AU2017208555B2 - New 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors - Google Patents
New 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors Download PDFInfo
- Publication number
- AU2017208555B2 AU2017208555B2 AU2017208555A AU2017208555A AU2017208555B2 AU 2017208555 B2 AU2017208555 B2 AU 2017208555B2 AU 2017208555 A AU2017208555 A AU 2017208555A AU 2017208555 A AU2017208555 A AU 2017208555A AU 2017208555 B2 AU2017208555 B2 AU 2017208555B2
- Authority
- AU
- Australia
- Prior art keywords
- substituted
- 4alkyl
- alkyl
- optionally
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16152414.5 | 2016-01-22 | ||
| EP16152415 | 2016-01-22 | ||
| EP16152415.2 | 2016-01-22 | ||
| EP16152414 | 2016-01-22 | ||
| EP16159659 | 2016-03-10 | ||
| EP16159658.0 | 2016-03-10 | ||
| EP16159658 | 2016-03-10 | ||
| EP16159659.8 | 2016-03-10 | ||
| PCT/EP2017/051160 WO2017125534A1 (fr) | 2016-01-22 | 2017-01-20 | Nouveaux dérivés de cyanoindoline à substitution hétéroaromatique à 6 chaînons utilisés comme inhibiteurs de nik |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017208555A1 AU2017208555A1 (en) | 2018-08-02 |
| AU2017208555B2 true AU2017208555B2 (en) | 2021-03-18 |
Family
ID=57868253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017208555A Active AU2017208555B2 (en) | 2016-01-22 | 2017-01-20 | New 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11001569B2 (fr) |
| EP (1) | EP3405464B1 (fr) |
| JP (1) | JP6916796B2 (fr) |
| KR (1) | KR102720461B1 (fr) |
| CN (1) | CN109311846B (fr) |
| AU (1) | AU2017208555B2 (fr) |
| CA (1) | CA3012031C (fr) |
| ES (1) | ES2776658T3 (fr) |
| WO (1) | WO2017125534A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017125534A1 (fr) | 2016-01-22 | 2017-07-27 | Janssen Pharmaceutica Nv | Nouveaux dérivés de cyanoindoline à substitution hétéroaromatique à 6 chaînons utilisés comme inhibiteurs de nik |
| JP6910359B2 (ja) | 2016-01-22 | 2021-07-28 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としての新たな置換されたシアノインドリン誘導体 |
| JP6936815B2 (ja) | 2016-06-30 | 2021-09-22 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としてのヘテロ芳香族誘導体 |
| AU2017289317B2 (en) * | 2016-06-30 | 2021-04-01 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as NIK inhibitors |
| WO2018199166A1 (fr) * | 2017-04-27 | 2018-11-01 | 持田製薬株式会社 | Nouveaux dérivés de tétrahydronaphtyle urée |
| SG11202002968UA (en) * | 2017-09-30 | 2020-04-29 | Shanghai Haihe Pharmaceutical Co Ltd | Compound having erk kinase inhibitory activity and use thereof |
| FI3870579T3 (fi) | 2018-10-22 | 2025-01-02 | Alumis Inc | Tyk2-inhibiittoreita ja niiden käyttöjä |
| FI3976597T3 (fi) | 2019-05-31 | 2024-09-25 | Janssen Pharmaceutica Nv | Nf-kb:tä indusoivan kinaasin pienimolekyylisiä estäjiä |
| CA3242545A1 (fr) * | 2021-12-20 | 2023-06-29 | Nimml Institute | Composes immunoregulateurs |
| PL4387730T3 (pl) * | 2022-09-08 | 2025-09-22 | Redx Pharma Limited | Stałe postaci inhibitora rock |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010042337A1 (fr) * | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Nouveaux dérivés de 6-azaindole aminopyrimidine ayant une activité inhibitrice de nik |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02007957A (es) | 2000-02-17 | 2002-11-29 | Amgen Inc | Inhibidores de cinasas. |
| ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| ES2292753T4 (es) * | 2001-03-29 | 2009-02-16 | Vertex Pharmaceuticals Incorporated | Inhibidores de quinasas n-terminales c-jun (jnk) y otras proteina quinasas. |
| JP2005500294A (ja) | 2001-06-19 | 2005-01-06 | ブリストル−マイヤーズ スクイブ カンパニー | ホスホジエステラーゼ７に対するピリミジン阻害剤 |
| WO2003030909A1 (fr) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer |
| US20110086834A1 (en) * | 2008-06-26 | 2011-04-14 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| CA2986640C (fr) | 2008-06-27 | 2019-03-26 | Celgene Avilomics Research, Inc. | Composes hetero-aryles et leurs utilisations |
| CN108752280A (zh) | 2009-08-17 | 2018-11-06 | 纪念斯隆-凯特琳癌症中心 | 热休克蛋白结合化合物、组合物以及其制备和使用方法 |
| WO2011153553A2 (fr) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Méthodes et compositions pour l'inhibition de kinases |
| ES2823350T3 (es) | 2010-07-29 | 2021-05-06 | Rigel Pharmaceuticals Inc | Compuestos heterocíclicos que activan AMPK y métodos de uso de los mismos |
| WO2012142329A1 (fr) * | 2011-04-12 | 2012-10-18 | Myrexis, Inc. | Compositions et utilisations thérapeutiques d'inhibiteurs de la kinase epsilon liée à ikk et de la kinase 1 de liaison à tank |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| WO2015030847A1 (fr) | 2013-08-30 | 2015-03-05 | Ptc Therapeutics, Inc. | Inhibiteurs de bmi-1 à base de pyrimidines substituées |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| SG11201608242XA (en) | 2014-04-04 | 2016-10-28 | Syros Pharmaceuticals Inc | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| WO2015176135A1 (fr) | 2014-05-22 | 2015-11-26 | The University Of Sydney | Analogues d'oméga-3 |
| WO2016022645A1 (fr) | 2014-08-06 | 2016-02-11 | Merck Sharp & Dohme Corp. | Antagonistes hétérocycliques du récepteur du cgrp |
| EP3209654B1 (fr) * | 2014-10-23 | 2018-10-03 | Janssen Pharmaceutica N.V. | Nouveaux dérivés pyrazoliques en tant qu'inhibiteurs de nik |
| CN106928216A (zh) | 2015-12-31 | 2017-07-07 | 中国科学院上海药物研究所 | 具有erk激酶抑制活性的化合物、其制备方法和用途 |
| JP6910359B2 (ja) | 2016-01-22 | 2021-07-28 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としての新たな置換されたシアノインドリン誘導体 |
| WO2017125534A1 (fr) | 2016-01-22 | 2017-07-27 | Janssen Pharmaceutica Nv | Nouveaux dérivés de cyanoindoline à substitution hétéroaromatique à 6 chaînons utilisés comme inhibiteurs de nik |
| SI3429591T1 (sl) | 2016-03-16 | 2023-07-31 | Kura Oncology, Inc. | Substituirani tieno(2,3-d)pirimidinski derivati kot inhibitorji menin-MLL in postopki uporabe |
| AU2017289317B2 (en) | 2016-06-30 | 2021-04-01 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as NIK inhibitors |
| JP6936815B2 (ja) | 2016-06-30 | 2021-09-22 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としてのヘテロ芳香族誘導体 |
-
2017
- 2017-01-20 WO PCT/EP2017/051160 patent/WO2017125534A1/fr not_active Ceased
- 2017-01-20 ES ES17701111T patent/ES2776658T3/es active Active
- 2017-01-20 CA CA3012031A patent/CA3012031C/fr active Active
- 2017-01-20 JP JP2018535877A patent/JP6916796B2/ja active Active
- 2017-01-20 AU AU2017208555A patent/AU2017208555B2/en active Active
- 2017-01-20 US US16/071,298 patent/US11001569B2/en active Active
- 2017-01-20 KR KR1020187024027A patent/KR102720461B1/ko active Active
- 2017-01-20 EP EP17701111.1A patent/EP3405464B1/fr active Active
- 2017-01-20 CN CN201780019718.7A patent/CN109311846B/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010042337A1 (fr) * | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Nouveaux dérivés de 6-azaindole aminopyrimidine ayant une activité inhibitrice de nik |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6916796B2 (ja) | 2021-08-11 |
| JP2019502714A (ja) | 2019-01-31 |
| CA3012031A1 (fr) | 2017-07-27 |
| KR102720461B1 (ko) | 2024-10-21 |
| CN109311846B (zh) | 2021-03-19 |
| AU2017208555A1 (en) | 2018-08-02 |
| US20200109129A1 (en) | 2020-04-09 |
| KR20180098679A (ko) | 2018-09-04 |
| ES2776658T3 (es) | 2020-07-31 |
| CN109311846A (zh) | 2019-02-05 |
| EP3405464B1 (fr) | 2019-12-04 |
| WO2017125534A1 (fr) | 2017-07-27 |
| CA3012031C (fr) | 2024-03-26 |
| EP3405464A1 (fr) | 2018-11-28 |
| US11001569B2 (en) | 2021-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |