AU2018301674A1 - Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter - Google Patents
Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter Download PDFInfo
- Publication number
- AU2018301674A1 AU2018301674A1 AU2018301674A AU2018301674A AU2018301674A1 AU 2018301674 A1 AU2018301674 A1 AU 2018301674A1 AU 2018301674 A AU2018301674 A AU 2018301674A AU 2018301674 A AU2018301674 A AU 2018301674A AU 2018301674 A1 AU2018301674 A1 AU 2018301674A1
- Authority
- AU
- Australia
- Prior art keywords
- yeast
- compositions
- matter
- generation
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 229930003827 cannabinoid Natural products 0.000 title 1
- 239000003557 cannabinoid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000004114 suspension culture Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
- C12N1/185—Saccharomyces isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/85—Saccharomyces
- C12R2001/865—Saccharomyces cerevisiae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762531123P | 2017-07-11 | 2017-07-11 | |
| US62/531,123 | 2017-07-11 | ||
| US201762588662P | 2017-11-20 | 2017-11-20 | |
| US62/588,662 | 2017-11-20 | ||
| US62/621,166 | 2018-01-21 | ||
| US201862621166P | 2018-01-24 | 2018-01-24 | |
| AUPCT/US2018/024409 | 2018-03-26 | ||
| PCT/US2018/024409 WO2018176055A2 (en) | 2017-03-24 | 2018-03-26 | High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems |
| PCT/US2018/041710 WO2019014395A1 (en) | 2017-07-11 | 2018-07-11 | Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2018301674A1 true AU2018301674A1 (en) | 2020-01-30 |
| AU2018301674B2 AU2018301674B2 (en) | 2024-03-28 |
Family
ID=65003635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018301674A Active AU2018301674B2 (en) | 2017-07-11 | 2018-07-11 | Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11466281B2 (en) |
| EP (2) | EP3679153A4 (en) |
| CN (1) | CN111465700A (en) |
| AU (1) | AU2018301674B2 (en) |
| CA (1) | CA3069178A1 (en) |
| IL (1) | IL271928A (en) |
| WO (1) | WO2019014395A1 (en) |
| ZA (1) | ZA202000840B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5927769A (en) * | 1996-01-24 | 1999-07-27 | Pullen; John Howard | Kid's safety latch |
| WO2020081357A1 (en) * | 2018-10-16 | 2020-04-23 | Golden Spice Liquors LLC | Beverage compositions and methods of making and using the same |
| US20220151977A1 (en) * | 2019-02-04 | 2022-05-19 | Trait Biosciences, Inc. | Generation Of Water-Soluble Cannabinoids Utilizing Protein Cannabinoid-Carriers |
| US12397061B2 (en) | 2019-02-04 | 2025-08-26 | Trait Biosciences, Inc. | Systems, methods, and compositions for the generation of water-soluble cannabinoids utilizing fatty-acid binding proteins and fatty-acid binding-like proteins as cannabinoid-carriers |
| US20200254271A1 (en) * | 2019-02-13 | 2020-08-13 | Chiscan Holdings, Llc | Devices and methods for application of non-thermal plasma |
| WO2020176547A1 (en) | 2019-02-25 | 2020-09-03 | Ginkgo Bioworks, Inc. | Biosynthesis of cannabinoids and cannabinoid precursors |
| US10682508B1 (en) * | 2019-04-04 | 2020-06-16 | Trevor Theriot | Electrically stimulated CBD infused anesthetic patch system |
| US20220046883A1 (en) * | 2019-04-28 | 2022-02-17 | Pluristem Ltd. | Methods and Compositions for Producing Cannabinoids |
| EP3966340A4 (en) * | 2019-05-08 | 2024-01-03 | The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Institute) | TERPENE SYNTHASES AND TRANSPORTERS |
| JP2022534707A (en) * | 2019-05-27 | 2022-08-03 | オクタリン バイオ アイブイエス | Genetically Engineered Host Cells Producing Glycosylated Cannabinoids |
| AU2020391209A1 (en) * | 2019-11-27 | 2022-06-02 | Genomatica, Inc. | Engineered cells for production of cannabinoids and other malonyl-CoA-derived products |
| US20230050379A1 (en) * | 2020-01-20 | 2023-02-16 | Nutramax Laboratories, Inc. | Novel formulations comprising cannabis |
| EP4153306A4 (en) | 2020-05-22 | 2024-06-26 | Ilera Derm LLC | Compositions for treating acne and dermatological conditions |
| US20230313154A1 (en) * | 2020-07-17 | 2023-10-05 | Cb Therapeutics, Inc. | Prenyltransferase enzymes |
| WO2022094075A1 (en) * | 2020-10-28 | 2022-05-05 | Canna Grow Innovations Llc | Methods and compositions for cbd-infused plants and plant products |
| CA3197361A1 (en) * | 2020-11-07 | 2022-05-12 | Mathias Schuetz | Production of glycosylated cannabinoids |
| CN112626047B (en) * | 2021-01-08 | 2022-05-17 | 中国科学院华南植物园 | A group of spermidine derivative glycosyltransferases and their encoding genes and applications |
| EP4370683A2 (en) * | 2021-07-13 | 2024-05-22 | Amyris, Inc. | High efficiency production of cannabidiolic acid |
| CN114262695B (en) * | 2021-12-10 | 2023-02-17 | 杭州恩和生物科技有限公司 | Saccharomyces cerevisiae engineering bacterium for producing CBGA precursor and construction method and application thereof |
| JP2025512059A (en) * | 2022-04-13 | 2025-04-16 | イエダ リサーチ アンド ディベロプメント カンパニー リミテッド | Uridine diphosphate-glycosyltransferase and transgenic cells, tissues, and organisms containing the same |
| CN116904412B (en) * | 2023-07-25 | 2024-04-26 | 森瑞斯生物科技(深圳)有限公司 | Construction method and application of saccharomyces cerevisiae strain with optimized cannabis diphenolic acid synthetase sequence |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL80411A (en) | 1986-10-24 | 1991-08-16 | Raphael Mechoulam | Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them |
| DE4100441A1 (en) | 1991-01-09 | 1992-07-16 | Mack Chem Pharm | PROCESS FOR PREPARING 6,12-DIHYDRO-6-HYDROXY-CANNABIDIOL AND USE THEREOF FOR THE PREPARATION OF TRANS-DELTA-9-TETRAHYDROCANNABINOL |
| US5292899A (en) | 1991-11-27 | 1994-03-08 | Synthetic Technology Corporation | Synthesis of 11-nor-Δ-9-tetrahydrocannabinol-9-carboxylic acid glucuronide |
| US5434295A (en) | 1994-02-07 | 1995-07-18 | Yissum Research Development Company | Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds |
| US6403126B1 (en) | 1999-05-26 | 2002-06-11 | Websar Innovations Inc. | Cannabinoid extraction method |
| DE10051427C1 (en) | 2000-10-17 | 2002-06-13 | Adam Mueller | Process for the production of an extract containing tetrahydrocannabinol and cannabidiol from cannabis plant material and cannabis extracts |
| ES2377819T3 (en) | 2002-08-14 | 2012-04-02 | Gw Pharma Limited | Liquid cannabinoid formulations for mucosal administration |
| DE60329505D1 (en) * | 2002-08-20 | 2009-11-12 | Suntory Holdings Ltd | NEW GLYCOSYL TRANSFERASE GENES |
| EP1559423A1 (en) * | 2004-02-02 | 2005-08-03 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Medicinal acidic cannabinoids |
| US7342010B2 (en) * | 2004-11-15 | 2008-03-11 | Board Of Trustees Of Michigan State University | 2-thiaquinolizidines and process for the preparation thereof |
| EP1919514B1 (en) | 2005-07-05 | 2012-05-16 | The Regents of the University of California | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof |
| GB2434312B (en) | 2006-01-18 | 2011-06-29 | Gw Pharma Ltd | Cannabinoid-containing plant extracts as neuroprotective agents |
| WO2008034648A1 (en) * | 2006-04-05 | 2008-03-27 | Metanomics Gmbh | Process for the production of a fine chemical |
| AU2007310870A1 (en) * | 2006-10-24 | 2008-05-02 | Novozymes A/S | Improved alpha factor signal peptide for producing a polypeptide |
| PL2173881T3 (en) * | 2007-07-23 | 2017-05-31 | Dsm Ip Assets B.V. | Acetyl-coa producing enzymes in yeast |
| JP5704925B2 (en) | 2008-02-08 | 2015-04-22 | ウェルズ ファーゴ バンク ナショナル アソシエイション | Oligomer-cannabinoid conjugate |
| US8410064B2 (en) | 2009-08-24 | 2013-04-02 | The Board Of Trustees Of The University Of Arkansas | Classical cannabinoid metabolites and methods of use thereof |
| US9611460B2 (en) | 2010-04-15 | 2017-04-04 | National Research Council Of Canada | Genes and proteins for aromatic polyketide synthesis |
| DK2732037T3 (en) | 2011-07-13 | 2018-02-26 | Nat Res Council Canada | GENES AND PROTEINS FOR ALKANOYL-COA SYNTHESIS |
| WO2013152359A1 (en) * | 2012-04-06 | 2013-10-10 | The Regents Of The University Of California | Novel tetrazines and method of synthesizing the same |
| CA2902452C (en) | 2013-02-28 | 2018-09-04 | Full Spectrum Laboratories Limited | Chemical engineering processes and apparatus for the synthesis of compounds |
| US20170044552A1 (en) * | 2014-04-25 | 2017-02-16 | Evolva Sa | Methods for Recombinant Production of Saffron Compounds |
| WO2016010827A1 (en) * | 2014-07-14 | 2016-01-21 | Librede Inc. | Production of cannabinoids in yeast |
| CN106922153B (en) | 2014-08-25 | 2018-11-02 | 蒂威诺特科技有限公司 | Apparatus and method for simultaneous production of cannabinoid compounds |
| US20160298151A1 (en) | 2015-04-09 | 2016-10-13 | Sher Ali Butt | Novel Method for the cheap, efficient, and effective production of pharmaceutical and therapeutic api's intermediates, and final products |
| EP3283614B1 (en) * | 2015-04-14 | 2020-07-08 | Conagen Inc. | Production of non-caloric sweeteners using engineered whole-cell catalysts |
| EP3291806A4 (en) | 2015-05-07 | 2018-09-26 | Axim Biotechnologies, Inc. | Process to extract and purify delta-9-tetrahydrocannabinol |
| WO2017034942A1 (en) | 2015-08-21 | 2017-03-02 | Manus Biosynthesis, Inc. | Increasing productivity of e. coli host cells that functionally express p450 enzymes |
| US11207414B2 (en) * | 2015-09-22 | 2021-12-28 | Graphium Biosciences, Inc. | Cannabinoid glycoside prodrugs and methods of synthesis |
| JP2022534707A (en) * | 2019-05-27 | 2022-08-03 | オクタリン バイオ アイブイエス | Genetically Engineered Host Cells Producing Glycosylated Cannabinoids |
-
2018
- 2018-07-11 CN CN201880058737.5A patent/CN111465700A/en active Pending
- 2018-07-11 EP EP18832956.9A patent/EP3679153A4/en active Pending
- 2018-07-11 AU AU2018301674A patent/AU2018301674B2/en active Active
- 2018-07-11 EP EP20176303.4A patent/EP3730145A1/en active Pending
- 2018-07-11 WO PCT/US2018/041710 patent/WO2019014395A1/en not_active Ceased
- 2018-07-11 CA CA3069178A patent/CA3069178A1/en active Pending
- 2018-08-23 US US16/110,954 patent/US11466281B2/en active Active
-
2020
- 2020-01-09 IL IL271928A patent/IL271928A/en unknown
- 2020-02-10 ZA ZA2020/00840A patent/ZA202000840B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018301674B2 (en) | 2024-03-28 |
| WO2019014395A8 (en) | 2019-02-07 |
| CN111465700A (en) | 2020-07-28 |
| ZA202000840B (en) | 2022-06-29 |
| US11466281B2 (en) | 2022-10-11 |
| IL271928A (en) | 2020-02-27 |
| EP3679153A1 (en) | 2020-07-15 |
| EP3730145A1 (en) | 2020-10-28 |
| CA3069178A1 (en) | 2019-01-17 |
| WO2019014395A1 (en) | 2019-01-17 |
| US20190078168A1 (en) | 2019-03-14 |
| EP3679153A4 (en) | 2021-01-06 |
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