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AU6011001A - Novel lhrh-antagonists, production and use thereof as medicament - Google Patents

Novel lhrh-antagonists, production and use thereof as medicament

Info

Publication number
AU6011001A
AU6011001A AU6011001A AU6011001A AU6011001A AU 6011001 A AU6011001 A AU 6011001A AU 6011001 A AU6011001 A AU 6011001A AU 6011001 A AU6011001 A AU 6011001A AU 6011001 A AU6011001 A AU 6011001A
Authority
AU
Australia
Prior art keywords
antagonists
medicament
production
hormone
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU6011001A
Inventor
Michael Bernd
Bernhard Kutscher
Eckhard Guenther
Peter Romeis
Thomas Reissmann
Thomas Beckers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Zentaris AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/525,007 external-priority patent/US6627609B1/en
Application filed by Zentaris AG filed Critical Zentaris AG
Publication of AU6011001A publication Critical patent/AU6011001A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to peptides, comprising an N-methylated amino acid component and an improved water solubility. According to the invention, medicaments containing the said peptides can be used for treatment of hormone-dependant tumours and hormone-influenced non-malignant disease states.
AU6011001A 2000-03-14 2001-03-12 Novel lhrh-antagonists, production and use thereof as medicament Pending AU6011001A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/525,007 US6627609B1 (en) 1999-03-17 2000-03-14 LHRH antagonists having improved solubility properties
PCT/EP2001/002719 WO2001068676A2 (en) 2000-03-14 2001-03-12 Lhrh-antagonists, production and use thereof as medicament

Publications (1)

Publication Number Publication Date
AU6011001A true AU6011001A (en) 2001-09-24

Family

ID=24091545

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001260110A Ceased AU2001260110B2 (en) 1999-03-17 2001-03-12 Novel LHRH-antagonists, production and use thereof as medicament
AU6011001A Pending AU6011001A (en) 2000-03-14 2001-03-12 Novel lhrh-antagonists, production and use thereof as medicament

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2001260110A Ceased AU2001260110B2 (en) 1999-03-17 2001-03-12 Novel LHRH-antagonists, production and use thereof as medicament

Country Status (25)

Country Link
EP (1) EP1268522B1 (en)
JP (1) JP3805679B2 (en)
KR (1) KR100607396B1 (en)
CN (2) CN1443195A (en)
AT (1) ATE408619T1 (en)
AU (2) AU2001260110B2 (en)
BG (1) BG107121A (en)
BR (1) BR0109279A (en)
CA (1) CA2402193C (en)
DE (1) DE50114335D1 (en)
DK (1) DK1268522T3 (en)
ES (1) ES2312435T3 (en)
HR (1) HRP20020810A2 (en)
HU (1) HUP0300222A3 (en)
IL (1) IL151647A0 (en)
MX (1) MXPA02008870A (en)
NO (1) NO20024363L (en)
NZ (1) NZ521273A (en)
PL (1) PL357999A1 (en)
PT (1) PT1268522E (en)
RU (1) RU2248982C9 (en)
SK (1) SK14332002A3 (en)
UA (1) UA79070C2 (en)
WO (1) WO2001068676A2 (en)
ZA (1) ZA200207248B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100340572C (en) * 2004-12-01 2007-10-03 中国人民解放军军事医学科学院毒物药物研究所 Novel LHRH antagonist
CN101037472B (en) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 LHRH antagonist with low-histamine releasing function
AU2009206212B2 (en) 2008-01-24 2014-01-16 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Lytic domain fusion constructs and methods of making and using same
TWI539959B (en) * 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 Method for treating prostate cancer during metastasis
CN101597321B (en) * 2008-06-03 2013-04-24 中国人民解放军军事医学科学院毒物药物研究所 LHRH antagonist with long-acting low-histamine release side effect
WO2010142060A1 (en) * 2009-06-11 2010-12-16 中国人民解放军军事医学科学院毒物药物研究所 Lhrh antagonist with long potency and low histamine releasing effect
IL238323B2 (en) 2012-10-30 2023-11-01 Esperance Pharmaceuticals Inc Antibody/drug conjugates and methods of use
CN104418936B (en) * 2013-08-20 2018-06-05 中国人民解放军军事医学科学院毒物药物研究所 Lhrh antagonist derivative and its medicinal usage
FR3024612B1 (en) * 2014-08-04 2018-03-09 Alstom Transp Tech POWER SUPPLY MODULE OF A MOTOR BLOCK, TRACTION SYSTEM AND ELECTRIC VEHICLE
RU2585367C1 (en) * 2014-11-05 2016-05-27 Наталья Владимировна Спиридонова Method of treating infertility in females suffering from uterine myoma

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA862570B (en) * 1985-04-09 1986-12-30 Univ Tulane Therapeutic decapeptides
US5300492A (en) 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs
US5140009A (en) 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
IL101074A (en) 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
ATE144538T1 (en) 1991-04-25 1996-11-15 Romano Deghenghi LHRH ANTAGONISTS
RU2043362C1 (en) * 1991-08-12 1995-09-10 Синтекс (Ю-Эс-Эй) Инк. Method of solid-phase peptide synthesis
WO1994013313A1 (en) 1992-12-04 1994-06-23 Abbott Laboratories 6-position modified decapeptide lhrh antagonists
DE69330838T2 (en) 1992-12-18 2002-04-25 Abbott Laboratories, Abbott Park LHRH ANTAGONISTS WITH MODIFIED AMINOACYL REMAINS IN POSITIONS 5 AND 6
IL108509A0 (en) 1993-02-22 1994-05-30 Salk Inst For Biological Studi GnRH antagonist peptides
DE4320201A1 (en) * 1993-06-18 1995-01-12 Asta Medica Ag Use of Cetrorelix and other nona and decapeptides for the manufacture of a medicament for combating AIDS and for growth stimulation
DE19544212A1 (en) 1995-11-28 1997-06-05 Asta Medica Ag New LH-RH antagonists with improved effects
DE19911771B4 (en) 1999-03-17 2006-03-30 Zentaris Gmbh LHRH antagonist, process for its preparation and its use

Also Published As

Publication number Publication date
BR0109279A (en) 2002-12-17
NO20024363L (en) 2002-11-13
CA2402193C (en) 2010-05-18
PL357999A1 (en) 2004-08-09
WO2001068676A3 (en) 2002-10-24
EP1268522B1 (en) 2008-09-17
JP3805679B2 (en) 2006-08-02
HUP0300222A2 (en) 2003-07-28
CN1443195A (en) 2003-09-17
NO20024363D0 (en) 2002-09-12
RU2248982C9 (en) 2005-06-10
BG107121A (en) 2003-05-30
KR20020083179A (en) 2002-11-01
CA2402193A1 (en) 2002-09-09
UA79070C2 (en) 2007-05-25
DE50114335D1 (en) 2008-10-30
EP1268522A2 (en) 2003-01-02
SK14332002A3 (en) 2003-09-11
PT1268522E (en) 2008-12-22
HRP20020810A2 (en) 2004-12-31
CN1876677A (en) 2006-12-13
NZ521273A (en) 2005-01-28
JP2003535044A (en) 2003-11-25
AU2001260110B2 (en) 2005-05-05
CN100500692C (en) 2009-06-17
DK1268522T3 (en) 2009-01-12
IL151647A0 (en) 2003-04-10
HUP0300222A3 (en) 2004-08-30
KR100607396B1 (en) 2006-08-02
WO2001068676A2 (en) 2001-09-20
RU2248982C2 (en) 2005-03-27
MXPA02008870A (en) 2003-06-24
ATE408619T1 (en) 2008-10-15
ES2312435T3 (en) 2009-03-01
ZA200207248B (en) 2003-02-21

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