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AU3362689A - Gene and gene product for preparing beta-lactam compounds - Google Patents

Gene and gene product for preparing beta-lactam compounds

Info

Publication number
AU3362689A
AU3362689A AU33626/89A AU3362689A AU3362689A AU 3362689 A AU3362689 A AU 3362689A AU 33626/89 A AU33626/89 A AU 33626/89A AU 3362689 A AU3362689 A AU 3362689A AU 3362689 A AU3362689 A AU 3362689A
Authority
AU
Australia
Prior art keywords
gene
lactam compounds
preparing beta
gene product
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU33626/89A
Other versions
AU637317B2 (en
Inventor
Franz Knauseder
Ernst Leitner
Norbert Palma
Gerhard Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT92288A external-priority patent/AT390268B/en
Priority claimed from AT180688A external-priority patent/AT391141B/en
Priority claimed from AT220188A external-priority patent/AT391142B/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU3362689A publication Critical patent/AU3362689A/en
Application granted granted Critical
Publication of AU637317B2 publication Critical patent/AU637317B2/en
Assigned to SANDOZ AG reassignment SANDOZ AG Alteration of Name(s) in Register under S187 Assignors: BIOCHEMIE GESELLSCHAFT MBH
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Mold Materials And Core Materials (AREA)
  • Luminescent Compositions (AREA)

Abstract

Gene and gene product of a key enzyme which is novel because of its structure and multivalent functionality, and catalyses the last stage of the biosynthesis of penicillin G and penicillin V.
AU33626/89A 1988-04-08 1989-04-07 Gene and gene product for preparing beta-lactam compounds Expired AU637317B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AT922/88 1988-04-08
AT92288A AT390268B (en) 1988-04-08 1988-04-08 DNA from Penicillium chrysogenum and protein for which this DNA codes
AT1806/88 1988-07-13
AT180688A AT391141B (en) 1988-07-13 1988-07-13 DNA which codes for the enzyme penicillin acyltransferase (PAT)
AT220188A AT391142B (en) 1988-09-08 1988-09-08 DNA from Penicillium chrysogenum
AT2201/88 1988-09-08

Publications (2)

Publication Number Publication Date
AU3362689A true AU3362689A (en) 1989-11-03
AU637317B2 AU637317B2 (en) 1993-05-27

Family

ID=27146880

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33626/89A Expired AU637317B2 (en) 1988-04-08 1989-04-07 Gene and gene product for preparing beta-lactam compounds

Country Status (12)

Country Link
EP (1) EP0336446B1 (en)
JP (1) JPH0767387B2 (en)
KR (1) KR900700610A (en)
AT (1) ATE105860T1 (en)
AU (1) AU637317B2 (en)
DE (1) DE58907667D1 (en)
DK (1) DK175769B1 (en)
ES (1) ES2054916T3 (en)
FI (1) FI103053B1 (en)
HK (1) HK99996A (en)
HU (1) HU208845B (en)
WO (1) WO1989009821A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747285A (en) * 1989-02-01 1998-05-05 Gist-Brocades, Nv. DNA comprising regulatory regions from gene y of penicillium chrysogenum
IL95766A (en) * 1989-09-27 1996-12-05 Lilly Co Eli Recombinant DNA expression vectors and DNA compounds that encode acyltransferase activity of aspergillus
US5882879A (en) * 1990-02-28 1999-03-16 Gist-Brocades, N.V. Method for influencing β-lactam antibiotic production and for isolation of large quantities of ACV synthetase
US5168048A (en) * 1990-04-18 1992-12-01 Gist-Brocades Nv Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme
US6368820B1 (en) * 1996-07-16 2002-04-09 Dsm N.V. Process for the preparation of cephalosporins using acremonium chrysogenum
WO2006089946A2 (en) * 2005-02-24 2006-08-31 Dsm Ip Assets B.V. Altered isopenicillin-n acyltransferase polypeptides and related polynucleotides

Also Published As

Publication number Publication date
ES2054916T3 (en) 1994-08-16
JPH0767387B2 (en) 1995-07-26
DE58907667D1 (en) 1994-06-23
EP0336446B1 (en) 1994-05-18
ATE105860T1 (en) 1994-06-15
DK175769B1 (en) 2005-02-14
FI103053B (en) 1999-04-15
JPH02503750A (en) 1990-11-08
HU892092D0 (en) 1990-02-28
EP0336446A1 (en) 1989-10-11
FI103053B1 (en) 1999-04-15
HUT52156A (en) 1990-06-28
FI895846A0 (en) 1989-12-07
KR900700610A (en) 1990-08-16
DK622189D0 (en) 1989-12-08
HK99996A (en) 1996-06-14
HU208845B (en) 1994-01-28
AU637317B2 (en) 1993-05-27
DK622189A (en) 1990-02-02
WO1989009821A1 (en) 1989-10-19

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