AU2393397A - Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof - Google Patents

Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof

Info

Publication number: AU2393397A
Authority: AU; Australia
Prior art keywords: preparation; therapeutical uses; novel furan; diarylmethylidene; derivatives
Prior art date: 1996-04-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU23933/97A

Other versions

AU717146B2 (en

Inventor

Eric Nicolai

Jean-Marie Teulon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

UPSA SAS

Original Assignee

UNION PHARMA SCIENT APPL

UPSA SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-04

Filing date

1997-04-03

Publication date

1997-10-29

1997-04-03 Application filed by UNION PHARMA SCIENT APPL, UPSA SAS filed Critical UNION PHARMA SCIENT APPL

1997-10-29 Publication of AU2393397A publication Critical patent/AU2393397A/en

2000-03-16 Application granted granted Critical

2000-03-16 Publication of AU717146B2 publication Critical patent/AU717146B2/en

2017-04-03 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AU23933/97A 1996-04-04 1997-04-03 Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof Ceased AU717146B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
FR9604236A FR2747123B1 (en)	1996-04-04	1996-04-04	NOVEL DIARYLMETHYLIDENE TETRAHYDROFURANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THERAPEUTIC USES
FR96/04236		1996-04-04
FR9607922A FR2747124B1 (en)	1996-04-04	1996-06-26	NOVEL FURANIC DIARYLMETHYLIDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
FR96/07922		1996-06-26
PCT/FR1997/000602 WO1997037984A1 (en)	1996-04-04	1997-04-03	Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof

Publications (2)

Publication Number	Publication Date
AU2393397A true AU2393397A (en)	1997-10-29
AU717146B2 AU717146B2 (en)	2000-03-16

Family

ID=9490907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU23933/97A Ceased AU717146B2 (en)	1996-04-04	1997-04-03	Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof

Country Status (28)

Country	Link
EP (1)	EP0891345B1 (en)
JP (1)	JP2000508638A (en)
KR (1)	KR20000005146A (en)
CN (1)	CN1215396A (en)
AR (1)	AR006539A1 (en)
AT (1)	ATE204268T1 (en)
AU (1)	AU717146B2 (en)
BG (1)	BG62808B1 (en)
BR (1)	BR9708510A (en)
CA (1)	CA2248949A1 (en)
CZ (1)	CZ318898A3 (en)
DE (1)	DE69706157T2 (en)
DK (1)	DK0891345T3 (en)
EE (1)	EE03687B1 (en)
ES (1)	ES2162678T3 (en)
FR (2)	FR2747123B1 (en)
GE (1)	GEP20032924B (en)
IL (1)	IL126105A (en)
NO (1)	NO984624L (en)
NZ (1)	NZ331672A (en)
PL (1)	PL329213A1 (en)
PT (1)	PT891345E (en)
RU (1)	RU2189979C2 (en)
SI (1)	SI0891345T1 (en)
SK (1)	SK283292B6 (en)
TW (1)	TW353660B (en)
WO (1)	WO1997037984A1 (en)
ZA (1)	ZA972894B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6180651B1 (en) *	1996-04-04	2001-01-30	Bristol-Myers Squibb	Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
US6026814A (en)	1997-03-06	2000-02-22	Scimed Life Systems, Inc.	System and method for percutaneous coronary artery bypass
JP2001518087A (en) *	1997-04-02	2001-10-09	メルクフロストカナダアンドカンパニー	Α-Methylene-γ-lactones as selective cyclooxygenase-2 inhibitors
FR2775477B1 (en) *	1998-02-27	2000-05-19	Union Pharma Scient Appl	NOVEL HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
CN1106392C (en) *	2000-10-24	2003-04-23	中国科学院上海有机化学研究所	Butenolide containing no substituent at beta position and its synthesis process
AR038957A1 (en)	2001-08-15	2005-02-02	Pharmacia Corp	COMBINATION THERAPY FOR CANCER TREATMENT
CA2504886C (en) *	2002-11-05	2011-07-05	Magnachem International Laboratories, Inc.	Synthetic lactone formulations and method of use
AU2003288644A1 (en) *	2003-03-31	2004-10-25	Council Of Scientific And Industrial Research	Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof
DK1534305T3 (en)	2003-05-07	2007-02-05	Osteologix As	Treatment of cartilage / bone disorders with water-soluble strontium salts
US8779168B2 (en) *	2010-12-16	2014-07-15	Transitions Optical, Inc.	Lactone compounds and materials made therefrom
US20240165148A1 (en)	2021-03-15	2024-05-23	Saul Yedgar	Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2293952A1 (en) *	1993-01-15	1994-07-21	David B. Reitz	Preparation of esters and analogs thereof
US5474995A (en) *	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
IL112249A (en) *	1994-01-25	2001-11-25	Warner Lambert Co	Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5585504A (en) *	1994-09-16	1996-12-17	Merck & Co., Inc.	Process of making cox-2 inhibitors having a lactone bridge

1996
- 1996-04-04 FR FR9604236A patent/FR2747123B1/en not_active Expired - Fee Related
- 1996-06-26 FR FR9607922A patent/FR2747124B1/en not_active Expired - Lifetime
1997
- 1997-03-24 TW TW086103701A patent/TW353660B/en active
- 1997-04-03 GE GEAP19974555A patent/GEP20032924B/en unknown
- 1997-04-03 CN CN97193543A patent/CN1215396A/en active Pending
- 1997-04-03 SK SK1375-98A patent/SK283292B6/en not_active IP Right Cessation
- 1997-04-03 SI SI9730222T patent/SI0891345T1/en unknown
- 1997-04-03 DK DK97919476T patent/DK0891345T3/en active
- 1997-04-03 AT AT97919476T patent/ATE204268T1/en active
- 1997-04-03 EP EP97919476A patent/EP0891345B1/en not_active Expired - Lifetime
- 1997-04-03 PT PT97919476T patent/PT891345E/en unknown
- 1997-04-03 RU RU98119887/04A patent/RU2189979C2/en not_active IP Right Cessation
- 1997-04-03 AU AU23933/97A patent/AU717146B2/en not_active Ceased
- 1997-04-03 JP JP9535910A patent/JP2000508638A/en active Pending
- 1997-04-03 DE DE69706157T patent/DE69706157T2/en not_active Expired - Lifetime
- 1997-04-03 CA CA002248949A patent/CA2248949A1/en not_active Abandoned
- 1997-04-03 ES ES97919476T patent/ES2162678T3/en not_active Expired - Lifetime
- 1997-04-03 BR BR9708510A patent/BR9708510A/en not_active IP Right Cessation
- 1997-04-03 IL IL12610597A patent/IL126105A/en not_active IP Right Cessation
- 1997-04-03 NZ NZ331672A patent/NZ331672A/en unknown
- 1997-04-03 WO PCT/FR1997/000602 patent/WO1997037984A1/en not_active Application Discontinuation
- 1997-04-03 EE EE9800333A patent/EE03687B1/en unknown
- 1997-04-03 CZ CZ983188A patent/CZ318898A3/en unknown
- 1997-04-03 PL PL97329213A patent/PL329213A1/en unknown
- 1997-04-03 KR KR1019980707808A patent/KR20000005146A/en not_active Ceased
- 1997-04-04 AR ARP970101359A patent/AR006539A1/en not_active Application Discontinuation
- 1997-04-04 ZA ZA9702894A patent/ZA972894B/en unknown
1998
- 1998-09-16 BG BG102771A patent/BG62808B1/en unknown
- 1998-10-02 NO NO984624A patent/NO984624L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
TW353660B (en)	1999-03-01
ZA972894B (en)	1997-11-04
PT891345E (en)	2002-02-28
CA2248949A1 (en)	1997-10-16
WO1997037984A1 (en)	1997-10-16
EP0891345A1 (en)	1999-01-20
ES2162678T3 (en)	2002-01-01
ATE204268T1 (en)	2001-09-15
BG102771A (en)	1999-06-30
NO984624D0 (en)	1998-10-02
AR006539A1 (en)	1999-09-08
EE03687B1 (en)	2002-04-15
EE9800333A (en)	1999-04-15
DE69706157T2 (en)	2002-04-11
NO984624L (en)	1998-11-30
FR2747123B1 (en)	1998-06-26
AU717146B2 (en)	2000-03-16
BR9708510A (en)	1999-08-03
SK283292B6 (en)	2003-05-02
BG62808B1 (en)	2000-08-31
FR2747124B1 (en)	1998-06-26
JP2000508638A (en)	2000-07-11
SK137598A3 (en)	1999-02-11
NZ331672A (en)	2000-02-28
CZ318898A3 (en)	1999-01-13
IL126105A0 (en)	1999-05-09
PL329213A1 (en)	1999-03-15
IL126105A (en)	2001-08-26
SI0891345T1 (en)	2002-02-28
CN1215396A (en)	1999-04-28
RU2189979C2 (en)	2002-09-27
FR2747123A1 (en)	1997-10-10
FR2747124A1 (en)	1997-10-10
DK0891345T3 (en)	2001-12-03
EP0891345B1 (en)	2001-08-16
GEP20032924B (en)	2003-03-25
KR20000005146A (en)	2000-01-25
DE69706157D1 (en)	2001-09-20

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Legal Events

Date	Code	Title	Description
2000-07-13	FGA	Letters patent sealed or granted (standard patent)
2004-11-04	MK14	Patent ceased section 143(a) (annual fees not paid) or expired