[go: up one dir, main page]

AU2334097A - 4-spiroindoline piperidines promote release of growth hormone - Google Patents

4-spiroindoline piperidines promote release of growth hormone

Info

Publication number
AU2334097A
AU2334097A AU23340/97A AU2334097A AU2334097A AU 2334097 A AU2334097 A AU 2334097A AU 23340/97 A AU23340/97 A AU 23340/97A AU 2334097 A AU2334097 A AU 2334097A AU 2334097 A AU2334097 A AU 2334097A
Authority
AU
Australia
Prior art keywords
spiroindoline
piperidines
growth hormone
promote release
promote
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU23340/97A
Inventor
Ravi Nargund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612276.7A external-priority patent/GB9612276D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2334097A publication Critical patent/AU2334097A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU23340/97A 1996-03-21 1997-03-18 4-spiroindoline piperidines promote release of growth hormone Abandoned AU2334097A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1630296P 1996-03-21 1996-03-21
US60016302 1996-03-21
GB9612276 1996-06-12
GBGB9612276.7A GB9612276D0 (en) 1996-06-12 1996-06-12 4-Spiroindoline piperidines promote release of growth hormone
PCT/US1997/004362 WO1997034604A1 (en) 1996-03-21 1997-03-18 4-spiroindoline piperidines promote release of growth hormone

Publications (1)

Publication Number Publication Date
AU2334097A true AU2334097A (en) 1997-10-10

Family

ID=26309497

Family Applications (1)

Application Number Title Priority Date Filing Date
AU23340/97A Abandoned AU2334097A (en) 1996-03-21 1997-03-18 4-spiroindoline piperidines promote release of growth hormone

Country Status (2)

Country Link
AU (1) AU2334097A (en)
WO (1) WO1997034604A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000511885A (en) * 1996-05-07 2000-09-12 メルク エンド カンパニー インコーポレーテッド Growth hormone secretagogue enhances sleep
WO1998051687A1 (en) * 1997-05-14 1998-11-19 Fujisawa Pharmaceutical Co., Ltd. Piperidino derivatives which promote growth hormone release
DE69837264T2 (en) 1997-06-25 2008-01-31 Pfizer Inc. Dipeptide compounds that are growth hormone secretagogues
US6329342B1 (en) 1997-08-19 2001-12-11 Eli Lilly And Company Treatment of congestive heart failure with growth hormone secretagogues
BR9906975A (en) 1998-01-16 2000-10-17 Novo Nordisk As Compound, use of it, pharmaceutical composition, and process to stimulate the release of growth hormone by the pituitary of a mammal
US6294534B1 (en) 1998-06-11 2001-09-25 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
CA2362290A1 (en) 1999-02-18 2000-08-24 Kaken Pharmaceutical Co., Ltd. Novel amide derivatives as growth hormone secretagogues
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
US6541634B2 (en) 1999-02-26 2003-04-01 Pfizer Inc. Process for preparing growth hormone secretagogues
CA2377369A1 (en) 1999-06-04 2000-12-14 Merck & Co., Inc. Substituted piperidines as melanocortin-4 receptor agonists
WO2001070337A1 (en) 2000-03-23 2001-09-27 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
JP2003528088A (en) 2000-03-23 2003-09-24 メルク エンド カムパニー インコーポレーテッド Substituted piperidines as melanocortin receptor agonists
EP1149583A3 (en) * 2000-04-13 2001-11-14 Pfizer Products Inc. Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
DE60140285D1 (en) 2000-05-31 2009-12-10 Pfizer Prod Inc Use of growth hormone secretagogues to promote the mobility of the digestive tract
IL143690A0 (en) * 2000-06-19 2002-04-21 Pfizer Prod Inc The use of growth hormone secretagogues to treat systemic lupus erythematosus and inflammatory bowel disease
EP1181933A3 (en) * 2000-06-29 2002-04-10 Pfizer Products Inc. Use of growth hormone secretagogues for stimulating or increasing appetite
IL143942A0 (en) * 2000-06-29 2002-04-21 Pfizer Prod Inc Use of growth hormone secretagogues for treatment of physical performance decline
IL144468A0 (en) * 2000-07-27 2002-05-23 Pfizer Prod Inc Use of growth hormone secretagogues for improvement of functional health status
JP2004506687A (en) 2000-08-23 2004-03-04 メルク　エンド　カムパニー　インコーポレーテッド Substituted piperidines as melanocortin receptor agonists
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
DE60306636T2 (en) 2002-04-09 2007-07-05 Eli Lilly And Co., Indianapolis WACHSTUMHORMONSEKRETIONSFÖRDERER
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CU23558A1 (en) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE
US9371297B2 (en) 2007-02-09 2016-06-21 Ocera Therapeutics, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017470A (en) * 1984-10-29 1991-05-21 Chaovanee Aroonsakul Method of diagnosing alzheimer's disease and senile dementia
US4870054A (en) * 1985-09-27 1989-09-26 Recker Robert R Treatment for osteoporosis using GRF or a biologically active analog thereof
US5126324A (en) * 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
US5317012A (en) * 1991-10-04 1994-05-31 The University Of Tennessee Research Corporation Human growth hormone induced improvement in depressed T4/T8 ratio
US5426096A (en) * 1992-03-18 1995-06-20 Soenksen; Peter Use of human growth hormone
US5378686A (en) * 1992-09-21 1995-01-03 Research Corporation Technologies, Inc. Therapeutic treatment of fibromyalgia
US5578593A (en) * 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
US5494919A (en) * 1993-11-09 1996-02-27 Merck & Co., Inc. 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US5610134A (en) * 1994-04-15 1997-03-11 Genentech, Inc. Treatment of congestive heart failure
US5552385A (en) * 1995-06-05 1996-09-03 Novo Nordisk A/S Pharmaceutical formulation

Also Published As

Publication number Publication date
WO1997034604A1 (en) 1997-09-25

Similar Documents

Publication Publication Date Title
AU2334097A (en) 4-spiroindoline piperidines promote release of growth hormone
AU3964795A (en) 4-heterocyclic piperidines promote release of growth hormone
AU5549896A (en) 3-substituted piperidines promote release of growth hormone
AU4342097A (en) Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
AU6122194A (en) Benzo-fused lactams promote release of growth hormone
AU7961694A (en) Benzo-fused lactams promote release of growth hormone
AU7401594A (en) Benzo-fused lactams promote release of growth hormone
AU2695795A (en) Piperazine compounds promote release of growth hormone
AU1224895A (en) Bone anchor
AU4413296A (en) Crystalline protein controlled release compositions
AU1868595A (en) Human growth hormone
AU3128195A (en) Piperidines and hexahydro-1h-azepines spiro substituted at the 4-position promote release of growth hormone
AU1793497A (en) Implants with phased release of medicaments
AU2722297A (en) Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
GB9612276D0 (en) 4-Spiroindoline piperidines promote release of growth hormone
AU3011497A (en) Novel human growth factors
AU1371895A (en) Benzo-fused lactams promote release of growth hormone
GB9604438D0 (en) Bridged piperidines promoter release of growth hormone
AU7169696A (en) 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone
AU2382097A (en) Compounds with growth hormone releasing properties
AU7906998A (en) Compounds with growth hormone releasing properties
AU5599898A (en) Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
AU1942995A (en) New use of growth hormone
GB9823422D0 (en) Naptho-fused lactams promate release of growth hormone
AU4325397A (en) Method of omeprazole preparation