 (fr) | 2004-06-07 | 2009-06-10 | Solianis Holding AG | Procede et dispositif permettant de determiner un parametre d'un tissu vivant |
| KR20070034169A (ko) * | 2005-09-23 | 2007-03-28 | 삼성전자주식회사 | 테라헤르츠파를 이용한 혈중 성분 농도 측정 장치 및 방법 |
| GB2435097B (en) * | 2005-09-30 | 2009-08-05 | Christopher Barnes | Method and apparatus for assessment of the state of a collection of erythrocytemembranes |
| EP1954175B1 (fr) | 2005-11-10 | 2016-07-13 | Biovotion AG | Dispositif permettant de determiner le niveau de glucose dans un tissu corporel |
| RU2393476C2 (ru) * | 2008-08-26 | 2010-06-27 | Государственное образовательное учреждение высшего профессионального образования Иркутский государственный университет | Устройство для диагностики функционального состояния крови человека |
| JP5691168B2 (ja) * | 2009-01-08 | 2015-04-01 | ソニー株式会社 | 血液凝固系解析装置、血液凝固系解析方法及びプログラム |
| WO2010118537A1 (fr) | 2009-04-17 | 2010-10-21 | Solianis Holding Ag | Dispositif de détection des propriétés d'un tissu corporel |
| DE102010028902A1 (de) | 2010-05-11 | 2011-11-17 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zur Bestimmung zellulärer und/oder extrazellulärer, insbesondere makromolekularer Anteile von Flüssigkeiten, vorzugsweise von Körperflüssigkeiten von Lebewesen |
| EP2800966B1 (fr) | 2012-01-06 | 2021-09-29 | Bend Research, Inc. | Procédé et dispositif pour la spectroscopie diélectrique |
| US9772280B2 (en) * | 2013-01-15 | 2017-09-26 | The Regents Of The University Of California | Portable broadband diffuse optical spectroscopic imaging (DOSI) device for noninvasive tissue characterization |
| GB2547271B (en) * | 2016-02-11 | 2020-07-22 | Barnes Christopher | A Contact Free Blood Assessment Device and Method |
| US11879860B2 (en) | 2019-06-11 | 2024-01-23 | Fresenius Medical Care Holdings, Inc. | Systems and methods for measuring electrical characteristic of medical fluids |
| CA3206491A1 (fr) | 2021-01-11 | 2022-07-14 | Fresenius Medical Care Holdings, Inc. | Systemes et procedes de mesure de caracteristique electrique de fluides medicaux |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB595720A (en) * | 1944-11-06 | 1947-12-15 | Ace Electronics Ltd | Electrical apparatus for measuring the proportions of mixtures and solutions |
| GB1018188A (en) * | 1962-11-01 | 1966-01-26 | Kaiser Nils | Method for testing the chemical and/or physical condition of media |
| US4135131A (en) * | 1977-10-14 | 1979-01-16 | The United States Of America As Represented By The Secretary Of The Army | Microwave time delay spectroscopic methods and apparatus for remote interrogation of biological targets |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3483860A (en) * | 1964-11-02 | 1969-12-16 | Norman Stanley Namerow | Method for monitoring intrasomatic circulatory functions and organ movement |
| GB1084860A (en) * | 1965-08-24 | 1967-09-27 | Kaiser Nils | Improvements in or relating to devices for investigating the chemical and/or physical nature of substance |
| FR2201762A5 (fr) * | 1972-09-29 | 1974-04-26 | Inst Nat Sante Rech Med | |
| DE2702557C3 (de) * | 1977-01-22 | 1979-10-11 | Labora Mannheim Gmbh Fuer Labortechnik, 6800 Mannheim | Vorrichtung zum Bestimmen der Blutsenkungsgeschwindigkeit |
| US4257001A (en) * | 1979-04-13 | 1981-03-17 | John G. Abramo | Resonant circuit sensor of multiple properties of objects |
| GB2130728B (en) * | 1982-09-23 | 1986-07-16 | De Beers Ind Diamond | Measuring settling rates |
| EP0157496A3 (fr) * | 1984-03-28 | 1987-03-25 | Northern Telecom Limited | Procédé pour mesurer la quantité de particules à forte permittivité dans un matériau porteur |
| DE3637549A1 (de) * | 1986-11-04 | 1988-05-11 | Hans Dr Med Rosenberger | Messgeraet zur pruefung der dielektrischen eigenschaften biologischer gewebe |
| DE3722213A1 (de) * | 1987-07-04 | 1989-01-12 | Klaus Weber | Messverfahren zur bestimmung der konzentration eines mediums |
| SE465140B (sv) * | 1989-12-13 | 1991-07-29 | Tesi Ab | Foerfarande och anordning foer att bestaemma blods saenkningsreaktion |
| GB2248301A (en) * | 1990-09-12 | 1992-04-01 | Ici Plc | Apparatus and method for the detection of changes in the composition of a material |
-
1993
- 1993-03-08 EP EP93905532A patent/EP0630471A1/fr not_active Withdrawn
- 1993-03-08 AU AU36429/93A patent/AU677001B2/en not_active Ceased
- 1993-03-08 WO PCT/GB1993/000475 patent/WO1993018395A1/fr not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB595720A (en) * | 1944-11-06 | 1947-12-15 | Ace Electronics Ltd | Electrical apparatus for measuring the proportions of mixtures and solutions |
| GB1018188A (en) * | 1962-11-01 | 1966-01-26 | Kaiser Nils | Method for testing the chemical and/or physical condition of media |
| US4135131A (en) * | 1977-10-14 | 1979-01-16 | The United States Of America As Represented By The Secretary Of The Army | Microwave time delay spectroscopic methods and apparatus for remote interrogation of biological targets |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993018395A1 (fr) | 1993-09-16 |
| EP0630471A1 (fr) | 1994-12-28 |
| AU3642993A (en) | 1993-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |