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AU5743994A - Glycolipid enzyme-polymer conjugates - Google Patents

Glycolipid enzyme-polymer conjugates

Info

Publication number
AU5743994A
AU5743994A AU57439/94A AU5743994A AU5743994A AU 5743994 A AU5743994 A AU 5743994A AU 57439/94 A AU57439/94 A AU 57439/94A AU 5743994 A AU5743994 A AU 5743994A AU 5743994 A AU5743994 A AU 5743994A
Authority
AU
Australia
Prior art keywords
polymer conjugates
glycolipid
enzyme
glycolipid enzyme
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU57439/94A
Inventor
Myung-Ok Cho
Carl W Gilbert
Robert G.L. Shorr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Publication of AU5743994A publication Critical patent/AU5743994A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AU57439/94A 1992-12-10 1993-12-08 Glycolipid enzyme-polymer conjugates Abandoned AU5743994A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98980292A 1992-12-10 1992-12-10
US989802 1992-12-10
PCT/US1993/011920 WO1994013311A1 (en) 1992-12-10 1993-12-08 Glycolipid enzyme-polymer conjugates

Publications (1)

Publication Number Publication Date
AU5743994A true AU5743994A (en) 1994-07-04

Family

ID=25535471

Family Applications (1)

Application Number Title Priority Date Filing Date
AU57439/94A Abandoned AU5743994A (en) 1992-12-10 1993-12-08 Glycolipid enzyme-polymer conjugates

Country Status (8)

Country Link
US (2) US5620884A (en)
EP (1) EP0675727B1 (en)
JP (1) JPH08507677A (en)
AU (1) AU5743994A (en)
CA (1) CA2150956A1 (en)
DE (1) DE69331805T2 (en)
DK (1) DK0675727T3 (en)
WO (1) WO1994013311A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8001694A (en) * 1993-11-03 1995-05-23 University Of Manitoba Cell control and suppression
EP0952841A4 (en) * 1994-08-05 2000-11-02 Molecular Structural Biotechno Site-specific biomolecular complexes
JPH11512439A (en) * 1995-09-14 1999-10-26 エルエックスアール バイオテクノロジー インコーポレイテッド Composition having anti-apoptotic activity comprising a mixture of phospholipids
SE9601817D0 (en) * 1996-05-13 1996-05-13 Karsten Buschard Novel glycolipid complexex and their uses
EP0912179B1 (en) 1996-07-15 2006-04-12 MacroZyme DNM B.V. Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors
AU4648697A (en) 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
WO1998021302A1 (en) * 1996-11-14 1998-05-22 Polymer Technology Corporation Use of water soluble enzyme-polymer conjugates for cleaning contact lenses
EP0973384A4 (en) 1997-02-13 2004-10-13 Sky High Llc ORGAN PRESERVATION SOLUTION
US6251866B1 (en) 1997-08-05 2001-06-26 Watson Laboratories, Inc. Conjugates targeted to the interleukin-2 receptor
US6638526B1 (en) 1998-06-23 2003-10-28 Novozymes A/S Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity
JP2002518044A (en) * 1998-06-23 2002-06-25 ノボザイムス アクティーゼルスカブ Polypeptide-polymer conjugate
BR9912158A (en) * 1998-07-17 2001-04-10 Novozymes As Polypeptide-polymer conjugate, industrial composition, use of a conjugate, and method to improve the washing performance of a polypeptide.
EP1196190B1 (en) * 1999-07-26 2003-03-19 G.D. SEARLE & CO. Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of a medicament for the treatment of glycolipid storage diseases
EP1246915A2 (en) * 1999-12-30 2002-10-09 Maxygen Aps Improved lysosomal enzymes and lysosomal enzyme activators
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
AU2002332637A1 (en) * 2001-08-22 2003-03-10 Watson Pharmaceuticals, Inc. Conjugates targeted to target receptors
US6887952B1 (en) 2004-02-12 2005-05-03 Biosite, Inc. N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use
US7740861B2 (en) * 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
WO2006031583A2 (en) * 2004-09-09 2006-03-23 Biosite Incorporated Methods and compositions for measuring canine bnp and uses thereof
CA2580537C (en) 2004-09-17 2015-04-21 University Of Massachusetts Compositions and their uses for lysosomal enzyme deficiencies
US7879979B2 (en) * 2005-01-21 2011-02-01 Alere International Arginine analogs, and methods for their synthesis and use
CA2595633C (en) 2005-02-09 2013-11-19 Ahmad R. Hadba Synthetic sealants
JP5489462B2 (en) * 2005-10-24 2014-05-14 ユニバーシティ オブ マサチューセッツ Compositions for gene therapy of bone pathology and methods of use thereof
SI1986612T1 (en) 2006-02-07 2013-01-31 Shire Human Genetic Therapies, Inc. Stabilized composition of glucocerebrosidase
WO2007097934A2 (en) * 2006-02-17 2007-08-30 Elusys Therapeutics, Inc. Methods and compositions for using erythrocytes as carriers for delivery of drugs
EP2222283A2 (en) * 2007-10-29 2010-09-01 University of Massachusetts Yeast cell wall protein (ycwp) encapsulated multilayered nanoparticles for nucleic acid delivery (sirna)
US20110318322A1 (en) * 2009-01-12 2011-12-29 Nektar Therapeutics Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer
US8765171B2 (en) * 2009-03-09 2014-07-01 The Regents Of The University Of California Methods and compositions for liposomal formulation of antigens and uses thereof
NZ598156A (en) * 2009-07-28 2014-06-27 Shire Human Genetic Therapies Compositions and methods for treating gaucher disease
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
WO2011107991A1 (en) * 2010-03-02 2011-09-09 Protalix Ltd. Glucocerebrosidase multimers and uses thereof
CA2865614A1 (en) 2012-03-02 2013-09-06 Shire Human Genetic Therapies, Inc. Compositions and methods for treating type iii gaucher disease
ES2927758T3 (en) 2013-03-14 2022-11-10 Alere San Diego Inc 6-Acetylmorphine analogues and procedures for their synthesis and use
CN107921143B (en) 2015-06-15 2021-11-19 安吉奥开米公司 Method for treating leptomeningeal carcinomatosis
AU2017267728B2 (en) 2016-05-18 2021-11-04 Alere San Diego, Inc. 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
US20200115324A1 (en) 2017-06-11 2020-04-16 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
US20230183354A1 (en) 2020-04-30 2023-06-15 Sairopa B.V. Anti-cd103 antibodies

