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AU2017271189A1 - Cytosol-penetrating antibody and use thereof - Google Patents

Cytosol-penetrating antibody and use thereof

Info

Publication number
AU2017271189A1
AU2017271189A1 AU2017271189A AU2017271189A AU2017271189A1 AU 2017271189 A1 AU2017271189 A1 AU 2017271189A1 AU 2017271189 A AU2017271189 A AU 2017271189A AU 2017271189 A AU2017271189 A AU 2017271189A AU 2017271189 A1 AU2017271189 A1 AU 2017271189A1
Authority
AU
Australia
Prior art keywords
cytosol
penetrating antibody
antibody
penetrating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2017271189A
Other versions
AU2017271189B2 (en
Inventor
Ji Sun Kim
Yong Sung Kim
Jae Yeong Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orum Therapeutics Inc
Original Assignee
Orum Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020160065365A external-priority patent/KR102000000B1/en
Priority claimed from KR1020160065379A external-priority patent/KR20170133933A/en
Application filed by Orum Therapeutics Inc filed Critical Orum Therapeutics Inc
Priority claimed from PCT/KR2017/005559 external-priority patent/WO2017204606A1/en
Priority claimed from KR1020170065670A external-priority patent/KR20180129514A/en
Publication of AU2017271189A1 publication Critical patent/AU2017271189A1/en
Application granted granted Critical
Publication of AU2017271189B2 publication Critical patent/AU2017271189B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

AU2017271189A 2016-05-27 2017-05-26 Cytosol-penetrating antibody and use thereof Ceased AU2017271189B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
KR1020160065365A KR102000000B1 (en) 2016-05-27 2016-05-27 Endosomal escape motif enabling antibody to escape from endosomes and uses thereof
KR1020160065379A KR20170133933A (en) 2016-05-27 2016-05-27 Method for inducing conformational changes in the complementarity determining regions of antibody
KR10-2016-0065379 2016-05-27
KR10-2016-0065365 2016-05-27
KR10-2017-0065670 2017-05-26
PCT/KR2017/005559 WO2017204606A1 (en) 2016-05-27 2017-05-26 Cytosol-penetrating antibody and use thereof
KR1020170065670A KR20180129514A (en) 2017-05-26 2017-05-26 Cytosol-Penetrating Antibodies and Uses Thereof

Publications (2)

Publication Number Publication Date
AU2017271189A1 true AU2017271189A1 (en) 2019-01-24
AU2017271189B2 AU2017271189B2 (en) 2020-02-20

Family

ID=60412784

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017271189A Ceased AU2017271189B2 (en) 2016-05-27 2017-05-26 Cytosol-penetrating antibody and use thereof

Country Status (8)

Country Link
US (1) US11155641B2 (en)
JP (1) JP2019520086A (en)
AU (1) AU2017271189B2 (en)
BR (1) BR112018074275A2 (en)
CA (1) CA3025757A1 (en)
IL (1) IL263242A (en)
MX (1) MX2018014554A (en)
WO (1) WO2017204606A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101602870B1 (en) 2014-07-22 2016-03-21 아주대학교산학협력단 Method for Cell-penetrating and cytosol-localizing of intact immunoglobulin antibody, and use thereof
KR101602876B1 (en) 2014-07-22 2016-03-11 아주대학교산학협력단 Method for inhibiting activated RAS using intact immunoglobulin antibody having Cell-penetrating ability and use thereof
JP7165943B2 (en) * 2017-11-01 2022-11-07 東洋紡株式会社 Compounds having a π-electron conjugated unit and a carbazole group
WO2019132579A2 (en) * 2017-12-28 2019-07-04 오름테라퓨틱 주식회사 Immunotoxin comprising ribonuclease fused to cytotransmab
WO2019244086A1 (en) * 2018-06-21 2019-12-26 Orum Therapeutics Inc. Cell/tissue-specific cell-penetrating antibodies
EP4267745A4 (en) * 2020-12-23 2025-06-18 Chugai Seiyaku Kabushiki Kaisha ANTIGEN-BINDING MOLECULES WITH ENHANCED CYTOSOL PENETRATION ACTIVITY
KR102623211B1 (en) 2021-07-20 2024-01-11 아주대학교산학협력단 A cell-penetrating degrading antibody that penetrates into the cytosol of cells and degrades to remove a targeted protein, and its uses thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3785186T2 (en) 1986-09-02 1993-07-15 Enzon Lab Inc BINDING MOLECULE WITH SINGLE POLYPEPTIDE CHAIN.
ATE114723T1 (en) 1987-03-02 1994-12-15 Enzon Lab Inc ORGANISM AS CARRIER FOR ''SINGLE CHAIN ANTIBODY DOMAIN (SCAD)''.
EP0305481B1 (en) 1987-03-20 1993-09-29 Creative Biomolecules, Inc. Leader sequences for the production of recombinant proteins
ATE113985T1 (en) 1987-03-20 1994-11-15 Creative Biomolecules Inc PROCEDURE FOR PURIFICATION OF RECOMBINANT POLYPEPTIDES.
WO1988009344A1 (en) 1987-05-21 1988-12-01 Creative Biomolecules, Inc. Targeted multifunctional proteins
FR2706486B1 (en) 1993-06-16 1995-09-01 Rhone Poulenc Rorer Sa Nucleic sequences, vectors containing them, pharmaceutical compositions and therapeutic uses.
CN1241574A (en) 1998-07-02 2000-01-19 中国人民解放军第四军医大学 Liver cancer-resisting monoclone antibody HAb25 and its single stranded antibody and bifunctional antibody
GB0226727D0 (en) 2002-11-15 2002-12-24 Medical Res Council Intrabodies
WO2003077945A1 (en) 2002-03-14 2003-09-25 Medical Research Council Intracellular antibodies
WO2004046188A2 (en) 2002-11-15 2004-06-03 Medical Research Council Anti-activated ras antibodies
BRPI0709340A2 (en) 2006-03-27 2013-04-16 Globeimmune Inc mutations and compositions and methods of use thereof
CN115043946A (en) 2008-01-03 2022-09-13 斯克里普斯研究院 Antibody targeting via modular recognition domains
KR100849941B1 (en) 2008-04-29 2008-08-01 원우이에프엔지니어링주식회사 Heat and smoke fire detector complex tester
WO2009134027A2 (en) 2008-04-30 2009-11-05 Ajou University Industry-Academic Cooperation Foundation Anti-nucleic acid antibody inducing cell death of cancer cells and composition for preventing or treating cancers comprising the same
KR101075123B1 (en) 2008-10-24 2011-10-19 아주대학교산학협력단 Humanized antibody with nucleic nucleic acid-hydrolyzing activity and tumor cell-penetrating ability and uses thereof
KR101130835B1 (en) 2008-11-11 2012-03-28 아주대학교산학협력단 Cell-penetrating, sequence-specific and nucleic acid-hydrolyzing antibody, method for preparing the same and pharmaceutical composition comprising the same
CN101402675B (en) 2008-11-28 2012-05-30 中国人民解放军第三军医大学第三附属医院 Target restraint alpha Nu beta3 positive cell proliferation cyclic peptides
US20110053829A1 (en) 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
WO2011140151A1 (en) 2010-05-04 2011-11-10 Dyax Corp. Antibodies against epidermal growth factor receptor (egfr)
GB201103631D0 (en) 2011-03-03 2011-04-13 Univ Leeds Identification of candidate therapeutics
US9701740B2 (en) 2011-04-01 2017-07-11 Yale University Cell-penetrating anti-DNA antibodies and uses thereof inhibit DNA repair
US9283272B2 (en) 2012-03-30 2016-03-15 The United States Of America As Represented By The Department Of Veterans Affairs Targeting intracellular target-binding determinants with intracellular antibodies
US9815866B2 (en) 2012-09-14 2017-11-14 Japanese Foundation For Cancer Research Peptides that bind to epithelial cell adhesion molecule
WO2015048477A1 (en) 2013-09-27 2015-04-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Cyclic peptide conjugates and methods of use
WO2016013871A1 (en) 2014-07-22 2016-01-28 아주대학교산학협력단 Method for suppressing ras activated in cell by using antibody having cytoplasm penetration capacity and complete immunoglobulin form, and use for same
WO2016013870A1 (en) * 2014-07-22 2016-01-28 아주대학교산학협력단 Method for positioning, in cytoplasm, antibody having complete immunoglobulin form by penetrating antibody through cell membrane, and use for same
KR101602876B1 (en) * 2014-07-22 2016-03-11 아주대학교산학협력단 Method for inhibiting activated RAS using intact immunoglobulin antibody having Cell-penetrating ability and use thereof
KR101602870B1 (en) 2014-07-22 2016-03-21 아주대학교산학협력단 Method for Cell-penetrating and cytosol-localizing of intact immunoglobulin antibody, and use thereof
RU2021124437A (en) 2015-04-03 2021-09-29 Еурека Терапьютикс, Инк. CONSTRUCTIONS AIMED AT THE AFP / MHC PEPTIDE COMPLEXES AND THEIR USES
KR101790669B1 (en) 2015-10-14 2017-10-26 아주대학교산학협력단 Enhanced split-GFP complementation system, and use thereof
KR101836392B1 (en) 2016-08-17 2018-03-08 한림대학교 산학협력단 A vaccine composition comprising cyclic peptide, an antibody against the cyclic peptide and an anticancer compositions comprising the same
US20200339681A1 (en) 2017-11-16 2020-10-29 Orum Therapeutics Inc. Antibody inhibiting activated ras in cell by internalizing into cytosol of cell, and use thereof
WO2019244086A1 (en) 2018-06-21 2019-12-26 Orum Therapeutics Inc. Cell/tissue-specific cell-penetrating antibodies

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