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AU2008334075A1 - Tetrahydro-isoquinoline PPAT inhibitors as antibacterial agents - Google Patents

Tetrahydro-isoquinoline PPAT inhibitors as antibacterial agents Download PDF

Info

Publication number
AU2008334075A1
AU2008334075A1 AU2008334075A AU2008334075A AU2008334075A1 AU 2008334075 A1 AU2008334075 A1 AU 2008334075A1 AU 2008334075 A AU2008334075 A AU 2008334075A AU 2008334075 A AU2008334075 A AU 2008334075A AU 2008334075 A1 AU2008334075 A1 AU 2008334075A1
Authority
AU
Australia
Prior art keywords
independently
alkyl
compound
aryl
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2008334075A
Other languages
English (en)
Inventor
Roger Frechette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biota Scientific Management Pty Ltd
Original Assignee
Biota Scientific Management Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scientific Management Pty Ltd filed Critical Biota Scientific Management Pty Ltd
Publication of AU2008334075A1 publication Critical patent/AU2008334075A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2008334075A 2007-11-30 2008-11-26 Tetrahydro-isoquinoline PPAT inhibitors as antibacterial agents Abandoned AU2008334075A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99152507P 2007-11-30 2007-11-30
US60/991,525 2007-11-30
PCT/US2008/084948 WO2009073545A2 (fr) 2007-11-30 2008-11-26 Inhibiteurs tétrahydro-isoquinolino de ppat utilisés en tant qu'agents antibactériens

Publications (1)

Publication Number Publication Date
AU2008334075A1 true AU2008334075A1 (en) 2009-06-11

Family

ID=40718459

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008334075A Abandoned AU2008334075A1 (en) 2007-11-30 2008-11-26 Tetrahydro-isoquinoline PPAT inhibitors as antibacterial agents

Country Status (6)

Country Link
EP (1) EP2225207A2 (fr)
JP (1) JP2011518109A (fr)
CN (1) CN102007101A (fr)
AU (1) AU2008334075A1 (fr)
CA (1) CA2707445A1 (fr)
WO (1) WO2009073545A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505373A (ja) 2007-11-30 2011-02-24 ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド 抗菌剤としての２環式ｐｐａｔ阻害剤
FR2986002B1 (fr) 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN102603755B (zh) * 2012-02-08 2015-09-09 中国人民解放军第二军医大学 一类具有协同氟康唑抗耐药真菌作用的化合物
FR3008977A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008975A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008976A1 (fr) 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
CN107108581B (zh) 2014-08-21 2020-06-23 百时美施贵宝公司 作为强效rock抑制剂的回接苯甲酰胺衍生物
BR112018002710B1 (pt) * 2015-08-12 2022-06-28 Syngenta Participations Ag Composto derivado heterobicíclico microbicida, composição compreendendo o mesmo e método de combate, prevenção ou controle de doenças fitopatogênicas
FI3870578T3 (fi) 2018-10-22 2023-11-03 C4X Discovery Ltd Terapeuttisia yhdisteitä
CN113461699B (zh) * 2021-04-14 2022-06-21 宁波大学 一种四环吡咯生物碱类化合物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2365401A1 (fr) * 1999-03-11 2000-10-05 Neurogen Corporation Pyridines 2,4-disubstituees fusionnees avec un aryle: ligands du recepteur nk-3
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
EP1637529A1 (fr) * 2004-09-20 2006-03-22 4Sc Ag Nouveaux analogues de piperidin-4-yl-thiazole-carboxamide en tant qu'inhibiteurs de proliferation de lymphocytes T er leurs utilisations
EP1994017A2 (fr) * 2006-03-15 2008-11-26 4Sc Ag Nouveaux inhibiteurs hétérocycliques de nf/kb

Also Published As

Publication number Publication date
WO2009073545A3 (fr) 2009-09-11
WO2009073545A2 (fr) 2009-06-11
CA2707445A1 (fr) 2009-06-11
EP2225207A2 (fr) 2010-09-08
JP2011518109A (ja) 2011-06-23
CN102007101A (zh) 2011-04-06

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period