AU2018261654A1 - Targeted drug rescue with novel compositions, combinations, and methods thereof - Google Patents

Targeted drug rescue with novel compositions, combinations, and methods thereof Download PDF

Info

Publication number: AU2018261654A1
Authority: AU; Australia
Prior art keywords: phenoxy; methyl; oxy; propan; dimethylamino
Prior art date: 2017-05-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2018261654A

Other languages

English (en)

Inventor

Anton Bespalov

Hans J. MOEBIUS

Sreenivasarao Vepachedu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Exciva GmbH

Original Assignee

Exciva GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-05-04

Filing date

2018-05-03

Publication date

2019-11-14

2017-08-25 Priority claimed from PCT/US2017/048748 external-priority patent/WO2018039642A1/en

2018-05-03 Application filed by Exciva GmbH filed Critical Exciva GmbH

2019-11-14 Publication of AU2018261654A1 publication Critical patent/AU2018261654A1/en

2021-08-13 Priority to AU2021215274A priority Critical patent/AU2021215274B2/en

Status Abandoned legal-status Critical Current

Links

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238000000034 method Methods 0.000 title claims abstract description 91
239000003814 drug Substances 0.000 title description 51
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150000003839 salts Chemical class 0.000 claims abstract description 66
239000002253 acid Substances 0.000 claims abstract description 48
229940002612 prodrug Drugs 0.000 claims abstract description 47
239000000651 prodrug Substances 0.000 claims abstract description 47
239000003795 chemical substances by application Substances 0.000 claims abstract description 33
239000002207 metabolite Substances 0.000 claims abstract description 26
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 20
150000001204 N-oxides Chemical class 0.000 claims abstract description 13
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 12
239000003446 ligand Substances 0.000 claims abstract description 3
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102100021704 Cytochrome P450 2D6 Human genes 0.000 claims abstract 2
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-1 (1-(dimethylamino) -3-(2-(3-methoxyphenethyl) phenoxy) propan-2-yl) oxy Chemical group 0.000 claims description 169
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QOBGWWQAMAPULA-RLLQIKCJSA-N n,n-dimethyl-2-[[(1r,3s,4r)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine Chemical compound C1([C@@]2([C@]3(C)CC[C@@H](C3(C)C)C2)OCCN(C)C)=CC=CC=C1 QOBGWWQAMAPULA-RLLQIKCJSA-N 0.000 claims description 60
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 58
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ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 22
125000000623 heterocyclic group Chemical group 0.000 claims description 22
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RGHNJXZEOKUKBD-MBMOQRBOSA-N D-mannonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O RGHNJXZEOKUKBD-MBMOQRBOSA-N 0.000 claims description 12
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 12
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Classifications

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AU2018261654A 2017-05-04 2018-05-03 Targeted drug rescue with novel compositions, combinations, and methods thereof Abandoned AU2018261654A1 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
AU2021215274A AU2021215274B2 (en)	2017-05-04	2021-08-13	Targeted drug rescue with novel compositions, combinations, and methods thereof

Applications Claiming Priority (15)

Application Number	Priority Date	Filing Date	Title
US201762501696P	2017-05-04	2017-05-04
US62/501,696		2017-05-04
PCT/US2017/048748 WO2018039642A1 (en)	2016-08-26	2017-08-25	Compositions and methods thereof
AUPCT/US2017/048748		2017-08-25
TW106129169		2017-08-28
TW106129169A TW201815387A (zh)	2016-08-26	2017-08-28	組成物及其方法
US201862634162P	2018-02-22	2018-02-22
US62/634,162		2018-02-22
US201862635554P	2018-02-27	2018-02-27
US201862636099P	2018-02-27	2018-02-27
US62/635,554		2018-02-27
US62/636,099		2018-02-27
US201862636171P	2018-02-28	2018-02-28
US62/636,171		2018-02-28
PCT/US2018/030978 WO2018204713A1 (en)	2017-05-04	2018-05-03	Targeted drug rescue with novel compositions, combinations, and methods thereof

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2021215274A Division AU2021215274B2 (en)	2017-05-04	2021-08-13	Targeted drug rescue with novel compositions, combinations, and methods thereof

Publications (1)

Publication Number	Publication Date
AU2018261654A1 true AU2018261654A1 (en)	2019-11-14

Family

ID=65431106

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU2018261654A Abandoned AU2018261654A1 (en)	2017-05-04	2018-05-03	Targeted drug rescue with novel compositions, combinations, and methods thereof
AU2021215274A Active AU2021215274B2 (en)	2017-05-04	2021-08-13	Targeted drug rescue with novel compositions, combinations, and methods thereof

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AU2021215274A Active AU2021215274B2 (en)	2017-05-04	2021-08-13	Targeted drug rescue with novel compositions, combinations, and methods thereof

Country Status (13)

Country	Link
EP (1)	EP3618819A4 (ru)
JP (2)	JP7514078B2 (ru)
KR (2)	KR102444803B1 (ru)
CN (1)	CN110831584B (ru)
AU (2)	AU2018261654A1 (ru)
BR (1)	BR112019022902A2 (ru)
CA (2)	CA3138116A1 (ru)
IL (1)	IL270326B2 (ru)
MA (1)	MA49464A (ru)
RU (1)	RU2760558C9 (ru)
TW (1)	TWI787260B (ru)
WO (1)	WO2018204713A1 (ru)
ZA (1)	ZA201908006B (ru)

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BR112019022902A2 (pt) *	2017-05-04	2020-05-19	Exciva GmbH	composição, composição farmacêutica, uso da composição terapeuticamente eficaz, método e uso de uma composição terapeuticamente eficaz em um método de tratamento
BR112021018564A2 (pt) *	2019-03-18	2021-11-30	Avanir Pharmaceuticals Inc	Métodos de tratamento de sintomas negativos de esquizofrenia usando dextrometorfano deuterado e quinidina
WO2020246143A1 (ja) *	2019-06-06	2020-12-10	Jsr株式会社	感放射線性樹脂組成物、レジストパターン形成方法及び化合物
IL312785A (en)	2020-05-19	2024-07-01	Cybin Irl Ltd	Denatured Tryptamine Derivatives and Methods of Use
CN116473073A (zh) *	2023-05-08	2023-07-25	广东方中高新材料有限公司	一种含镓配合物的吡唑醚菌酯增效悬浮制剂及其制备方法
CN116473077B (zh) *	2023-05-08	2025-04-11	广东方中高新材料有限公司	一种n,n配位的镓配合物抗菌剂的合成和应用
CN119432479B (zh) *	2023-08-04	2025-10-03	中国石油天然气股份有限公司	柴油机润滑油组合物及其制备方法
CN120987847A (zh) *	2024-11-29	2025-11-21	江苏恩华药业股份有限公司	一种氢溴酸右美沙芬的制备方法

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US4241065A (en) *	1979-07-02	1980-12-23	E. I. Du Pont De Nemours And Company	Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
US4950658A (en) *	1988-12-06	1990-08-21	Board Of Trustees Of Southern Illinois Univ.	Method of medical treatment of Alzheimer's disease
US5891885A (en) *	1996-10-09	1999-04-06	Algos Pharmaceutical Corporation	Method for treating migraine
US6207674B1 (en) *	1999-12-22	2001-03-27	Richard A. Smith	Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants
US6335371B1 (en) *	2000-11-28	2002-01-01	Orion Corporation	Method for inducing cognition enhancement
TWI326214B (en)	2002-07-17	2010-06-21	Avanir Pharmaceuticals Inc	Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
US20070099947A1 (en) *	2005-11-03	2007-05-03	Alkermes, Inc.	Methods and compositions for the treatment of brain reward system disorders by combination therapy
KR20080097443A (ko)	2006-02-03	2008-11-05	아바니르 파마슈티컬스	덱스트로메토판 및 퀴니딘을 포함하는, 우울, 불안 및 신경퇴행성 장애 치료용 약제학적 조성물
EP2345653B1 (en) *	2007-05-01	2012-12-26	Concert Pharmaceuticals Inc.	Morphinan compounds
CA2688784A1 (en) *	2007-05-21	2008-11-27	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents
US8017623B2 (en) *	2008-07-03	2011-09-13	Trinity Laboratories, Inc.	Dextromethorphan hydrochloride
US9737531B2 (en) *	2012-07-12	2017-08-22	Glytech, Llc	Composition and method for treatment of depression and psychosis in humans
EP2964022B1 (en) *	2013-03-07	2019-11-06	Mindlab LLC	Pain medicine combination and uses thereof
WO2014145568A2 (en) *	2013-03-15	2014-09-18	Kinemed, Inc.	Biomarkers
TWI869633B (zh) *	2014-09-14	2025-01-11	美商阿瓦尼爾製藥股份有限公司	用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物
CA3034895A1 (en) *	2016-08-26	2018-03-01	Exciva Ug (Haftungsbeschrankt)	Compositions and methods thereof
BR112019022902A2 (pt) *	2017-05-04	2020-05-19	Exciva GmbH	composição, composição farmacêutica, uso da composição terapeuticamente eficaz, método e uso de uma composição terapeuticamente eficaz em um método de tratamento

2018
- 2018-05-03 BR BR112019022902A patent/BR112019022902A2/pt not_active Application Discontinuation
- 2018-05-03 CN CN201880037396.3A patent/CN110831584B/zh active Active
- 2018-05-03 WO PCT/US2018/030978 patent/WO2018204713A1/en not_active Ceased
- 2018-05-03 CA CA3138116A patent/CA3138116A1/en active Pending
- 2018-05-03 MA MA049464A patent/MA49464A/fr unknown
- 2018-05-03 KR KR1020217033764A patent/KR102444803B1/ko active Active
- 2018-05-03 CA CA3062452A patent/CA3062452C/en active Active
- 2018-05-03 EP EP18794381.6A patent/EP3618819A4/en active Pending
- 2018-05-03 AU AU2018261654A patent/AU2018261654A1/en not_active Abandoned
- 2018-05-03 RU RU2019137004A patent/RU2760558C9/ru active
- 2018-05-03 KR KR1020197035796A patent/KR20200062078A/ko not_active Ceased
- 2018-05-03 JP JP2019560216A patent/JP7514078B2/ja active Active
- 2018-05-04 TW TW107115320A patent/TWI787260B/zh active
2019
- 2019-10-31 IL IL270326A patent/IL270326B2/en unknown
- 2019-12-02 ZA ZA2019/08006A patent/ZA201908006B/en unknown
2021
- 2021-08-13 AU AU2021215274A patent/AU2021215274B2/en active Active
2023
- 2023-07-21 JP JP2023119151A patent/JP2023143940A/ja active Pending

Also Published As

Publication number	Publication date
IL270326B (en)	2022-10-01
MA49464A (fr)	2020-04-29
JP7514078B2 (ja)	2024-07-10
KR20210130827A (ko)	2021-11-01
KR20200062078A (ko)	2020-06-03
IL270326B2 (en)	2023-02-01
ZA201908006B (en)	2021-04-28
KR102444803B1 (ko)	2022-09-19
BR112019022902A2 (pt)	2020-05-19
JP2023143940A (ja)	2023-10-06
CA3062452C (en)	2023-10-24
TWI787260B (zh)	2022-12-21
TW201842902A (zh)	2018-12-16
EP3618819A4 (en)	2021-01-20
AU2021215274B2 (en)	2022-11-03
CN110831584A (zh)	2020-02-21
JP2020518617A (ja)	2020-06-25
CA3138116A1 (en)	2018-11-08
EP3618819A1 (en)	2020-03-11
AU2021215274A1 (en)	2021-09-02
CN110831584B (zh)	2023-03-10
RU2019137004A (ru)	2021-06-04
WO2018204713A1 (en)	2018-11-08
RU2019137004A3 (ru)	2021-06-04
RU2760558C2 (ru)	2021-11-29
CA3062452A1 (en)	2018-11-08
RU2760558C9 (ru)	2022-02-22
IL270326A (ru)	2018-05-03

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AU2021215274B2 (en)	2022-11-03	Targeted drug rescue with novel compositions, combinations, and methods thereof
US11103499B2 (en)	2021-08-31	Compositions and methods thereof
US20200261442A1 (en)	2020-08-20	Targeted drug rescue with novel compositions, combinations, and methods thereof
AU2022283967A1 (en)	2024-01-18	Enantiomeric entactogen compositions and methods of their use
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