[go: up one dir, main page]

AU2014375637A1 - Formula of neuregulin preparation - Google Patents

Formula of neuregulin preparation

Info

Publication number
AU2014375637A1
AU2014375637A1 AU2014375637A AU2014375637A AU2014375637A1 AU 2014375637 A1 AU2014375637 A1 AU 2014375637A1 AU 2014375637 A AU2014375637 A AU 2014375637A AU 2014375637 A AU2014375637 A AU 2014375637A AU 2014375637 A1 AU2014375637 A1 AU 2014375637A1
Authority
AU
Australia
Prior art keywords
neuregulin
formula
preparation
treating
heart failure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2014375637A
Inventor
Mingdong Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zensun Shanghai Science and Technology Ltd
Original Assignee
Zensun Shanghai Science and Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53493186&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2014375637(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zensun Shanghai Science and Technology Ltd filed Critical Zensun Shanghai Science and Technology Ltd
Publication of AU2014375637A1 publication Critical patent/AU2014375637A1/en
Assigned to ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY, CO., LTD. reassignment ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY, CO., LTD. Alteration of Name(s) of Applicant(s) under S113 Assignors: ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY LIMITED
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a pharmaceutical preparation for treating a cardiovascular disease. Particularly, the present invention provides a formula of a neuregulin pharmaceutical preparation. The formula consist of neuregulin polypeptide, a buffer, a stabilizer, an excipient, a salt, and another component, can ensure the long-term stability of the neuregulin polypeptide, and can be used for treating a heart failure patient or a patient in a risk of the heart failure.
AU2014375637A 2014-01-03 2014-12-17 Formula of neuregulin preparation Abandoned AU2014375637A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410002665.6A CN104758922A (en) 2014-01-03 2014-01-03 Formula of neuregulin preparation
CN201410002665.6 2014-01-03
PCT/CN2014/094073 WO2015101182A1 (en) 2014-01-03 2014-12-17 Formula of neuregulin preparation

Publications (1)

Publication Number Publication Date
AU2014375637A1 true AU2014375637A1 (en) 2016-07-14

Family

ID=53493186

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014375637A Abandoned AU2014375637A1 (en) 2014-01-03 2014-12-17 Formula of neuregulin preparation

Country Status (10)

Country Link
US (3) US10702585B2 (en)
EP (2) EP3090756B2 (en)
JP (4) JP6703483B2 (en)
KR (3) KR102522140B1 (en)
CN (4) CN104758922A (en)
AU (1) AU2014375637A1 (en)
BR (1) BR112016015660A2 (en)
CA (1) CA2935607A1 (en)
RU (1) RU2738158C2 (en)
WO (1) WO2015101182A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070190127A1 (en) 2005-12-30 2007-08-16 Mingdong Zhou Extended release of neuregulin for improved cardiac function
JP6096262B2 (en) 2009-08-25 2017-03-15 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． Treatment of heart failure based on neuregulin
CN102139095A (en) 2010-01-29 2011-08-03 上海泽生科技开发有限公司 Methods and compositions for the prevention, treatment or delay of cardiac ischemia reperfusion injury using neuregulin
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
CN104519879B (en) 2012-06-07 2018-10-02 洛杉矶儿童医院 Use the method for retinoid agonist treatment neutrophilic granulocytopenia
RU2650635C2 (en) 2012-10-08 2018-04-16 Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи, Ко., Лтд. Compositions and methods for treating heart failure in diabetic patients
BR112015029293A2 (en) 2013-05-22 2018-04-24 Zensun Shanghai Science & Tech Ltd method and kit for preventing, treating or delaying a cardiovascular disease or disorder in a mammal
CN104758922A (en) 2014-01-03 2015-07-08 上海泽生科技开发有限公司 Formula of neuregulin preparation
CN105497876B (en) 2014-09-24 2021-01-15 上海泽生科技开发股份有限公司 Methods and compositions for the prevention, treatment or delay of cardiac ventricular arrhythmias with neuregulin
CN105561298A (en) 2014-10-17 2016-05-11 上海泽生科技开发有限公司 Methods and compositions of neuregulin for preventing, treating or delaying heart failure with preserved ejection fraction
BR112020020646A2 (en) 2018-04-11 2021-02-23 Salubris Biotherapeutics, Inc. recombinant human neuregulin-1 (nrg-1) fusion protein compositions and methods of using these
AR121035A1 (en) 2019-04-01 2022-04-13 Lilly Co Eli NEUREGULIN-4 COMPOUNDS AND METHODS OF USE
KR20220066116A (en) * 2019-09-16 2022-05-23 젠순 (상하이) 사이언스 앤드 테크놀로지 캄파니 리미티드 Recombinant human neuregulin derivatives and uses thereof
JP7425459B2 (en) * 2019-10-11 2024-01-31 株式会社シノテスト Stabilized HMGB1-containing solution
AU2020407172A1 (en) * 2019-12-16 2022-07-14 Seagen Inc. High performance liquid chromatography quantification of excipients

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001489A1 (en) 1987-08-10 1989-02-23 Commonwealth Scientific And Industrial Research Or Control of angiogenesis and compositions and methods therefor
US7115554B1 (en) 1993-05-06 2006-10-03 Acorda Therapeutics, Inc. Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III
US5716930A (en) 1991-04-10 1998-02-10 Ludwig Institute For Cancer Research Glial growth factors
US5530109A (en) 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US5834229A (en) 1991-05-24 1998-11-10 Genentech, Inc. Nucleic acids vectors and host cells encoding and expressing heregulin 2-α
US6750196B1 (en) 1995-03-27 2004-06-15 Acorda Therapeutics Methods of treating disorders of the eye
US5912326A (en) 1995-09-08 1999-06-15 President And Fellows Of Harvard College Cerebellum-derived growth factors
JP4515542B2 (en) 1997-02-10 2010-08-04 ジェネンテック， インコーポレイテッド Hillegrin mutant
CA2306228A1 (en) 1997-10-14 1999-04-22 Cambridge Neuroscience, Inc. Therapeutic methods comprising use of a neuregulin
US6054261A (en) 1998-05-20 2000-04-25 Q-Pharma, Inc. Coenzyme Q10 compositions for organ protection during perfusion
AUPP785098A0 (en) 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6635249B1 (en) 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
CN1138785C (en) 1999-06-04 2004-02-18 周明东 Application of growth factor neuregulin and its analogs
AUPQ105799A0 (en) 1999-06-18 1999-07-08 Victor Chang Cardiac Research Institute, The Cell growth inhibition
EP1265999A2 (en) 2000-02-28 2002-12-18 Decode Genetics EHF. Human schizophrenia gene
EP2357004B1 (en) * 2000-05-23 2016-10-12 CeNeS Pharmaceuticals, Inc. NRG-2 nucleic acid molecules, polypeptides and diagnostic and therapeutical methods
US7375185B2 (en) 2000-09-12 2008-05-20 The United States Of America As Represented By The Department Of Health And Human Services Cardiac myosin light chain kinase polypeptide, encoding nucleic acid, and methods of use
US6482624B2 (en) 2000-11-14 2002-11-19 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
RU2180843C1 (en) 2001-02-19 2002-03-27 Новокузнецкий государственный институт усовершенствования врачей Method of preventing recurrent cardiac infarction
DE10124387A1 (en) * 2001-05-18 2002-11-28 Basf Ag Hydrophobically modified polyethyleneimine and polyvinylamine as anticrease agents for treatment of cellulose containing textiles, useful as textile finishing agents in both solid and liquid formulations
CN1498656A (en) 2002-11-08 2004-05-26 上海泽生科技开发有限公司 Method and compsn. of nervous regulation protein for treating myocardial infarction
WO2003099320A1 (en) 2002-05-24 2003-12-04 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
MXPA05005653A (en) 2002-11-27 2005-11-23 Artesian Therapeutics Inc Heart failure gene determination and therapeutic screening.
MXPA05012619A (en) 2003-05-21 2006-02-08 Univ Texas Inhibition of protein kinase c-mu (pkd) as a treatment for cardiac hypertrophy and heart failure.
GB0413005D0 (en) 2004-06-11 2004-07-14 Coletica Ligand
CA2583972A1 (en) 2004-10-14 2006-10-19 Adventures Plus Pty Ltd A method for the treatment of gastrointestinal and other disorders with an admixture of vitamins and minerals
US20060160062A1 (en) 2005-01-14 2006-07-20 Young Lindon H Perfusion and/or preservation solution for organs
AU2006208241B2 (en) * 2005-01-25 2011-08-04 Five Prime Therapeutics, Inc. Compositions and methods for treating cardiac conditions
US20070141548A1 (en) 2005-03-11 2007-06-21 Jorg Kohl Organ transplant solutions and method for transplanting organs
CN100361709C (en) 2005-08-30 2008-01-16 山东省生物药物研究院 A combination of carbohydrates with a protective effect on vital active substances
CN1768859A (en) 2005-10-24 2006-05-10 天津大学 Aldehyde-based assembly method of multiple biological functional factors on the surface of microparticles
