AU2005336924A1 - Enhancing treatment of cancer and HIF-1 mediated disoders with adenosine A3 receptor antagonists - Google Patents

Enhancing treatment of cancer and HIF-1 mediated disoders with adenosine A3 receptor antagonists Download PDF

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Publication number: AU2005336924A1
Authority: AU; Australia
Prior art keywords: substituted; cancer; hif; adenosine; alkyl
Prior art date: 2004-11-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2005336924A

Other languages

English (en)

Inventor

Pier Giovani Baraldi

Pier Andrea Borea

Edward Leung

Stephen Maclennan

Stefania Merighi

Allan Moorman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

King Pharmaceuticals Research and Development Inc

Original Assignee

King Pharmaceuticals Research and Development Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-22

Filing date

2005-11-22

Publication date

2007-04-12

2005-11-22 Application filed by King Pharmaceuticals Research and Development Inc filed Critical King Pharmaceuticals Research and Development Inc

2007-04-12 Publication of AU2005336924A1 publication Critical patent/AU2005336924A1/en

Status Abandoned legal-status Critical Current

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AU2005336924A 2004-11-22 2005-11-22 Enhancing treatment of cancer and HIF-1 mediated disoders with adenosine A3 receptor antagonists Abandoned AU2005336924A1 (en)

Applications Claiming Priority (3)

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US63055704P	2004-11-22	2004-11-22
US60/630,557		2004-11-22
PCT/US2005/042551 WO2007040565A2 (fr)	2004-11-22	2005-11-22	Amelioration du traitement du cancer et de troubles medies par hif-1 au moyen d'antagonistes des recepteurs de l'adenosine a3

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AU2005336924A1 true AU2005336924A1 (en)	2007-04-12

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AU2005336924A Abandoned AU2005336924A1 (en)	2004-11-22	2005-11-22	Enhancing treatment of cancer and HIF-1 mediated disoders with adenosine A3 receptor antagonists

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EP (1)	EP1827445A2 (fr)
JP (1)	JP2008520746A (fr)
AU (1)	AU2005336924A1 (fr)
CA (1)	CA2586420A1 (fr)
IL (1)	IL183307A0 (fr)
WO (1)	WO2007040565A2 (fr)

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EP1604665B1 (fr)	2003-03-10	2011-05-11	Eisai R&D Management Co., Ltd.	Inhibiteur de kinase c-kit
WO2005044788A1 (fr)	2003-11-11	2005-05-19	Eisai Co., Ltd.	Derive d'uree et son procede de production
JP4834553B2 (ja)	2004-09-17	2011-12-14	エーザイ・アール・アンド・ディー・マネジメント株式会社	医薬組成物
JP4989476B2 (ja)	2005-08-02	2012-08-01	エーザイ・アール・アンド・ディー・マネジメント株式会社	血管新生阻害物質の効果を検定する方法
EP2036557B1 (fr)	2006-05-18	2015-10-21	Eisai R&D Management Co., Ltd.	Agent antitumoral destiné au cancer de la thyroïde
CN101511793B (zh)	2006-08-28	2011-08-03	卫材R&D管理有限公司	针对未分化型胃癌的抗肿瘤剂
WO2008093855A1 (fr)	2007-01-29	2008-08-07	Eisai R & D Management Co., Ltd.	Composition destinée au traitement d'un cancer de l'estomac de type indifférencié
EP2218712B1 (fr)	2007-11-09	2015-07-01	Eisai R&D Management Co., Ltd.	Combinaison d'une substance antiangiogénique et d'un complexe de platine antitumoral
JP5399926B2 (ja) *	2008-01-29	2014-01-29	エーザイ・アール・アンド・ディー・マネジメント株式会社	血管阻害物質とタキサンとの併用
PL2356113T3 (pl) *	2008-11-14	2015-06-30	Bayer Ip Gmbh	Heterocyklicznie podstawione związki arylowe jako inhibitory HIF
RU2560683C2 (ru)	2010-06-25	2015-08-20	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Противоопухолевое средство, задействующее соединения с ингибирующим эффектом к киназам в комбинации
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JP6038128B2 (ja)	2011-06-03	2016-12-07	エーザイ・アール・アンド・ディー・マネジメント株式会社	レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
US9334239B2 (en)	2012-12-21	2016-05-10	Eisai R&D Management Co., Ltd.	Amorphous form of quinoline derivative, and method for producing same
US9782428B2 (en)	2013-03-18	2017-10-10	Northeastern University	Method for generation of broadly neutralizing anti-pathogen antibodies
MX368099B (es)	2013-05-14	2019-09-19	Eisai R&D Man Co Ltd	Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib.
JP6659554B2 (ja)	2014-08-28	2020-03-04	エーザイ・アール・アンド・ディー・マネジメント株式会社	高純度キノリン誘導体およびその製造方法
HUE064614T2 (hu)	2015-02-25	2024-04-28	Eisai R&D Man Co Ltd	Eljárás egy kinolin-származék keserû ízének elnyomására
KR20240064733A (ko)	2015-03-04	2024-05-13	머크 샤프 앤드 돔 코포레이션	암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
BR112017027227B1 (pt)	2015-06-16	2023-12-12	Eisai R&D Management Co., Ltd	Agente anti-câncer
JP6553726B2 (ja)	2015-08-20	2019-07-31	エーザイ・アール・アンド・ディー・マネジメント株式会社	腫瘍治療剤
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2005
- 2005-11-22 EP EP05858564A patent/EP1827445A2/fr not_active Withdrawn
- 2005-11-22 AU AU2005336924A patent/AU2005336924A1/en not_active Abandoned
- 2005-11-22 JP JP2007543474A patent/JP2008520746A/ja active Pending
- 2005-11-22 WO PCT/US2005/042551 patent/WO2007040565A2/fr not_active Ceased
- 2005-11-22 CA CA002586420A patent/CA2586420A1/fr not_active Abandoned
2007
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Also Published As

Publication number	Publication date
CA2586420A1 (fr)	2007-04-12
JP2008520746A (ja)	2008-06-19
IL183307A0 (en)	2008-04-13
EP1827445A2 (fr)	2007-09-05
WO2007040565A9 (fr)	2007-07-05
WO2007040565A3 (fr)	2009-04-16
WO2007040565A2 (fr)	2007-04-12

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