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AU2019260608A1 - Tricyclic Heterocycle Compounds useful as HIV integrase inhibitors - Google Patents

Tricyclic Heterocycle Compounds useful as HIV integrase inhibitors Download PDF

Info

Publication number
AU2019260608A1
AU2019260608A1 AU2019260608A AU2019260608A AU2019260608A1 AU 2019260608 A1 AU2019260608 A1 AU 2019260608A1 AU 2019260608 A AU2019260608 A AU 2019260608A AU 2019260608 A AU2019260608 A AU 2019260608A AU 2019260608 A1 AU2019260608 A1 AU 2019260608A1
Authority
AU
Australia
Prior art keywords
compound
mmol
isomer
compound int
int
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2019260608A
Other languages
English (en)
Inventor
James M. Apgar
Zhiyong Hu
John A. Mccauley
Izzat T. Raheem
Valerie W. SHURTLEFF
Alan Whitehead
Tao Yu
Yonglian Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of AU2019260608A1 publication Critical patent/AU2019260608A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2019260608A 2018-04-27 2019-04-22 Tricyclic Heterocycle Compounds useful as HIV integrase inhibitors Abandoned AU2019260608A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862663377P 2018-04-27 2018-04-27
US62/663,377 2018-04-27
US201862664527P 2018-04-30 2018-04-30
US62/664,527 2018-04-30
PCT/US2019/028432 WO2019209667A1 (fr) 2018-04-27 2019-04-22 Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih

Publications (1)

Publication Number Publication Date
AU2019260608A1 true AU2019260608A1 (en) 2020-10-29

Family

ID=68294232

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019260608A Abandoned AU2019260608A1 (en) 2018-04-27 2019-04-22 Tricyclic Heterocycle Compounds useful as HIV integrase inhibitors

Country Status (10)

Country Link
EP (1) EP3784241A4 (fr)
JP (1) JP2021522254A (fr)
KR (1) KR20210005139A (fr)
CN (1) CN112088005A (fr)
AU (1) AU2019260608A1 (fr)
BR (1) BR112020021768A2 (fr)
CA (1) CA3101180A1 (fr)
MA (1) MA52367A (fr)
MX (1) MX2020011317A (fr)
WO (1) WO2019209667A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4257137A3 (fr) 2018-05-31 2023-11-01 Shionogi & Co., Ltd Dérivés de carbamoylpyridone polycycliques pour le traitement du vih
SG11202011386QA (en) 2018-05-31 2020-12-30 Shionogi & Co Polycyclic pyridone derivative
WO2019236396A1 (fr) 2018-06-05 2019-12-12 Merck Sharp & Dohme Corp. Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih
WO2020197991A1 (fr) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Composés de carbamoylpyridone tricyclique pontés et leur utilisation pharmaceutique
US11325891B2 (en) 2019-11-26 2022-05-10 Gilead Sciences, Inc. Processes and intermediates for preparing MCL1 inhibitors
IL295677A (en) * 2020-02-24 2022-10-01 Gilead Sciences Inc Tetracyclic compounds for treating hiv infection
US12421235B2 (en) 2020-09-30 2025-09-23 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
CN116457334A (zh) 2020-11-19 2023-07-18 吉利德科学公司 用于制备大环mcl1抑制剂的方法和中间体
PT4196479T (pt) 2021-01-19 2024-01-03 Gilead Sciences Inc Compostos de piridotriazinas substituídos e suas utilizações
TWI856796B (zh) 2022-04-06 2024-09-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1441734T3 (da) * 2001-10-26 2007-06-11 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carboxamid-inhibitorer a HIV-integrase
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
LT2997033T (lt) * 2013-05-17 2018-02-12 Merck Sharp & Dohme Corp. Kondensuoti tricikliniai heterocikliniai junginiai, kaip živ integrazės inhibitoriai
WO2017113288A1 (fr) * 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih

Also Published As

Publication number Publication date
WO2019209667A1 (fr) 2019-10-31
CN112088005A (zh) 2020-12-15
EP3784241A4 (fr) 2022-01-19
KR20210005139A (ko) 2021-01-13
BR112020021768A2 (pt) 2021-01-26
JP2021522254A (ja) 2021-08-30
MX2020011317A (es) 2020-11-18
EP3784241A1 (fr) 2021-03-03
CA3101180A1 (fr) 2019-10-31
MA52367A (fr) 2021-03-03

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period