AU2020346810C1

AU2020346810C1 - Articles and formulations for smoking products and vaporizers

Info

Publication number: AU2020346810C1
Application number: AU2020346810A
Authority: AU
Inventors: Joseph Pandolfino
Original assignee: Cabbacis LLC
Current assignee: Cabbacis LLC
Priority date: 2019-09-12
Filing date: 2020-09-10
Publication date: 2022-10-06
Anticipated expiration: 2040-09-10
Also published as: AU2020346810B2; KR20220056246A; AU2020346810A1; CA3151047A1; JP2022537602A; EP4027814B1; PH12022550604A1; KR102519563B1; MX2022002859A; WO2021050682A1; ES2956536T3; EP4027814A4; CN115087368A; BR112022004480A2; CA3151047C; JP7148756B2; NZ787184A; EP4027814A1; WO2021050682A9; EP4027814C0

Abstract

Methods and apparatuses for the customization of tobacco and cannabis smoking products including formulations for onserts, precision rods and precision pods for harm reduction products particularly for those who simultaneously smoke or vape tobacco and marijuana, as well as methods and apparatuses for blending a salt of nicotine in crystalline form and one or more cannabinoids in crystalline form for a precision pod for use in a vaporizer.

Description

ARTICLES AND FORMULATIONS FOR SMOKING PRODUCTS AND VAPORIZERS CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority from U.S. Patent Application No. 16/569,318, filed

on September 12, 2019, in the U.S. Patent and Trademark Office, the disclosure of which is

incorporated herein by reference in its entirety.

BACKGROUND

1. Field

[0002] The present disclosure relates to tobacco and cannabis products.

2. Description of the Related Art

[0003] Tobacco product manufacturers possess the methods and knowhow to produce

products with a wide range of nicotine content and alkaloid profiles. For example, they can

produce cigarettes ranging from approximately 0.20 mg per cigarette of nicotine to at least 30 mg

per cigarette. Very low nicotine cigarettes and low tar-to-nicotine yield-ratio cigarettes are both

useful for tobacco harm reduction for different purposes; the former is to quit smoking and

tobacco use altogether or transition smokers to smokeless tobacco products, and the latter is to

smoke less. The methods and knowhow of tobacco product manufacturers include genetic

engineering and plant breeding techniques to decrease or increase nicotine content in tobacco

plants. Nicotine can also be extracted from tobacco for production of very low nicotine cigarettes

or nicotine can be added for production of low tar-to-nicotine yield-ratio cigarettes. See, for

example, U.S. Patents 3,612,066, 9,738,622, 9,814,258 and 10,113,174, which describe these

methods employed by tobacco product manufacturers to produce factory-made tobacco products.

Tobacco end users, on the other hand, do not possess these method or knowhow capabilities; nor

have they had devices or the alkaloids in the appropriate formulations to conveniently and economically add alkaloids, cannabinoids, flavors, or other additives to their smoking products, which include cigarettes, cigars and marijuana cigarettes.

[0004] Some people smoke or vape tobacco and cannabis simultaneously, including those

who do not otherwise smoke tobacco, since there are reciprocal and fortifying effects from the

combination of the nicotine in tobacco and the cannabinoids in cannabis. Inhaling smoke or vapor

is the most efficient and quickest way of experiencing the effects of these compounds, whether

tobacco or cannabis is smoked or vaped separately or simultaneously. The main issue with

smoking or vaping a blend of tobacco and cannabis is that many non-nicotine and non

cannabinoid compounds must be inhaled along with the nicotine and cannabinoids. This is

especially the case when smoking a blend of tobacco and cannabis or smoking cigarettes with any

added cannabinoids since in either case, many carcinogenic tobacco compounds must be inhaled

concurrently with the nicotine and cannabinoids. Michael Russell, referred to as the father of

tobacco harm reduction, famously declared, "People smoke for nicotine but they die from the tar."

However, using tobacco in any form, including in smokeless tobacco products, is not without risk

since tobacco contains tobacco-specific nitrosamines (TSNAs), which are carcinogenic, and

include N-Nitrosonornicotine (NNN), 4-N-Nitrosomethylamino-1-(3-pyridyl)-1-butanone (NNK),

N-Nitrosoanatabine (NAT), and N-Nitrosoanabasine (NAB). U.S. Patent 10,369,178 discloses

tobacco products with added cannabinoids; however, this disclosure in no way solves the problem

of smokers being exposed to many tobacco carcinogens including TSNAs in order to enjoy the

pleasurable effects of consuming nicotine and cannabinoids simultaneously. Nor does the

disclosure propose any device that facilitates consumers modifying their factory-made cigarettes.

[0005] Accordingly, there is a need for products comprising appropriate formulations

which enable consumers to (i) conveniently, economically, and precisely customize the nicotine,

other alkaloid, and/or flavoring content of their factory-made smoking products and (ii) enjoy the pleasurable combined effects of nicotine, cannabinoids and combinations of other compounds through ready-to-vape and ready-to-smoke precision pods without exposure to other tobacco compounds.

[0005a] It is to be appreciated that any discussion of documents, devices, acts or knowledge

in this specification is included to explain the context of the present invention. Further, the

discussion throughout this specification comes about due to the realisation of the inventor and/or

the identification of certain related art problems by the inventor. Moreover, any discussion of

material such as documents, devices, acts or knowledge in this specification is included to explain

the context of the invention in terms of the inventor's knowledge and experience and, accordingly,

any such discussion should not be taken as an admission that any of the material forms part of the

prior art base or the common general knowledge in the relevant art in Australia, or elsewhere, on

or before the priority date of the disclosure and claims herein.

[0005b] The preceding discussion of background art is intended to facilitate an

understanding of the present invention only. The discussion is not an acknowledgement or

admission that any of the material referred to is or was part of the common general knowledge as

at the priority date of the application.

SUMMARY

[0005c] Generally, the present invention provides a disposable ready-to-vape precision pod

for use with a vaporizer as a smoking cessation treatment, to assist transitioning smokers to e

cigarettes or a tobacco heating product, or to quit tobacco and nicotine products altogether, the

ready-to-vape precision pod comprising:

one or more compounds equaling at least 2 mg selected from the group consisting of

nicotine, anatabine, anabasine, flavor, A9-tetrahydrocannabinolic acid (THCA), Cannabidiolic

acid (CBDA), Cannabichromenenic acid (CBCA), Cannabigerolic acid (CBGA),

Cannabigerovarinic acid (CBGVA), Tetrahydrocanabivarinic acid (THCVA), Cannabidivarinic

acid (CBDVA), Cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene, limonene

and humulene;

at least 5 mg of very low THC cannabis;

at least 5 mg of low nicotine tobacco;

a compartment that houses the one or more compounds, the very low THC cannabisand

the low nicotine tobacco; and

one or more vents for ventilation of air and vapor into and out of the compartment,

wherein the ready-to-vape precision pod is configured for an oven chamber of the

vaporizer for placement into the oven chamber,

wherein the at least 5 mg very low THC cannabis comprises a collective THCA/THC

content of equal to or less than 3 mg/g, and

wherein the at least 5 mg low nicotine tobacco comprises a nicotine content of equal to or less than

3 mg/g.

[0005d] Preferably, the one or more compounds is one of:

a flavor comprising menthol.

Tetrahydrocanabivarinic acid (THCVA).

anatabine.

Cannabidiolic acid (CBDA).

[0005e] Preferably, the ready-to-vape precision pod further comprises at least 2 mg of

cytisinicline.

[0005f] In general, the present invention also provides a ready-to-vape precision pod for

use with a vaporizer configured to generate vapor from dry herbs or plant extracts to assist

transitioning cigarette smokers to e-cigarettes or a tobacco heating product, for use as a smoking

3a cessation treatment, or to quit tobacco and nicotine products altogether, the ready-to-vape precision pod comprising: one or more compounds equaling at least 2 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, THCA/THC, CBDA/CBD, CBCA/CBC, CBGA/CBG,

THCVA/THCV, CBDVA/CBDV, CBCVA/CBCV, CBGVA/CBGV, myrcene, caryophyllene,

pinene, limonene and humulene;

at least 5 mg of very low THC Cannabis;

at least 5 mg of low nicotine tobacco;

a compartment that houses the one or more compounds, the very low THC Cannabis and

the low nicotine tobacco; and

wherein the at least 5 mg very low THC Cannabis comprises a collective THCA/THC

content of equal to or less than 3 mg/g, and

wherein the at least 5 mg low nicotine tobacco comprises a nicotine content of equal to or

less than 3 mg/g.

[0005g] Preferably, the one or more compounds is one of:

anatabine;

anabasine;

CBCA/CBC; CBCVA/CBCV; CBDA/CBD; CBDVA/CBDV; CBGA/CBG; CBGVA/CBGV;

3b

THCVA/THCV; and,

a flavor comprising menthol.

[0005h] In general, the present invention also provides a ready-to-vape precision pod for

cessation treatment, or to quit tobacco and nicotine products altogether, the ready-to-vape

precision pod comprising:

nicotine, anatabine, anabasine, flavor, THCA/THC, CBDA/CBD, CBCA/CBC, CBGA/CBG,

THCVA/THCV, CBDVA/CBDV, CBCVA/CBCV, CBGVA/CBGV, myrcene, caryophyllene,

pinene, limonene and humulene;

at least 5 mg of Cannabis;

at least 5 mg of low nicotine tobacco;

a compartment that houses the one or more compounds, the Cannabis and the low nicotine

tobacco; and

less than 3 mg/g.

[0005i] Preferably, the one or more compounds is one of:

anatabine.

anabasine.

a flavor comprising menthol.

[0005j] Generally, the present invention also provides a ready-to-smoke precision pod for

use with a smoking product for inhalation of mainstream smoke as a smoking cessation treatment,

3c to assist transitioning smokers to e-cigarettes or a tobacco heating product, or to quit tobacco and nicotine products altogether, the ready-to-smoke precision pod comprising: one or more compounds equaling at least 2 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, THCA/THC, CBDA/CBD, CBCA/CBC, CBGA/CBG,

THCVA/THCV, CBDVA/CBDV, CBCVA/CBCV, CBGVA/CBGV, myrcene, caryophyllene,

pinene, limonene and humulene;

at least 5 mg of low nicotine tobacco;

at least 5 mg of very low THC Cannabis;

a compartment that houses the one or more compounds, the low nicotine tobacco and very

low THC cannabis; and

one or more vents for ventilation of air and smoke into and out of the compartment,

wherein the smoking product comprises a pipe, bowl or bong,

wherein the ready-to-smoke precision pod is configured for a tobacco or Cannabis

chamber of a pipe, bowl or bong,

wherein the at least 5 mg very low THC Cannabiscomprises a collective THCA/THC

content of equal to or less than 3 mg/g, and

less than 3 mg/g.

[0005k] Preferably, the one or more compounds is one of:

anabasine;

anatabine;

a flavor comprising menthol;

THCVA/THCV; CBDA/CBD.

3d

[0006] According to an embodiment of the disclosure, there is provided an onsert to apply

onto, around, or within a smoking product for transferring one or more compounds to mainstream

smoke of the smoking product, the onsert including a cellulosic wrapper, an adhesive disposed on

the cellulosic wrapper for adhering the onsert to the smoking product, and one or more compounds

disposed on the cellulosic wrapper, the one or more compounds individually equaling at least 1

mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, A9

tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid

(CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic

acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA),

myrcene, caryophyllene, pinene, limonene and humulene.

[0007] For the onsert, the smoking product may be a cigarette, and the one or more

compounds may be nicotine.

[0008] In the onsert, the nicotine may include a nicotine salt.

[0009] For the onsert, the smoking product may be a cigarette, and the one or more

compounds may be anatabine.

[0010] For the onsert, the smoking product may be a cigarette, and the one or more

compounds may be A9-tetrahydrocannabinolic acid (THCA).

[0011] For the onsert, the smoking product may be a cigarette, and the one or more

compounds may be cannabidiolic acid (CBDA).

3e

[0012] For the onsert, the smoking product may be a cigarette, and the one or more

compounds may be A9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA)

collectively equaling at least 5 mg.

[0013] For the onsert, the smoking product may be tobacco, and the one or more

compounds may be nicotine.

[0014] For the onsert, the smoking product may be tobacco, and the one or more

compounds may be anatabine.

[0015] For the onsert, the smoking product may be tobacco, and the one or more

compounds may be A9-tetrahydrocannabinolic acid (THCA).

[0016] For the onsert, the smoking product may be tobacco, and the one or more

compounds may be cannabidiolic acid (CBDA).

[0017] For the onsert, the smoking product may be cannabis, and the one or more

compounds may be nicotine.

[0018] For the onsert, the smoking product may be cannabis, and the one or more

compounds may be anatabine.

[0019] For the onsert, the smoking product may be cannabis, and the one or more

compounds may be A9-tetrahydrocannabinolic acid (THCA).

[0020] For the onsert, the smoking product may be cannabis, and the one or more

compounds may be CBDA.

[0021] For the onsert, the smoking product may be cannabis, and the one or more

compounds may be THCA and CBDA collectively equaling at least 5 mg.

[0022] For the onsert, the smoking product may be a marijuana cigarette, and the one or

more compounds may be nicotine.

[0023] For the onsert, the smoking product may be a marijuana cigarette, and the one or

more compounds may be anatabine.

[0024] In the onsert, the adhesive may be self-sticking.

[0025] In the onsert, the adhesive may be moisture activated.

[0026] According to an embodiment of the disclosure, there is provided a precision rod for

insertion into a smoking product to transfer one or more compounds to mainstream smoke of the

smoking product, the precision rod including one or more compounds individually equaling at

least 1 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, A9

myrcene, caryophyllene, pinene, limonene and humulene, and a cellulosic rod having an ignition

temperature of less than 350 degrees Celsius to which the one or more compounds may be adhered

to or housed within the cellulosic rod.

[0027] For the precision rod, the smoking product may be a cigarette, and the one or more

compounds may be nicotine.

[0028] In the precision rod, the nicotine may be a nicotine salt.

[0029] For the precision rod, the smoking product may be a cigarette, and the one or more

compounds may be A9-tetrahydrocannabinolic acid (THCA).

[0030] For the precision rod, the smoking product may be a cigarette, and the one or more

compounds may be cannabidiolic acid (CBDA).

[0031] For the precision rod, the smoking product may be a cigarette, and the one or more

collectively equaling at least 5 mg.

[0032] For the precision rod, the smoking product may be a marijuana cigarette, and the

one or more compounds may be nicotine.

[0033] For the precision rod, the smoking product may be a cigarette, and the one or more

compounds may be anatabine.

[0034] According to an embodiment of the disclosure, there is provided a precision rod for

myrcene, caryophyllene, pinene, limonene and humulene, an inner chamber that houses the one or

more compounds, a flame-resistant rigid material around the inner chamber having an ignition

temperature of more than 350 degrees Celsius in which the one or more compounds may be

disposed, and at least one vent for ventilation of inbound air into the precision rod and outbound

smoke out of the precision rod.

[0035] For the precision rod, the smoking product may be a cigarette and, the one or more

compounds may be nicotine.

[0036] In the precision rod, the nicotine may be a nicotine salt.

[0037] For the precision rod, the smoking product may be a cigarette, and the one or more

compounds may be A9-tetrahydrocannabinolic acid (THCA).

[0038] For the precision rod, the smoking product may be a cigarette, and the one or more

compounds may be cannabidiolic acid (CBDA).

[0039] For the precision rod, the smoking product may be a cigarette, and the one or more

compounds may be A9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA).

[0040] For the precision rod, the smoking product may be a marijuana cigarette, and the

one or more compounds may be nicotine.

[0041] According to an embodiment of the disclosure, there is provided a ready-to-vape

precision pod for use with a vaporizer configured to generate vapor from dry herbs or concentrated

plant extracts for the simultaneous inhalation of two or more compounds, the ready-to-vape

precision pod including each of two or more blended compounds equaling at least 1 mg selected

from the group consisting of nicotine, anatabine, anabasine, flavor, A9-tetrahydrocannabinolic

acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid

(CBGA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA),

cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene,

caryophyllene, pinene, limonene and humulene, a compartment that houses the two or more

blended compounds, and one or more vents for ventilation of inbound air into the compartment

and outbound vapor out of the compartment, wherein the ready-to-vape precision pod may be

configured for placement into an oven chamber of the vaporizer.

[0042] In the ready-to-vape precision rod, the two or more blended compounds may be

nicotine and A9-tetrahydrocannabinolic acid (THCA).

[0043] In the ready-to-vape precision rod, the nicotine may be a nicotine salt.

[0044] In the ready-to-vape precision rod, the two or more blended compounds may be

nicotine, A9-tetrahydrocannabinolic acid (THCA), and Cannabidiolic acid (CBDA).

[0045] In the ready-to-vape precision rod, the two or more blended compounds may be

nicotine, A9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and

cannabichromenenic acid (CBCA).

[0046] In the ready-to-vape precision rod, the two or more blended compounds may be

nicotine and anatabine.

[0047] In the ready-to-vape precision rod, the two or more blended compounds may be

anatabine and A9-tetrahydrocannabinolic acid (THCA).

[0048] In the ready-to-vape precision rod, the two or more blended compounds may be

anatabine and cannabidiolic acid (CBDA).

[0049] In the ready-to-vape precision rod, the two or more blended compounds may be

anatabine, A9-tetrahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA).

[0050] According to an embodiment of the disclosure, there is provided a ready-to-vape

precision pod for use with a vaporizer, the ready-to-vape precision pod including one or more

compounds equaling at least 1 mg selected from the group consisting of nicotine, anatabine,

anabasine, flavor, A9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA),

cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid

(THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA),

cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene, limonene and humulene,

marijuana equaling at least 5 mg, a compartment that houses the one or more compounds and the

marijuana, and one or more vents for ventilation of inbound air into the compartment and

outbound vapor out of the compartment, wherein the ready-to-vape precision pod may be

configured for placement into an oven chamber of the vaporizer.