US20070213264A1 (en) 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
CN101394861A (en) * 2005-12-30 2009-03-25 上海泽生科技开发有限公司 Sustained administration of neuregulin can improve cardiac function
US20070190127A1 (en) * 2005-12-30 2007-08-16 Mingdong Zhou Extended release of neuregulin for improved cardiac function
ATE502998T1 (en) * 2006-07-07 2011-04-15 Procter & Gamble DETERGENT COMPOSITIONS
US9580515B2 (en) 2006-08-21 2017-02-28 Zensun (Shanghai) Science & Technology, Co., Ltd. Neukinase, a downstream protein of neuregulin
PL2115477T3 (en) 2007-01-25 2015-12-31 Hoffmann La Roche Use of igfbp-7 in the assessment of heart failure
CN101310779A (en) 2007-05-25 2008-11-26 上海泽生科技开发有限公司 Device comprising neuregulin and pharmaceutical preparation
CN101310766B (en) 2007-05-25 2014-04-16 上海泽生科技开发有限公司 New use of neuroregulation protein
US20090156488A1 (en) 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation
WO2009137837A2 (en) 2008-05-09 2009-11-12 The Regents Of The University Of California Neuregulin/erbb signaling and integrin
EP3632459A1 (en) 2008-07-17 2020-04-08 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure
CN102231987A (en) * 2008-11-28 2011-11-02 上海泽生科技开发有限公司 Neuregulin and cardiac stem cells
EP2808339B1 (en) 2008-11-28 2017-02-15 Zensun (Shanghai) Science & Technology, Co., Ltd. Neuregulin peptides and their use
ES2748886T3 (en) 2009-06-09 2020-03-18 Zensun Shanghai Science & Tech Co Ltd Neuregulin-based methods for the treatment of heart failure
WO2010142141A1 (en) 2009-06-09 2010-12-16 Zensun (Shanghai) Science & Technology Limited Neuregulin based methods for treating heart failure
JP6096262B2 (en) 2009-08-25 2017-03-15 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． Treatment of heart failure based on neuregulin
CN102139095A (en) 2010-01-29 2011-08-03 上海泽生科技开发有限公司 Methods and compositions for the prevention, treatment or delay of cardiac ischemia reperfusion injury using neuregulin
PL2544537T3 (en) * 2010-03-10 2017-10-31 Cempra Pharmaceuticals Inc Parenteral formulations of macrolide antibiotics
US9029328B2 (en) 2010-03-24 2015-05-12 The Brigham And Women's Hospital, Inc. Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands
WO2012012682A2 (en) 2010-07-22 2012-01-26 Zishan Haroon Methods of treating or ameliorating diseases and enhancing performance comprising the use of a magnetic dipole stabilized solution
CN102230084B (en) * 2011-06-14 2013-01-23 东北大学 Coated biological oxidation pretreatment method of low-level arsenic refractory gold ores
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
DE18200782T1 (en) * 2012-04-02 2021-10-21 Modernatx, Inc. MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH DISEASES IN HUMANS
RU2650635C2 (en) 2012-10-08 2018-04-16 Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи, Ко., Лтд. Compositions and methods for treating heart failure in diabetic patients
AU2014225534A1 (en) 2013-03-06 2015-09-24 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure
BR112015029293A2 (en) 2013-05-22 2018-04-24 Zensun Shanghai Science & Tech Ltd method and kit for preventing, treating or delaying a cardiovascular disease or disorder in a mammal
CN104337813A (en) 2013-07-23 2015-02-11 上海泽生科技开发有限公司 Methods of promoting motility of the gastrointestinal system using vitamin B compositions
CN104758300A (en) 2014-01-02 2015-07-08 上海泽生科技开发有限公司 Antibacterial applications of vitamin D and vitamin D composition
CN104758922A (en) 2014-01-03 2015-07-08 上海泽生科技开发有限公司 Formula of neuregulin preparation
CN105497876B (en) 2014-09-24 2021-01-15 上海泽生科技开发股份有限公司 Methods and compositions for the prevention, treatment or delay of cardiac ventricular arrhythmias with neuregulin
CN105561298A (en) 2014-10-17 2016-05-11 上海泽生科技开发有限公司 Methods and compositions of neuregulin for preventing, treating or delaying heart failure with preserved ejection fraction

