AU2186497A - Milk of transgenic animals containing human alpha1-antitrypsin and use of human alpha1-antitrypsin to treat bile acid related diseases - Google Patents

Milk of transgenic animals containing human alpha1-antitrypsin and use of human alpha1-antitrypsin to treat bile acid related diseases

Info

Publication number: AU2186497A
Authority: AU; Australia
Prior art keywords: antitrypsin; human alpha1; milk; related diseases; transgenic animals
Prior art date: 1996-03-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU21864/97A

Inventor

Joyce Carlson

Sabina-Marija Janciauskiene

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

JANCIAUSKIENE SABINA MARIJA

Original Assignee

JANCIAUSKIENE SABINA MARIJA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-21

Filing date

1997-03-20

Publication date

1997-10-10

1997-03-20 Application filed by JANCIAUSKIENE SABINA MARIJA filed Critical JANCIAUSKIENE SABINA MARIJA

1997-10-10 Publication of AU2186497A publication Critical patent/AU2186497A/en

Status Abandoned legal-status Critical Current

Links

101000823116 Homo sapiens Alpha-1-antitrypsin Proteins 0.000 title 2
102000051631 human SERPINA1 Human genes 0.000 title 2
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
241001465754 Metazoa Species 0.000 title 1
239000003613 bile acid Substances 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
239000008267 milk Substances 0.000 title 1
210000004080 milk Anatomy 0.000 title 1
235000013336 milk Nutrition 0.000 title 1
230000009261 transgenic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Developmental Biology & Embryology (AREA)
Virology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AU21864/97A 1996-03-21 1997-03-20 Milk of transgenic animals containing human alpha1-antitrypsin and use of human alpha1-antitrypsin to treat bile acid related diseases Abandoned AU2186497A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE9601091A SE9601091L (en)	1996-03-21	1996-03-21	Use of a protein substance for the binding of steroid-like molecules
SE9601091		1996-03-21
PCT/SE1997/000465 WO1997034628A1 (en)	1996-03-21	1997-03-20	Milk of transgenic animals containing human alpha1-antitrypsin and use of human alpha1-antitrypsin to treat bile acid related diseases

Publications (1)

Publication Number	Publication Date
AU2186497A true AU2186497A (en)	1997-10-10

Family

ID=20401887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU21864/97A Abandoned AU2186497A (en)	1996-03-21	1997-03-20	Milk of transgenic animals containing human alpha1-antitrypsin and use of human alpha1-antitrypsin to treat bile acid related diseases

Country Status (4)

Country	Link
EP (1)	EP0904102A1 (en)
AU (1)	AU2186497A (en)
SE (1)	SE9601091L (en)
WO (1)	WO1997034628A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU765315B2 (en) *	1998-11-19	2003-09-18	Pharming Intellectual Property Bv	Stabilisation of milk from transgenic animals
US7030289B2 (en)	1998-11-19	2006-04-18	Ppl Therapeutics (Scotland) Ltd	Stabilization of milk from transgenic animals
EP1150699A4 (en) *	1999-02-01	2004-06-30	John Lezdey	Treatment of bladder and gastrointestinal mastocytosis
AUPP971399A0 (en) *	1999-04-12	1999-05-06	Life Therapeutics Limited	Separation of plasma components
US20100152487A1 (en) *	2007-07-12	2010-06-17	Yuichi Sugiyama	Agent and method for stabilizing membrane protein
AU2017223148B2 (en)	2016-02-22	2019-07-18	Novartis Ag	Methods for using FXR agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4873316A (en) *	1987-06-23	1989-10-10	Biogen, Inc.	Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5439824A (en) *	1993-05-06	1995-08-08	The United States Of America	Increased expression of α-1-antitrypsin in expression vectors through the inclusion of intron II

1996
- 1996-03-21 SE SE9601091A patent/SE9601091L/en not_active Application Discontinuation
1997
- 1997-03-20 WO PCT/SE1997/000465 patent/WO1997034628A1/en not_active Ceased
- 1997-03-20 AU AU21864/97A patent/AU2186497A/en not_active Abandoned
- 1997-03-20 EP EP97914726A patent/EP0904102A1/en not_active Withdrawn

Also Published As

Publication number	Publication date
SE9601091L (en)	1997-09-22
SE9601091D0 (en)	1996-03-21
WO1997034628A1 (en)	1997-09-25
EP0904102A1 (en)	1999-03-31

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