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3910822A (en) * 1974-03-14 1975-10-07 Us Health Isolation of glucocerebrosidase from human placental tissue
US4749570A (en) * 1981-12-31 1988-06-07 The Governors Of The University Of Alberta Targeting conjugates of albumin and therapeutic agents
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
JPS61275978A (en) * 1985-05-31 1986-12-06 Toshiba Corp Arithmetic processing unit
WO1989005850A1 (en) * 1987-12-23 1989-06-29 The United States Of America, As Represented By Th Cloned dna for synthesizing unique glucocerebrosidase
DE68926569T2 (en) * 1988-12-23 1996-09-26 Genzyme Corp CHO CELLS ENABLED TO ENCYMATIVE ACTIVE RECOMBINANT GLUCOCEREBROSIDASE PRODUCTION
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
EP0568647B1 (en) * 1991-01-21 1996-09-11 Genzyme Corporation Production of enzymatically active glucocerebrosidase from recombinant cells

Also Published As

Publication number Publication date
EP0675727A4 (en) 1997-01-08
DE69331805D1 (en) 2002-05-16
EP0675727A1 (en) 1995-10-11
US5705153A (en) 1998-01-06
DK0675727T3 (en) 2002-08-05
EP0675727B1 (en) 2002-04-10
JPH08507677A (en) 1996-08-20
WO1994013311A1 (en) 1994-06-23
CA2150956A1 (en) 1994-06-23
DE69331805T2 (en) 2002-11-28
US5620884A (en) 1997-04-15

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