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AU2014265021B2 - Prodrugs of nh-acidic compounds - Google Patents

Prodrugs of nh-acidic compounds

Info

Publication number
AU2014265021B2
AU2014265021B2 AU2014265021A AU2014265021A AU2014265021B2 AU 2014265021 B2 AU2014265021 B2 AU 2014265021B2 AU 2014265021 A AU2014265021 A AU 2014265021A AU 2014265021 A AU2014265021 A AU 2014265021A AU 2014265021 B2 AU2014265021 B2 AU 2014265021B2
Authority
AU
Australia
Prior art keywords
prodrug
parent drug
lactam
sulfonamide
carbamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2014265021A
Other versions
AU2014265021A1 (en
Inventor
Orn Almarsson
Laura Cook Blumberg
Julius F. Remenar
Tarek A. Zeidan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Pharma Ireland Ltd
Original Assignee
Alkermes Pharma Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2010266040A external-priority patent/AU2010266040B2/en
Application filed by Alkermes Pharma Ireland Ltd filed Critical Alkermes Pharma Ireland Ltd
Priority to AU2014265021A priority Critical patent/AU2014265021B2/en
Publication of AU2014265021A1 publication Critical patent/AU2014265021A1/en
Priority to AU2016204605A priority patent/AU2016204605B2/en
Application granted granted Critical
Publication of AU2014265021B2 publication Critical patent/AU2014265021B2/en
Priority to AU2016234918A priority patent/AU2016234918A1/en
Priority to AU2018205087A priority patent/AU2018205087B2/en
Priority to AU2020201426A priority patent/AU2020201426B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
AU2014265021A 2009-06-25 2014-11-18 Prodrugs of nh-acidic compounds Active AU2014265021B2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2014265021A AU2014265021B2 (en) 2009-06-25 2014-11-18 Prodrugs of nh-acidic compounds
AU2016204605A AU2016204605B2 (en) 2009-06-25 2016-07-04 Prodrugs of nh-acidic compounds
AU2016234918A AU2016234918A1 (en) 2009-06-25 2016-09-28 Prodrugs of nh-acidic compounds
AU2018205087A AU2018205087B2 (en) 2009-06-25 2018-07-10 Prodrugs of nh-acidic compounds
AU2020201426A AU2020201426B2 (en) 2009-06-25 2020-02-27 Prodrugs of nh-acidic compounds

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US61/220,480 2009-06-25
US61/293,087 2010-01-07
US61/293,133 2010-01-07
AU2010266040A AU2010266040B2 (en) 2009-06-25 2010-06-24 Prodrugs of NH-acidic compounds
AU2014265021A AU2014265021B2 (en) 2009-06-25 2014-11-18 Prodrugs of nh-acidic compounds

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2010266040A Division AU2010266040B2 (en) 2009-06-25 2010-06-24 Prodrugs of NH-acidic compounds

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2016204605A Division AU2016204605B2 (en) 2009-06-25 2016-07-04 Prodrugs of nh-acidic compounds
AU2016234918A Division AU2016234918A1 (en) 2009-06-25 2016-09-28 Prodrugs of nh-acidic compounds

Publications (2)

Publication Number Publication Date
AU2014265021A1 AU2014265021A1 (en) 2014-12-04
AU2014265021B2 true AU2014265021B2 (en) 2016-07-21

Family

ID=51999623

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014265021A Active AU2014265021B2 (en) 2009-06-25 2014-11-18 Prodrugs of nh-acidic compounds

Country Status (1)

Country Link
AU (1) AU2014265021B2 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2418499A (en) * 1944-06-20 1947-04-08 Du Pont 2-alkoxymethylmercapto-thiazoles and thiazolines and a process for preparing the same
US3266984A (en) * 1964-08-28 1966-08-16 Sumitomo Chemical Co Chrysanthemic acid esters
US3523121A (en) * 1967-03-09 1970-08-04 Rohm & Haas Certain 2-carbamoyl-3-isothiazolenes
US3957808A (en) * 1969-09-03 1976-05-18 Rohm And Haas Company 3-alkoxyisothiazoles
US4837337A (en) * 1984-12-15 1989-06-06 Mitsubishi Chemical Industries Limited Process for producing pyrrolidone derivative
US5206386A (en) * 1991-03-20 1993-04-27 Isp Investments Inc. Controlled release N-substituted pyrrolidone esters and process for the use thereof
US5700946A (en) * 1995-04-18 1997-12-23 Nippon Shokubai Co., Ltd. Process for production of N-vinyl compound
WO2004026864A1 (en) * 2002-09-17 2004-04-01 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2418499A (en) * 1944-06-20 1947-04-08 Du Pont 2-alkoxymethylmercapto-thiazoles and thiazolines and a process for preparing the same
US3266984A (en) * 1964-08-28 1966-08-16 Sumitomo Chemical Co Chrysanthemic acid esters
US3523121A (en) * 1967-03-09 1970-08-04 Rohm & Haas Certain 2-carbamoyl-3-isothiazolenes
US3957808A (en) * 1969-09-03 1976-05-18 Rohm And Haas Company 3-alkoxyisothiazoles
US4837337A (en) * 1984-12-15 1989-06-06 Mitsubishi Chemical Industries Limited Process for producing pyrrolidone derivative
US5206386A (en) * 1991-03-20 1993-04-27 Isp Investments Inc. Controlled release N-substituted pyrrolidone esters and process for the use thereof
US5700946A (en) * 1995-04-18 1997-12-23 Nippon Shokubai Co., Ltd. Process for production of N-vinyl compound
WO2004026864A1 (en) * 2002-09-17 2004-04-01 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia

Also Published As

Publication number Publication date
AU2014265021A1 (en) 2014-12-04

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