[0051] In the ready-to-vape precision rod, the one or more compounds may be nicotine.

[0052] In the ready-to-vape precision rod, the one or more compounds may be

Tetrahydrocanabivarinic acid (THCVA).

[0053] In the ready-to-vape precision rod, the one or more compounds may be A9

tetrahydrocannabinolic acid (THCA).

[0054] According to an embodiment of the disclosure, there is provided a flavor injection

system for infusing one or more compounds into a smoking product to transfer the one or more

compounds to mainstream smoke of the smoking product, the flavor injection system including a

plunger mechanism, a precision rod for insertion into the smoking product, and one or more

compounds individually equaling at least 1 mg selected from the group consisting of nicotine,

anatabine, anabasine, flavor, A9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid

(CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic

acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA),

cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene, limonene and humulene,

wherein the plunger mechanism is connected to the precision rod, wherein the precision rod

comprises one or more holes and an inner chamber that houses the one or more compounds, and

wherein the plunger is configured to infuse the mainstream smoke of the smoking product with the

one or more compounds by pushing the compounds through the one or more holes in the precision

rod into the mainstream smoke of the smoking product.

[0055] According to an embodiment of the disclosure, there is provided a method of

increasing the nicotine smoke yield of a factory-made cigarette, the method including providing an

onsert including a salt of nicotine, wherein the onsert may be for insertion into the factory-made

cigarette.

[0056] According to an embodiment of the disclosure, there is provided a method of

increasing nicotine smoke yield of a factory-made cigarette, the method including providing a

precision rod including a salt of nicotine, wherein the precision rod may be for insertion into the

factory-made cigarette.

[0057] According to an embodiment of the disclosure, there is provided a nicotine

enhanced cigarette including a cigarette and an adjunct source of nicotine connected to or inserted into the cigarette, wherein the adjunct source of nicotine increases the nicotine yield of the cigarette by at least 10 percent.

[0058] The adjunct source of nicotine may be an onsert connected to the cigarette.

[0059] The adjunct source of nicotine may be a precision rod inserted into the cigarette.

[0060] According to an embodiment of the disclosure, there is provided a ready-to-smoke

precision pod for use with a smoking product for the simultaneous inhalation of two or more

compounds, the ready-to-smoke precision pod including each of two or more blended compounds

equaling at least 1 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor,

A9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid

myrcene, caryophyllene, pinene, limonene and humulene, a compartment that houses the two or

more blended compounds, and one or more vents for ventilation of inbound air into the

compartment and outbound smoke out of the compartment, wherein the smoking product includes

a pipe, bowl or bong, and wherein the ready-to-smoke precision pod may be configured for

placement into a chamber of the smoking product.

[0061] In the ready-to-smoke precision pod, the two or more blended compounds may be

nicotine and A9-tetrahydrocannabinolic acid (THCA).

[0062] In the ready-to-smoke precision pod, the nicotine may be a nicotine salt.

[0063] In the ready-to-smoke precision pod, the two or more blended compounds may be

nicotine, A9-tetrahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA).

[0064] In the ready-to-smoke precision pod, the two or more blended compounds may be

nicotine, A9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and

Cannabichromenenic acid (CBCA).

[0065] In the ready-to-smoke precision pod, the two or more blended compounds may be a

nicotine salt and anatabine.

[0066] In the ready-to-smoke precision pod, the two or more blended compounds may be

anatabine and A9-tetrahydrocannabinolic acid (THCA).

[0067] In the ready-to-smoke precision pod, the two or more blended compounds may be

anatabine and cannabidiolic acid (CBDA).

[0068] In the ready-to-smoke precision pod, the two or more blended compounds may be

[0069] According to an embodiment of the disclosure, there is provided a ready-to-smoke

precision pod for use with a smoking product, the ready-to-smoke precision pod including one or

more compounds equaling at least 1 mg selected from the group consisting of nicotine, anatabine,

(THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA),

very low nicotine tobacco equaling at least 5 mg, a compartment that houses the one or more

compounds and the very low nicotine tobacco, and one or more vents for ventilation of inbound

air into the compartment and outbound smoke out of the compartment, wherein the smoking

product includes a pipe, bowl, or bong, wherein the very low nicotine tobacco includes less than 3

mg/g nicotine, and wherein the ready-to-smoke precision pod may be configured for placement

into a chamber of the smoking product.

[0070] In the ready-to-smoke precision pod, the one or more compounds may be

anatabine.

[0071] In the ready-to-smoke precision pod, the one or more compounds may be

cannabidiolic acid (CBDA).

BRIEF DESCRIPTION OF THE DRAWINGS

[0072] The above and/or other aspects of the present disclosure will be more apparent by

describing certain embodiments of the present disclosure with reference to the accompanying

drawings, in which:

[0073] FIG. 1A is a top view of an exemplary embodiment of a self-stick onsert for a

cigarette;

[0074] FIG. 1B is a perspective view of the self-stick onsert of FIG. 1A partially wrapped

around the cigarette;

[0075] FIG. IC is a top view of the self-stick onsert of FIGS. 1A and 1B fully wrapped

around and stuck to the cigarette;

[0076] FIG. ID is a top view of two exemplary embodiments of self-stick onserts;

[0077] FIG. 1E is a top view of an exemplary embodiment of self-stick onserts;

[0078] FIG. IF is a top view of an exemplary embodiment of a self-stick onsert;

[0079] FIG. 2A is a front exploded view of an exemplary embodiment of a precision rod

and a view of this precision rod assembled;

[0080] FIG. 2B is a perspective view of exemplary embodiments of precision rods, each

with varying size;

[0081] FIG. 2C is a top view of an exemplary embodiment of a precision rod inserted into

a cigarette;

[0082] FIG. 2D is a perspective view of an exemplary embodiment of a flavor injection

system;

[0083] FIG. 3A is a perspective view of an exemplary embodiment of a ready-to-smoke

precision pod for a bowl or pipe;

[0084] FIG. 3B is a is a perspective view of the ready-to-smoke precision pod of FIG. 3A

that has been placed in a smoking product, namely a bowl;

[0085] FIG. 3C is a perspective view of a prior art vaporizer being held in which the oven

cover has been removed exposing the oven chamber; and

[0086] FIG. 3D is a perspective view of an exemplary embodiment of a ready-to-vape

precision pod placed within the oven chamber of the prior art vaporizer of FIG. 3C.

DETAILED DESCRIPTION OF THE EMBODIMENTS

[0087] Devices and formulations disclosed herein allow tobacco and cannabis end users to

conveniently, economically and precisely customize the content of nicotine, cannabinoids,

flavoring and/or other additives in the mainstream smoke from their smoking products such as

cigarettes and in the mainstream vapor from their vaporizers to meet preferred product and taste

preferences regardless of manufacturers' product offerings in a given market. Very low nicotine

cigarettes are an important tool for transitioning smokers to e-cigarettes or tobacco heating

products and for smokers quitting tobacco and nicotine products altogether; therefore, very low

nicotine cigarettes, along with e-cigarettes and tobacco heating products, have great potential for

tobacco harm reduction. Since the rate of metabolizing nicotine varies widely across different

populations of smokers, consumers having the ability, for example, to slightly increase the

nicotine content of their own very low nicotine cigarettes is important. Devices and formulations

disclosed herein empower consumers to modify the compounds in the smoke from smoking

products and the precisely customize the compounds in vapor from vaporizers to their preferences.

[0088] Regarding very low nicotine cigarettes, these modifications allow a greater

percentage of smokers to tolerate these cigarettes and exclusively smoke them (without smoking any conventional cigarettes) while attempting to quit tobacco and nicotine products altogether or switch to a less harmful product such as e-cigarettes or ready-to-vape precision pods comprising unique blends of compounds. See U.S. Patent Application No. 16/047,948 for methods and various types of very low nicotine cigarettes and other products to assist smokers in transitioning to e-cigarettes or a tobacco heating device or to assist smokers in quitting tobacco and nicotine altogether.

[0089] In a phase III clinical trial published in The Journalof the American Medical

Association to determine if there is a difference in biomarkers of smoke exposure between

reducing the nicotine content of cigarettes immediately versus gradually, the immediate reduction

in nicotine caused greater withdrawal symptoms, greater use of non-study conventional cigarettes,

and higher dropout rates. For these study subjects, the immediate reduction to very low nicotine

cigarettes containing tobacco with 0.4 mg nicotine per gram (nicotine content per cigarette is

approximately 0.3 mg) was likely too low of a nicotine reduction too quickly. See JAMA

September 4, 2018, Volume 320, Number 9, pages 880-891. Some of these subjects who dropped

out of this study (and other studies using very low nicotine cigarettes) would likely have

completed the study if they had access to a device which easily connected to their very low

nicotine cigarettes and provided an adjunct source of nicotine transferred to mainstream smoke, as

needed by the smoker. Mainstream smoke is the smoke that is inhaled and includes the smoke

that emerges from a smoker's mouth or that emerges from the mouth end of a smoking product

(e.g., filter end of a filtered cigarette) as a result of a smoker smoking the smoking product. The

amount of nicotine provided for this purpose would be quite low.

[0090] In a phase II clinical trial to examine the effects of reduced nicotine cigarettes on

smoking behavior, toxicant exposure, dependence and abstinence, there were three interventions:

six weeks of (i) 0.05 mg nicotine yield cigarettes (very low nicotine content cigarette), (ii) 0.3 mg nicotine yield cigarettes (low nicotine content cigarette with approximately 6-fold the nicotine content of the very low nicotine cigarette), and (iii) a 4 mg nicotine lozenge. Although dropout rates were highest for the nicotine lozenge arm at 48 percent, dropout rates for the 0.05 mg nicotine yield cigarette arm was second highest at 40%, followed by 25 percent for the 0.3 mg nicotine yield cigarette arm. Dropouts were considered treatment failures so reducing the dropout rate among those using the very low nicotine cigarette would have been beneficial since the very low nicotine cigarette arm had the highest abstinence rate post treatment among the 3 interventions. See Hatsukami et al. 2010, Addiction, 105(2):343-55. If those in the very low nicotine cigarette arm of the study had access to a product which easily connected to their very low nicotine cigarettes to slightly increase nicotine in mainstream smoke, as needed, the dropout rate would likely have been less and the cessation rate higher.

[0091] For smokers not interested in quitting or switching to a smokeless product,

increasing the nicotine content of conventional cigarettes, which results in low tar-to-nicotine

yield-ratio cigarettes and decreased smoke inhalation due to the increased concentration of

nicotine. Since cigarettes which have a low tar-to-nicotine yield ratio ('tar' machine yield divided

by nicotine machine yield which may be an ISO method or other method) of approximately 8 or

less are not currently sold by tobacco companies, consumers enhancing the nicotine yield of their

factory-made conventional cigarettes is advantageous for those who desire to reduce their harm

from smoking but cannot quit smoking cigarettes or will not quit smoking cigarettes.

Conventional cigarettes typically have a tar-to-nicotine yield ratio from 10 to 14 (e.g., ISO 'tar'

yield of 13 mg and nicotine yield of 1mg), which means in this example, for every 1 milligram of

nicotine, a smoker must inhale about 13 milligrams 'tar.' It is important to note that although

people smoke for nicotine, smoking related disease results from the smoke including 'tar.'

Reducing the dose of smoke reduces harm.

[0092] Due to compensatory smoking behaviors, as compared to conventional cigarettes,

exposure to harmful "tar" and gases is decreased with nicotine-enhanced cigarettes (as defined

below) while exposure to nicotine remains approximately the same. Although there is variation,

smokers generally desire approximately 1mg of nicotine per cigarette, and any more nicotine per

cigarette than what a smoker desires becomes an unpleasant experience. Smokers easily titrate

down their smoke exposure when smoking nicotine-enhanced cigarettes by taking smaller puffs

and fewer puffs per cigarette. Conventional cigarettes in which the nicotine yield has been

enhanced in the mainstream smoke by embodiments herein, allow smokers to obtain this

approximate 1 mg of nicotine per cigarette (or any other per cigarette amount a smoker finds

acceptable) more efficiently and smokers inhale less smoke, as compared to conventional

cigarettes in which the nicotine yield has not been enhanced. See, for example, Armitage et al.

1998, Psychopharmacology, 96:447-453; Fagerstrom 1982, Pharmacology,77:164-167; Russell

M.A., Nicotine andPublicHealth, Chapter 15, American Public Health Organization, 2000; and

Pandolfino 2005, Presentation on October 19, 2005 at Life Science Research Organization

(LSRO), Reducing the Adverse Health Impact of Cigaretteson Smokers Who Will Not or Cannot

Abstain Through Modification ofLeafNicotine Content, which may be downloaded at the LSRO

website.

[0093] A conventional cigarette that has a tar-to-nicotine yield ratio of 13, which now

includes a sufficient adjunct nicotine source (e.g., a precision rod comprising 18 mg of nicotine

inserted into a cigarette), results in a nicotine-enhanced cigarette with a tar-to-nicotine yield ratio

of less than eight. The result is that smokers inhale significantly less smoke including less 'tar.'

The exact tar-to-nicotine yield ratio depends on the features of the cigarette being enhanced

including overall ventilation, type of filter, level of additives, etcetera.

[0094] There are various reasons manufacturers do not make certain products available to

consumers (e.g., low tar-to-nicotine yield-ratio cigarettes of < 8) even though there is demand.

These include corporate decisions to not cannibalize sales of existing products on the market, lack

of technology or intellectual property, high cost or limited availability of raw materials, law or

regulations prohibiting manufacturers from selling a product (but not consumers from making or

modifying a factory-made product), and/or the level of demand in a market may not justify the

large capital expenditures required to bring a product to market (e.g., required machinery).

[0095] Each of the terms 'about' or 'approximately' is used herein to mean roughly,

around, nearly, or in the region of. When the term 'about' or 'approximately' is used in

conjunction with a numerical value or range, it modifies that value or range by reasonably

extending the boundaries above and below the numerical values set forth.

[0096] "Alkaloids" are a group of nitrogenous compounds typically of plant origin. For

example, nicotine is the primary alkaloid found in commercialized cigarette tobacco accounting

for, depending on tobacco type (e.g., flue cured, burley and oriental) and variety (e.g., K326),

about 95 percent of the total alkaloids in tobacco leaf. Anatabine, nornicotine, anabasine and other

alkaloids account for the remaining portion of total alkaloids. The alkaloid profile, which is the

percentage or contribution of each alkaloid to the total content of all alkaloids, differs across

tobacco types, tobacco varieties and cigarette brand fillers. Depending on tobacco type and

variety, anatabine accounts for about 1% to about 4%, nornicotine accounts for about 1% to about

3%, and anabasine accounts for about 0.02% to about 0. 4 %. As used herein 'nicotine,' 'anatabine'

and 'anabasine' may be extracted from any plant species including any species of the genus

Nicotiana, and any of these alkaloids may also be synthesized, or be an analog, or be made in the

form of salts of organic acids. See, e.g., Sisson et al 1990, Beitragezur Tabakforschung

International, Volume 14, No. 6, June-July. Synthetic nicotine, nicotine salts derived from synthetic nicotine, synthetic anatabine, anatabine salts derived from synthetic anatabine, synthetic anabasine, anabasine salts derived from synthetic anabasine, analogs of nicotine, analogs of anatabine, analogs of anabasine, nicotine salts of organic acids, anatabine salts of organic acids, and anabasine salts of organic acids are included herein in the meaning of nicotine, anatabine and anabasine, respectively. Nicotine salts, nicotine co-crystals, and nicotine salt co-crystals are all included in the meaning of nicotine herein and any of these including combination may be used in any embodiment herein.

[0097] Although nicotine is a hygroscopic oily liquid which may be utilized in the

embodiments herein in that form, end users enhancing the delivery of nicotine in finished tobacco

products with nicotine as a solid or semi-solid is preferred for the embodiments herein due to

increased stability and cleaner and easier applications for end users, as compared to liquid forms

of nicotine. See, for example, U.S. Patent No. 9,738,622, which discloses nicotine salts, nicotine

co-crystals and nicotine salt co-crystals that are in a solid or semi-solid form, but does not disclose

methods or devices for consumers to incorporate these as an adjunct source of nicotine to finished

tobacco products or smoking products such as factory-made cigarettes. Liquid forms of nicotine

such as e-liquids or e-juice would inhibit the ignition and burning of smoking products to produce

smoke, and the nicotine content is too diluted to be a significant and effective adjunct nicotine

source. Besides being too voluminous for the embodiments herein, these liquid and dilute forms

of nicotine would defeat the purpose of some of the aerosol embodiments herein for vaporizers

since too much aerosol would be required to be generated for a given dose of nicotine. Whether

smoke or vapor, the less inhaled the better, which is an advantage of concentrating nicotine and

cannabinoids in the embodiments herein.

[0098] In addition to solid or semi-solid forms of nicotine, other compounds utilized in the

formulations herein for onserts, precision rods, and precision pods are preferably in a solid or semi-solid form. A solid, of course, is a fundamental and commonly referred to state of matter

(others are liquid, gas and plasma). A semi-solid is the physical term for something whose state

lies between a solid and a liquid. A semi-solid material is similar to a solid in some characteristics

such as the ability to support its own weight and to hold its own shape. Examples of semi-solids

are peanut butter, toothpaste and petroleum jelly. Blends of compounds and components for

formulations in, on or within onserts, precision rods or precision pods may include solids, semi

solids and liquids; however, the final blended formulation is preferably a solid or semi-solid (not a

liquid such as an e-liquid). For example, a blend of ingredients in the compartment of a precision

pod may include a crystalline nicotine salt, a wax of concentrated cannabis, and liquid glycerin

resulting in the final blended formulation being a solid or semi-solid (which depends on

proportions of each of the 3 ingredients used) even though a liquid was utilized (to add an

appropriate level of moisture).

[0099] A nicotine salt is a form of nicotine characterized by the interaction between

nicotine in ionic form and a coformer in ionic form such as an acid by the transfer of one or more

protons from the coformer donor to the nicotine acceptor. The structure of nicotine has two

nitrogen atoms capable of accepting protons from a coformer so it can be present in non

protonated, mono-protonated or di-protonated form. Examples of nicotine salts include but are not

limited to the following: nicotine 4-acetamidobenzoate, nicotine ascorbate, nicotine aspartate,

nicotine benzoic, nicotine bitartrate, nicotine chloride such as nicotine dihydrochloride and

nicotine hydrochloride, nicotine citrate, nicotine 2,3-dihydroxybenzoate, nicotine 3,5

dihydroxybenzoate, nicotine fumarate, nicotine gentisate (2,5-hydroxybenzoic), nicotine

glutamate, nicotine 1-hydroxy-2-naphthoate, nicotine 3-hydroxybenzoate, nicotine lactate, nicotine

levulinic, nicotine malate, nicotine mono-pyruvate, nicotine mucate, nicotine perchlorate, nicotine pyruvate, nicotine salicylate, nicotine succinate, nicotine sulfate, nicotine tartrate and nicotine zinc chloride.

[0100] A nicotine co-crystal is a form of nicotine encompassing nicotine and at least one

other component (coformer) in which both are in neutral form. Co-crystals are usually

characterized by a crystalline structure, which is generally held together by freely reversible, non

covalent interactions. Co-crystals are typically made up of nicotine and at least one other

component in a defined stoichiometric ratio and can include hydrates, solvates and clathrates. Co

crystals can comprise nicotine in combination with an organic and/or an inorganic component and

are generally distinguished from salts by the absence of a proton transfer between the components

(the nicotine and the one or more coformers) in a co-crystal. In contrast, a nicotine salt co-crystal

is a type of hybrid structure with both salt and co-crystal features. Typically, a nicotine molecule

within a salt co-crystal is associated with at least two coformers (which may be the same or

different), in which one coformer is in ionic form such as an acid and transfers a proton to the

nicotine molecule and the second coformer does not transfer a proton to the nicotine molecule.

Any form of nicotine, including nicotine salts, nicotine co-crystals, and/or nicotine salt co-crystals

may be utilized herein for any onsert, precision rod or precision pod embodiment.

[0101] As used herein, "cigarette" means any roll of tobacco, which may include non

tobacco materials, wrapped in paper that when lit combusts and produces smoke. A cigarette

usually also includes a filter, plug wrap (constrains the filtration materials) and tipping paper

(holds the cigarette paper to the filter and plug wrap). Glue seals the cigarette paper together, and

if the cigarette has a filter, glue holds these other components together. The term cigarette shall

also include any roll of tobacco wrapped in any substance containing tobacco which, because of its

appearance, the type of tobacco used, or its packaging and labeling, is likely to be offered to, or

purchased by, consumers as a cigarette. An example is a 'little cigar' which may include a filter and generally looks very similar to a cigarette. Factory-made cigarettes mean cigarettes that are fabricated and rolled in a factory by a tobacco manufacturer, and unless provided to smokers as research cigarettes, factory-made cigarettes are typically purchased at retail stores by end users.

Factory-made cigarettes usually come in packs of twenty cigarettes. As used herein, "marijuana

cigarette" means any roll of cannabis wrapped in paper or any other non-tobacco material that

when lit combusts and produces smoke for inhalation. A marijuana cigarette (i.e., joint) does not

contain tobacco; however, may yield nicotine or other tobacco alkaloids if an onsert or precision

rod, as disclosed herein, is attached to or is inserted within the marijuana cigarette. A marijuana

cigarette may be rolled by cannabis end users or fabricated in a factory by a cannabis

manufacturer. Unlike a marijuana cigarette, a blunt is marijuana rolled in a tobacco leaf or cigar

wrapper that comprises tobacco, and a spliff is a marijuana cigarette which also contains tobacco.

[0102] As opposed to factory-made cigarettes, roll-your-own (RYO) cigarettes or make

your-own (MYO) cigarettes are put together by tobacco end users. RYO cigarettes are made with

tobacco and rolling papers. A cigarette roller may also be utilized to roll the tobacco into the

rolling paper. MYO cigarettes are generally made with tobacco and a mechanical MYO machine

in which the tobacco is inserted into an empty cigarette tube (with or without a filter). A

mechanism inserts the tobacco into the tube and the result is a cigarette that looks very similar to

typical store-bought factory-rolled cigarettes. Although RYO (tobacco and rolling papers) or

MYO (tobacco and tubes) cigarettes are generally each cheaper for consumers to purchase than

factory-made cigarettes, RYO and MYO cigarettes are time consuming and tedious to assemble

and usually do not have the uniformity or quality of factory-made cigarettes. RYO tobacco and

MYO tobacco are essentially the same and closely resemble filler of factory-made cigarettes.

RYO tobacco, MYO tobacco and pipe tobacco are all finished tobacco products (as defined

below) which tobacco end users purchase to smoke.

[0103] As used herein, "filler" means the cumulative smokable material (besides cigarette

paper), wrapped in the rod of a cigarette, or in a tobacco stick of a tobacco heating device (or in

tobacco heating rod [e.g., TEEPS®] if no separate holder in a tobacco heating product), selected

from the group consisting of cut tobacco leaf (cut-rag), tobacco stem, reconstituted tobacco,

expanded tobacco, cannabis, casings, flavorings and other additives or ingredients such as

cannabinoids or additional alkaloids such as anatabine. Reconstituted tobacco is usually included

in the filler of factory-made cigarettes and resembles cut-rag tobacco. Expanded tobacco is also

usually included in the filler of factory-made cigarettes and is processed through the expansion of

suitable gases so that the tobacco is 'puffed' resulting in reduced density and greater filling

capacity of the tobacco rod. Expanded tobacco reduces the weight of tobacco used in cigarettes.

[0104] As used herein, "reconstituted tobacco," also known as Recon, means tobacco sheet

produced by the rolling or casting of tobacco dust, stems and/or by-products that have previously

been finely ground are then mixed with a cohesive agent or binder and typically humectants,

flavors and preservatives are included. The result in a paper-like malleable sheet which is

essentially recycled tobacco. The two types of reconstituted tobacco known in the art are band

cast and paper cast. For each of these, every producer has a slightly different process. The Recon

process allows virtually any compound or plant fraction to be added. Once the reconstituted

tobacco sheet is fabricated, it is then cut into small strips. The size and shape of the strips are

typically similar to the size of cut-rag tobacco, and the reconstituted tobacco may be blended into

the filler of cigarettes; however, the large sheets of Recon can be cut to any size. See,e.g.,U.S.

Patents 4,270,552 and 5,724,998 and Chapter 11, 377-379, Tobacco: Production, Chemistry and

Technology, 1999. Nicotine, anatabine, anabasine, THCA, CBDA, CBCA, CBGA, THCVA,

CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene may be

further incorporated during the Recon production process before the sheets are fabricated. In some exemplary embodiments herein, the reconstituted tobacco sheet is utilized for production of wrappers for onserts and the Recon sheets are cut accordingly, or the reconstituted tobacco sheet may be very finely cut, ground and incorporated into precision pods or precision rods. In other exemplary embodiments, very low nicotine tobacco is reconstituted and utilized for onserts, precision rods or precision pods.

[0105] As used herein, "reconstituted cannabis" means a cannabis sheet produced in

the same fashion as reconstituted tobacco sheet in which cannabis flowers, leaves, dust, stems

and/or by-products that have been previously finely ground are then rolled or casted and mixed

with a cohesive agent or binder which usually includes humectants, flavors and preservatives.

Reconstituted cannabis sheet does not require any tobacco portions so it can be made tobacco free,

and if no nicotine is desired, it can be made nicotine free, and is easily made into reconstituted

sheets similar to reconstituted tobacco. The cannabis portion of the reconstituted cannabis sheet

may be made from approximately 70 percent to approximately 90 percent cannabis plant parts.

Once fabricated, reconstituted cannabis sheet is cut to any size desired. In some exemplary

embodiments, the reconstituted cannabis is utilized for production of wrappers for onserts or cut

very fine and incorporated into precision pods or precision rods. Nicotine, anatabine, anabasine,

THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene,

pinene, limonene and/or humulene may be further incorporated during the Recon production

process before the reconstituted cannabis sheets are fabricated. Very low THC cannabis or THC

free cannabis may be produced from hemp strains or varieties, or strains or varieties of cannabis

that are genetically engineered for very low THC content and utilized for reconstituted cannabis.

Very low THC cannabis and low nicotine (or zero nicotine) tobacco may both be utilized in the

same reconstituted sheet.

[0106] In other exemplary embodiments, reconstituted plant material (e.g., leaves and

stems) is utilized for production of wrappers for onserts or for use in precision pods or precision

rods, and the reconstituted sheet does not include any tobacco or cannabis. Herbs such as jasmine

and ginseng, for example, are utilized for production of "reconstituted herbal sheet." Whether

reconstituted tobacco, reconstituted cannabis and/or reconstituted jasmine, for example, nicotine,

anatabine, anabasine, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA,

myrcene, caryophyllene, pinene, limonene and/or humulene are incorporated (infused) during the

Recon production process before the reconstituted sheets are fabricated.

[0107] As used herein, "finished tobacco product" means a tobacco product that is ready

for consumer use or consumption and includes but is not limited to cigarettes, cigars, little cigars,

cigarillos, roll-your-own (RYO) tobacco (used with rolling papers by end users to roll their own

cigarettes or marijuana cigarettes), make-your-own (MYO) tobacco (used with cigarette tubes and

a mechanical MYO machine, typically by end users to make their own cigarettes or marijuana

cigarettes, in which the tobacco or cannabis is inserted by the machine into an empty cigarette

tube), cannabis, pipe tobacco, tobacco heating products (e.g., IQOS@), snuff, snus, and chewing

tobacco such as dipping tobacco. E-cigarettes are not tobacco products since the only fraction of

tobacco they contain is nicotine. RYO tobacco or MYO tobacco may not be designated as either

on packaging and may be referred to as "tobacco" since it can be used as RYO tobacco or MYO

tobacco.

[0108] As used herein, "smoking product" means any product that is ready for consumer

use or consumption that when used by itself (e.g., cigarette) or used with an interdependent

smoking product (e.g., a pipe and pipe tobacco are interdependent on one another) produces

mainstream smoke for inhalation (except smoke from certain cigars may not be inhaled by some

cigar smokers, due to the high nicotine content and high pH of the smoke resulting in nicotine being absorbed through the mouth) when ignited, and includes but is not limited to cigarettes, cigars, roll-your-own (RYO) tobacco, cannabis, rolling papers for RYO tobacco or cannabis, make-your-own (MYO) tobacco, cigarette tubes for MYO tobacco or cannabis, pipes, bowls, bongs, tobacco, reconstituted tobacco, spliffs, blunts, and marijuana cigarettes. RYO tobacco and

MYO tobacco, individually or collectively, may be referred to herein as 'tobacco' or 'finished

tobacco.' A bowl is a type of pipe that typically has a shorter stem. The 'tobacco chamber,'

'cannabis chamber' or 'chamber' is where tobacco or cannabis is burned in pipes, bowls and

bongs. Onserts, precision rods and certain precision pods (those not for vaporizers) are also

smoking products.

[0109] As used herein, "conventional cigarette" means a cigarette having a conventional

nicotine content of at least 9 mg per cigarette. The average nicotine content of conventional

commercial cigarette brands is approximately 14 mg of nicotine per cigarette but may range from

approximately 9 mg to over 20 mg of nicotine per cigarette. See Morton et al. 2008, Regul

ToxicolPharmacol.doi: 10.1016/j.yrtph.2008.03.001.

[0110] As used herein, "very low nicotine cigarette" means a cigarette containing 2.0

milligrams (mg) nicotine per cigarette or less such as less than 0.05 mg, 0.10 mg, 0.15 mg, 0.20

mg, 0.25 mg, 0.30 mg, 0.35 mg, 0.40 mg, 0.45 mg, 0.50 mg, 0.55 mg, 0.60 mg, 0.65 mg, 0.70 mg,

0.75 mg, 0.80 mg, 0.85 mg, 0.90 mg, 0.95 mg, 1.00 mg, 1.05 mg, 1.10 mg, 1.15 mg, 1.20 mg, 1.25

mg, 1.30 mg, 1.35 mg, 1.40 mg, 1.45 mg, 1.50 mg, 1.55 mg, 1.60 mg, 1.65 mg, 1.70 mg, 1.75 mg,

1.80 mg 1.85 mg, 1.90 mg or 1.95 mg nicotine per cigarette. Per cigarette nicotine content is

calculated by multiplying the weight of the filler in a cigarette rod by the nicotine content of the

filler in the cigarette rod. For example, if the filler of a cigarette weighs 0.666 gram and has a

nicotine content of 3 mg/g, the nicotine content of the cigarette is about 2 mg. Filler having a nicotine content of 3 mg/g equates to an approximate 85% reduction of the average nicotine content of tobacco filler in conventional cigarette brands which is approximately 20 mg/g.

[0111] Very low nicotine cigarettes have been manufactured by the tobacco industry at

various times for decades. For example, John Alden Tobacco Company manufactured the John

Alden very low nicotine cigarette brand in the 1950s and advertised the brand as "At least 85%

less nicotine than the two leading filter tip brands." The low-nicotine tobacco used in John Alden

very low nicotine cigarettes was classified by the U.S. Department of Agriculture as Type 31-V.

In addition to growing tobacco that already has very low nicotine, other processes have been

developed. For example, Philip Morris USA developed a commercial supercritical C02 process

to remove 97% of nicotine from filler and sold various brands of very low nicotine cigarettes.

[0112] As used herein, a "nicotine-enhanced cigarette" means a cigarette which includes

an adjunct source of nicotine (e.g., from an onsert or precision pod) resulting in the nicotine smoke

yield of the cigarette being increased by equal to or greater than 7 percent, as measured by an

industry-accepted, standardized, smoking-machine test method (e.g., International Standards

Organization [ISO] smoking-machine test method 4387:2000 [Cigarettes - Determination of total

and nicotine free dry particulate matter using a routine analytical smoking machine]), as compared

to the nicotine smoke yield of the cigarette without the adjunct source of nicotine as measured by

the same said test method. The nicotine yield of very low nicotine cigarettes or conventional

cigarettes may be enhanced by an adjunct source of nicotine. Other examples of industry

accepted, standardized, smoking-machine test methods are the Canadian intense method, the

Massachusetts method, and the Federal Trade Commission (FTC) method. Besides an adjunct

source of nicotine, nicotine-enhanced cigarettes, may also utilize a device used in conjunction with

the adjunct source of nicotine such as a cigarette holder.

[0113] Depending on the design of the cigarettes being infused with an adjunct nicotine

source, including the level of ventilation of the cigarette, the increase in nicotine smoke yield will

vary from cigarette type to cigarette type for a given amount of adjunct nicotine (e.g., a precision

rod comprising of 10 mg nicotine). Just as a small percentage of the nicotine in the filler of a

cigarette (the average nicotine content of a cigarette is about 14 mg) transfers to mainstream

smoke (may be measured by a smoking machine), which ranges from approximately one percent

of the nicotine content for highly ventilated cigarettes to approximately ten percent of the nicotine

content for virtually non-ventilated cigarettes, a similarly small percentage of nicotine is

transferred from an onsert or precision rod to mainstream smoke. This nicotine transfer rate,

which is the rate that the nicotine content in the filler of a cigarette (and/or the nicotine content of

the nicotine onsert) transfers to the mainstream smoke as measured by a smoking machine, also

depends on if any (or the level of) bum accelerators or ash conditioners are included in the

cigarette paper and/or source of adjunct nicotine (e.g., onsert). The way smoking products

including cigarettes are smoked (i.e., intensely, by taking large and frequent puffs, or not) also

affects the nicotine transfer rate of cigarettes with or without adjunct nicotine sources. Specific

smoking regimes such as the ISO, Canadian intense method, or Massachusetts method each

standardizes nicotine yields with or without onserts or precision rods.

[0114] The increased nicotine yield of the smoke of a nicotine-enhanced cigarette may be

equal to, for example, at least 0.002 mg, 0.003 mg, 0.004 mg, 0.005 mg, 0.006 mg, 0.007 mg,

0.008 mg, 0.009 mg, 0.010 mg, 0.011 mg, 0.012 mg, 0.013 mg, 0.014 mg, 0.015 mg, 0.016 mg,

0.017 mg, 0.018 mg, 0.019 mg, 0.020 mg, 0.025 mg, 0.030 mg, 0.035 mg, 0.040 mg, 0.045 mg,

0.050 mg, 0.055 mg, 0.060 mg, 0.065 mg, 0.070 mg, 0.075 mg, 0.080 mg, 0.085 mg, 0.090 mg,

0.095 mg, 0.100 mg, 0.125 mg, 0.150 mg, 0.175 mg, 0.200 mg, 0.225 mg, 0.250 mg, 0.275 mg,

0.300 mg, 0.325 mg, 0.350 mg, 0.375 mg, 0.400 mg, 0.425 mg, 0.450 mg, 0.475 mg, 0.500 mg,

0.525 mg, 0.550 mg, 0.575 mg, 0.600 mg, 0.625 mg, 0.650 mg, 0.675 mg, 0.700 mg, 0.725 mg,

0.750 mg, 0.775 mg, 0.800 mg, 0.825 mg, 0.850 mg, 0.875 mg, 0.900 mg, 0.925 mg, 0.950 mg,

0.975 mg or 1.000 mg nicotine, et cetera. For example, a nicotine-enhanced cigarette may be a

very low nicotine cigarette in which the nicotine yield increased from 0.03 mg to 0.05 mg.

[0115] As used herein, an "anatabine-enhanced cigarette" means a cigarette which

includes an adjunct source of anatabine resulting in the cigarette having an increased anatabine

yield of equal to or greater than 7 percent, as measured by a testing method capable of quantitating

anatabine in smoke, and as compared to the same type of factory-made cigarette without said

adjunct source of anatabine and measured by the same test method. For an example of such a

testing method, see Zhang et al. 2018, Rapid CommunMass Spectrom., 32:1791-1798 (DOI:

10.1002/rcm.8222). The anatabine yield of very low nicotine cigarettes or conventional cigarettes

may be enhanced by an adjunct source of anatabine such as from an onsert or precision rod.

[0116] This anatabine source may be plants including tobacco plants with high anatabine

in which the anatabine is extracted by, for example, a supercritical CO 2 extraction process. The

anatabine content may also be enhanced by anatabine salts of organic acids, anatabine analogs or

synthesized anatabine. The increased anatabine yield of the smoke of an anatabine-enhanced

cigarette may be equal to, for example, at least: 0.10 g, 0.15 g, 0.20 g, 0.25 g, 0.30 g, 0.35

jg, 0.40 jg, 0.45 jg, 0.50 jg, 0.55 jg, 0.60 jg, 0.65 jg, 0.70 jg, 0.75jg, 0.80 g, 0.85 g, 0.90

jg, 0.95 jg, 1.00 jg, 1.10 jg, 1.20 jg, 1.30 jg, 1.40 jg, 1.50 jg, 1.60jg, 1.70 g, 1.80 g, 1.90

jg, 2.0 jg, 2.25 jg, 2.50 jg, 2.75 jg, 3.0 jg, 3.25 jg, 3.50 g, 3.75 g, 4.0 g, 4.25 g, 4.50 g,

4.75 jg, 5.0 jg, 5.25 jg, 5.50 jg, 5.75 jg, 6.0 jg, 6.25jg, 6.50jg, 6.75jg, 7.0 g, 7.25 g, 7.50

jg, 7.75 g, 8.0 g, 8.25 g, 8.50 g, 8.75 g, 9.0 g, 9.25 g, 9.50 g, 9.75 g, 10 g, 11 g, 12

g, 13 g, 14 g, 15 g, 16 g, 17 g, 18 g, 19 jg,20 jg,21 jg,22jg,23 jg,24 g,25 g, 30

g, 35 g, 40 g, 45 g or 50 g of anatabine per cigarette. An advantage of an anatabine enhanced very low nicotine cigarette is that this type of cigarette reduces withdrawal and craving of conventional cigarettes more effectively than very low nicotine cigarettes without enhanced anatabine. Anatabine-enhanced very low nicotine cigarettes are especially useful when used to assist smokers in transitioning to e-cigarettes or a tobacco heating device or to assist smokers in quitting tobacco and nicotine use altogether.

[0117] As used herein, an "anabasine-enhanced cigarette" means a cigarette which

includes an adjunct source of anabasine resulting in the cigarette having an increased anabasine

smoke yield of equal to or greater than 7 percent, as measured by a testing method capable of

quantitating anabasine in smoke, and as compared to the same type of factory-made cigarette

without said adjunct source of anabasine and measured by the same test method. For an example

of such a testing method, see Zhang et al. 2018, Rapid CommunMass Spectrom., 32:1791-1798

(DOI: 10.1002/rcm.8222). The anabasine yield of very low nicotine cigarettes or conventional

cigarettes may be enhanced by an adjunct source of anabasine such as from an onsert or precision

rod.

[0118] This anabasine source may be plants including tobacco plants or plants in which the

predominant alkaloid is anabasine such as Nicotianaglauca, Nicotiananoctiflora, Nicotiana

petunioides and/or Nicotianadebneyi plants. The anabasine may be extracted by, for example, a

supercritical C02 extraction process from any type of tobacco. The anabasine content may also be

enhanced by anabasine salts of organic acids, anabasine analogs or synthesized anabasine. The

increased anabasine yield of an anabasine-enhanced cigarette may be equal to, for example, at

least: 0.01 [g, 0.02 [g, 0.03 [g, 0.04jg, 0.05jg, 0.06 g, 0.07 g, 0.08 g, 0.09 g, 0.10 g, 0.15

jg, 0.20 jg, 0.25 jg, 0.30 jg, 0.35 jg, 0.40 jg, 0.45 jg, 0.50 jg, 0.55jg, 0.60 g, 0.65 g, 0.70

jg, 0.75 jg, 0.80 jg, 0.85 jg, 0.90 jg, 0.95 jg, 1.00 jg, 1.10 jg, 1.20jg, 1.30 g, 1.40 g, 1.50

jg, 1.60 jg, 1.70 jg, 1.80 jg, 1.90 jg, 2.0 jg, 2.25 jg, 2.50jg, 2.75jg, 3.0 g, 3.25 g, 3.50 g,

3.75 [g, 4.0 [g, 4.25 [g, 4.50 [g, 4.75 [g, 5.0 jg, 5.25 jg, 5.50 ag, 5.75 jg, 6.0 g, 6.25jg, 6.50

jg, 6.75 jg, 7.0 jg, 7.25 jg, 7.50 jg, 7.75 jg, 8.0jg, 8.25jg, 8.50 g, 8.75 g, 9.0 g, 9.25 g,

9.50 jg, 9.75 g, 10 g, 11 g, 12 g, 13 g, 14 g, 15 g, 16 g, 17 g, 18 g, 19 g, 20 g, 21

g, 22 g, 23 g, 24 g, 25 g, 26 g, 27 g, 28 g, 29 g or 30 g of anabasine per cigarette. An

advantage of an anabasine-enhanced very low nicotine cigarette is that this type of cigarette

reduces withdrawal and craving of conventional cigarettes more effectively than very low nicotine

cigarettes without enhanced anabasine. Anabasine-enhanced very low nicotine cigarettes are

especially useful when used to assist smokers in transitioning to e-cigarettes or a tobacco heating

device or to assist smokers in quitting tobacco and nicotine use altogether.

[0119] Total alkaloid levels or individual alkaloid levels such as the level of nicotine,

anatabine or anabasine in tobacco or filler can be measured by several methods known in the art.

Examples include quantification based on gas chromatography (GC) and high-performance liquid

chromatography. See, e.g., Lisko et al. 2013, Anal Chem. March 19; 85(6): 3380-3384, which

provides the following methods used to measure quantities of alkaloids in the filler of cigarette

brands and in tobacco types (e.g., burley tobacco). The analysis of minor alkaloids such as

anatabine or anabasine has been performed with gas chromatography (GC) coupled with a wide

spectrum of detection techniques including flame ionization detection (FID), nitrogen-phosphorus

detection (NPD), and mass spectrometry (MS). Other analysis approaches have included high

performance liquid chromatography-ultraviolet detection (HPLC-UV), capillary zone

electrophoresis-ultraviolet detection (CZE-UV), micellar electrokinetic capillary chromatography

ultraviolet detection (MECC-UV), nitrogen chemiluminescence detection (NCD), and

microemulsion electrokinetic chromatography-ultraviolet detection (MEEKC-UV). Utilization of

gas chromatography-tandem mass spectrometry (GC-MS/MS) in multiple reaction mode (MRM)

allows for greater compound specificity by eliminating matrix ions arising from other compounds that share the same parent mass but lack the correct transition ion, drastically decreasing background interferences and reducing detection limits. The amount of nicotine (and propylene glycol and glycerol) in e-liquids or blends in precision rods or precision pods may be determined by ISO/DIS 20714, which is a gas chromatographic method, or any other method known in the art.

Unless specified or insinuated otherwise, analyte measurements (e.g., nicotine) are on a dry weight

basis.

[0120] For any exemplary embodiment herein, nicotine is first provided by any of the

various methods known in the art for extracting nicotine, anatabine and anabasine from Nicotiana

plants such as high nicotine N. rustica plants and then purifying the extract. These methods are

utilized for nicotine replacement therapy products like the nicotine lozenge and nicotine patch.

Alternatively, in other embodiments, synthetic nicotine, synthetic anatabine or synthetic anabasine

is first provided, which offers advantages of not being extracted from tobacco. See, for example,

U.S. Patent No. 9,556,142 and Ayers et al. 2005 The AAPSJournal; 7(3) Article 75, E752-E758

(http://www.aapsj.org). The nicotine is then prepared preferably in a solid or semi-solid form by

any of the methods known in the art. These may be in crystalline and/or amorphous form.

[0121] Upon crystallization or solidification, the nicotine salt may be cut or ground to

form any shape or size depending on the application. For nicotine powder applications, the size

may be as small as 25 microns, and for other application the size may be 5 mm. Alternatively,

nicotine salts are available commercially. For example, nicotine bitartrate dehydrate, a pure,

water-soluble crystalline salt of nicotine in a powder form and used for the production of nicotine

lozenges and gums is available from Alchem International SA.

[0122] ELECTRONIC NICOTINE DELIVERY SYSTEMS (ENDS)

Many types of ENDS have been developed and marketed over the past decade. For

example, a tobacco heating product is comprised of a holder, tobacco sticks and a charger. The

IQOS@ tobacco stick (HeatStick®), for example, is inserted into the IQOS@ holder which heats

the tobacco material by means of an electronically-controlled heating blade. The HeatStick®

differs from a cigarette in many ways. For example, the tobacco in the HeatSticks@ for the

IQOS@ product does not bum and is made from tobacco powder uniquely processed and

specifically designed to function with the holder to produce an aerosol. In another exemplary

configuration, a tobacco heating device is ignited like a conventional cigarette. There may not be

any holder, charger or battery and the tobacco may be directly heated in a tobacco heating rod.

For example, an ignited carbon heat source heats (and does not burn) the tobacco and produces an

aerosol similar to tobacco heating devices which comprise of separate tobacco sticks. The types of

tobacco heating devices with carbon heat sources, for example, closely resemble a typical cigarette

physically, but do not bum. The disposable heating element is contained in each rod producing

the aerosol that is inhaled, known herein as a "tobacco heating rod" or "heating rod." An example

is TEEPS@ which is being developed by Philip Morris International. Other examples include

Eclipse@ and Revo®, which were previously sold in the United States but are no longer on the

market. In another configuration, a tobacco heating device has no holder or charger and includes a

battery in every heating rod and each heating rod may be disposable. Accordingly, it is understood

that any device that heats tobacco (or tobacco extract or a form of tobacco such as reconstituted

tobacco) below combustion (does not burn the tobacco) to produce an aerosol is a tobacco heating

device regardless whether there are separate tobacco sticks from the holder or heating element,

whether charging a battery is required or a battery is even required, whether something needs to be

ignited such as the end of a carbon heat source, and/or whether any electronics are involved. The

terms, tobacco heating device, tobacco heating product, heat-not-burn tobacco device, and heat

not-bum tobacco product as used herein are synonymous.

[0123] An e-cigarette is a rechargeable electronic device which includes a heating coil,

atomizer that transforms the e-liquid (also known as e-juice) to an aerosol, cartridge or the like

(sticks or pods) containing the e-liquid, mouthpiece and battery for recharging the device.

Although there are many appearances and designs that may encompass varying steps, they

generally operate by drawing on the e-cigarette, activating a heating element which aerosolizes the

e-liquid, allowing the aerosol to be inhaled. E-liquids typically contain nicotine, water, flavors

and humectants. The humectant acts as a carrier solvent which dissolves the nicotine and flavors

and aerosolizes at a certain temperature on the atomizer of the e-cigarette. Typically, propylene

glycol and/or glycerol are the solvents used in e-liquids. The e-liquid of e-cigarettes which is

contained in cartridges, for example, have nicotine contents which vary widely by brand and brand

style.

[0124] A vaporizer (vape) vaporizes substances, typically plant material such as cannabis,

for inhalation without burning the substances. These include both dry herb vaporizers (e.g., for

cannabis flowers) and vaporizers configured for plant extracts such as concentrates or waxy

extracts. Some vaporizers are configured for both dry herbs and concentrated extracts such as the

PAX 3@. Vaporizers configured for dry herbs and/or concentrates are typically open systems

allowing the user to place whatever is desired to be heated into the oven chamber and then the

oven chamber is closed with a cover or the like. These types of open system vaporizers such as

the PAX 2® are differentiated from closed system vaporizers such as glo@ and IQOS@ which use

tobacco sticks and the tobacco is not accessible; however, open system vaporizers work similarly

to glo@ and IQOS@ since open systems like the also generate vapor from smokable plant material

(e.g., cannabis), which typically have moisture levels from about 10 percent to about 17 percent.

The ready-to-vape precision pods disclosed herein are capable of working with dry herb

vaporizers and vaporizers for concentrates which is advantageous. Open system vaporizers are also differentiated from e-cigarettes in that e-cigarettes utilize e-liquids and open system vaporizers do not. As compared to the exemplary embodiments herein of the ready-to-vape precision pods comprising concentrated forms of nicotine, e-cigarettes cause the user to inhale a much greater volume of vapor for a satisfying dose of nicotine (e.g., 1 mg) since the nicotine in e liquids is drastically diluted to concentrations generally not greater than 0.7 ml nicotine by volume, which equals 5% nicotine by weight. Some other vape devices offer e-liquids at higher concentrations, but none are close to the concentration of nicotine in blends of ready-to-vape precision pods, for example, comprising a crystalline cannabinoid and crystalline salt of nicotine.

[0125] A vaporizer includes an electronic heater with temperature regulator, oven or

vaporization chamber (where the materials to be heated are placed), cover for oven chamber,

mouthpiece, sensors and a rechargeable battery. Generally, as compared to burning cannabis from

smoking products, significantly more extraction of cannabinoids occurs with vaporizers heating

cannabis due to lack of combustion. Typical temperatures of vaporizers in the oven chamber

range from about 1600 C. to about 2300 C. resulting in a vapor for inhalation; however, ranges can

be wider (e.g., 1000 C. to 265 C.) since higher temperatures are needed for concentrates.

Mainstream vapor is vapor that is inhaled and includes the vapor that emerges from the mouth of a

person using a vaporizer or that emerges from the mouth end of a vaporizer.

[0126] CANNABIS AND CANNABIS FORMULATIONS

[0127] "Cannabis" as used herein includes Cannabissativa, Cannabisindica and

Cannabisruderalis. Both marijuana and hemp strains or cultivars are cannabis. Hemp is

genetically more similar to the indica type of marijuana than to sativa strains. Cannabinoids are

the group of more than 100 natural chemical compounds that mainly accumulate in female flowers

(also known as buds) of cannabis plants. They act on cannabinoid receptors in cells that alter

neurotransmitter release in the brain. THCA/THC is one of the dozens of cannabinoids present in cannabis plants. Cannabinoids may be produced intrinsically by a genetically engineered tobacco plant, produced synthetically (see, for example, U.S. Patent 9,587,212) or extracted from cannabis plants for use onserts, precision rods and precision pods. When smokers cease smoking conventional cigarettes their levels of anxiety and depression usually increase; therefore, very low nicotine cigarettes in conjunction with an onsert or precision rod comprising a minimal amount of crystalline CBDA is beneficial in assisting smokers to switch to e-cigarettes or a tobacco heating device or to quit tobacco and nicotine use altogether. For these applications, smoke from very low nicotine cigarettes also containing non-THC cannabinoids from an onsert or precision rod is an improvement over smoke from very low nicotine cigarettes without cannabinoids. The greater period of time during a transitional period smokers are able to exclusively smoke very low nicotine cigarettes (while not smoking any conventional cigarettes), as disclosed in U.S. Patent

Application No. 16/047,948, the greater probability of them switching to e-cigarettes or a tobacco

heating product or quitting tobacco and nicotine use altogether.

[0128] The psychoactive effects of THC are primarily mediated by the activation of

cannabinoid receptors located throughout the body and are part of the endocannabinoid system,

which is involved in a variety of physiological processes such as mood and appetite. Utilizing

hemp strains (containing significant THCA content) or marijuana strains or varieties is

problematic to include in very low nicotine cigarettes to assist smokers in switching to e-cigarettes

or a tobacco heating device since the psychoactive effects of THC would interfere with the daily

lives of smokers in that their physical and mental control would be diminished. For example, a

smoker attempting to switch to e-cigarettes or a tobacco heating device would not be able to

smoke very low nicotine cigarettes containing significant levels of THCA during a lunch break

while at work without becoming intoxicated and therefore may not be able to function normally

upon returning to work and may become a danger to coworkers. Moreover, employees may fail drug tests if their very low nicotine cigarettes include cannabis which contains THCA. Therefore, it is useful and advantageous to include crystalline CBDA (and not cannabis) from an onsert or precision rod in conjunction with very low nicotine cigarettes or conventional cigarettes, or from a precision pod in conjunction with a vaporizer to prevent any of the psychoactive effects of THC while retaining the benefits CBD. Crystalline CBDA which is 99.5 percent pure does not have any of the intoxicating effects of THC whatsoever.

[0129] The cannabinoid biosynthetic pathway in Cannabissativa is understood.

Cannabigerolic acid (CBGA) is the precursor to the three main cannabinoid lines:

tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid

(CBCA). During decarboxylation, which occurs during drying and curing of the plant material

and/or upon the application of heat (e.g., smoking) to the cannabinoid acid, each of the following 8

cannabinoid acids: CBGA (cannabigerolic acid), THCA (A9-tetrahydrocannabinolic acid), CBDA

(cannabidiolic acid), CBCA (cannabichromenenic acid), CBGVA (cannabigerovarinic acid),

THCVA (tetrahydrocanabivarinic acid), CBDVA (cannabidivarinic acid) and CBCVA

(cannabichromevarinic acid), converts to and yields the following corresponding 8 cannabinoid

compounds: CBG (cannabigerol), THC (A9-tetrahydrocannabinol), CBD (cannabidiol), CBC

(cannabichromene), CBGV (cannabigerivarin), THCV (tetrahydrocannabivarin), CBDV

(cannabidivarin) and CBCV (cannabichromevarin). As cannabis cures and moisture is reduced,

the cannabinoid compounds in their acidic form mature and are slowly converted into related

compounds (e.g., THCA to THC). Curing cannabis and storing it over time only causes partial

decarboxylation to occur, which is the reason cannabis flowers generally test positive, for

example, for both THCA and THC (designated herein as THCA/THC). Smoking or vaporizing

cannabis will decarboxylate cannabinoids in acidic form (e.g., THCA to THC) due to the high

temperatures present, making them instantly available for absorption through inhalation.

[0130] The cannabinoid acid content of the exemplary embodiments herein of onserts,

precision rods or precision pods such as CBDA includes the corresponding cannabinoid since

partial decarboxylation may have occurred to the cannabinoid acid such as CBDA to CBD. For

example, during analytical testing of cannabinoid acids and cannabinoids of onserts, precision

rods, precision pods, cannabis plants, cannabis strains and cannabis varieties, an item that is

quantified as containing 24 mg CBDA and 1 mg CBD is equivalent to the item described herein as

25 mg CBDA. Therefore, it is understood herein that due to the potential partial decarboxylation

of cannabinoid acids to cannabinoids, a cannabinoid acid and cannabinoid may at times be used

interchangeably and expressed as, in this instance, 25 mg CBDA, 25 mg CBD or 25 mg

CBDA/CBD, all of which have the equivalent meaning.

[0131] Every strain or variety of cannabis has a unique cannabinoid profile, which is the

content of each cannabinoid in a batch or blend of cannabis divided by the total content of all

cannabinoids, measured in percent, or the ratio of one or more cannabinoids to one or more other

cannabinoids. An example of a cannabinoid profile in a 10-pound batch of a cannabis is that the

THCA/THC content is 65 percent of the total content of all cannabinoids and the remaining

cannabinoids comprise the remaining 35 percent. The non-THCA/THC cannabinoids may be

further characterized. The ratio of THCA to CBDA is also an example of a cannabinoid profile.

Multiple samples are taken from a batch or plant and blended for testing purposes and more than

one replicate may be done. Regardless of cannabis strains or variety, CBDA/CBD and

THCA/THC are typically the two most prevalent cannabinoids in cannabis. There's usually an

inverse relationship between THCA and CBDA across cannabis strains and varieties. The higher

the THCA/THC content, the lower the CBDA/CBD content, and the higher the CBDA/CBD

content, the lower the THCA/THC content. CBDA/CBD is generally the most abundant

cannabinoid combination in hemp strains or varieties. THCA/THC is generally the most abundant cannabinoid combination in marijuana strains, which typically can be approximately between 10 and 20 percent of the weight of the cannabis flower. This CBDA-CBD/THCA-THC relationship of hemp and marijuana is due to the fact that for centuries hemp has been bred for seed and biomass and therefore contains more CBDA/CBD, while marijuana has been bred for pleasurable effects and therefore contains more THCA/THC. While THCA is the more accurate label for cannabis flower that has not been decarboxylated, THCA or THC are often used interchangeably and are essentially equivalent if the flower is going to be smoked, vaporized or heated in some way since heat converts the remaining THCA to THC.

[0132] As described herein, precise dose formulations of blends of one or more crystalline

salts of nicotine and one or more crystalline cannabinoids used with devices disclosed herein

(onserts, precision rods and precision pods) present many types of harm reduction products

particularly for those smokers who simultaneously use tobacco and marijuana. Tobacco enhances

the pleasurable effects of marijuana when both are smoked simultaneously or when tobacco is

smoked shortly after marijuana is smoked. This synergistic effect is due in part to the stimulatory

properties of nicotine such as increased heart rate. Some smokers combine tobacco and marijuana

in blunts or spliffs. A blunt is marijuana rolled in a tobacco leaf or cigar wrapper that comprises

tobacco, and a spliff is a joint which also contains tobacco. Blunts and spliffs are combusted and

therefore produce 'tar' and harmful gases which contain thousands of chemicals. Inhaling smoke

from burning highly pure forms of crystalline CBDA or THCA, for example, in conjunction with

burning a crystalline salt of nicotine, and without any cannabis and tobacco plant material, is less

harmful than inhaling smoke from blunts or spliffs since the blend of these pure or nearly-pure

crystals results in a significant reduction of mainstream smoke for a given level of cannabinoid

and nicotine. Moreover, vaping highly pure, blended forms of crystalline THCA and a crystalline

nicotine salt in precision pods, for example, without any propylene glycol and glycerin or with very small amounts (as compared to e-cigarettes), is less harmful than smoking a blunt or spliff.

Propylene glycol and vegetable glycerin, which are in e-liquids at high percentages, are considered

safe and acceptable substances as food additives; however, there is insufficient data for inhaling

these compounds long-term. During the summer of 2019, reports began surfacing about irritated

and inflamed lungs from vaping e-liquids that included oils containing THC and vitamin E acetate.

Separately, a study showed that inhaling nicotine-free e-cigarette aerosol transiently impacted

endothelial function in healthy nonsmokers. See Caporale et al. 2019, doi:

10.1148/radiol.2019190562. These highlight the usefulness of the devices disclosed herein which

deliver formulations of active ingredients (e.g., nicotine and cannabinoids) that are concentrated

while eliminating or minimizing the level of carriers such as propylene glycol and glycerin.

Whether smoked or vaped, for a given dose of nicotine or THCA, for example, highly pure forms

of THCA and/or salts of nicotine result is less smoke being inhaled, as compared to blunts or

spliffs, and less vapor being inhaled, as compared to vaping cannabis flowers (buds).

[0133] Any extraction method known in the art may produce a cannabinoid acid in

crystalline form or near crystalline form. These extracted cannabinoid acids, as measured by high

performance liquid chromatography, are preferably at least 90 percent pure, more preferably at

least 95 percent pure, more preferably at least 98 percent pure, more preferably at least 99 percent

pure, and most preferably at least 99.5 percent pure. These extraction methods include those with

liquid carbon dioxide (C02) under supercritical or sub-critical conditions, followed by at least one

other further extraction, such as an ethanolic precipitation method to remove a substantial

proportion of any remaining non-cannabinoid materials such as plant waxes, wax esters and

glycerides, terpenes, carotenes, flavonoids and unsaturated fatty acid residues. See, for example,

U.S. Patents 7,700,368 and 8,846,409.

[0134] The combination of one or more cannabinoid acids and/or one or more salts of

nicotine may be included in any exemplary embodiment herein of onserts, precision rods, or

precision pods. Any cannabinoid acid, including those in crystalline or near crystalline form, may

be utilized including one or more cannabinoid acids selected from the following: CBGA

(Cannabigerolic acid), THCA (A9-tetrahydrocannabinolic acid), CBDA (cannabidiolic acid),

CBCA (cannabichromenenic acid), CBGVA (cannabigerovarinic acid), THCVA

(tetrahydrocanabivarinic acid), CBDVA (cannabidivarinic acid) and CBCVA

(cannabichromevarinic acid). Any salt of nicotine (nicotine salt), whether in crystalline form, near

crystalline form, polymorphic crystalline form, and/or amorphous form, may be utilized including

one or more selected from the following: nicotine 4-acetamidobenzoate, nicotine ascorbate,

nicotine aspartate, nicotine benzoic, nicotine bitartrate, nicotine chloride such as nicotine

dihydrochloride and nicotine hydrochloride, nicotine citrate, nicotine 2,3-dihydroxybenzoate,

nicotine 3,5-dihydroxybenzoate, nicotine fumarate, nicotine gentisate (2,5-hydroxybenzoic),

nicotine glutamate, nicotine 1-hydroxy-2-naphthoate, nicotine 3-hydroxybenzoate, nicotine lactate,

nicotine levulinic, nicotine malate, nicotine mono-pyruvate, nicotine mucate, nicotine perchlorate,

nicotine pyruvate, nicotine salicylate, nicotine succinate, nicotine sulfate, nicotine tartrate and

nicotine zinc chloride.

[0135] FLAVORINGS AND ADDITIVES

[0136] The onserts, precision rods and precision pods disclosed herein, in addition to

alkaloids and cannabinoids, may also contain any flavoring and/or additives. Smokers being able

to customize their very low nicotine cigarettes with additives or characterizing flavorings during

the treatment period of methods to facilitate switching smokers to e-cigarettes or a tobacco heating

product, as disclosed in U.S. Patent Application No. 16/047,948, is crucial for smokers to better

tolerate these non-conventional cigarettes. For example, natural menthol crystals from peppermint oil or oils of other mints may be included in any embodiment herein. Crystalline menthol is clear or white in color and becomes a vapor when tobacco smoke goes through the crystals in precision rods or when precision pods are heated in vaporizers causing the menthol essence to permeate mainstream vapor. Menthol crystals, as a solid, blend well with crystalline cannabinoid acids and crystalline salts of nicotine formulations. Any type of flavoring, whether or not in crystalline form, may be included in onserts, precision rods or precision pods and other examples of characterizing flavors include vanilla (e.g., vanillin), cherry, grape, mango, orange, clove, blueberry, peach, cinnamon, coconut, licorice, chocolate, fruit, coffee, strawberry, pineapple, cucumber, lemon, lime, mint and toffee. Commercial cigarettes characterized and labeled

'menthol' contain anywhere from about 2 mg to 20 mg of menthol. Any onsert, precision rod or

precision pod may comprise an amount of the foregoing characterizing flavors of at least 1 mg, 2

mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16

mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29

mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42

mg, 43 mg, 44 mg, 45 mg, 50 mg, etcetera.

[0137] Additives are also important to enhance some of the formulations of the onsert,

precision rod and precision pod embodiments herein. For example, formulations of crystalline

cannabinoids and salts of nicotine are devoid of flavors and aromas since all of the plant terpenes

have been extracted or were never present in the case of compounds being synthesized. Terpenes

are the pungent oils which give cannabis its distinctive aroma and taste. Every strain has a distinct

terpene profile. These cannabis terpenes may be reintroduced into formulations of onserts,

precision rods and precision pods to add character such as taste and aroma to the smoke or vapor.

Although more than 100 terpenes have been identified, the most prevalent terpenes in cannabis

include myrcene, caryophyllene, pinene, limonene and humulene.

[0138] Additives may also be utilized in the exemplary embodiments of onserts, precision

rods, or precision pods to ameliorate any harshness of a crystalline nicotine salt, other crystalline

alkaloids, crystalline cannabinoids, and/or other crystalline compounds. The pH of the smoke or

vapor produced from the formulations of onserts, precision rods and precision pods is analyzed

and adjusted accordingly by the addition of ingredients to shift the pH of the smoke or vapor. For

example, if the pH of smoke generated from the formulation of a precision pod under development

is greater than about 5.5, sugars, mild acids such as citric acid or fatty acids may be added to

blends in precision pods, precision rods or onserts. Plant materials or other constituents may also

be added to formulations herein which include plant parts, plant fractions, or plants constituents

from herbs (e.g., jasmine or ginseng), cannabis, tobacco and/other plants.

[0139] Other functional additives such as preservatives or non-tobacco alkaloids such as

cytisine, also known as cytisinicline, are useful. Cytisine is a plant-based alkaloid present in many

plant genera, such as Cytisus and Laburnum (e.g., Cytisus laborinum or golden rain acacia).

Cytisinicline has a high binding affinity to the nicotinic acetylcholine receptor. It has been used as

a smoking cessation treatment in pill form in some European countries. In some exemplary

embodiments, including at least 2 mg of cytisinicline in an onsert, precision rod or precision pod

reduces the urge to smoke conventional cigarettes and assists smokers transitioning to e-cigarettes

or a tobacco heating product or to quit tobacco and nicotine use altogether.

[0140] In some aspects of the present invention, products and formulations are provided

for smokers to enhance the nicotine, anatabine and/or anabasine smoke yield (i.e., levels) of

smoking products such as factory-made very low nicotine cigarettes to facilitate smokers, who are

not interested in quitting tobacco and nicotine products altogether, to switch from smoking

conventional cigarettes to using e-cigarettes or a tobacco heating device. In this methodology, very low nicotine cigarettes may be utilized as a bridge between the smoker's usual cigarette brand and e-cigarettes or between the smoker's usual cigarette brand a tobacco heating product.

[0141] In other aspects, products and formulations are provided for smokers to enhance the

nicotine smoke yield of their factory-made conventional cigarettes to reduce a smoker's exposure

to cigarette smoke including 'tar' and carbon monoxide.

[0142] In other aspects, products are provided for smokers to add new characterizing

flavor(s) or to enhance flavor(s) in the smoke of smoking products such as cigarettes.

[0143] In other aspects, products are provided for smokers to add nicotine, anatabine

and/or anabasine to marijuana cigarettes.

[0144] In other aspects, products are provided for smokers to include cannabinoids or

other additives or constituents to their smoking products.

[0145] In other aspects, products and formulations are provided to allow smokers to enjoy

the effects of cannabinoids and nicotine without being exposed to non-nicotine tobacco

compounds.

[0146] EXAMPLE 1

[0147] ONSERTS FOR SMOKING PRODUCTS

[0148] To enhance the nicotine smoke yield, nicotine is combined with onserts for the

consumer to apply the onserts onto, around, or within smoking products such as cigarettes. The

nicotine adhered or infused to the onsert is preferably in the form of a salt of nicotine. The onsert,

which comprises of a wrapper made from or including cellulose (e.g., reconstituted cannabis), may

be approximately as long as the smoking product such as a cigar and may be any shape or size

including wide enough to wrap around a cigarette. As shown in the exemplary embodiment of

FIGS. 1A-IC, an onsert 1 comprising a cellulosic wrapper 2 is configured for wrapping around the

entire circumference of the cigarette rod 3 of a factory-made cigarette. The width of the cellulosic wrapper 2 of the onsert 1 is larger than the circumference of the cigarette so that both sides 4, 5 of the onsert overlap the cigarette rod to sufficiently seal the cigarette. The self-adhesive (self-stick) side 6 of the onsert 1, which has self-stick adhesive around the entire perimeter (all four sides) 7 of the onsert, is rolled around the cigarette rod 3 while pressing the onsert to the cigarette rod 3. As shown in FIG. 1A and FIG. 1B, the nicotine salt 8 or any other form of nicotine (along with any other compounds or constituents the onsert may comprise) is adhered to the cellulosic wrapper 2 of the onsert, and in this exemplary embodiment, there is no nicotine on the opposite side 9 of the onsert 1. Alternatively, in some exemplary embodiments, the nicotine and any other compounds or constituents are infused within the cellulosic wrapper during the production process by methods known in the art such as those for reconstituting plant materials (e.g., reconstituted tobacco sheet or reconstituted cannabis sheet). In other exemplary embodiments, the nicotine is housed, that is, encased between a closed pocket of opposing sheets (i.e., an encasement or closed pouch) by methods known in the art for producing sugar packets or silica gel packets.

[0149] The entire cigarette rod 3 is now wrapped within the onsert 1, as shown in FIG. IC.

The onsert 1 and the cigarette are adhered to one another and the seal is improved by the smoker

pressing along the length of the nicotine-enhanced cigarette at the seam 10. The self-stick onserts

may be packaged for distribution in any form such as on non-stick sheets (backing paper), each

sheet comprising at least one onsert which is peeled off the non-stick sheet, or the self-stick

onserts may be on a continuous roll of multiple onserts in series which are be peeled off the roll

one at a time from non-stick backing paper. Although self-stick onserts are preferred, adhesives

may be utilized that are activated when moistened (e.g., licked) in order to stick. Any moisture

activated adhesive that is known in the art may be utilized on onserts.

[0150] Once the cigarette is lit and smoked, a portion of the nicotine from the onsert is

transferred to, and becomes part of, the mainstream smoke. The onsert may comprise of any cellulosic material in the form of a wrapper or strip which is burnable and smokable such as any paper or cellulosic material, cigarette paper, reconstituted tobacco sheet including forms used to roll machine made cigars, reconstituted cannabis sheet, formulations of hemp such as hemp paper, and/or cellulosic materials made from other plants such as herbal plants (e.g., ginseng or jasmine).

An advantage of the configuration of the onsert in FIGS. 1A-IC is that other ingredients may be

easily added to the onsert (between the onsert and cigarette) before the onsert is completely rolled

around the cigarette.

[0151] In some exemplary embodiments, the onsert is fabricated by covering the onsert

with a nicotine salt in conjunction with a binder, stabilizer and/or adhesive known in the art. In

this methodology, for example, about 3 parts gum arabic (from the acacia tree and also known as

arabic gum or acacia gum) are mixed with about 1 part glycerin and about 1/6 part water in a

container for 15 minutes resulting in an adhesive to hold the nicotine salt to the onsert. A thin coat

of the binder, stabilizer or adhesive may be applied to uncut sheets after formation (e.g., hemp

paper) on the same and/or opposite side of the self-adhesive side for sticking the onsert onto the

cigarette. If the nicotine salt is applied to the self-adhesive side, none is applied to where the

adhesive is present such as around the perimeter 7 of the onsert, as shown in FIG. 1A. The

nicotine salt covering in powder or flake form is then applied at the desired rate to one or both

sides of the sheets shortly following the application of the binder, stabilizer or adhesive causing

the nicotine salt coating to stick to the sheets. After drying, subsequent coats of the binder,

stabilizer or adhesive and nicotine salt may be applied to the sheets. The binder, stabilizer or

adhesive may be applied as the final coat thereby better trapping the nicotine on the sheets. The

uncut sheets are then cut into multiple onserts at the desired shape and sizes. Onserts configured

to wrap around the entire circumference of the smoking product may be any size such as those

sizes to completely wrap around, for example, cigars or 100 mm cigarettes. Therefore, the size and type of the smoking product in part dictates the size and configuration of the onsert. The amount of nicotine salt (and/or other compounds) applied to the onsert is also based on the type and characteristics of the smoking product (e.g., ventilation level) and on the level of increase of nicotine yield desired (or the level of increase in yield of any other compounds desired). The increase in nicotine yield (or yield of other compounds) is therefore a function of the type and characteristics of the smoking product and the type and size of the onserts being utilized, including the level compounds included in or on the onsert.

[0152] In other exemplary embodiments, a nicotine salt along with other compounds may

be infused between two onsert sheets or among more than two onsert sheets, with or without the

onsert sheets being covered with nicotine salts on the outside portions of each sheet. In this

fabrication arrangement, the gum arabic formulation above (or any other binder, stabilizer or

adhesive formulation being utilized) may be used to seal the edges of the two or more sheets or the

onserts after the sheets are subsequently cut into multiple onserts for packaging. Self-stick onserts

are preferably utilized in this embodiment for the consumer to peel and stick the nicotine onsert

onto a cigarette or other smoking product. By not covering and adhering the onsert sheets with

nicotine, the nicotine in this fabrication arrangement essentially remains in an encasement between

the sheets for a neater consumer application.

[0153] The nicotine onserts disclosed herein (and the precision rods and precision pods

disclosed and described below) may also include other alkaloids, flavors, cannabinoids, terpenes

and/or other additives or constituents. For example, any of the exemplary embodiments herein

may be carried out with anatabine or anabasine instead of nicotine or in combination with nicotine,

including the exemplary onsert embodiments of FIGS. 1A-IF, whether in nicotine salt formats,

nicotine co-crystal formats, or nicotine salt co-crystal formats. Both anatabine and anabasine are

alkaloids similar to nicotine and instead of producing salts of nicotine, salts of anatabine or salts of anabasine may be produced for anatabine-enhanced cigarettes and anabasine-enhanced cigarettes.

Salts of nicotine may be blended with salts of anatabine and/or salts of anabasine, and salts of

anatabine may be blended with salts of anabasine for cigarettes or for marijuana cigarettes with

any level or combination of enhanced nicotine, enhanced anatabine or enhanced anabasine.

Synthetic versions of these alkaloids may also be utilized.

[0154] Each onsert, regardless of which type, may comprise one or more compounds

selected from the group consisting of nicotine, anatabine, anabasine, flavor, A9

myrcene, caryophyllene, pinene, limonene and humulene. Each onsert may comprise at least the

following amounts of each of the aforementioned compounds: 0.10mg,0.20mg,0.30mg,0.40

mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5

mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11

mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24

mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37

mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50

mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63

mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76

mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89

mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg,

120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, 250 mg, et cetera.

For example, an onsert may contain at least 30 mg of nicotine and not any other component listed

above or may contain, for example, at least 10 mg nicotine, at least 10 mg THCA and at least 10 mg CBCA. An onsert may contain more than one alkaloid, compound or additive. In some exemplary embodiments, onserts such as the type of onsert shown in FIG. 1A may be utilized specifically to directly roll cannabis and/or tobacco including MYO or RYO finished tobacco blends into the onsert. In other exemplary embodiments, onserts may comprise any of the aforementioned amounts (i.e., at least 0.10 mg through at least 250 mg) of conventional tobacco, low nicotine tobacco, conventional cannabis (i.e., marijuana) and/or very low THC cannabis, with or without any of the aforementioned one or more compounds.

[0155] In some exemplary embodiments, the self-stick or moisture-activated adhesive is

on the same side of the cellulosic wrapper as the one or more compounds, and in other

embodiments, the adhesive is on the opposite side of the cellulosic wrapper as the one or more

compounds. In still other embodiments, the one or more compounds are within an encasement

and the encasement may be in the middle of the cellulosic wrapper. An onsert may comprise of

any compound or combination of compounds, whether the compounds are in an encasement

within a cellulosic wrapper or adhered to a cellulosic wrapper, including any of the above amounts

(i.e., at least 0.10 mg through at least 250 mg) of nicotine, anatabine or anabasine not extracted

from a Nicotianaplant; that is synthesized nicotine, anatabine or anabasine, and the onsert may

comprise any of the above amounts (i.e., at least 0.10 mg through at least 250 mg) of one or more

of the following cannabinoid acids: THCA, CBDA, CBCA, CBGA, CBGVA, THCVA, CBDVA

and CBCVA that are synthesized, that is, produced outside a Cannabisplant.

[0156] Any strain, variety or blend of cannabis may be enhanced by onserts comprising

one or more cannabinoids for rolling a marijuana strain, variety or blend of cannabis flowers or

other plant parts into the onsert such as the type of onsert shown in FIG. 1A. This is sometimes

required since the cannabinoid profile of the dozens of cannabinoids, including the THCA/CBDA

ratio and content, of flowers of the same marijuana strain can vary significantly from one harvest to another, especially when grown in different growing conditions. These onserts may be nicotine free and tobacco free and are an ideal way to modify the cannabinoid profile of the smoke from any strain, variety or blend of cannabis flowers without requiring an additional strain, variety or blend of cannabis flowers. For example, an onsert may comprise THCA, CBDA, CBGA, and/or any other cannabinoid for cannabis users to either fortify their marijuana cigarettes, blunts, or spliffs or to change the cannabinoid profile of the smoke from any strain, variety or blend of cannabis in order to achieve desired effects.

[0157] In addition to the advantage of any compounds being present on the onsert so that

they are included as a new compound not present in the smoking product or provided as an adjunct

to a compound already present in the smoking product, the design of the onsert shown in FIG. 1A

for directly rolling cannabis and/or tobacco into the onsert has other important advantages over

typical RYO cigarettes or RYO marijuana cigarettes. For example, the onsert is more convenient

and less messy especially when implemented as a self-stick onsert, the onsert provides a seal on all

four sides thereby reducing smoke dilution from unwanted air flow caused by loose rolls. Also,

less tobacco or cannabis can be used, especially if the nicotine and/or cannabinoids included with

the onserts are pure or semi-pure (e.g., > 90 pure). In fact, as compared to a cigarette (with or

without added cannabinoids), which averages about 650 mg of tobacco (plus the weight of any

cannabinoids), an onsert for a smoking product comprising, for example, 20 mg THCA, 10 mg of

a nicotine salt, and 200 mg of plant material (whether it is tobacco, cannabis or a blend of the two)

rolled into the onsert translates into a smoking product with about 69 percent less plant material.

This in turn means that there will be a significant reduction in smoke inhalation including 'tar'

inhalation from the onsert, as compared to an average cigarette (with or without added

cannabinoids). There will also be a significant reduction in carcinogenic TSNAs since less

tobacco is used in conjunction with the onsert.

[0158] In some exemplary embodiments, synthetic nicotine may be the only active

ingredient included with an onsert (or with a precision rod) so that cannabis users can enjoy the

effects of nicotine (not extracted from tobacco) with their cannabis. Whether synthetic nicotine or

nicotine extracted from a Nicotianaplant is utilized, onserts (or a precision rod comprising

nicotine) that provide nicotine to the mainstream smoke from marijuana cigarettes (e.g., cannabis

rolled with an onsert such as the onsert in FIGS. 1A-C) effectively eliminates the need to include

any tobacco and the result is a less harmful smoking product, as compared to a spliff, since less

plant material needs to be combusted because tobacco is not needed for its nicotine content,

thereby reducing smoke inhalation and eliminating tobacco carcinogens such as TSNAs.

[0159] It will be appreciated that onserts herein may be any shape or form and any self

stick adhesive (or other adhesives such as those that require moisture to activate) on the onsert

may be continuous or in any pattern. For example, the self-stick adhesive is on all four sides 7

surrounding the nicotine salt 8 of the onsert 1 in FIG. 1A. In modified exemplary embodiments,

one, two or three sides of the onsert may comprise the self-stick adhesive (or other adhesives such

as those that require moisture to activate), or one or more additional strips of adhesive may be

added such as through either axis of symmetry of the onsert. Any percentage of either side of an

onsert may be comprised of an adhesive. Onserts, including the onserts of FIGS. lA-iF, may also

contain filters, which would be attached to one end of the onsert. Bum accelerators or ash

conditioners may be included in or on the onserts. It will also be appreciated that onserts may

actually be used as more of an 'insert' in that they may be stuck to the inside of roll-your-own

(RYO) rolling papers or placed inside of empty make-your-own (MYO) cigarette tubes (or mixed

into the loose tobacco or cannabis for RYO or MYO) before the smoking product is rolled or

made by a smoker (i.e., the onsert is hidden after the RYO smoking product is rolled or the after

the MYO smoking product is made). When used in this fashion, the transfer rate of one or more alkaloids, flavors, cannabinoids, terpenes, and/or other additives into the mainstream smoke of the smoking product is typically higher, as compared to placing an identical onsert on the outside of the smoking product (e.g., placed on a filled MYO cigarette). Of course, for onserts made specifically to be placed on the inside of RYO or MYO smoking products, the self-stick adhesive feature is optional as is any other adhesive that is activated when moistened (e.g., licked) in order to stick to the smoking product. These exemplary embodiments of onserts which may be inserted into a smoking product may not comprise of any adhesives to stick to smoking products.

[0160] FIGS. ID-IF show exemplary configurations of self-adhesive (self-stick) onserts

comprising of cellulosic wrappers which differ in shape from the onsert in FIGS. 1A-iC. As

shown in FIG. ID, the first type of onsert includes a circular window 11 with either two wings 12

or four wings 13 and comprises one or more alkaloids, flavors, cannabinoids, terpenes, and/or

other additives. Each of these onserts are positioned around the circular tip of a smoking product

such as a cigarette, cigar or marijuana cigarette and the wings, which may be any length, are

extended and stuck to the smoking product. Another type are elongated onserts 14 shown in FIG.

1E, which may be positioned, for example, both in parallel along the side of a smoking product

such as a cigar or one or both onserts may be wrapped around the smoking product. The

alkaloids, flavors, cannabinoids, terpenes, and/or other additives of the onserts in the exemplary

embodiments of FIGS. ID-1E, may be encased between a closed pocket of opposing sheets of the

onsert, adhered to either side of the onserts by an adhesive, or infused within the onsert during the

production process of the onsert.

[0161] Another type of onsert configuration is a web pattern onsert shown in exemplary

embodiment of FIG. IF, which is similar to the onsert of FIGS. 1A-iC as it pertains to function

since the onsert may be wrapped around a smoking product such as a cigarette, be used in

conjunction with tobacco and/or cannabis to roll (RYO) a cigarette, marijuana cigarette, blunt or spliff, or simply may be rolled and smoked by itself without any interdependent smoking product.

On the self-stick adhesive side of the onsert 15, there may be one, two, three or four sides of

adhesive around the webbing 16, which comprises the alkaloids, flavors, cannabinoids, terpenes

and/or other additives encased in the webbing that is in front of a back sheet 17. These types of

non-continuous (i.e., webbed) onserts may be any shape or size and may cover any portion of a

smoking product.

[0162] In some exemplary embodiments, the onserts may be included inside of a pack of

factory-made cigarettes or may be bundled together (e.g., 20) and adhered to the outside of a

cigarette pack or rolling paper box as a package onsert. An advantage of packaging the nicotine

onserts within or on factory-made cigarette packs is the convenience such packaging presents

when an adjunct amount of nicotine may be required by some smokers when using very low

nicotine cigarettes to exclusively switch from smoking conventional cigarettes to e-cigarettes or a

tobacco heating device, as outlined in U.S. Patent Application No. 16/047,948. These nicotine

enhanced cigarettes (e.g., nicotine onserts plus very low nicotine cigarettes) assist the smoker to

exclusively use the very low nicotine cigarettes during the treatment period, as directed by the

protocol, so that the smoker does not cheat and smoke conventional cigarettes during the treatment

period. The adjunct amount of nicotine provided by the nicotine onsert(s) may increase the

nicotine smoke yield, for example, from 0.04 mgto 0.10 mg per cigarette. Although the nicotine

smoke yield more than doubled in this example, the 0.10 mg nicotine yield is still dramatically

lower than the typical 1 mg nicotine yield of conventional cigarettes. Nicotine onserts providing

an adjunct amount of nicotine to factory-make conventional cigarettes afford great flexibility to

smokers customizing their cigarettes in the interest of smoking less of each cigarette. A nicotine

enhanced cigarette in which an onsert comprising nicotine has been attached to a conventional

cigarette results in a reduction of the tar-to-nicotine ratio.

[0163] EXAMPLE2

[0164] PRECISION RODS FOR SMOKING PRODCUTS

[0165] Precision rods comprising an exact amount of one or more flavors, alkaloids,

cannabinoids, terpenes and/or other additives, or constituents are fabricated to be inserted into a

smoking product to remain in the smoking product during the combustion of the smoking product

with the purpose of transferring one or more flavors, alkaloids, cannabinoids, terpenes and/or other

additives, or constituents into the mainstream smoke generated by the smoking product. Precision

rods provide precisely quantified formulations of compounds of interest as either an adjunct to the

intrinsic content of one or more compounds already included in smoking product or as one or

more new compounds. There are three types of precision rods. The first type of precision rod is

comprised of materials that combust and burn down as the smoking product bums down such as a

cigar. Suitable cellulosic materials of these types of precision rods are those which have an

ignition temperature of equal to or less than 350 degrees Celsius. Ignition temperature is the least

temperature at which a substance starts combustion. These materials must also be sufficiently

rigid (or by design can be made to be sufficiently rigid) to be inserted into, for example, the

tobacco end of a filtered cigarette and can be burned with the smoking product without presenting

unacceptable levels of toxins into the mainstream smoke of the smoking product. Examples of

suitable materials for cellulosic precision rods include but are not limited to fiberboard, paper,

paperboard or other cellulosic or woody materials, which are preferably produced from hemp or

reconstituted hemp, tobacco or reconstituted tobacco, or other plants in which the flavor, alkaloid,

cannabinoid, terpene, and/or other additives, or constituents of interest, are adhered to or housed

(contained) within a chamber or hollow space in the precision rod. In some exemplary

embodiments of precision rods (and precision pods), the compounds and constituents are included

in reconstituted hemp, reconstituted tobacco, or other plant material that has been reconstituted, which is then included in the space or inner chamber of precision rods (or in the compartment of precision pods).

[0166] As shown in the exemplary embodiment of FIG. 2A, a cellulosic precision rod 18 is

comprised of six layers of multi-ply paperboard 19 in which each layer of the multi-ply

paperboard is covered, for example, by a nicotine salt (and/or any other compounds), and then all

the layers are bound together by a binder or adhesive that is designated, Generally Recognized As

Safe (GRAS), by the U.S. Food and Drug Administration (FDA). A cellulosic precision rod may

comprise of one or more layers of a cellulosic material. One or more layers of the cellulosic

precision rod are bound together during the production process of the layer(s) so that no additional

binder or adhesive is necessary. The entire assembled precision rod may be covered with a thin

GRAS coating or film so that the compounds are sealed onto the precision rod and they don't get

on the user's hands. In other exemplary embodiments, one or two thick layers may be utilized for

a cellulosic precision rod, and these types of cellulosic precision rods that utilize thick layers may

also comprise at least one chamber or hollow space to house greater amounts of a nicotine salt

and/or other compounds.

[0167] The second type of precision rod in other exemplary embodiments is comprised of

materials that do not combust or bum down as the smoking product bums down and have an

ignition temperature of more than 350 degrees Celsius. These precision rods comprise of one or

more flavors, alkaloids, cannabinoids, terpenes, and/or other additives, or constituents of interest,

and are fabricated to be inserted into either end of the smoking product to remain in the smoking

product during the combustion of the smoking product with the purpose of transferring these

compounds or constituents to the mainstream smoke generated by the smoking product. Examples

of suitable flame-resistant, rigid materials include but are not limited to fused quartz or silica,

ceramics such as earthenware or porcelain, or non-toxic ultra-high-temperature ceramics. For embodiments in which only a few puffs will be taken so that the precision rod cannot escape the smoking product and burn the smoker, non-toxic metal or metal alloys such as titanium or food grade stainless steel may be employed.

[0168] As shown in FIG. 2B, there are three exemplary embodiments of cylindrical

precision rods of various sizes that do not combust or burn down as the smoking product bums

down, including the first precision rod 20. These three precision rods comprise of an inner

chamber to house compounds and/or plant materials. The inner chamber 21 begins at the opening

at the end of the first precision rod 20, has a diameter of about 1.25 mm and a length of about 13

mm. The first precision rod 20 comprises about 15 mg of a salt of nicotine in powder form

(density of about 900 kg/m3) within the inner chamber 21. One end of each precision rod may be

pointed for easy insertion into any smoking product such as a factory-made cigarette. A precision

rod comprises of one or more holes or vents which also lead to the inner chamber 21. There are

various holes 22 across each precision rod in FIG. 2B (only a portion of them are labeled). The

number of holes or vents depends on the type of smoking product, the type of compounds or

constituents included in the precision rod and their boiling points, the amount of each compound

in the precision rod, and the total weight of contents in the precision rod. The holes or vents and

the end opening of a precision rod, all of which lead to the inner chamber, facilitate the flow of air,

heat and smoke entering and exiting the precision rod. The end opening and holes or vents of a

precision rod may be sealed with arabic gum or any GRAS material which easily melts upon being

heated. The holes or vents may be kept unsealed, in which case the particle sizes of the

compounds are made larger than the holes or vents, and during production the compounds are

inserted through the end opening. The end opening may be covered with a peel off tab which the

consumer removes before inserting the precision rod into the smoking product. The entire

precision rod may be sealed with plastic for the consumer to peel off before use.

[0169] As shown in FIG. 2C, the precision rod 20 of FIG. 2B has been inserted into a

cigarette 23. Upon the nicotine-enhanced cigarette being smoked, which now includes the

precision rod, the holes allow air, heat and smoke to enter the precision rod as nicotine (and/or

other compounds in other exemplary embodiments) contained within the rod vaporizes and

permeate into the mainstream smoke. Once the nicotine-enhanced cigarette 23 (or other smoking

product in other embodiments) is partially smoked down, the cigarette may be snuffed out or the

precision rod may be released with the ashes of the cigarette. The smoker will likely be satisfied

with only a portion of the nicotine-enhanced cigarette being smoked (e.g., 40%) due to the adjunct

nicotine in the precision rod of 15 mg. The smoker may dispose of the partially smoked cigarette

or may save the unsmoked portion for later when another precision rod can be inserted into the

remaining portion of the cigarette. In either case, the smoker inhales approximately half of the

smoke, which includes 'tar,' as compared to smoking the same cigarette without the precision rod.

The amount of nicotine inhaled is about the same as if the same cigarette without the precision rod

was smoked since the average cigarette contains about 15 mg of nicotine; the same amount in the

precision rod. In addition to reducing harm, the smoker also has the option of benefitting

economically by purchasing fewer cigarettes if the other half of each cigarette is saved.

[0170] The first two types of precision rods may also be inserted into the mouth end of a

smoking product which may be the filter of a smoking product such as a filtered cigarette or

filtered cigar. For example, a precision rod comprising 8 mg of menthol crystals may be inserted

into the mouth end (e.g., filter end) of a cigarette. The holes or vents of precision rods allow the

essence of the menthol crystals to enter the mainstream smoke and deliver menthol sensations and

satisfaction to the smoker. Since smoking very low nicotine cigarettes do not result in any

significant throat impact, as compared to smoking conventional cigarettes, menthol or other

flavoring(s) in precision rods increase the acceptability of very low nicotine cigarettes, which facilitate smokers quitting tobacco products altogether and facilitate smokers switching to e cigarettes or a tobacco heating device (as disclosed in U.S. Patent Application No. 16/047,948).

E-cigarettes and tobacco heating devices are both generally accepted to be much less harmful than

smoking cigarettes. Vaping e-cigarettes, for example, is believed to be approximately 90 percent

less harmful than smoking cigarettes.

[0171] The third type of precision rod is used in conjunction with a flavor injection

system. This type of precision rod also comprises one or more flavors, alkaloids, cannabinoids,

terpenes and/or other additives, or constituents, and is inserted into a smoking product such as one

or more cigarettes or cigars. The compounds in the inner chamber are injected into the smoking

product and the precision rod is then removed from the smoking product. As shown in FIG. 2D,

the flavor injection system comprises a precision rod 24 and a plunger mechanism 25. The

plunger mechanism 25 includes a plunger which is not shown in FIG. 2D. The precision rod 24

includes a fastening mechanism at one end, which in this exemplary embodiment is thread 26 so

that the precision rod can be screwed into the thread 27 of the plunger mechanism 25. The

precision rod includes an end hole 28, which is the beginning of the inner chamber that houses the

compounds or constituents before they are injected into a smoking product. Once the precision

rod 24 is inserted into a smoking product and the precision rod and the plunger mechanism 25 are

then connected (or the order may be reversed), the plunger, which is connected to the plunger

mechanism, is pushed into the plunger mechanism 25 and the contents in the precision rod are

emptied into the smoking product. Upon the smoking product being ignited, the mainstream

smoke of the smoking product will be infused with the one or more compounds (and any

constituents) now included in the smoking product.

[0172] In some exemplary embodiments, the flavor injection system and the precision rod

are one piece and do not have to be connected. The flavors, alkaloids, cannabinoids, terpenes and/or other additives or constituents may be loaded directly into the plunger mechanism or precision rod by a variety of ways. For example, the plunger may be removed from the plunger mechanism, and the compounds and constituents are emptied or placed into the plunger mechanism which pass through to the precision rod. The plunger is then reattached. The flavor injection system is now ready to infuse a smoking product with the contents in the flavor injection system. Any of the foregoing exemplary embodiments of flavor injection systems may be automated with any type of machine in which one or more smoking products, i.e., one or more cigarettes, for example, are infused with compounds at once or in succession.

[0173] Each precision rod, regardless of which of the three types, may comprise one or

more compounds selected from the group consisting of nicotine, anatabine, anabasine, flavor, A9

myrcene, caryophyllene, pinene, limonene and humulene. Each of the three types of precision

rods may comprise at least the following amounts of one or more of the aforementioned

compounds: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg,

1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4

mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg,

18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg,

31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg,

44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg,

57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg,

70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg,

83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg,

96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170

mg, 180 mg, 190 mg, 200 mg, et cetera. For example, a precision rod may contain at least 30 mg

of anatabine and not any other component listed above or may contain at least 10 mg nicotine, at

least 10 mg THCA and at least 10 mg CBGVA. A precision rod may contain more than one

alkaloid, compound or additive. In some exemplary embodiments, each of the three types of

precision rods may further comprise any of the aforementioned amounts, i.e., at least 0.10 mg

through at least 200 mg, of conventional tobacco, low nicotine tobacco, conventional cannabis

(i.e., marijuana) and/or very low THC cannabis, with or without any of the aforementioned one or

more compounds.

[0174] In other exemplary embodiments, a precision rod may comprise any of the

aforementioned amounts (i.e., at least 0.10 mg through at least 200 mg) of nicotine, anatabine or

anabasine not extracted from a Nicotianaplant; that is synthesized nicotine, anatabine or

anabasine, and they may comprise any of the aforementioned amounts (i.e., at least 0.10 mg

through at least 200 mg) of one or more of the following cannabinoid acids: THCA, CBDA,

CBCA, CBGA, CBGVA, THCVA, CBDVA and CBCVA that are synthesized, that is, produced

outside a Cannabisplant. For example, a precision rod may contain 30 mg of THCA and not any

other component listed above or may contain 10 mg nicotine, 10 mg THCA and 10 mg CBCA. A

precision rod may also contain more than one alkaloid, flavor or other additive.

[0175] Precision rods may be any shape or length and depend in part on the amount of

flavor, alkaloid, cannabinoid and/or other additive desired to be transferred to the mainstream

smoke. Elongated shapes with a pointed end are generally preferred for easier insertion into

smoking products such as cigars. Precision rods may be fabricated including, for example, CBDA

crystalline (e.g., 20 mg), which is 'pure' CBD and resembles sugar. The crystalline CBDA or any

other crystalline cannabinoid may be provided by any method known in the art such as supercritical C02 extraction processes followed by various pass throughs of purification by ethanolic precipitation, for example, in order to remove remaining impurities until the CBDA is approximately 99 percent pure. The preparation is then ground to a size no smaller than about 100 microns or so and may be blended with other compounds or constituents and it's then incorporated into the precision rod. These precision rods may be utilized by smokers using very low nicotine cigarettes to transition to e-cigarettes or a tobacco heating product, or for quitting tobacco and nicotine products altogether; the methods and products of which are disclosed in U.S. Patent

Application No. 16/047,948. Precision rods may contain any combination of flavors, alkaloids,

cannabinoids and/or other additives, or constituents. For example, and for recreational purposes, a

precision rod may contain 10 mg nicotine, 10 mg of CBDA crystalline, 20 mg of THCA

crystalline, and 10 mg of menthol crystals.

[0176] Any onsert, insert, or precision rod disclosed herein may be applied to any type of

cigarette, including make-your-own (MYO) cigarettes in which the adjunct nicotine source may be

positioned on the inside of the empty cigarette tube before filling the tube with tobacco, and roll

your-own (RYO) cigarettes in which the adjunct nicotine source may be positioned on the inside

of a flat rolling paper before the tobacco is rolled. Otherwise, the onsert, insert, or precision rod

may be used with MYO and RYO cigarettes (that are already filled with tobacco) similarly to how

they are used with factory-made cigarettes. Any onsert, insert, or precision rod disclosed herein

may be applied to any other type of smoking product such as cigars or marijuana smoking

products (e.g., joints), whether these smoking products are factory made or hand made by

consumers. For example, after removing some tobacco from the tobacco end of a factory-made

cigarette, an onsert or precision rod may be placed within that tobacco end, and a portion of the

removed tobacco may be put back into the cigarette before lighting the cigarette.

[0177] EXAMPLE3

[0178] PRECISION PODS FOR VAPORIZERS AND SMOKING PRODUCTS

[0179] Tobacco and cannabis users lack the capability, including product devices and

formulations, to conveniently vape or smoke a precisely quantified amount of solid or semi solid

form of nicotine and cannabinoids such as one or more crystalline cannabinoid acids in

conjunction with one or more crystalline alkaloids (with or without terpenes, flavors and other

additives, or plant constituents). Ready-to-vape or ready-to-smoke precision pods are configured

for use with vaporizers, pipes, bongs, bowls and the like for the purpose of conveniently vaping or

smoking an exact pre-measured and blended amount of one or more compounds, which the

precision pods comprise, such as cannabinoids and alkaloids with both the cannabinoid and

alkaloid in a solid or semi-solid form. In some exemplary embodiments, precise formulations of

blended crystalline cannabinoid acid(s) and crystalline salt(s) of nicotine are provided in precision

pods. Precision pods are advantageous on many fronts, especially for those who simultaneously

smoke or vape tobacco and cannabis or for those who may not necessarily smoke or vape tobacco

and cannabis simultaneously, but are dual users of tobacco and cannabis.

[0180] From a harm reduction standpoint, vaping crystalline cannabinoid acid(s) and a

crystalline salt of nicotine in ready-to-vape precision pods is less harmful than vaping marijuana

buds and tobacco together or vaping an e-cigarette and marijuana buds separately. In the

exemplary precision pod embodiments for a vaporizer, less vapor is required to inhale for a given

dose of nicotine or a cannabinoid in a solid or semi solid format, as compared to vaping tobacco

and cannabis together or separately since the active ingredients are much more concentrated in

solid or semi-solid formats (e.g., crystalline compounds) included in precision pods. For example,

e-liquids of e-cigarettes contain less than 6 percent nicotine (more than about 95 percent non

active ingredients), and e-liquids of medical vape pens typically contain concentrates of less than

50% cannabinoids which are not crystalline. In contrast, precision pods either do not include any carriers such as propylene glycol or glycerin, or they contain just enough to mimic the moisture levels found in tobacco products or cannabis buds (about 10 to about 17 percent). The result is that ready-to-vape crystalline blends of compounds in precision pods are less harmful to the lungs since the active ingredients are much more concentrated resulting in less vapor required to be inhaled for a given dose of nicotine or a given dose of a cannabinoid.

[0181] Propylene glycol and vegetable glycerin are designated, Generally Recognized As

Safe (GRAS) by the FDA for ingestion as food additives, but not for inhalation; however, even

though using e-cigarettes is widely believed to be less harmful than smoking cigarettes (since

smoke is not produced and inhaled), there is insufficient long-term data for inhaling large amounts

of propylene glycol or vegetable glycerin from e-cigarettes. Vaping a highly pure crystalline

nicotine salt with blends of crystalline cannabinoid acid formulations, for example, without any

propylene glycol or glycerin or with low amounts of these carriers (e.g., 5-15 percent by weight of

the total blend in the precision pod), results in less mainstream vapor which is less harmful to the

lungs, as compared to vaping e-liquids containing a very large proportion of propylene glycol

and/or glycerin (e.g., 90%) or vaping whole cannabis flowers or vaping less concentrated forms of

cannabinoids.

[0182] Likewise, and for those who prefer to smoke and not vape, ready-to-smoke

precision pods allow smokers to inhale smoke from highly pure forms of cannabinoids and

nicotine. Ready-to-smoke precision pods comprising blends of solid or semi solid crystalline

cannabinoid acids (e.g., CBDA and/or THCA) and a salt of nicotine (with or without terpenes,

flavors, and/or other additives) contained in the compartment of a precision pod and smoked in a

pipe or bowl result in a significant reduction of smoke generated and inhaled for a given level of a

cannabinoid and for a given level of nicotine, as compared to smoking blunts, spliffs, or factory

made cigarettes comprising cannabinoids. Since tobacco-related diseases are dose dependent on the cumulative level of tobacco smoke, reducing smoke intake reduces harm. Indeed, the more non-tobacco material (e.g., cannabinoids) in the filler of a conventional, factory-made cigarette, the more likely smokers are to compensate for the reduced levels of nicotine including taking larger puffs, more puffs per cigarette, or more cigarettes per day. A conventional cigarette comprised of any significant portion of cannabinoids in the filler may in fact increase harm to the smoker since a portion of the tobacco, and therefore nicotine, is being reduced. It would be impossible to reduce nicotine levels of a conventional cigarette to levels of a very low nicotine cigarette, in which compensation does not occur, by replacing 80 to 90 percent of the tobacco with cannabinoids since at that point, the cigarette would not function.

[0183] Ready-to-smoke precision pods allow the smoker to achieve the same nicotine

satisfaction with significantly less smoke, and importantly, there are no carcinogenic tobacco

specific nitrosamines (TSNAs) and other tobacco-related compounds that result from smoking

blunts, spliffs, or factory-made cigarettes comprising cannabinoids. If a form of synthetic nicotine

is utilized, the precision pod is 100 percent tobacco free. In addition to being less harmful by

reducing smoke exposure, as compared to smoking blunts, spliffs or other smoking products such

as factory-made cigarettes comprising cannabinoids, ready-to-smoke precision pods comprised of

crystalline THCA/THC eliminate the guesswork as to the type and magnitude of intoxicating

effects for a given level and ratio of blended compounds since the formulations are consistent due

to their purity levels. Flavors, terpenes and other additives, or constituents such as plant

constituents (e.g., minimal amounts of very low THC cannabis) may also be incorporated into

precision pod formulations at minimal levels.

[0184] As shown in the exemplary embodiment of FIG. 3A, a precision pod 29 in the

shape of a hexagonal prism comprises a blend of a nicotine salt (which may comprise any single

or combination of the foregoing listed nicotine salts), crystalline THCA, crystalline CBDA and menthol crystals within the compartment of the precision pod 29. Appropriate levels of ameliorators are added to the blend to smooth out the smoke and remove harshness, and propylene glycol and/or glycerin may also be included so that the blend has the appropriate moisture level.

Between about 12 and about 14 percent is the ideal moisture level for tobacco filler and cannabis

flowers. The moisture level of formulations of ready-to-smoke precision pods depends on many

factors including the boiling point temperature and amount of each compound (and any plant

constituents) in the formulation, and the boiling point and total amount of the blend. Different

formulations may have different moisture levels. These compounds have been blended together

and are in a solid or semi-solid form. Precision pods may comprise two or more vents. The

precision pod 29 in FIG. 3A comprises many vents (only one is labeled). A precision pod's vents

are for ventilation of inbound air into the compartment and outbound smoke or vapor out of the

compartment for inhalation.

[0185] Each ready-to-vape or ready-to-smoke precision pod may comprise two or more

compounds selected from the group consisting of nicotine, anatabine, anabasine, flavor, A9

(CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA),

tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic

acid (CBCVA), myrcene, caryophyllene, pinene, limonene and/or humulene. Each ready-to-vape

or ready-to-smoke precision pod may comprise at least the following amounts of each of the

aforementioned compounds:0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg,

0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9

mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15

mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28

mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg 190 mg, 200 mg, 250 mg, 300 mg, et cetera. For example, a precision pod may comprise at least 10 mg CBDA, at least 5 mg nicotine and at least 5 mg menthol. As a smoking cessation treatment or to assist transitioning smokers to a tobacco heating product or e-cigarettes, as disclosed in U.S. Patent Application No. 16/047,948, any of the aforementioned amounts (i.e., at least 0.10 mg to at least 300 mg) of low nicotine tobacco and/or very low THC cannabis may be included in precision pods along with at least one of the aforementioned compounds for ready-to-vape or ready-to-smoke precision pods.

[0186] In some exemplary embodiments, a precision pod may comprise any of the

aforementioned amounts (i.e., at least 0.10 mg through at least 300 mg) of nicotine, anatabine or

anabasine, and a precision pod may comprise any of the aforementioned amounts (i.e., at least

0.10 mg through at least 300 mg) of two or more of the following cannabinoid acids: THCA,

CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA and CBGVA that are synthesized, that is,

produced outside a Cannabisplant. In other exemplary embodiments, any of the aforementioned

amounts (i.e., at least 0.10 mg through at least 300 mg) of conventional tobacco, low nicotine

tobacco, conventional cannabis (i.e., marijuana) and/or very low THC cannabis may be included

in ready-to-vape or ready-to-smoke precision pods along with at least one of the following

compounds: nicotine, anatabine, anabasine, flavor, THCA, CBDA, CBCA, CBGA, THCVA,

CBDVA, CBCVA and CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene.

[0187] In some exemplary embodiments, ready-to-vape or ready-to-smoke precision pods

each comprises at least 5 mg of tobacco (conventional or very low nicotine) and/or at least 5 mg of

cannabis (marijuana or very low THC cannabis) and at least 2 mg of one or more of the

aforementioned compounds such as THCVA (Tetrahydrocanabivarinic acid). For ready-to-vape

or ready-to-smoke precision pods (and onserts or precision rods) herein, low nicotine tobacco

means tobacco with a nicotine content equal to or less than 3 mg/g, and very low THC cannabis

means cannabis with a collective THCA/THC content equal to or less than 3 mg/g.

[0188] Precision pods may be any size or shape including those designed for a specific

model of vaporizer, pipe, bowl or bong. The precision pod is configured for the oven chamber of

a vaporizer or the tobacco or cannabis chamber of a pipe, bowl or bong. Examples of suitable

materials of rigid precision pods include but are not limited to fused quartz or silica, ceramics

including non-toxic ultra-high-temperature ceramics, and any metal and preferably a non-toxic

metal or metal alloy such as titanium and food-grade stainless steel; however, any material may be

utilized for precision pods whether configured for a vaporizer or a pipe, bowl or bong. The

material utilized for a vaporizer may depend on the capabilities or temperature ranges of a

vaporizer since different materials including metals heat up at different rates. In some exemplary

embodiments, a precision pod is configured for a specific model of vaporizer already on the

market or a precision pod and a vaporizer are configured for one another during the product

development phase of a newly designed vaporizer. In other exemplary embodiments, generic

precision pods are configured for multiple types of smoking products or multiple types of

vaporizers.

[0189] For precision pods configured for smoking products, materials that do not result in

combustion or partial combustion are preferred; however, those materials that do result in

combustion may also be utilized and comprised of paper-like materials like reconstituted tobacco or other cellulosic materials like those produced from hemp. These types of less rigid precision pods are useful for low doses of compounds. Likewise, for precision pods configured for vaporizers, it is preferred that only the contents in the compartment of the precision pod should be transferred to the mainstream vapor, not compounds or constituents of the precision pod itself.

One of the main advantages of disposable ready-to-smoke or ready-to-vape precision pods,

whether rigid or not rigid, is the convenience of the precise blends of desired compounds in exact

ratios; however in other exemplary embodiments, precision pods may be reusable in which case

there may be an access panel that opens and closes with a fastener to provide access for removing

spent material and adding fresh compounds. There may be legs at the bottom of a precision pod

so the air vents at the bottom of the oven chamber of a vaporizer or the draught hole in the

chamber in bowl, pipe or bong is not blocked by the floor of the precision pod. In some

exemplary embodiments of ready-to-vape precision pods, the vents at the bottom of the precision

pod are configured so that they exactly line up with the vents at the bottom of the oven chamber in

a vaporizer. In other exemplary embodiments of ready-to-smoke precision pods, the vent(s) at the

bottom of the precision pod are configured so that they exactly line up with the draught hole of the

chamber in a bowl, pipe or bong. There may be one or more shelves within the compartment of a

precision pod so that the compounds and any constituents are not resting on the floor of the

compartment. This depends on the type of compounds in a precision pod and their boiling points,

the amount of total compounds in the precision pod, whether there is any plant material in the

precision pod and whether a precision pod is specifically made for a specific model of vaporizer or

smoking product.

[0190] As shown in FIG. 3B, a ready-to-smoke precision pod 31 has been placed within a

bowl 32 and may be used with other smoking products such as a pipe or bong. The precision pod

comprises the exact blend of compounds and constituents desired and allows the blend in the compartment of the precision pod to heat, melt and bum evenly. An exact blend of crystalline nicotine, crystalline cannabinoid acids (e.g., THCA and CBDA), menthol and ameliorators, for example, dramatically reduces the amount of smoke inhaled for a given dose of nicotine or a given dose of a cannabinoid, as compared to smoking spliffs, bluffs or factory-made cigarettes that include cannabinoids. This is due to the higher concentration of nicotine in this formulation which causes smokers to compensate (i.e., titrate down). Since some embodiments of ready-to-smoke precision pods do not include cannabis plant material (other than crystalline cannabinoids) or tobacco plant material (other than a crystalline nicotine salt), less smoke and 'tar' are produced and inhaled resulting in a less harmful product. In other exemplary embodiments, precision pods do not comprise of any compounds or constituents extracted or derived from tobacco; however, they include synthetic nicotine which results in tobacco-free and nicotine-free precision pod blends.

[0191] As shown in FIG. 3C, a vaporizer 33 is being held and the oven cover 34 has been

removed from the top of the vaporizer 33. The oven chamber 35 is exposed which is where a

ready-to-vape precision pod may be placed so that a precise amount of two or more compounds or

one or more compounds plus plant material(s) such as cannabis may be vaped. As shown in FIG.

3D, the vaporizer 33 now includes an exemplary embodiment of a ready-to-vape-precision pod 36

which has been placed in the vaporizer's oven chamber 35 where it is resting. The ready-to-vape

precision pod includes an exact formulation of compounds within its compartment and the

precision pod is ready to be used right out of the packaging. Four legs 37 are included on the

precision pod to increase air and vapor flow at the bottom of the precision pod. Upon the

vaporizer's power being turned on, the oven chamber 35 heats up and the contents of the precision

pod, which include at least 5 mg of a crystalline salt of nicotine, at least 5 mg of a crystalline

cannabidiolic acid (CBDA) and ameliorators (such as one or more food grade acids like citric acid to smooth out the vapor and remove harshness). This solid or semi solid formulation does not contain, or transfer to the mainstream vapor, carcinogenic tobacco compounds such as

TSNAs. The ready-to-vape precision pod 36 of FIG. 3D reduces mainstream vapor exposure, as

compared to vaping nicotine containing e-cigarettes, since there is a much greater concentration of

nicotine in the mainstream vapor from the precision pod than from e-liquids so the person vaping

the precision pod compensates accordingly by inhaling less vapor. Likewise, as compared to a

tobacco heating product, there is also a greater concentration of nicotine in the mainstream vapor

from the precision pod so less mainstream vapor needs to be inhaled per 1 mg of nicotine desired,

which is in addition to the advantage that the mainstream vapor of the precision pod does not

contain tobacco carcinogens since the precision pod does not contain tobacco.

[0192] Of course, each of the three products: ready-to-vape precision pods, e-cigarettes,

and tobacco heating products, results in reduced harm, as compared to combustible cigarettes

(with or without added cannabinoids), since nothing is being burned in these three products, there

is no tobacco smoke produced which contains thousands of compounds including dozens of

carcinogens. Another incidental advantage of ready-to-vape-precision pods is that they keep

vaporizers cleaner, as compared to using vaporizers without precision pods, since much of the

remaining spent material is kept in the precision pod and does seep into the vents at the bottom of

the vaporizer's oven chamber, which results in the vaporizer having to be cleaned less frequently.

[0193] In some exemplary embodiments, precision pods include at least 5 mg of low

nicotine tobacco and/or at least 5 mg of very low THC cannabis to assist smokers to quit tobacco

and nicotine products altogether or to switch to a less harmful product such as e-cigarettes,

tobacco heating products or precision pods. See U.S. Patent Application No. 16/047,948 for

methods and various types of products to transition conventional cigarette smokers to less harmful

products. Precision pods that comprise low nicotine tobacco and/or very low THC cannabis may further comprise at least 2 mg of one or more compounds selected from the group consisting of

THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, nicotine, anatabine,

anabasine, myrcene, caryophyllene, pinene, limonene and humulene. For example, a precision

pod comprising at least 50 mg of low nicotine tobacco, at least 50 mg of very low THC cannabis,

and at least 5 mg of CBDA, results in much less smoke exposure than a very low nicotine cigarette

comprising about 600 mg of low nicotine tobacco.

[0194] For formulations of precision pods comprising intoxicating compounds such as

THCA/THC, the type and magnitude of intoxicating effects are predictable from using precision

pods with precisely quantified ready-to-vape or ready-to-smoke blends. For example, blends of

crystalline or near crystalline cannabinoid acids, including A9-tetrahydrocannabinolic acid

(THCA), and a crystalline or near crystalline salt(s) of nicotine (with or without terpenes, flavors,

and/or other additives, or constituents such as plant constituents), are advantageous for dual users

of tobacco and recreational marijuana in terms of exposure to tobacco toxins and convenience.

Ready-to-vape precision pods comprising blends of crystalline or near crystalline cannabinoid

acids, including cannabidiolic acid (CBDA), are advantageous for those who seek relief from pain

and do not desire to inhale the voluminous vapor from vape pens.

[0195] As potency of cannabis concentrates increases, accurate dosing gets more difficult,

and THC effects can be quite variable. Consuming cannabis concentrates such as crystalline

cannabinoids, wax, budder, oil, shatter or sap, is typically accomplished by 'dabbing,' which is

positioning the concentrate on an extremely hot metal object such as a nail that is heated by a

blowtorch or the like, and then the vapor is inhaled. Besides being a dangerous and cumbersome

procedure, it is extremely difficult to obtain the correct amount of concentrate which often leads to

over-consumption and unpleasant effects. The potential safety issues and potential intoxicating

effects of the THC concoction are often unknown, and the actual intoxicating effects may vary widely including from one cannabis-concentrate production batch to another. The THC percentage may not be known or accurate and the 'entourage effect' from the interactions of the various cannabinoids and impurities is difficult to predict. These downsides also occur with concentrates used in vaporizers.

[0196] Benefits of ready-to-smoke and ready-to-vape precision pods comprising one or

more crystalline cannabinoid acids, as compared to dabbing, is that each of the one or more

crystalline cannabinoid acids comprise an exact measured dose of the cannabinoid acid (up to

about to 99% pure) that is ready to smoke or vape without preparation and the precision pod

results in virtually consistent effects for the same person. In some exemplary embodiments of

precision pods, the aforementioned amounts of THCA in milligrams, along with the purity level of

THCA (THCA weight divided by total weight of the compounds and any additives or constituents

in the precision pod), is clearly conveyed on the packaging such as at least about 80%, at least

about 85%, at least about 90%, at least about 93%, at least about 95%, at least about 97%, at least

about 98%, or at least about 99%, so that end users know what effects to expect for a given THCA

content and THCA ratio of the blend. For example, the predictability and consistency of the

effects of a precision pod which includes 5 mg of a salt of nicotine, 50 mg of crystalline THCA

and 20 mg of crystalline CBDA, 17.5 mg of very low THC cannabis (> 0.30% THCA) and 7.5 mg

of a carrier and/or ameliorator is quite beneficial for cannabis users who desire exact, potent and

consistent effects along with concurrent THC/nicotine effects. The THC purity level of this 100

mg precision pod blend is 50% (50 mg/100 mg). The nicotine/THC ratio is 10%, and the

CBD/THC ratio is 40%. As compared to dabbing or vaping other concentrates in which the

cannabinoid ratios and THC levels are either not known or not consistent in every production

batch, ready-to-vape and ready-to-smoke precision pods comprising crystalline cannabinoids are

beneficial for cannabis users who desire consistency with concentrates and do not want to consume too much THC at once. The purity of exactly measured quantities of and ratios of crystalline cannabinoids and forms of crystalline nicotine in combination with precision pods not only results in consistency and reduced harm, the convenience of ready-to-smoke and ready-to vape precision pods is also advantageous over dabbing or using multiple vaping devices.

[0197] The advantages of precision pods readily become apparent for overcoming the

biological constraints on the cannabis plant of intrinsically producing certain minor cannabinoids and

certain ratios of cannabinoids. For example, Tetrahydrocanabivarinic acid (THCVA) which

decarboxylates to Tetrahydrocannabivarin (THCV), is a minor cannabinoid found at trace levels in

most cannabis strains. Sativa strains tend to have higher THCVA content. THCV may be an important

appetite suppressant, therapeutic to reduce panic attacks, and therapeutic for the treatment of

nicotine dependence and possibly other types of dependence. Due to THCV being a minor

cannabinoid, it would be extremely difficult if not impossible to vape or smoke flowers from a

cannabis strain which comprises a THCVA to THCA ratio of at least 3/2 or a THCVA to CBDA

ratio of at least 3/2. In some exemplary embodiments, THCVA is extracted and isolated for use in

precision pods (or onserts or precision rods) comprising a THCVA to THCA ratio of at least 3/2.

In other exemplary embodiments, THCVA is extracted and isolated for use in precision pods (or

onserts or precision rods) comprising a THCVA to CBDA ratio of at least 3/2.

Tetrahydrocanabivarinic acid (THCVA) may be synthesized and utilized in precision pods,

precision rods and onserts.

[0198] It will be appreciated that any exemplary embodiment herein may be automated

with a machine whether it is a purely mechanical machine, table-top machine, or more substantial

electrical type of machine. For example, in some exemplary embodiments, machines may provide

adjunct nicotine sources (e.g., precision rods) to multiple cigarettes at once such as an entire pack

of twenty cigarettes.

[0199] Certain precision rods, onserts, ready-to-vape precision pods and ready-to-smoke

precision pods that comprise crystalline alkaloids may not be considered tobacco products in some

jurisdictions since, among other reasons, they do not contain tobacco other than alkaloids, which

may or may not be derived from tobacco plants. The alkaloids of these articles may be

synthesized so that no ingredients whatsoever are from tobacco plants. Likewise, in some

exemplary embodiments, the cannabinoids used in onserts, precision rods or precision pods may

be synthesized and produced outside of a cannabis plant. In other exemplary embodiments,

synthetic alkaloids and synthetic cannabinoids are blended resulting in formulations used in

onserts, precision rods or precision pods which do not contain any Nicotiana or Cannabisplant

material.

[0200] "Comprises/comprising" and "includes/including" when used in this specification

is taken to specify the presence of stated features, integers, steps or components but does not

preclude the presence or addition of one or more other features, integers, steps, components or

groups thereof. Thus, unless the context clearly requires otherwise, throughout the description and

the claims, the words 'comprise', 'comprising', 'includes', 'including' and the like are to be

construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in

the sense of "including, but not limited to".

Claims

The CLAIMS defining the present invention are as follows:

1. A disposable ready-to-vape precision pod for use with a vaporizer as a smoking

cessation treatment, to assist transitioning smokers to e-cigarettes or a tobacco heating product, or

to quit tobacco and nicotine products altogether, the ready-to-vape precision pod comprising:

acid (CBDA), Cannabichromenenic acid (CBCA), Cannabigerolic acid (CBGA),

and humulene;

at least 5 mg of very low THC cannabis;

at least 5 mg of low nicotine tobacco;

the low nicotine tobacco; and

vaporizer for placement into the oven chamber,

wherein the at least 5 mg very low THC cannabis comprises a collective THCA/THC

content of equal to or less than 3 mg/g, and

less than 3 mg/g.

2. The ready-to-vape precision pod of claim 1, wherein the one or more compounds is

a flavor comprising menthol.

3. The ready-to-vape precision pod of claim 1, wherein the one or more compounds is

Tetrahydrocanabivarinic acid (THCVA).

4. The ready-to-vape precision pod of claim 1, wherein the one or more compounds is

anatabine.

5. The ready-to-vape precision pod of claim 1, wherein the one or more compounds is

Cannabidiolic acid (CBDA).

6. The ready-to-vape precision pod of claim 5, further comprising at least 2 mg of

cytisinicline.

7. A ready-to-vape precision pod for use with a vaporizer configured to generate

vapor from dry herbs or plant extracts to assist transitioning cigarette smokers to e-cigarettes or a

tobacco heating product, for use as a smoking cessation treatment, or to quit tobacco and nicotine

products altogether, the ready-to-vape precision pod comprising:

nicotine, anatabine, anabasine, flavor, THCA/THC, CBDA/CBD, CBCA/CBC, CBGA/CBG,

THCVA/THCV, CBDVA/CBDV, CBCVA/CBCV, CBGVA/CBGV, myrcene, caryophyllene,

pinene, limonene and humulene;

at least 5 mg of very low THC Cannabis;

at least 5 mg of low nicotine tobacco;

the low nicotine tobacco; and one or more vents for ventilation of air and vapor into and out of the compartment, wherein the at least 5 mg very low THC Cannabiscomprises a collective THCA/THC content of equal to or less than 3 mg/g, and wherein the at least 5 mg low nicotine tobacco comprises a nicotine content of equal to or less than 3 mg/g.

8. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

anatabine.

9. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

anabasine.

10. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

CBCA/CBC.

11. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

CBCVA/CBCV.

12. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

CBDA/CBD.

13. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

CBDVA/CBDV.

14. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

CBGA/CBG.

15. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

CBGVA/CBGV.

16. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

THCVA/THCV.

17. The ready-to-vape precision pod of claim 7, wherein the one or more compounds is

a flavor comprising menthol.

18. A ready-to-vape precision pod for use with a vaporizer configured to generate

products altogether, the ready-to-vape precision pod comprising:

nicotine, anatabine, anabasine, flavor, THCA/THC, CBDA/CBD, CBCA/CBC, CBGA/CBG,

THCVA/THCV, CBDVA/CBDV, CBCVA/CBCV, CBGVA/CBGV, myrcene, caryophyllene,

pinene, limonene and humulene;

at least 5 mg of Cannabis;

at least 5 mg of low nicotine tobacco;

tobacco; and one or more vents for ventilation of air and vapor into and out of the compartment, wherein the at least 5 mg low nicotine tobacco comprises a nicotine content of equal to or less than 3 mg/g.

19. The ready-to-vape precision pod of claim 18, wherein the one or more compounds

is anatabine.

20. The ready-to-vape precision pod of claim 18, wherein the one or more compounds

is anabasine.

21. The ready-to-vape precision pod of claim 18, wherein the one or more compounds

is a flavor comprising menthol.

22. A ready-to-smoke precision pod for use with a smoking product for inhalation of

mainstream smoke as a smoking cessation treatment, to assist transitioning smokers to e-cigarettes

or a tobacco heating product, or to quit tobacco and nicotine products altogether, the ready-to

smoke precision pod comprising:

nicotine, anatabine, anabasine, flavor, THCA/THC, CBDA/CBD, CBCA/CBC, CBGA/CBG,

THCVA/THCV, CBDVA/CBDV, CBCVA/CBCV, CBGVA/CBGV, myrcene, caryophyllene,

pinene, limonene and humulene;

at least 5 mg of low nicotine tobacco;

at least 5 mg of very low THC Cannabis; a compartment that houses the one or more compounds, the low nicotine tobacco and very low THC cannabis; and one or more vents for ventilation of air and smoke into and out of the compartment, wherein the smoking product comprises a pipe, bowl or bong, wherein the ready-to-smoke precision pod is configured for a tobacco or Cannabis chamber of a pipe, bowl or bong, wherein the at least 5 mg very low THC Cannabiscomprises a collective THCA/THC content of equal to or less than 3 mg/g, and wherein the at least 5 mg low nicotine tobacco comprises a nicotine content of equal to or less than 3 mg/g.

23. The ready-to-smoke precision pod of claim 22, wherein the one or more

compounds is anabasine.

24. The ready-to-smoke precision pod of claim 22, wherein the one or more

compounds is anatabine.

25. The ready-to-smoke precision pod of claim 22, wherein the one or more

compounds is a flavor comprising menthol.

26. The ready-to-smoke precision pod of claim 22, wherein the one or more

compounds is THCVA/THCV.

27. The ready-to-smoke precision pod of claim 22, wherein the one or more

compounds is CBDA/CBD.