Also Published As

Publication number Publication date
CN110946993A (en) 2020-04-03
KR20230054749A (en) 2023-04-25
EP3090756A4 (en) 2017-07-19
EP3821904A1 (en) 2021-05-19
RU2016131667A3 (en) 2018-08-21
RU2016131667A (en) 2018-02-08
US11969458B2 (en) 2024-04-30
JP7479068B2 (en) 2024-05-08
JP7100083B2 (en) 2022-07-12
JP6703483B2 (en) 2020-06-03
KR20160105443A (en) 2016-09-06
US20170007671A1 (en) 2017-01-12
BR112016015660A2 (en) 2017-10-24
CA2935607A1 (en) 2015-07-09
US20250073306A1 (en) 2025-03-06
EP3090756A1 (en) 2016-11-09
WO2015101182A1 (en) 2015-07-09
JP2022130627A (en) 2022-09-06
JP2017502969A (en) 2017-01-26
KR20220093387A (en) 2022-07-05
CN104758922A (en) 2015-07-08
EP3090756B1 (en) 2020-09-30
EP3090756B2 (en) 2024-09-25
JP2024099628A (en) 2024-07-25
US20210113661A1 (en) 2021-04-22
KR102522140B1 (en) 2023-04-17
US10702585B2 (en) 2020-07-07
JP2020143101A (en) 2020-09-10
CN105960248A (en) 2016-09-21
RU2738158C2 (en) 2020-12-08
CN111012898A (en) 2020-04-17
EP3821904B1 (en) 2025-02-05

Similar Documents

Publication Publication Date Title
AU2014375637A1 (en) Formula of neuregulin preparation
EP3674314A3 (en) Apelin polypeptides
EP3340935A4 (en) Replacement heart valves and methods of delivery
PH12016501809A1 (en) Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
MX2021014242A (en) USE OF LINAGLIPTIN IN CARDIO- AND RENOPROTECTIVE ANTI-DIABETIC THERAPY.
LT3513809T (en) MEDICAL COMPOSITION INCLUDING TIVOZANIB
PH12019501018A1 (en) Pharmaceutical composition, methods for treating and uses thereof
IL259711A (en) Protein kinase inhibitor, preparation method and medical use thereof
EP4599780A3 (en) Matrix implant
MX2015015518A (en) Methods and compositions for the treatment of cancer.
EP3117802A4 (en) Stent with mechanical or biological heart valve for minimally invasive valve replacement procedure, and applicator
MX2017009417A (en) Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof.
PT3110840T (en) An a22k, desb27, b29r, des b30, at epsilon position of lysine 22 acylated human insulin analogue.
PT3527552T (en) Fused tricyclic -amino acid derivative, preparation method therefor, and medical use thereof
IL257173A (en) Novel insulin derivatives and the medical uses hereof
DK3294449T3 (en) Powdered titanium oxide, process for its preparation and use
BR112017012406A2 (en) fixed ratio formulation of insulin glargine / lixisenatide
EP3331583B8 (en) Medical implant based on nanocellulose
EP3423021A4 (en) Medical chair
EP3160579A4 (en) Prefitting evaluation of cochlear implant patients
EP3297636A4 (en) Pharmaceutical composition of carboplatin based co-crystals and use thereof
MX2019014090A (en) Methods for the treatment of chronic pouchitis.
EP3235808A4 (en) Modified taurine, and pharmaceutical composition for preventing or treating metabolic diseases containing same
MA40642A (en) Novel peptide derivatives and uses thereof
MX2016012825A (en) Combinations of cancer therapeutics.

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted