AU2005205218A1 - Methods of assessing a tissue inflammatory response using expression profiles of endothelial cells - Google Patents

Description

WO 2005/068655 PCT/GB2005/000057 1 METHODS-OF ASSESSING A TISSUE INFLAMMATORY RESPONSE USING EXPRESSION PROFILES OF ENDOTHELIAL CELLS Field of the Invention The present invention relates to gene expression profiles of endothelial cells and to the use of these profiles in the assessment of disease conditions and in therapy. Background to the Invention The migration of leucocytes into tissues is a key part of the normal function of the immune system, mucosal surfaces, the uterine endometrium, mammary gland and ovary. However, emigration of leucocytes from the intravascular space into the tissues can also be stimulated by the inflammation response. Inflammation is a response of the body to damage or infection, and typically involves movement of leucocytes and proteins across endothelial walls and into tissues. The inflammation response involves a number of signalling molecules. Some of these act on the endothelium to cause the endothelial cells to adhere less tightly to one another and/or to make their surfaces adhesive to passing white blood cells. Other signals act as chemoattractants for the leucocytes, or promote expression of adhesion molecules on the leucocytes. Yet other signals regulate leucocyte activation and survival. Signalling molecules include 'quick release' mediators that are involved in increased vascular permeability, such as histamine. These act synergistically with the later stage 'process induced' mediators. These later stage mediators include chemokines, which attract leukocytes into areas of inflammation, and cytokines, subsequently released from inflammatory cells and activated endothelial cells.

WO 2005/068655 PCT/GB2005/000057 2 TNF-a, TL-11 and IL-8 are inflammatory mediators found at high concentrations at sites of inflammation, and endothelial cells possess receptors for these mediators (1-3). TNF-a is a prototypical cytokine, which was originally isolated from macrophages, but is now known to be generated by a variety of cells, including lymphocytes, monocytes, neutrophils, T-cells, myocytes and smooth muscle cells. TNF receptor 1 engagement by TNF-a leads to the initiation of apoptosis in a wide variety of cell types. Receptor binding also results in sustained NF-KB activation, required for expression of a repertoire of genes involved not only in the inflammatory response, but also increased cell survival and enhanced resistance to TNF-a-induced apoptosis. Signalling pathways also activated in endothelial cells by TNF-a include the phosphatidylinositol (PI) kinase dependent kinases, stress activated protein kinases (SAPK) and mitogen activated protein kinases (MAPK) (3, 4). IL-1r is another prototypical cytokine. The main source of secreted Il-1 is monocytes, but it is also generated by a wide variety of other cell types, including, notably, activated macrophages, neutrophils, platelets, T- and B-cells, natural killer (NK) cells, endothelial cells, SMCs (smooth muscle cells) and fibroblasts. IL-13 is synthesised as a precursor and, once proteolytically cleaved, can activate many cell types with roles in immunity and inflammation. As with TNF-a, IL-l@ activates the NF-KB (nuclear factor KB) survival pathway, as well as MAPK cascades p42/p44, p38 and Jnk (5). IL-8 is a chemokine that has been closely linked with angiogenesis. The main sources of IL-B are monocytes, neutrophils, T-cells, NK cells, endothelial cells, fibroblasts and epithelial cells. IL-8 is involved in the process of WO 2005/068655 PCT/GB2005/000057 3 leukocyte transmigration into tissues, as well as other aspects of the inflammatory response. Its production is not constitutive but is induced by pro-inflammatory cytokines. IL-8 binds to heparin and induces endothelial cell migration, proliferation and survival in vitro (6). IL-8 and its receptors appear to be critical in angiogenesis and tumour progression (7, 8). Molecular mediators of inflammation such as TNF-a, IL-1 and IL-8 act on target cells within inflamed tissues such as endothelial cells, fibroblasts and leukocytes. The effects of combinations of inflammatory mediators such as these three is synergistic - i.e. the action of these factors 'in concert' is likely to be different from the sum of their individual effects. The inflammatory response of tissues, such as is typified in inflammatory diseases, typically involves the abnormal or excessive movement of leucocytes and proteins into the tissue. This can result in a large number of acute or chronic inflammation disorders. Leucocyte and protein movement can also play a role in conditions which are not primarily inflammatory diseases, but in which the tissues demonstrate an inflammatory response. For example, the diseases of atherosclerosis and endometriosis may rely on the migration of leucocytes into the lesions. Repair of tissue necrosis that occurs in stroke or heart attack also requires inflammation responses. Tumour growth may be regulated by leucocytes that migrate from the blood into the tumour. These leucocytes release factors that directly promote tumour cell growth and tumour angiogenesis. In addition, leucocytes that migrate into tumours mediate an immune responses towards tumour cell specific antigens with subsequent anti-tumour effect. The role of inflammation in tumour growth is therefore complex, WO 2005/068655 PCT/GB2005/000057 4 and involves a balance between stimulatory and inhibitory pathways. In view of the role of inflammation responses in a wide variety of pathological conditions, there is a continuing need for the development of methods for the assessment or treatment of human medical conditions associated with such responses. In addition, inflammation responses are essential features of physiological processes such as female fertility and wound healing. There is a need for methods to modulate inflammatory responses in order to modulate these processes. Disclosure of the Invention We have analysed the changes in transcript abundance which occur when human umbilical vein endothelial cells (HUVECs) are contacted with a mixture of TNF-a, Interleukin-1l and Interleukin-8. These factors are typically present at increased concentrations in tissues during an inflammatory response and are secreted by a wide variety of cell types over sustained periods. Primary cell cultures of endothelial cells derived from a number of different individuals were tested in order to obtain a consensus set of transcripts regulated in endothelial cells of multiple individuals during an inflammatory response. Data were analysed using a novel combination of bio-informatic algorithms, including a modified Loess normalisation and a CyberT algorithm. In addition, we analysed expression in different endothelial cells types obtained from different parts of the body, namely HUVEC, human coronary artery endothelial cells (HCAEC) and human uterine microvascular endothelial cells (UtMVEC). It was found that many transcripts, including those which were WO 2005/068655 PCT/GB2005/000057 5 most strongly regulated in HUVECs, were consistently regulated by inflammatory signals in all three cell types. Thus, in the present invention we have used a novel methodology to identify for the first time a pattern of changes in the regulation of expression of certain genes in endothelial cells responding to inflammatory signals as well as a consensus set of genes whose transcripts are modified in response to inflammatory signals in endothelial cells derived from many individuals, and which are therefore likely to have wide applicability to populations of patients. Accordingly, the present invention provides a means for assessment of (e.g., diagnosis, prognosis or monitoring of) a tissue inflammatory response or a condition associated therewith. Such a response is typically associated with one of a number of conditions and it may also involve the migration of leucocytes across an endothelium. Therefore, by determining a tissue inflammatory response, a determination may also be made of the condition with which that response may be associated. Also, the finding that a number of transcripts are regulated in these responses and hence conditions, both of genes known as such and from ESTs, allows the provision of novel assay targets and the development of new therapies for such conditions. Accordingly, in a first aspect, the present invention provides a method of assessing a tissue inflammatory response, comprising: making a quantitative determination of the level of at least five transcripts shown in Table 1, or proteins encoded thereby, in a sample; and WO 2005/068655 PCT/GB2005/000057 6 comparing the abundance of said transcripts or proteins so determined with the level of said transcripts or proteins obtained from a control sample of cells. Preferably, the sample comprises cells obtained from a site within a patient believed to be affected by a tissue inflammatory response, suitably endothelial cells, or patient blood, serum or urine. In another aspect, the invention provides a gene chip array suitable for use in the above-described method of the invention, comprising at least five nucleic acids suitable for detection of at least five transcripts shown in Table 1; optionally a control specific for said transcripts; and optionally at least one control for the gene chip. In a further aspect, the invention provides a protein based assay suitable for use in the above-described method of the invention, for the assessment of at least five proteins encoded by transcripts including those shown in Table 1; optionally a control specific for said proteins; and optionally at least one control for the assay. In a further aspect, the invention provides an assay method for determining a modulator of a tissue inflammatory response or a condition associated therewith, wherein said method comprises a) providing a protein encoded by transcripts from Table 1; b) bringing the protein into contact with a candidate modulator of its activity; c) determining whether said candidate modulator is capable of modulating the activity of the protein; or wherein said method comprises; WO 2005/068655 PCT/GB2005/000057 7 a) providing an endothelial cell in culture; b) bringing said cell into contact with a candidate modulator of said tissue inflammatory response; and c) determining whether said candidate modulator is capable of modulating the level of at least one transcript selected from the transcripts of Table 1. Modulators obtained by such methods may be used in a method of modulating tissue inflammatory responses in a human or animal subject, e.g., so as to treat a condition discussed below. In another aspect, the identification of genes of previously unknown function and of ESTs, has allowed new potential targets for therapeutic intervention to be developed. Thus, the invention provides a vector comprising a sequence encoding a transcript from Table lb operably linked to a promoter for the transcription of said sequence. Such vectors are useful in the expression of proteins which may be therapeutics or therapeutic targets. The vectors may also have direct therapeutic use in themselves, e.g., in gene therapy applications. Description of the Tables Table la lists transcripts of genes whose levels are regulated in endothelial cells by inflammatory mediators TNFa, IL-1p, and IL-8, where the genes have a previously ascribed function. Table lb lists transcripts of genes or ESTs whose levels are regulated in endothelial cells by inflammatory mediators TNFa, IL-1P and IL-8, where the genes/ESTs do not have a previously ascribed function.

WO 2005/068655 PCT/GB2005/000057 8 Table 2a provides nucleic acid sequences for each of the probes mentioned in Table la. Table 2b provides nucleic acid sequences for each of the probes mentioned in Table lb. Detailed Description of the Invention Reference herein to Table 1 and 2 is to be construed as meaning Tables la or lb together, or Tables 2a and 2b together, respectively, unless the context is explicit to only one of these component parts of Table 1 or Table 2 respectively. Conditions associated with tissue inflammatory responses In its first aspect, the present invention is concerned with a method for the assessment of a tissue inflammatory response. It is generally recognised, as is discussed above, that leucocytes are involved in the inflammatory responses of tissues. An inflammatory response may involve the movement of leucocytes across an endothelium. However, proteins which are involved in such an inflammatory response may also cause the movement of leucocytes to the inflamed tissue, may participate in or be responsible for the activation of the leucocytes, the activation and angiogenesis of endothelial cells, or may influence the inflammatory response by inhibiting the apoptosis of leucocytes or endothelial cells. A tissue inflammatory response is typically involved with a condition or disease state of the patient. By "condition" as used herein is meant any disease state or body response which involves, causes or is associated with the tissue inflammatory response.

WO 2005/068655 PCT/GB2005/000057 9 The tissue inflammatory response may either be excessive or unwanted, for example as may be the case in an inflammatory disease such as those discussed herein below, or may be insufficient, such as, for example in conditions associated with defective adhesion proteins, such as leucocyte adhesion deficiency types 1 and 2 (LAD-1 and LAD-2). Tissue inflammatory responses and trans-endothelial leucocyte movement can be affected by changes in the endothelial cells, for example by changes in adhesion molecule expression, which alters the ability of the leucocytes to adhere to the endothelial cells, or alters the chemokine-mediated recruitment of leucocytes to the inflammed tissue. In respect of the present invention, it is preferred that the changes in the endothelial cells are in response to an inflammatory signal. A condition to be assessed by the method of the invention may be one in which endothelial cells in the location of the inflammatory response or affected by the inflammatory response are altered so as to promote an inflammatory process and allow the movement of leucocytes across that endothelium. Typically the movement of leucocytes across an endothelium occurs as a response to inflammatory signals. Therefore, a tissue inflammatory response to be assessed by the method of the invention is one in which inflammatory signals are issued. Exemplary of such conditions are inflammatory diseases, vasculitic syndromes, atherosclerosis and associated diseases, conditions involving tumour growth and chronic transplant rejection. Inflammatory diseases include inflammatory bowel disorders, psoriasis, ischemic reperfusion, adult respiratory distress WO 2005/068655 PCT/GB2005/000057 10 syndrome, asthma, allergic rhinitis, dermatitis, meningitis, encephalitis, uveitis, diseases involving leucocyte diapedesis, central nervous system inflammatory disorders, Alzheimer's, endometriosis, multiple sclerosis, multiple organ injury syndrome, alcoholic hepatitis, bacterial pneumonia, antigen-antibody complex mediated diseases; inflammation of the lung (including pleurisy, alveolitis, pneumonia, chronic bronchitis, bronchiectasis, cystic fibrosis and COPD), vasculitis, polyarteritis nodosa, giant cell arteritis, microscopic polyarteritis, pre-eclampsia and autoimmune diseases (such as rheumatoid arthritis, Sjorgen's syndrome, and the multiple forms of renal failure which are primarily due to autoimmune attack directed at the endothelial cells in the kidney glomeruli). In atherosclerosis and associated diseases, such as coronary heart disease, peripheral vascular disease and cerebrovascular accident, leucocyte migration across the endothelial layer into blood vessel walls at the site of an atherosclerotic plaque is driven by inflammatory signals from leucocytes associated with the plaque and the underlying endothelial cells. Plaque instability and subsequent rupture leading to thrombosis and vessel stenosis or occlusion may be associated with inflammatory effects on the endothelial cells within the area of the plaque. Tumour growth may be regulated by leucocytes that migrate from the blood into the tumour, and which release factors that directly promote tumour cell growth and tumour angiogenesis. Thus, cancers and especially those involving solid tumours may also be a relevant therapeutic indication. Chronic transplant rejection critically involves immune cell migration across blood vessels and immune attack directed WO 2005/068655 PCT/GB2005/000057 11 towards endothelial cells and hence is suitable for assessment by the method of the invention. These and other conditions associated with the release of inflammatory signals may be the subject of methods of the present invention. Assessment of a tissue inflammatory response In the present invention, it will be understood that the determination of cells "obtained from a site" believed to be affected by a tissue inflammatory response is reference to an in vitro method practiced on a sample after removal from the body. The step of removing the sample, e.g., by biopsy, is not part of the invention as such. In addition to or as an alternative to techniques such as tissue biopsies, bodily fluids such as blood, serum and urine may be collected to reveal inflammation-induced changes within these fluids. Such changes may be demonstrated by, for example, an alteration in the sample in the abundance of endothelial cell-derived proteins that are encoded by the sequences in table 1. Accordingly, the present invention provides a method for the diagnosis of a condition with which a tissue inflammatory response is associated comprising the determination of the abundance of endothelial cell-derived proteins encoded by at least five of the transcripts of Table 1 in a sample from a patient suspected of suffering from such a condition. As explained above, the data obtained in the present invention shows that contacting endothelial cells with TNFa, IL-lp and IL-8 results in characteristic changes to certain transcripts, taking into account variation between individuals and between WO 2005/068655 PCT/GB2005/000057 12 different endothelial tissues. These changes may take the form either of a pattern of response or may affect individual transcripts. Accordingly, it is possible to use these characteristic changes as a reference for the diagnosis of conditions such as those discussed above. In addition to, or as an alternative to, diagnosis, assessment of the condition may be a determination of the severity or precise clinical sub-type of the condition. It may also be a method of prognosis of the future course of the condition. Furthermore assessment can be over a period of time, for example in the monitoring of the treatment of a condition. In its first aspect, the present invention provides a method of assessing a tissue inflammatory response by comparing the transcript levels in a sample taken from a patient showing an inflammatory response with the transcript levels of the same genes in a control sample. As discussed above, the sample may be either of cells from a specific tissue demonstrating an inflammatory response, such as endothelial cells, or may alternatively be of a protein containing bodily fluid, such as blood, serum or urine. A control sample for the above methods is typically a sample of unaffected cells, that is cells from a tissue not demonstrating a tissue inflammatory response or cells believed not to be affected by the condition. It is preferred that the test and control sample are both of the same cell type and more preferred that the test and control sample are of endothelial cells. Most preferably, the test and control sample are of the same endothelial cell type, i.e. from the same tissue location.

WO 2005/068655 PCT/GB2005/000057 13 If required, the control sample may be taken from a population of subjects. Where a population of subjects is used, the comparison may be made with the average (e.g., mean or median) transcript level in samples of cells from said population. Affected tissue may also be used as a control. Typically the affected tissue will be from a patient other than that from which the test sample was taken. It is generally preferred that, if affected tissue is being used as a control, the patient from which that sample is removed has or is believed to have the same condition as the patient from which the test sample is removed. In some embodiments, the method of the invention may comprise the use of more than one control; for example the sample to be tested may be compared to a normal or unaffected sample from the same patient and the transcript level of an affected sample from another patient or patients. As discussed above, the method of the invention allows for the monitoring of a condition, either before, during or after treatment. Where the test sample is from a patient having or believed to have tissue inflammation, it is generally preferred that a sample is also obtained from the patient at an earlier time point, so as to provide a historical record. In another embodiment, the method allows for assessment of the effectiveness of a particular treatment. By comparing the severity of the tissue inflammation in a single patient at two or more time points, it is possible to determine whether or not a particular treatment regime is having a positive effect. The effectiveness of any one regime may differ from patient to patient, or during the course of the disease.

WO 2005/068655 PCT/GB2005/000057 14 In a preferred embodiment, the invention is performed by looking at the level of a plurality of gene transcripts or plurality of proteins derived from these transcripts. This is because we have found that between individual subjects, the transcript level of individual genes may vary. It is therefore desirable that the transcript level is assessed for several genes. For example, it may be assessed for at least 5, preferably at least 10 and more preferably at least 20 transcripts or proteins derived from transcripts of Table 1. The level of expression may be determined either for the genes or proteins individually or in specific combinations, or a pattern of expression of a plurality of genes may be determined. In the first aspect of the present invention, the level of the transcripts assessed is compared in a test and a control sample. It may be that the response to an inflammatory signal causes the level of the transcripts either to rise or to fall. Hence there may be either up-regulation of the transcripts in response to an inflammatory signal or down-regulation. It is not important to the present invention whether there is either up-regulation or down-regulation, but rather that there is change from the control. As an aid to determining the difference in transcript or protein regulation between a test and a control sample, the specific amount of up- or down-regulation may be determined. This can be expressed as a "fold" increase or decrease. It is not important to the present invention how large is the increase or decrease in transcript level, but rather it is important that there is a significant change from the control. In the present invention it is generally preferred that there be at least a two-fold change, i.e. increase or decrease, in WO 2005/068655 PCT/GB2005/000057 15 the transcript level. There is no upper limit on the amount of increase or decrease in transcript or protein level, but we have found that a 50-fold change in the level of certain transcripts and apparent de novo upregulation of certain proteins can be demonstrated. Furthermore, in the assessment of up- or down-regulation of transcript or protein levels, it is not necessary for all transcripts or proteins being assessed to be regulated by the same amount. Of more significance in this respect is the establishment of a pattern of regulation. In one embodiment of the present invention, the transcripts or proteins assessed may include one or from transcripts from one or more families or groups of protein. Preferably, the method involves determining the levels of at least one transcript or protein in two or more of such families or groups of protein, preferably three, four, five or more, and more preferably each of such families or groups of protein. Typical such groups or families include proteases, bone morphogenetic proteins, cell signalling proteins, proteins involved in transcriptional regulation, enzymes, cell cycle regulation proteins, cell communication proteins, nuclear proteins, complement proteins, extracellular matrix proteins, proteosomes, heavy metal binding proteins, TNF-receptor superfamily proteins, HLA proteins, cell adhesion proteins, cytokines/chemokines, cytokine/chemokine receptors, cytoskeletal proteins, regulators of apoptosis, growth factors and growth factor receptors. It is generally preferred that the transcripts or proteins assessed include one or more selected from cytokines/ chemokines, cytokine/chemokine receptors, cytoskeletal WO 2005/068655 PCT/GB2005/000057 16 proteins, extracellular matrix protins, regulators of apoptosis, growth factors and growth factor receptors. Of particular interest to the method of the present invention is the regulation of particular transcripts or proteins. These can be assessed either per se or as part of a pattern of regulation. Therefore, in the method of the present invention, it is preferred that the transcripts or proteins assessed include one or more of: colony stimulating factor 3 (granulocyte), colony stimulating factor 2 (granulocyte macrophage), granulocyte chemotactic protein 2, diubiquitin, ELAM-1, TNF-induced protein 6, Exodus 1, IL-1, VCAM-1, ICAM 1, IAP1, TNF-inducible A20, RIPK2, MMP 10, TRAF1, JAK binding protein, dual specificity phosphatase 4, IL-6, IL-8, Gro gamma, MCP-1, Gro-beta, Gro-alpha, ENA-78, fractalkine, small inducible cytokine subfamily A14, small inducible cytokine A5, LI7 receptor, toll/interleukin 1 receptor-like 4, CCAAT, MAD 3, COX-2, Mn SOD, NO synthase, L-kynurenine hydrolase, tissue factor pathway inhibitor 2, laminin gamma 2, Toll-like receptor 2, natural killer cell transcript 4, TNF-alpha induced protein 2, cationic amino acid transporter 2A, fatty acid binding protein 4, TNF receptor superfamily member 11b and TNF superfamily member 9. It is more preferred that in the method of the present invention the transcripts or proteins assessed include one or more of: colony stimulating factor 3 (granulocyte), colony stimulating factor 2 (granulocyte-macrophage), granulocyte chemotactic protein 2, diubiquitin, ELAM-1, TNF-induced protein 6, Exodus 1 and IL-1p. Alternatively, the method involves determining a pattern of expression of transcripts, wherein the transcripts include at least some of the transcripts illustrated in Table 1 herein.

WO 2005/068655 PCT/GB2005/000057 17 The transcript or protein level of a gene or genes may be determined by any suitable means. Where many different gene transcripts are being examined, a convenient method is by hybridisation of the sample (either directly or after generation of cDNA or cRNA) to a gene chip array. Where gene chip technology is used, the genes (this term used herein includes the ESTs of Table 1) are all present in commercially available chips from Affymetrix, and these chips may be used in accordance with protocols from the manufacturer. Generally, methods for the provision of microarrays and their use may also be found in, for example, W084/01031, W088/1058, W089/01157, W093/8472, W095/18376/ W095/18377, W095/24649 and EP-A-0373203 and reference may also be made to this and other literature in the art. Where many different proteins are being examined, a convenient method is antibody chip, multi-target ELISA, or proteomic analysis. Generally, methods for the provision of protein assays and their use may also be found in, for example, -U.S. Patent 6,329,209 and U.S. Patent No. 2,656,508. Such methods are common within the art. Further information on such methods may be obtained by reference to http://www.marketresearch.com/map/prod/904611.html Table 1 provides the names of genes and these may be used to obtain their DNA sequences and encoded protein sequences from databases such as Genbank. In addition, the particular sequences used on the Affymetrix chip we have used may be determined by the Affymetrix reference numbers supplied in the Table, which are publicly available and may be related directly to Genbank reference numbers. EST gene sequences in some cases are also given by Genbank reference numbers. Those WO 2005/068655 PCT/GB2005/000057 18 of skill in the art may refer to either of the Affymetrix reference number or the Genbank reference number in practicing the present invention. Table 2 provides cDNA sequence information for each of the probes used on the Affymetrix chip that are also listed in Table 1. Table 1 lists the probe set used to obtain the specific protein/EST listed therein and Table 2 provides the cDNA sequence for each probe set mentioned in Table 1. In Tables 2a and 2b, "n" represents in each case a region of the nucleic acid that was not probed by the probe set sequences on the gene chips. Thus, in order to make the arrays as specific as possible, only selected regions of the full cDNA's have been used, with the exclusion of some intervening sequences. Excluded sequences are those in which the single nucleotide code (a, g, c or t) has been replaced with "n". Alternatively, or in addition, quantitative PCR methods may be used, e.g. based upon the ABI TaqMan- technology, which is widely used in the art. It is described in a number of prior art publications, for example reference may be made to WO00/05409. PCR methods require a primer pair which target opposite strands of the target gene at a suitable distance apart (typically 50 to 300 bases). Suitable target sequences for the primers may be determined by reference to Genbank sequences as mentioned above. Gene Chips Although the prior art provides a gene chip which includes, as part of a very large array, the genes of one or more of Tables la and lb, the identification of a relatively small set of genes of use in assessing the conditions discussed above WO 2005/068655 PCT/GB2005/000057 19 allows the provision of a small chip specifically designed to be suitable for use in the present invention (a tailored gene array). Thus the invention provides a gene chip array comprising at least five nucleic acids suitable for detection of at least five transcripts shown in Table 1 (either directly or after generation of cDNA or cRNA); optionally a control specific for said transcripts; and optionally at least one control for said gene chip. In an alternative embodiment of this aspect, the invention provides a gene chip array for detection of at least five transcripts shown in Table 1 comprising at least five nucleic acids selected from Table 2 capable of detecting the presence of said at least five transcripts; optionally a control specific for said transcripts and optionally at least one control for said gene chip. The gene chip array comprises at least five different nucleic acids, preferably at least 10 or 20 different nucleic acids. Desirably, the number of sequences in the array will be such that where the number of nucleic acids suitable for detection of the Table 1 transcripts (or the number of Table 2 sequences) is n, the number of control nucleic acids specific for individual transcripts is n', where n' is from 0 to 2n, and the number of control nucleic acids (e.g. negative controls or controls for detection of "housekeeping" transcripts, abundant endothelial cell transcripts, transcripts which have a higher level of expression in endothelial cells, transcripts which have a higher level of expression in the particular endothelial type being assessed, or the like) on said gene chip is m where m is from 0 to 100, WO 2005/068655 PCT/GB2005/000057 20 preferably from 1 to 30, then n + n' + m represent at least 50%, preferably 75% and more preferably at least 90% of the nucleic acids on said chip. Protein Chips As discussed above in relation to gene chips, the provision of the transcripts and proteins encoded thereby in Table 1 allows for the production of appropriate tailored protein chips. Such chips may be used in the form of an antibody chip, or may encompass multi-target ELISA, or proteomic analysis. Generally, methods for the provision of protein assays and their use may be found in, for example, U.S. Patent 6,329,209 and U.S. Patent No. 2,656,508. Such methods are common within the art. Accordingly, in a further aspect, the present invention provides a protein based-assay suitable for use in the above described method of the invention, for the assessment of at least five proteins encoded by transcripts including those shown in Table 1; optionally a control specific for said proteins; and optionally at least one control for the assay. In a preferred embodiment, the protein-based assay is an antibody chip or ELISA, preferably multi-target ELISA. Assay Methods Assay methods of the present invention may be practiced in a wide variety of formats, for example on protein or nucleic acid components or in whole cells in culture. The present invention provides in its second aspect an assay method for a modulator of a tissue inflammatory response or a condition associated therewith, comprising: WO 2005/068655 PCT/GB2005/000057 21 (a) providing a protein encoded by a transcript of Table 1; (b) bringing said protein into contact with a candidate modulator of its activity; and (c) determining whether said candidate modulator is capable of modulating the activity of said protein. Where the response of an endothelial cell to inflammatory signals involves down-regulation of a transcript, the assay is preferably for an activator of the protein, and the assay preferably involves determining whether the modulator is capable of increasing the activity of the protein. In this embodiment, the assay may be carried out under conditions where the protein normally shows low or no activity. Where the response of an endothelial cell to inflammatory signals involves up-regulation of a transcript, the assay is preferably for an inhibitor of the activity of the protein, and the assay preferably involves determining whether the modulator is capable of reducing the activity of the protein. In this embodiment, the assay may be carried out under conditions in which the protein is normally active. In this assay method, the determination of modulation of activity will depend upon the nature of the protein being assayed. For example, proteins with enzymatic function may be assayed in the presence of a substrate for the enzyme, such that the presence of a modulator capable of modulating the activity results in a faster or slower turnover of substrate. The substrate may be the natural substrate for the enzyme or a synthetic analogue. In either case, the substrate may be labelled with a detectable label to monitor its conversion into a final product.

WO 2005/068655 PCT/GB2005/000057 22 For proteins with a ligand binding function, such as receptors, the candidate modulator may be examined for ligand binding function in a manner that leads to antagonism or agonism of the ligand binding property. For proteins with DNA binding activity, such as transcription regulators, the DNA binding or transcriptional activating activity may be determined, wherein a modulator is able to either enhance or reduce such activity. For example, DNA binding may be determined in a mobility shift assay. Alternatively, the DNA region to which the protein binds may be operably linked to a reporter gene (and additionally, if needed, a promoter region and/or transcription initiation region between said DNA region and reporter gene), such that transcription of the gene is determined and the modulation of this transcription, when it occurs, can be seen. Suitable reporter genes include, for example,' chloramphenicol acetyl transferase or more preferably, fluorescent reporter genes such as green fluorescent protein. Alternatively, or in a third aspect, the present invention provides an assay method for a modulator of a tissue inflammatory response or a condition associated therewith comprising: (a) providing an endothelial cell in culture; (b) bringing said cell into contact with a candidate modulator of said condition; and (c) determining whether said candidate modulator is capable of modulating the level of at least one transcript selected from the transcripts of Table 1. In the first step of this method, an endothelial cell is cultured. Any appropriate method may be used for the WO 2005/068655 PCT/GB2005/000057 23 harvesting and culture of the cells. Techniques for the culture of endothelial cells are common in the art. Candidate modulator compounds may be natural or synthetic chemical compounds used in drug screening programmes. Extracts of plants, microbes or other organisms, which contain several characterised or uncharacterised components, may also be used. Combinatorial library technology (including solid phase synthesis and parallel synthesis methodologies) provides an efficient way of testing a potentially vast number of different substances for the ability to modulate an interaction. Such libraries and their use are known in the art for all manner of natural products, small molecules and peptides, among others. Many such libraries are commercially available and sold for drug screening programmes of the type now envisaged by the present invention. A further class of candidate modulator comprises antibodies or binding fragments thereof which bind a protein target. Examples of antibody fragments, capable of binding an antigen or other binding partner, are the Fab fragment consisting of the VL, VH, Cl and CH1 domains; the Fd fragment consisting of the VH and CH1 domains; the Fv fragment consisting of the VL and VH domains of a single arm of an antibody; the dAb fragment which consists of a VH domain; isolated CDR regions and F(ab')2 fragments, a bivalent fragment including two Fab fragments linked by a disulphide bridge at the hinge region. Single chain Fv fragments are also included. An antibody specific for a protein may be obtained from a recombinantly produced library of expressed immunoglobulin variable domains, e.g. using lambda bacteriophage or filamentous bacteriophage which display functional immunoglobulin binding domains on their surfaces; for instance see W092/01047. Such a technique WO 2005/068655 PCT/GB2005/000057 24 allows the rapid production of antibodies against an antigen, and these antibodies may then be screening in accordance with the invention. Another class of candidate molecules is peptides, based upon a fragment of the protein sequence to be inhibited. In particular, fragments of the protein corresponding to portions of the protein which interact with other proteins or with DNA, may be a target for small peptides which act as competitive inhibitors of protein function. Such peptides may be for example from 5 to 20 amino acids in length. The peptides may also provide the basis for design of mimetics. Such mimetics will be based upon analysis of the peptide to determine the amino acid residues or portions of their side chains essential and important for biological activity to define a pharmacophore followed by modelling of the pharmacophore to design mimetics which retain the essential residues or portions thereof in an appropriate three-dimensional relationship. Various computer-aided techniques exist in the art in order to facilitate the design of such mimetics. Cell based assay methods can be configured to determine expression of the gene either at the level of transcription or at the level-of translation. Where transcripts are to be measured, then this may be determined using the methods of the first aspect of the invention described above, e.g. on gene chips, by multiplex PCR, or the like. As above, where the transcript is one which is down-regulated in response to inflammatory signals, the assay is preferably for agents which increase the expression of the gene (e.g., by increasing the quantity of the transcript). Such an agent may WO 2005/068655 PCT/GB2005/000057 25 comprise the coding sequence of the gene itself (i.e., it may be a gene therapy vector). Where the transcript is one which is up-regulated in response to inflammatory signals, the assay is preferably for agents which decrease the expression of the gene. Cell based assay methods may be used to screen candidate modulators as described above. They may also be used to screen further classes of candidate modulator, including antisense oligonucleotides. Such oligonucleotides are typically from 12 to 25, e.g. about 15 to 20 nucleotides in length, and may include or consist of modified backbone structures, e.g. methylphosphonate and phosphorothioate backbones, to help stabilise the oligonucleotide. The antisense oligonucleotides may be derived from the coding region of a target gene or be from the 5' or 3' untranslated region. Candidate molecules may further include RNAi, i.e. short double stranded RNA molecules which are sequence specific for a gene transcript, or a longer RNA sequence which can be processed by the cell into siRNA, and which can be provided to the cell e.g., as a DNA sequence (eliRNA, or expressed long interfering RNA). They may also include ribozymes which specifically target the transcript mRNA, i.e., a catalytic RNA molecule which cleaves other RNA molecules of a particular nucleic acid sequence. General methods for the construction of ribozymes are known in the art. In a preferred embodiment of these aspects of the invention, the assay methods described above are used to determine modulators of activity of a protein or level of a transcript from Table 1b. Modulators obtained in accordance with these aspects of the present invention may be used in methods of modulating tissue WO 2005/068655 PCT/GB2005/000057 26 inflammatory responses and/or conditions associated therewith, e.g., inflammatory conditions, in a patient. The present invention therefore also provides a pharmaceutical composition comprising a modulator of a tissue inflammatory response and/or a condition associated therewith together with a pharmaceutically acceptable carrier therefor. Generally, the modulator will be formulated with one or more pharmaceutically acceptable carriers suitable for a chosen route of administration to a subject. For solid compositions, conventional non-toxic solid carriers include, for example, pharmaceutical grades of mannitol, lactose, cellulose, cellulose derivatives, starch, magnesium stearate, sodium saccharin, talcum, glucose, sucrose, magnesium carbonate, and the like may be used. Liquid pharmaceutically administrable compositions can, for example, be prepared by dissolving, dispersing, etc, a modulator and optional pharmaceutical adjuvants in a carrier, such as, for example, water, saline aqueous dextrose, glycerol, ethanol, and the like, to thereby form a solution or suspension. If desired, the pharmaceutical composition to be administered may also contain minor amounts of non-toxic auxiliary substances such as wetting or emulsifying agents, pH buffering agents and the like, for example, sodium acetate, sorbitan monolaurate, triethanolamine sodium acetate, sorbitan monolaurate, triethanolamine oleate, etc. Actual methods of preparing such dosage forms are known, or will be apparent, to those skilled in this art; for example, see Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pennsylvania, 15th Edition, 1975. The composition or formulation to be administered will, in any event, contain a quantity of the active compound(s) in an amount effective to alleviate the symptoms of the subject being treated.

WO 2005/068655 PCT/GB2005/000057 27 Routes of administration may depend upon the precise condition being treated, though since endothelial cells form the lining of the vasculature, administration into the blood stream (e.g. by i.v. injection) is one possible route. In addition, the present invention provides a modulator of a tissue inflammatory response and/or a condition associated therewith for use in therapy. Furthermore, the present invention provides the use of a modulator of a tissue inflammatory response in the manufacture of a medicament for the treatment of a condition associated with said response. Vectors The identification of a number of ESTs and other genes of previously unknown function associated with regulation of endothelial cells by inflammatory signals provides the basis for novel vector systems useful in aspects of the invention described above, as well as further aspects described herein below. Preferably, the sequence encoding a transcript listed in Table lb is operably linked to a control sequence which is capable of providing for expression of the coding sequence by a host cell, i.e., the vector is an expression vector. The term "operably linked" refers to a juxtaposition wherein the components described are in a relationship permitting them to function in their intended manner. A control sequence "operably linked" to a coding sequence is ligated in such a way that expression of the coding sequence is achieved under condition compatible with the control sequences.

WO 2005/068655 PCT/GB2005/000057 28 Suitable host cells include bacteria, eukaryotic cells such as mammalian and yeast, and baculovirus systems. Mammalian cell lines available in the art for expression of a heterologous polypeptide include Chinese hamster ovary cells, HeLa cells, baby hamster kidney cells, COS cells and many others. The vectors may include other sequences such as promoters or enhancers to drive the expression of the inserted nucleic acid, nucleic acid sequences so that the polypeptide is produced as a fusion and/or nucleic acid encoding secretion signals so that the polypeptide produced in the host cell is secreted from the cell. The vectors may contain one or more selectable marker genes, for example an ampicillin resistance gene in the case of a bacterial plasmid or a neomycin resistance gene for a mammalian vector. Vectors may further include enhancer sequences, terminator fragments, polyadenylation sequences and other sequences as appropriate. Vectors may be used in vitro, for example for the production of RNA or used to transfect or transform a host cell. The vector may also be adapted to be used in vivo, for example in methods of gene therapy. Systems for cloning and expression of a polypeptide in a variety of different host cells are well known. Vectors include gene therapy vectors, for example vectors based on adenovirus, adeno-associated virus, retrovirus (such as HIV or MLV) or alpha virus vectors. Promoters and other expression regulation signals may be selected to be compatible with the host cell for which the WO 2005/068655 PCT/GB2005/000057 29 expression vector is designed. For example, yeast promoters include S. cerevisiae GAL4 and ADH promoters, S. pombe nmtl and adh promoter. Mammalian promoters include the metallothionein promoter which is can be included in response to heavy metals such as cadmium. Viral promoters such as the SV40 large T antigen promoter or adenovirus promoters may also be used. All these promoters are readily available in the art. Vectors for production of polypeptides encoded by a transcript of Table lb for use in gene therapy include vectors which carry a mini-gene sequence. Vectors may be transformed into a suitable host cell as described above to provide for expression of a polypeptide of the invention. Thus, in a further aspect the invention provides a process for preparing polypeptides encoded by a transcript of Table lb which comprises cultivating a host cell transformed or transfected with an expression vector as described above under conditions to provide for expression by the vector of a coding sequence encoding the polypeptides, and recovering the expressed polypeptides. Polypeptides may also be expressed using in vitro systems, such as reticulocyte lysate. Polypeptides or fragments thereof in substantially isolated form encoded by an EST or gene of Table lb form a further aspect of the present invention. Fragments of the polypeptides will preferably be at least 20 amino acids in size, and preferably from 25 amino acids up to the full length of the polypeptide. A further aspect of the invention is nucleic acid sequences which encode said polypeptides and fragments thereof. Such WO 2005/068655 PCT/GB2005/000057 30 nucleic acid sequences may be included in vectors such as those described above. For further details see, for example, Molecular Cloning: a Laboratory Manual: 2nd edition, Sambrook et al., 1989, Cold Spring Harbor Laboratory Press. Many known techniques and protocols for manipulation of nucleic acid, for example in preparation of nucleic acid constructs, mutagenesis, sequencing, introduction of DNA into cells and gene expression, and analysis of proteins, are described in detail in Current Protocols in Molecular Biology, Ausubel et al. eds., John Wiley & Sons, 1992. Where a gene or EST of Table lb is present in a vector, it may be linked in-frame to a translational initiation region for translation of said sequence, or alternatively it may be in an anti-sense orientation for transcription of anti-sense RNA. Examples TNFa, IL-13 and Interleukin-8 regulate transcript abundance To allow a study of the effect of TNFa, IL-l and Interleukin 8 on transcript abundance, seven independent primary cultures of HUVEC were cultured with a mixture of 15ng/mL of each of TNF-a, Interleukin-l1 and Interleukin 8 for 24 hours. The RNAs extracted from these cultures were then used to prepare complex cRNA probes, which were hybridised to an Affymetrix U95A genechip (a 12,600-element Affymetrix gene array chip). Analysis of Gene Chip Data Transcript abundance data ("average differences") were globally scaled to bring the median gene expression of each chip (excluding control genes) to 1. To ensure transcript expression levels were comparable between arrays, the "LOESS" WO 2005/068655 PCT/GB2005/000057 31 function of the "R" statistical software system was applied to the log transformed average difference values of each array in comparison to a control array. The control array chosen was that which bore the closest similarity to the other six controls by Euclidean distance. Normalised transcript abundance data was then compared using the CyberT algorithm (version 7.03; sliding window=301, Bayes estimate=21). This algorithm is an unpaired T-test, modified by the inclusion of a Baysian prior based on the variance of the other transcripts in the data set (Long et al, 2001, J. Biol Chem 276, 19937-19944). For further statistical analysis, the "R" statistical software system and GeneSpring Expression Analysis Software (Silicon Genetics, Redwood City, Ca), were used. Individual transcripts were categorised according to the functions of the proteins they encoded, using the GO database (www.geneontology.org), Entrez (www.ncbi.nlm.nih.gov/entrez) or OMIM (www.ncbi.nlm.nih.gov:80/entrez/Omim) databases. In the Tables, fold changes are expressed as unpaired means over the seven experiments (i.e., mean of inflammatory treated/mean of control). Difference in transcript levels in different endothelial cell types To determine whether the modulation of the transcriptome is comparable amongst different endothelial cell types, we obtained a further culture using one each of human coronary artery endothelial cells (HCAEC) and human uterine microvascular endothelial cells (UtMVEC).

WO 2005/068655 PCT/GB2005/000057 32 The three different cell types were treated with inflammatory signals as above, and the extent to which the transcript abundance is regulated in each of the three cell types was assessed. A pattern of regulation between the three cell types was also determined. It was found that most transcripts are regulated in all three cell types, while some are regulated in only two or only one of these cell types. Those transcripts which are regulated in all three cell types are believed to be particularly useful in the various methods of the present invention, since they are likely to be meaningful in a variety of inflammatory conditions affecting distinct organs. Moreover, it was also found that the transcripts which are modulated by inflammatory signals in all three endothelial cell types tend also to be strongly modulated by inflammatory signals in HUVEC. Consensus data Table la and lb show a consensus set of transcripts. These were selected on the basis that their level before and after treatment with inflammatory mediators differs by a factor of two or more (in either direction), with a Baysian P value of less than 0.001. These have been grouped according to gene family. Table 1 shows the extent of regulation in HUVEC cells, and also in HCAEC and UtMVEC cells. ESTs A number of ESTs and genes of previously unknown function identified as relevant to the present invention are of particular interest in the various methods of the invention WO 2005/068655 PCT/GB2005/000057 33 and as possible therapeutics for use in treatments. These are summarised in Table 1b. The specific sequences of the probes used to isolate these ESTs are shown in Table 2b. Materials and Methods: Preparation of endothelial cells HUVECs isolated from seven different individuals were cultured in Microvascular Endothelial Cell Growth Medium-2 (EBM-MV, Biowhittaker). Medium was supplemented with a proprietary mixture of human Epidermal Growth Factor, Hydrocortisone, Vascular Endothelial Growth Factor, human Fibroblast Growth Factor, human recombinant Insulin-like Growth Factor, Ascorbic Acid, Gentamicin, Amphotericin-B and FBS (5%) (Microvascular BulletkitTM reagents, Biowhittaker. At passage 5, each HUVEC isolate was divided between two 175cm 2 culture flasks and grown to 70% confluence. For each HUVEC isolate, growth medium in one flask was replaced with fresh medium containing a cocktail of 15 ng each IL-8, IL-1F and TNF-a. As a control, medium in replicate cultures was replaced with fresh medium only. Cytokine-treated HUVECs and controls were cultured for a further 24 hrs Single donor-derived human coronary artery ECs and uterine myometrial microvascular ECs were purchased from Biowhittaker. Cells were cultured and treated under identical conditions as HUVECs RNA Extraction RNA was extracted from each culture using Trizol reagent (Gibco/BRL, UK), followed by a clean up through an RNeasyT spin column (Qiagen, UK) and ethanol precipitation. RNA' integrity was assessed using an Aligent 2100 bioanalyser.

WO 2005/068655 PCT/GB2005/000057 34 Analysis of RNA Biotinylated target cRNA was prepared according to Affymetrix protocol, hybridised to Affymetrix human U95Av2 chips and globally scaled using Microarray Suite Version 4.0 or 5.0 software.

WO 2005/068655 PCT/GB2005/000057 35 References 1. Schraufstatter, I. U., Chung, J., and Burger, M. (2001) IL-8 activates endothelial cell CXCRI and CXCR2 through Rho and Rac signaling pathways. American Journal of Physiology 280, L1094-L1103 2. Dinarello, C. A. (1998) Interlukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Intern Rev Immunol 16, 457-499 3. Aggarwal, B. B. (2000) Tumour necrosis factor receptors associated signalling molecules and their role in activation of apoptosis, JNK and NF-kB. Annals of Rheumatic Disease 59 (suppl), i6-i16 4. Madge, L. A., and Pober, J. S. (2001) TNF Signalling in Vascular Endothelial Cells. Experimental and Molecular Pathology 70, 317-325 5. O'Neill, L. A. J., and Dinarello, C. A. (2000) The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunology Today 21, 206-209 6. Li, A., Dubey, S., Varney, M. L., and Singh, R. K. (2002) Interleukin-8-induced proliferation, survival, and MMP production in CXCR1 AND CXCR2 expressing human umbilical vein endothelial cells. Microvascular Research 64, 476 481 7. ,-Strieter, R. M., Polverini, P. J., Arenberg, D. A., Walz, A., Opdendakker, G., Van Damme, J., and Kunkel, S. L. (1995) Role of C-X-C chemokines as regulators of angiogenesis in lung cancer. Journal of Leukocyte Biology 57, 752-762 8. Kitadai, Y., Haruma, K., Sumii, K., Yamamoto, S., Ue, T., Yokozaxi, H., Yasui, W., Ohmoto, Y., Kajiyama, G., Fidler, I. J., and Tahara, E. (1998) Expression of interleukin-8 correlates with vascularity in human gastric carcinomas. American Journal of Pathology 152, 93-100 WO 2005/068655 PCT/GB2005/000057 36 Table la. Transcripts regulated by inflammatory mediators Probe set Descriptions LocusLink HUVEC FC (n=7) Bayes.p HCAEC FC (n=1) MVEC FC (n=1) 265_s_at ELAM-1 6401 94.12407276 0 52.80610911 48.1406623 38453_at ICAM-2 3384 -4.919652169 0 -3.172225055 -4.126639495 38454_g.at ICAM-2 3384 -4.273813746 6.85E-14 -3.222848571 -4.756558142 41433 at VCAM-1 7412 41.92536277 4.44E-16 19.68500876 7.08367969 590 at ICAM-2 3384 -4.355207383 0 -2.939770867 3.513733465 32640 at ICAM-1 3383 30.3312002 0 22.98537954 17.77124304 1372_at TNF-induced protein 6 7130 72.77639371 2.64E-12 102.0554489 132.4555661 (high homology to CD44) 583 s at VCAM-1 7412 21.72229281 4.54E-14 12.47672759 8.084337024 37286 at Neuronal CAM 4897 3.057294936 2.6E-1 1 4.522694277 3.0468789B5 37287 at Neuronal CAM 4B97 2.118308598 0.00016866 3.028078666 1.459527209 1126 s at CD44 --- 5.908575047 1.69E-10 5.164794759 4.433329962 2036_s at CD44 960 .280337829 4.8E-10 4.346849483 4.014976193 31472_s at CD44 5.028849347 1.41E-10 5.268492975 .537170724 41475_at Ninjurin 1 4814 4.254200441 1.25E-12 8.697922867 .140258321 1385_at TGF beta induced gene 7045 3.148463542 4.32E-08 2.554804325 5.017906407 big-h3 (inhibits cell adhesion) 40493 at CD44 960 2.314611255 0.000015 2.992670691 2.618091422 41534 at Protocadherin (brain-heart) 5099 -3.130162659 5.24E-11 -3.950798183 !1.443373336 37288 g.at Neuronal CAM 4897 2.32386108 0.00000712 3.096319968 2.468852275 41266_at integrin, alpha 6 3655 -2.905539743 6.34E-14 -6.443317073 -4.825692909 33410 at Integrin alpha SB 3655 -3.555248053 5,49E-1 1 -3.460672051 -7.074752389 3341 1_g_.at Integrin alpha SB 3655 -4.026330886 1.62E-08 -7.112851076 -10.75631742 120 at Integrin alpha 1 3672 5.394552373 546E-1 1 8.278974088 15.79277269 37484_at integrin, alpha 1 3672 7,015160862 2.69E-09 15.12333177 12.4416517 257_at Integrin alpha V 3685 2,327640731 0.00028556 1.203881437 3.677134895 39071 at Integrin alpha V 3685 4.093727059 1.1E-15 2.057183486 4.695101368 406_at integrin, beta 4 3691 -2.516147583 0.0000113 -1.175618714 1.170070754 2073_s_at cadherin 13, H-cadherin 1012 2.169729435 0.00074496 1.053001021 1.209382473 (heart) 39878 at protocadherin 9 5101 -4.59180328 0.00000262 -4.173958272 -1.224887851 34760_at C-type lectin BIMLEC 9936 -2.931920451 0.0004342 -2.84198351 -3.951644147 precursor 40698 at C-type lectin, 9976 -2.090795467 0.0000308 -1.170337293 -1.25139979 Apoptosis regulation 1717_s_at lAPI 330 13.25120688 2.22E-16 24.06057001 10.88814977 595_at TNF-inducible A20 7128 23.99969733 0 24.66171353 36.22756341 41384_at RIPK2 (interacts with 8767 33.39955874 0 10.50930817 27.65190479 CD40) 33243_at TNF-induced protein (? 25816 4.48308487 3.44E-15 5.510033362 5.437586371 negative mediator of apoptosis) 1237_at immediate early response 8870 804193654 3.02E-13 3.090900931 7.298832868 3 r. _ 1867 at CLARP 8837 2.893895437 2.76E-12 2,965378608 2.598032615 36578_at MIHB (lAP homologue) 329 2.20726532 6.59E-10 1.998610122 2.184746309 1868_g-at CLARP 8837 2.741709407 2.77E-12 1.892992274 2.014557756 40049_at death-associated protein 1612 -2.30278615 2.271-07 -3.336581791 -2.887251828 kinase 1 _____________

_______

WO 2005/068655 PCT/GB2005/000057 37 Probe set Descriptions LocusLink HUVEC FC (n=7) Bayes.p HCAEC FC (n=1)MVEC FC (n=1) 41816_at caspase recruitment 29775 -2.002003766 3.91E-08 -2.186735523 -2.029925561 domain family, member 10 2002_s_at BCL2-related protein Al 597 2.613589324 0.00018672 3.9139111 1.474571201 574_a-at caspase I (interleukin 1, 834 3.488039515 0.0000158 5.206924741 2.289334595 beta, convertase) Proteases 1006_at MMP 10 (stromelysin) 4319 20.673524 2.94E-09 54.6446216 12.16240346 1227_g_at disintegrin/metalloproteina 6868 3.813351746 5.27E-09 1.452030457 5.668869009 se domain 17 (TNF-alpha converting enzyme) 129_g_at cathepsin K 1513 2.462139973 0.00000177 1.72558228 2.194661317 (pycnodysostosis) 38466_at cathepsin K 1513 3.61266368 3.93E-10 2.466729636 1.611499 (pycnodysostosis) 128_at cathepsin K 1513 5.727765674 3.54E-07 2.95658194 1.862569449 (pycnodysostosis) 41239 r at cathepsin S 1520 6.178963194 0.00010333 8.40720437 7.301525957 Growth factors/Growth factor receptors/binding proteins insulin-like growth factor 3489 -2.014 0.0147 -1.977 -6.608 1736 at binding protein 6 34021 at interleukin 2 3558 -3.214 0.0041 1.1863 -1.027 insulin-like growth factor 2 3481 2.9966 0.0197 1.0001 -1 36782 s at (somatomedin A) insulin-like growth factor 3486 -2.874 0.0035 -3,36 -1.027 37319 at binding protein 3 159_at VEGF C 7424 2.357296176 2.67E-10 9.487520679 2.865003832 37461 at anglopoletin 2 285 -2.319743262 0.00000274 -6.975448459 -7.930241469 1951 at angiopoietin 2 285 -2.685484753 4.54E-07 -8.039282583 -12.53026423 36879_at endothelial cell growth 1890 9.066420458 9.88E-09 23.27852668 1,656563558 factor 1 (platelet-derived) 1334_sat colony stimulating factor 3 1440 110.4374129 0 107.7019762 95.9009041 (granulocyte) 1400_at colony stimulating factor 2 1437 59.85609631 0 128.3173278 115.0807894 (granulocyte-macrophage) 1401gat colony stimulating factor 2 1437 69.22778507 0 164.8742173 97.00671055 (granulocyte-macrophage) 39781_at IGFBP4 3487 -2,32298013 2.63E-12 -3.202031547 -2.304705004 1573_at platelet-derived growth 5155 2.364292483 4.72E-11 2.310014432 3.576039834 factor beta polypeptide 1737_s at IGFBP4 3487 -3.134319307 3.56E-11 -4.670559679 -2.390794223 1987_at platelet-derived growth 5156 5.414971705 2.1E-10 5,239961839 5.489227387 factor receptor, alpha polypeptide 1897_at transforming growth factor, 7049 -3.075084973 0,00000944 -2.117136032 -6.575991342 beta receptor III 1761at platelet-derived growth 5157 2.189929847 0.0000242 1.689699835 -1.658417287 factor receptor-like 1968_gat platelet-derived growth 5156 3.489609752 0.00017615 7.37795097 3.825705997 factor receptor, alpha polypeptide 36314_at fms-related tyrosine kinase 2323 2.928004872 4.78E-07 4.061156781 1.381073451 3 ligand 1664 at Insulin-Like Growth Factor --- 2.468425254 1.35E-07 1.028272127 1.071858187 2 1591 a-at insulin-like growth factor 2 3481 4.554886105 0.000025 2.380846497 -1.095495947 WO 2005/068655 PCT/GB2005/000057 38 Probe set Descriptions LocusLink HUVEC FC (n7) Bayes-p HCAEC FC (n1)MVEC FC (n1) Bone morphogenetic proteins 40333 at BMP4 652 -8.689531567 2.23E-11 -11.51217679 -13.66978546 1114_at BMP4 652 -5.224251224 1.06E-10 -8.834024069 -3.466631976 1113 at BMP2 650 4.225472624 5.05E-10 5.016446479 10.99944132 40367 at BMP-2A 650 3.76567886 2.92E-09 5.685709393 9.647738498 Cell Signalling 849_g at TRAF1 165 17.5138547 0 8.878582574 11.87121514 848_at TRAF1(signal 7185 7.479968747 0 7.120389129 7.914739757 transduction) 1633_g-at pim-2 oncogene (serine 11040 9.160464547 0 14.689145 15.21104429 threonine kinase) 32737_at Rac2 (small GTP binding 5880 3.658480457 3.89E-15 2.744061787 1.789830328 protein) 38433_at AXL receptor tyrosine 558 -2.808585886 127E-13 -3.296941327 -2.913417469 kinase 32736_al ras-related C3 botulinum 28963 2,682083886 4,F-I3 1.753959656 1.421575242 toxin substrate 2 962_at BMX non-receptortyrosine 660 -2.535033842 2.24E-10 -2.901079423 -3.416983113 kinase 1278_at Tyrosine Kinase, Receptor --- -2.419620683 15E-12 -2,432209903 -3.146520458 Axl, Alt. Splice 2 35666_at semaphorin 3F 6405 -2.323822657 1.19E-11 -3.747425517 -3.105083997 41592_at JAK binding protein 8651 15.5029436 4.44E-16 13.24058381 18.69333246 37745_s_at suppression of 6764 3.798748042 8.78E-12 1.673006765 3.978566319 tumorigenicity 5 (regulates MAPK1 IERK2 kinase) 35414_s at jagged 1 182 3.938751608 3.97E-10 1.916173689 3.913844547 38129 at glycerol kinase 2710 4.156535178 2.03E-li 4.389062428 4.783183323 33925_at neurogranin (protein 4900 -2.874103959 1.01 E-09 -2.584237728 -2.07114957 kinase C substrate) 37637_at regulator of G-protein 5998 2.316785124 1.21E-09 2.467991159 3.293642315 signalling 3 32616_at v-yes-1 4067 3.430788342 7.13E-11 2.724701376 1.854721285 1402_at V-yes-1 homolog, Lyn 4067 3.523004339 1.68E-08 2.854373847 1.829548828 (tyrosine kinase) 37701_at regulator of G-protein 5997 .813879055 2.08E-08 3.885900214 3.315667451 signalling 2 (negative regulator) 36215_at protein kinase, cAMP- 5567 -2.628783273 1.51 E-08 -3.752926478 -6,755566769 dependent, catalytic, beta 1674 at v-yes-i homolog 1 7525 -2.152710145 3.31 E-08 -1.530253982 -2.804444302 36233_at 3'-phosphoadenosine 5'- 9060 2.027727485 4.72E-08 1.510192698 -1.077558923 phosphosulfate synthase 2 38130_s_at glycerol kinase (testis --- 7.973762615 2.5E-09 8.084790212 2.068851547 specific) 1788_s_at dual specificity 1846 -11.76290841 7.65E-07 -2.071776576 -3.485764407 phosphatase 4 (negatively regulates MAP kinases) 1637 at MAPKAP kinase 3 7867 -2.182787462 0.00000659 -2.402844278 -4.904366595 34273_at regulator of G-protein --- -2.496810967 2.85E-07 -4.377804301 -9.38699972 signalling 4 34272_at regulator of G-protein 5999 -3.344620441 9.24E-09 -6.561315389 -16.14378204 signalling 4 _ 1652_at pim-2 oncogene (serine 11040 2.699937536 1.09E-09 3.836282227 4.323718343 threonine kinase) 1 31862 at Wnt5A 7474 4.219642672 10.0000149 -1.366311375 1.011983622 WO 2005/068655 PCT/GB2005/000057 39 Probe set Descriptions LocusLink HUVEC FC (4)Bayes.p HCAEC FC (n1) MVEC FC (n=l) 1669_at Wnt-5a 7474 3.479040912 0.00069910 -1.444116368 1.01235564 1457_at JAK 1 3716 2.045332134 6.78E08 1.365238795 1.006354866 1845_at MAP kinase kinase 4 6416 2.521474928 0.00063222 2.41305386 -1.836490086 40648at c-mer proto-oncogene 10461 -2.063640257 0.0000592 -2.37B445569 -2.262491022 tyrosine kinase 38880_at likely ortholog of mouse 23005 2.215609357 4.77E-09 1.944472584 1.888827336 mitogen activated protein kinase binding proten I 2014_s_at mitogen-activated protein 5608 -2.618846506 0.00012111 -2.956702088 -5.484778343 kinase kinase 6 1223_at PCTAIRE protein kinase 3 5129 2.680986947 0.00064597 2.263745506 1.108537941 37221_at protein kinase, cAMP- 5577 -2.08567496 0.00000622 -2.915269541 -2.071588434 dependent, regulatory, type II, beta 2024_s at v-yes-I 4067 2.379576108 1.34E-08 2.02017671 1.392260421 323 at Serine Kinase Psk-HI --- -2.016724782 0.0000125 -1.359560601 -1.12682497 481 at SNF-1 related kinase 54861 -2.583587042 0.00000144 -1.719525409 -2.586396156 Cytokines/Chemokines chemokine (C-X-C motif) 3627 2.8162 0.0131 21.833 5.9624 431 at ligand 10 chemokine (C-X-C motif) 6373 2.1907 0.0158 19.314 6.2232 35061 at ligand 11 chemokine (C-C motif) 6368 -4.887 0.001 -2.116 -1.418 36444 s at ligand 23 38299_at |IL6 3569 24.14721637 0 22.56841253 61.5630336 35372 r at 11L8 3576 15.51735527 0 15.55547961 12.15835237 1369 s at 1L8 --. 41.62876467 0 22.98760049 12.09571155 34022 at Gro-gamma 2921 48.02792301 0 73.85427422 86.20366678 35410_at granulocyte chemotactic 6372 121.6423846 0 114.3849865 29.67507825 protein 2 40385_at Exodus-I (MIP-3 alpha) 6364 82.45859231 0 189.9224072 106.6857086 34375 at MCP-1 --- 14.29518512 0 3.308055282 11.6027416 875_g-al MCP-1 6347 10.76460673 0 3.43922774 8.863220251 37187 at Gro-beta 2920 39.20393321 0 14.16208753 39.61686592 408_at Gro-alpha --- 23.14045021 0 6.291677693 7,986953794 35025_at ENA-78 (neutrophil 6374 11.02707172 4.25E-10 9.840379417 41.69374269 activation) 874 at MCP-1 6347 5.836636513 2.1IE-15 4.481375208 9.794572686 1520 s at IL-I beta 3553 91.84552248 8.47E-13 205.4748788 177.3630307 33849_at pre-B-cell colony- 10135 3.813578354 3.97E-10 4.108018493 4.081292457 enhancing factor 39402 at IL-1 beta 3553 31.54329146 3.09E-13 82.81268573 85.84762636 823_at fractalkine 6376 17.68369443 2.56E-12 19.7422482 22.71709814 33790_at small inducible cytokine 6358 -12.67742209 1.52E-08 -48.34300032 -66.0221188 A15 1403_s_at small inducible cytokine A5 6352 11.20684756 5.42E-07 37.22680311 12.48514714 (RANTES) 1405_i at small inducible cytokine A5 6352 85.06201489 0.00049761 72.24870591 43.38032562 (RANTES) 38488 s at IL15 3600 2.963696814 0.00000871 4.781012455 3.292355333 36445_at chemokine (C-C motif) 6368 -3.602748819 0.00039698 -2.406722814 -1,030688433 ligand 23 37823_at chemokine (C-C motif) 6355 23.02933617 0.00052146 258.0717884 125.0305056 ligand 8 37712_g_at Myocyte enhancer-binding --- 4.26612691 2.43E-07 -5.003135162 -6.008429791 factor 2; MEF2 3756 t monocyte to macrophage 123531 32.119735439 0.0000216 1.4049682 1.977961258 WO 2005/068655 PCT/GB2005/000057 40 Probe set Descriptions LocusLink HUVEC FC (n=7) Bayes.p HCAEC FC (n=1)MVEC FC (n=1) differentiation-associated Cytokine/Chemokine Receptors 1370 at IL7 receptor 3575 9.161091199 0 4.303383875 8.240362396 36227_at IL7 receptor 3575 18.86860288 0 21.47752128 19.22542292 40322at interleukin I receptor-like 1 9173 2.413606464 4.3E-14 3.10203053 1.491371089 36377 at interleukin 18 receptor 1 8809 4.044516303 2.99E-11 5.074365709 3.86178169 37493_at colony stimulating factor 2 1439 3.657465472 5.4E-11 4.215999509 4,372152437 receptor, beta 41677_at IL 15 receptor alpha 3601 2.771385255 3.93E-09 6.171752712 4.132002608 40310_at toll/interleukin 1 receptor- 7097 17.04231159 6.34E-08 41.69446428 92.69458196 like 4 1061_at interleukin 10 receptor, 3587 2.396040273 0.00025159 1.656307749 2.726745302 alpha 1086_at colony stimulating factor 2 1439 3.132593874 0.00070665 3.024617357 -1.320929175 receptor, beta, low-affinity 37494_at colony stimulating factor 2 1439 2.857904787 0.00000274 4.308632923 1.561972298 receptor, beta, low-affinity Transcriptional regulation 1052_s_at CCAAT/enhancer binding 1052 11.91692976 0 11.83059529 10.65191899 protein, delta (COX-2 promoter regulation) 2049 s at jun B 3726 5.153898931 1.81E-14 3.431192771 6.223449667 1461at MAD-3 (encoding I-kappa- 4792 10.50494004 0 8.003192106 5.490720521 B activity) 38438 at NF kappa B (p105) 4790 4.04722666 0 4.805775558 3.759579948 545_g_at NF kappa B (p50) 4791 4.794779209 7.11E-15 9.451858522 5.944229815 1377_at NF kappa B (p105) 4790 4.434308127 0 3.02369062 3.934373217 1378_.gat NF kappa B (p105) 4790 5.534025442 1.11E-16 7.587979568 5.198094808 669_sat interferon regulatory factor 3659 7.50488352 1.73E-14 7.563755727 4.851132396 1 40362_at NF kappa B 2 (p49/p1OO) 4791 5.793454912 1.11E-16 7.300267454 7.131728502 35724_at Pirin (transcription co- 8544 -3.930125583 6.44E-15 -4.412262675 -4.67615839 factor) 32786 at jun B 3726 3.920893987 5.77E-12 2.207915162 3.564535817 31895_at basic leucine zipper 571 4.475370873 1.25E-14 5.111364686 4.25002483 transcription factor 1 570_at RELB (inhibits NF kappa 5971 3.894337906 9.21 E-15 3.223675004 3.270575768 B) 40088_at nuclear receptor 8204 3.771630231 1.19E-13 4.396979347 3.998851735 interacting protein I 37353_g_at nuclear antigen Sp1O0 6672 2.880868474 1.02E-10 2.394226199 2.256154686 (stimulates transcriptional activity of Ets-1) 35638_at core-binding factoralpha 862 -4.316374281 5.68E-13 -4.593414984 -2.069158236 subunit 2; cyclin D-related 34720 at nuclear factor I/B 4781 -2.891380748 9.37E-12 -5.585236612 -6.207114141 36057_at armadillo repeat protein 9823 3.105240733 1.54E-1 1 1.835928633 2.175918631 ALEX2 544_at NF kappa B (p50) 4791 7.587736834 4.66E-15 10.21368896 6.96686111 38944_at MAD-3 homolog 4088 2.544980211 2.89E-1 1 2.527083313 1.211400339 41743_i at transcription factor IIIA- 10133 3.2823426 8.83E-12 2.335070811 1.505620716 interacting protein (TNF inducible) 37352_at nuclear antigen Sp100 6672 3.210793569 1.98E-11 2.197590225 2.387759855 (stimulates transcriptional WO 2005/068655 PCT/GB2005/000057 41 Probe set Descriptions LocusLink HUVEC FC (n=7)5Baycap HCAEC FC (n)MVEC FC (n) activity of Ets-1) I433_gat MAD-3 4088 2.098641883 8.83E-09 1.666043623 1.27364714 41742_s at transcription factor 11lA- 10133 3.401140074 4.64E-13 2.930879849 1.665969002 interacting protein (TNF inducible) 36825_at stimulated trans-acting 10346 2.40612763 7.67E-09 1.625963386 1.79546906 factor (50 kDa), repressor of viral transcription 32588 s at EGF-response factor 2 678 -2.246354328 4.4E-09 -3.889915623 -3.550964514 40091_at bcl-6 (transcriptional 604 3.560324596 2.07E-10 4.016477251 4.918915862 repressor) 32794_g_at T cell receptor beta locus 6957 -4.582802536 1.56E-10 -6.335942518 -5.302631449 35844_at syndecan 4 (intracellular 6385 6.189681078 2.01E-10 9.509706352 7.651058689 communication) 205_g at homeo box A4 3201 2.867789963 1.07E-09 1.253183174 1.356465181 33281_at IKK-related kinase epsilon 9641 3.036807944 IE-13 2.812228259 3.716110089 38276_at I kappa B epsilon 4794 2.587016943 4E-10 3.454608864 1.573492134 463 gat nuclear factor I/B 4781 -3.326218015 3.38E-09 -2.789337322 -2.93715476 40511_at GATA-binding protein 3 (T- 2625 -3.077856942 1.74E-09 -2.214428235 -1.15998505 cell antigen regulation) 1102_s_at glucocorticoid receptor 2908 2.639244551 0.00000028 3.1698879 2.569716707 alpha 873_at homeo box A5 --- 2.56550767 5.85E-07 1.169613734 1.194134559 32168_s-at Down syndrome ciical 1827 2.21618204 0.0000103 2,997097995 1.558897138 region gene 1 ._____ 40493_at zinc finger protein 6 960 2.31461126 0.000015 2.992670691 2.618091422 (CMPXI), function unknown 40393 at homeo box A4 3201 14.225364843 1.13E-10 1.732294373 1.372777345 39742at TRAF-intaracting factor 10010 2.142165615 0.0000156 1.785436095 2.694870743 33113_at Cbp/p300-interacting 10370 -2.08039694 6.98E-08 -1710148426 -2.094438928 fransactivator 204 at homeo box A4 3201 6.799784725 3.76E-12 2.135352044 1.228357243 38439_at nuclear factor-like 1(Q 4779 2.105432331 1.0811-10 1.731916025 2.233679314 ferritin gene expression) 35992_at musculin (transcriptional 9242 4.59261857 1.66E-07 5.0459609 9.910746814 repressor 38278_at modulator recognition 10865 2.090810626 1.95E-07 1.797705792 1.362064745 factor I____ ___ 1577_at androgen receptor 367 -2.998677788 2.74E-07 1.084402729 -2.024294255 33439_at transcription factor 8 6935 2.463550746 1.13E-07 1.432420689 2.276427567 (represses IL-2 expression) 36690_at Glucocorticoid receptor, 2908 2.202243881 3.5E-08 1.694016378 1.871546701 lymphocyte 39032_at TGF beta stimulated 8848 -2.226498199 2.04E-07 -2.979839304 -1.815182699 protein (regulates C-type natriuretic peptide gene) 32034_at Kruppel-like transcription 7764 247161582 9.04E-07 2.1386648 1.611108294 factor r.____ 287_at activating transcription 467 037944598 0.00021361 5.867934682 2.449017154 factor 3fucto 37419g at POU domain, class 2, 6452 3.570311319 8.54E-07 10.2030961 7.279581414 transcription factor 2 1001 37417_at POU domain, class 2, 5452 3.15917466 1.82E-09 6.743320713 3.658601746 transcription factor 2.184 .00 29 99 1581 943_at runt-related transcription 861 3.123404286 3.88E-11 2.595679083 2.208405598 factor iva 3939_sat runt-related transcription 861 2.718511505 5.28E-07 2.094702547 1.753450444 factor I 1 1 1 WO 2005/068655 PCT/GB2005/000057 42 Probe set Descriptions LocusLink HUVEC FG (n_7)Baye.p HCAEC FC (n1)MVEC FC (n=i) 39421_at runt-related transcription 861 2.330472883 1.54E-08 2.842674795 1.989573274 factor I 535 s at NF-kappa B 2 (p49/p10 0 ) 4791 7.014437801 8.77E-09 12.09195342 6.581215622 40823_sat transcription factor 4775 -2.078620759 0.00095663 -1.45270611 -1.629367546 NFATx4 33130_at homeo box D1 3231 -5.00861908 368E-08 -2.579094814 -5.352803906 35824 at zinc finger protein 238 10472 -2.383931066 6.72E-07 -4.13316475 -3.964515214 32034 at zinc finger protein 217 7764 2.247161582 9.04E-07 2.1386648 1.611108294 39681_at zinc finger protein 145 7704 2.477517897 0.00000829 1.736511126 1.220799652 (Kruppel-Iike) 41612 at zinc finger protein 264 9422 4.296329969 0.0000447 -1.079860264 -6.156102305 39633_at S100 calcium binding 6274 2.829339235 0.00036814 12.49571209 5.162186098 protein A3 40126_at paired mesoderm homeo 5396 3.283107586 0.00034973 10.49393725 8.156341582 box i 40199 at msh home box homolog 4487 2.409909357 0.0000071 2.521903121 2.708781174 1 (Drosophila) 215_g_at msh homeo box homolog 4487 2.329390033 0.0002391 3.803589095 7.060846295 1 (Drosophila) Enzymes 34304_s_at spermidine N,1- 6303 6.704420999 6.44E-15 3.431292345 4.27011499 acetyltransferase (polyamine catabolism) 1173_gat spermidine/spermine NI- --- 4.132527389 0 2.917946858 3.523924496 Acetyltransferase, Alt. Splice 2 1069_at COX-2 --- 34.72962658 0 60.94542155 124.409157 33862_at phosphatidic acid 8613 3.214894884 2.78E-13 3.604930643 3.689974385 phosphatase type 2B 34666 at Mn SOD 6648 21.14199305 0 41,56950623 36.7453472 39640_at glutamine-fructose-6- 9945 5.640667138 2.42E-14 5.982698011 8.612059352 phosphate transaminase 2 (hexosamine biosynthesis) 40215_at UDP-glucose ceramide 7357 4.897679713 0 3.893723735 4.931113889 _ glucosyltransferase 41352_at beta-galactoside alpha- 6480 5.993191486 0 3.047035442 4.933917672 2,6-sialyltransferase (glycosylation) 34390_at proline 4-hydroxylase, 8974 3.99041836 5.55E-16 5.868560288 4.278419323 alpha polypeptide Il 40290_f at beta-galactosidase alpha- 6482 8.686428065 9.24E-12 4.85511756 2.420407432 2,3-sialytransferase (glycosylation) 576_at NO synthase 4846 -10.63785461 0 -13.32725039 -5.923096431 37402_at Rnase 1, pancreatic 6035 -U45955517 1,46E-10 -5.030206449 -6.634617447 38066_at diaphorase 1728 2,415151638 6.38E-09 -1.305264298 -3.114333412 (NADH/NADPH) (cytochrome b-5 reductase) 36658_at 3-beta-hydroxysterol delta- 1718 2.643697649 9.12E-12 -2.593239368 -3.836044468 24-reductase (cholesterol biosynthesis) 40568_at ATPase, H+ transporting, 526 2.371659873 4.34E-11 3.185827679 2.637705921 lysosomal 33707_at Phosholipase A2 gamma 8605 3.261679914 3.69E-11 3.522257814 2.301935515 (cytosolic) I_1_1 34876 at carboxypeptidase D 1362 3.076753085 1.94E-10 2.897736214 3.000177375 231_at transglutaminase 2 7052 -2.617617679 8.12E-14 -3.334570859 -2.678284178 (crosslinks proteins)

I______I______I__

WO 2005/068655 PCT/GB2005/000057 43 Probe set Descriptions LocusLink HUVEC FC (n=7 Bayes.p HCAEC FC (n=1)MVEC FC (n=1) 35938_at phospholipase A2 5321 3.619599149 3.8E-13 2.366489356 3.253061315 (cytosolic, calcium dependent) 38129_at glycerol kinase 2710 4.156535178 2.03E-11 4.389062428 4.783183323 (metabolizes endogenous and dietary glycerol) 40671_g-at L-kynurenine hydrolase 8942 19.54992096 7.83E-1 3 31.92023266 35.93860554 (tryptophan metabolism) 41654 at adenosine deaminase 100 2.826089391 3.24E-10 3.599789192 3.713396127 33802_at Heme Oxygenase 1 3162 -3.426190665 1.24E-08 1.138813035 -3.346040419 37015_at aldehyde dehydrogenase 216 -4.815533737 1.03E-13 -7.172622822 -5.357724575 1, soluble 36149_at dihydropyrimidinase-like 3 1809 2.348831769 2.55E-10 1.790570365 2.165038959 32718_at tyrosylprotein 8460 2.226480677 3.24E-07 1.761306768 2.35714199 sulfotransferase 1 (modifies proteins in inflammation) 41656_at N-myristoyltransferase 2 9397 -2.01967345 5.85E-09 -2.434231443 -3.519602144 1227_g-at TNF alpha converting 6868 3.813351746 5.27E-09 1.452030457 5.668869009 enzyme 41601_at TNF alpha converting 6868 2.795464504 4.04E-09 1.860960363 2.545861043 enzyme 39663_at mannosidase, alpha, class 4124 2.172987708 1.64E-09 2.83218502 2.310898922 2A, member I (golgi enzyme) 37944_at GTP cyclohydrolase 1 2643 4.438893651 1.76E-09 14.75969444 8.812737944 (dopa-responsive dystonia, NO synthesis) 40672_at L-kynurenine hydrolase 8942 2.673122374 4.73E-10 3.563621638 4.441970617 (involved in biosynthesis of nad cofactors) 38463_s at adenosine 272 3.252956552 0.0000363 4.881773924 2.28032833 monophosphate deaminase, erythrocyte isoform 40505_at ubiquitin-conjugating 9246 2.260319502 0.00000441 6.11613235 1.848697939 enzyme E2L 6 38315_at retinaldehyde 8854 -3.141750466 8.22E-10 -1.56562427 -1.111060049 dehydrogenase 2 34261_at phosphate 5833 -2.168441607 2.43E-07 -2.495275565 -3.137010475 cytidylyltransferase 2, ethanclamine 1226_at TNF alpha converting 6868 2.300272424 0.00000707 1.004340971 2.756217115 enzyme 37255_at N-deacetylase/N- 8509 2.216017066 0.0000592 2.306019166 1.291774578 sulfotransferase (heparan glucosaminyl) 2 35396_at hyaluronan synthase 2 3037 .945257021 0.0000787 100129624 3.057807352 37608_g_at ketohexokinase 3795 2.946029683 0.0000001 -2.552822874 -1.840790023 (fructokinase) 35702_at hydroxysteroid (11-beta) 3290 5.464059097 2,13E-07 4.384698173 7.735231534 dehydrogenase I 1212_at glutathione transferase 2954 2.588622811 1.25E-07 1.930737369 1.42806759 zeta 1 (maleylacetoacetate isomerase) 39791_at ATPase, Ca++ 488 2.012343217 0.00000004 1.822188224 2.032942103 transporting, cardiac muscle, slow twitch 2 40214_at UIDP-glucose ceramide 7357 4.72644372 7.22E-09 3.814508262 4.080889627 glucosyltransferase 41711 at thioredoxin reductase 2 10587 -2.948650383 2.67E-08 -6.378914918 -8.72831537 35966 atl-peptide 25797 2.328202379 3.1E-08 .2,329644161 2.391292262 WO 2005/068655 PCT/GB2005/000057 44 Probe set Descriptions LocusLink HUVEC FC (n7) Bayes.p HCAEC FC (n1)MVEC FC (n1) cyclotransferase (glutaminyl cyclase) 32772_s_at UDP-Gal:betaGlcNAc beta 2683 4.456181198 0.0000175 1.238263347 1.497110144 1,4- gal actosyltransferase, polypeptide 1 39107_at lanosterol synthase (2,3- 4047 3.358766219 0.00073095 1.390518246 1.534806813 oxidosqualene-lanosterol cyclase) 34636_ at arachidonate 15- 246 2.440589489 0.00057786 2.682402797 4.947969996 lipoxygenase 40670_at kynureninase (L- 8942 7.008740575 0.00043779 1.470999146 1,901287336 kynurenine hydrolase) 37841 at butyrylcholinesterase 590 -4.246686347 .0000456 1.724782943 -1.270228337 712_s_at Serine --- -2.610161222 0.000031 -1.94665557 -2.625365856 -lydroxymethytransferase, Cytosolic, Alt. Splice 3 34209_at inositol 1,4,5-trisphosphate 80271 2.90950996 0.00040388 3,289484052 -1.391614528 3-kinase C 39267 at phosphoglucomutase 3 5238 2.053010541 0.00000242 1.904710164 1.542414689 Cell cycle regulation 37218_at BTG3 (negative control of 10950 2.624092795 2.45E-10 3.856424559 3.197893027 cell proliferation) 35153 at P95 (nibrin) 4683 2.136226929 2.84E-09 2.994019488 2.441142021 425 at P27 3429 2.762082411 3.66E-09 2.627038307 1.886894848 1207_at cyclin-dependent kinase 6 1021 2,455451672 0.0000135 -1.062090681 1.219554564 40399_r at mesenchyme homeo box 2 4223 -2.245407634 0.00018939 -1.677937769 1.360388999 (growth arrest-specific homeo box) 38326_at putative lymphocyte 50486 5.210351552 9.34E-07 4.501028149 2.835700322 GOIGI switch gene Cell communication 32531at Connexin343 2697 2.368387646 2.65E-1 1 1.97846913 2.001682474 2018 at Connexin 43 2697 3.031077047 1.69E-07 2.474557415 2.815825621 40687at gap junction protein, alpha 2701 -5.56891197 0.0000116 -3.0254658771 -2.091117495 4, 37kDa connexionn 37) Nuclear proteins 37027_at AHNAK2 nucleoprotein 195 2.16666252 1.49E-09 -2.455018307 -3.26541786 (desmoyokin) 286_at H2A histone family, 8337 3.115339124 7.26E-09 4.90449378 3.960532543 _____member 0 37354 at nuclear antigen Sp2 00 6672 3.058654921 1.07E-07 2.643890811 1.040688287 32609_at H2A histonefamily, 8337 15.67613628 9.49E-10 13.14154378 5.736367488 member 0 ______ 39397_at nuclear receptor subfamily 7026 -2.044215909 1.98E-09 -2.272605283 -2.260646545 2, group F, member 2 37377 i at lamin A/C (structural 4000 -2.350943533 1.75E-10 -2.555422079 -1.767515468 protein of nuclear envelope) 33249at nuclear receptor subfamily 4306 -2.584848636 3.41 E-08 -1.739378234 -1.562212566 3, group , member 2 34690at SWISNe related subfamily0601 -2.088814752 0.00000536 -1.565957305 -1.282789174 2,_groupF, member 2 32668_at single-stranded DNA 23635 -3.149577521 0.00031465 -1.640548596 -2.145738917 WO 2005/068655 PCT/GB2005/000057 45 Probe set Descriptions |LocusLink HUVEC FC(n=7) Bayes.p HCAEC FC (n=1) MVEC FC (n=1) binding protein 2 Cytoskeletal 41439_at myosin class I (mutated 4430 9.740468685 2.06E-10 14.70291906 10.25673133 allele) 33102_at adducin 3 (gamma) 120 3.391355995 1.1E-12 6.424336776 3.508692997 34082_at slingshot 1 (F-actin 54434 2.484987537 2.07E-10 1.636955316 1.21353576 binding) 36792_at tropomyosin 1 (alpha) 7168 2.572958966 2.38E-11 1.214714872 1.819080175 36790_at tropomyosin I (alpha) 7168 2.209718995 4.39E-10 1.104623941 1.666863013 35766 at keratin 18 3875 -4.242007604 2.68E-14 -4.656673789 -6.504888937 36791_g_at tropomyosin I (alpha) 7168 2.9249265 8.61E-13 1.468402341 1.880703517 33103_sat adducin 3 (gamma) 120 3.920756358 2.92E-10 6.031570788 3.575830825 37785_at RHO6 GTP-binding protein 27289 4.221025029 2.48E-12 1.273849496 7.406673709 (?actin cytoskeleton regulation) 39070_at fascin (actin-bundling 6624 -2.330745344 6.37E-13 -1.68300774 -2.694414931 protein) 35803_at ras homolog gene family, 390 -2.233636127 2.29E-10 -1.065779002 1.038111944 member E (disassembly of actin stress fibres) 34886_at radixin 5962 2.420953001 1.22E-07 1.584145112 1.542677121 34887_at radixin (crosslinks actin 5962 2.278449836 6.64E-08 1,199811512 1.794183039 and integral membrane proteins) 32847_at myosin light chain kinase 4638 4.896958824 9.13E-09 18.11380806 2.725943964 40069_at supervillin 6840 2.682759032 0.0000725 3.169652491 2.028055227 1058_at WASP 3 (actin- 10810 -2.0972916B1 1.68E-07 -1.631969908 -3.144102457 cytoskelaton associated) 38022_s4at plectin 1, intermediate 5339 -2.55700404 0.0000137 -4.301607614 -3.040635806 filament binding protein ______ O~kDa 40899at keratin 19 3880 .- 6.322934628 1.59E-09 -13.66744481 -8.25383859 41294__at Ikeratin 7 655 -4.318997454 0.0000126 -74.99352182 -6,560418569 Complement 37388at tissue factor pathway 7980 23.78384351 2.22E-13 5.35937334 33.8370157 inhibitor 2 35664 at multimerin 22915 -3.742143256 1.5E-14 -9.087085855 -4.496252381 38022_t oagulation factor 11 2150 2.846565472 7.74-08 4.471805084 4.865728749 fiathrombin) receptor-like 39409_at complement component 1 715 5.781697808 0.00000211 13.33715147 6.459955952 36344_at coagulation factor 11 2150 5.790500377 1.15E-12 6.773344893 4.683025515 (thrombin) receptor-like 1 37185 at PAI-2 5055 3.441427028 0.00000798 3.324772251 1.431092156 33803_at thrombomodulin --- -4.010890247 0.01 E-11 -4.187934083 -2.823656854 35822_at B-factor, properdin 629 3.628127319 5.92E-07 19.71747326 3.665782889 40496_at complement component 1, 716 5.442703249 0.00000145 27.82653223 13.55862174 s subcomponent 31825_at serine (or cysteine) 3053 3.710911406 1.09E-07 2.145669756 1.468699812 proteinase inhibitor, clade D member I 36543_at coagulation factor 1i1 2152 9.446520842 0.0000041 8.829602345 9.990355775 (thromboplastin, tissue factor) 33295at3.21 7 0.0000079 4.74993939 2.160165669 WO 2005/068655 PCT/GB2005/000057 46 Probe set Descriptions LocusLink HUVEC FC (n=7) Dayes.p , HCAEC FC (n=l)MVEC FC (n=l) Extracellular matrix 39333_at collagen, type IV, alpha 1 --- 3.294038599 1.4E-10 2.248373685 2.640671802 32551_at EGF-containing fibulin-like 2202 -2,645292659 6.16E-10 -3.672557726 -4.730137915 extracellular matrix protein 1 36929_at laminin, beta 3 (125kD)) 3914 4.113164884 3.73E-12 8.332528001 5.436782952 36659 at collagen, type IV, alpha 2 1284 2.338145488 4.1IE-10 2.675850693 2.28281283 35366_at nidogen (enactin) 4811 -2.021024484 0.00000479 -2.914727592 -3.017493076 35280 at laminin, gamma 2 3918 10.39471638 0.0000158 3.017362805 15.60150516 37459 at collagen, type VillI, alpha 1 1295 3.050351654 0.00000175 3.148028315 5.176396595 32818_at tenascin C (hexabrachion) 3371 44.41053365 0.00000808 4.803724568 5.681119838 35168 f at collagen, type XVI, alpha 1 1307 7.746991041 0.00000406 11.09936614 5,956620288 G-Protein and Miscellaneous Receptors 32114_s-at 3 protein-coupled receptor 135 7.585528941 0 8.109402646 8.790666973 (A2a receptor) _____ 34288_t Orphan G protein-coupled 57007 8.088266305 4.55E-15 27.11397321 30.67795921 receptor 38247_at Orphan G protein-coupled 2150 6.820758815 3.54E-1 0 8.161820702 7.968953316 receptor 3211 5r2at G protein-coupled receptor 135 3.353944077 1.11E-10 7.275228636 9.470302722 (A2a receptor) 1105 s at T cell receptor beta locus --- -2.885206906 7.15E-12 -1.709061111 -1.489399158 37645_at D69 (cell surface 969 4.1627256 9.18E-08 4.927757479 4.516514511 glycoprotein) 39310 at bradykinin receptor B2 624 5.506990833 8.25E-11 21.40768199 26.4865604 40310 at Toll-like receptor 2 7097 17.04231159 6.34E-08 41.69446428 92.69458196 33764_at G protein-coupled receptor 9568 -4.114163378 7,43E-08 -6.496935914 -5.999971299 51 40240_at G protein-coupled 51704 3.405092443 3.75E-08 2.244472511 3.77994146 receptor, C513 41831_al low density lipoprotein 4041 -2.020184601 0.00000334 -2.92443917 -1.967658837 receptor-related protein 5 41831_at low density lipoprotein 4041 -2.02018401 0.00000334 -2,92443917 -1.967658837 receptor-related protein 5 36059_at low density lipoprotein 4038 2.167124662 0.00049742 1.712017357 1.571062091 receptor-related rotein 4 33236_at retinoic acid receptor 5920 2.254357183 0.000037 2.573139814 1.387068386 responder (tazarotene induced)p3 33772_at prostaglandin E receptor 54 -2.821392903 0.00000285 -333146064 -5.979710428 (subtype EP4) 706_at Glucocorticoid Receptor, -- 2,732594537 0.00000824 1.92549503 2.243726671 Beta 38222_at pyrimidinergic receptor 5031 5.12709451 0.00050913 5.150230333 -1 .000345091 P2Y, G-protein coupled, 6 51704 37534_at coxsaokie virus and 1525 -7.953355635 6.94E-07 -10.03852045 -6.352677218 adenovirus receptor 34975_at killer cell lectin-like 10219 -7.631896619 0.0000201 -3.597564002 -1.580902467 receptor subfamily 0, member I _____ Interferon-inducible genes 33304_at interferon stimulated gene 3669 6.368043453 6.66E-16 21.37131919 8.654897863 _____ (200)~ 41140_at interferon gamma receptor 3460 3.843792475 3E-15 6.009122949 4.473233377 2 (taza roten WO 2005/068655 PCT/GB2005/000057 47 Probe set Descriptions LocusLink HUVEC F6 (n7) Uayesp HCAEC FC (n1)MVEC FC (n=1) 32700_at guanylate binding protein 22634 3.552701285 1.08E-10 4.864506689 2.105432487 464_s_at interferon-induced protein 3430 2.673886964 3.22E-08 9.148025083 3.018968778 35 39728_at interferon, gamma- 10437 5774728675 3.99E-07 14.1357142 14.8277104 inducible protein 30 425_at interferon, alpha-inducible 3429 2.762082411 3.66E-09 2.627038307 1.886894848 protein 27 925_at interferon, gamma- 10437 7.680903539 1.26E-12 13.2183993 9.629877375 inducible protein 30 35735 at guanylate binding protein 1 2633 2.943798001 3.26E-09 6.637940419 4.567149794 626_s_at interferon-induced protein 3430 2.126602914 2.81 E-07 9.365638399 2.209101255 35 38584_at interferon-induced protein 3437 2.968612864 0.00000601 19.75380759 2.995063164 with tetratricopeptide repeats 4 Proteosomne system 41171_at Proteosome activator 5721 2.632747876 2.94E-08 5.101785113 3.339110072 subunit 2 ______ 1184_at proteasome activator 5721 3.562723482 1.92E-12 4.791072135 2.802359636 subunit 2, beta 384_at Proteosome subunit, beta- 5699 3.877228796 4.E-14 5.603185012 3.630961741 _____type, 10 E____ 38287_at Proteosome subunit, beta- 5698 4.659894959 4.8E-08 7.53567814 2.324895346 type, 9 ______ 36600_at proteasome activator 5720 2.628955624 7.22E-01 3.416274304 1.918170839 ______subunit I 41184-__at proteasome subunit, beta --- 2.245374672 2.58E-08 3.576681689 1.36914074 ______type, 0 Heavy metal binding 31622 fat metallothionein 1F -2.113411119 9.82E-13 1.9075731 2.31465058 (functional)______ 36564_at metallothionein 1IE 127544 2,12687658 2.86E-09 1.738158583 3.383316024 (functional) ? seudogene 39120at metallothionein IL 4500 2.155505079 0.00010668 1.438072627 1.49279098 39081 at ot onein 2A 52 3.88346697 9.5E-14 1.07990076 4.037912602 TNF ligand and receptor superfamily 37611_at TNp receptor superfamily, me2 22.5815417 1.85E-11 6.732948102 23.80716306 member , b 3__I4_atr(osteoprotegerin) 32319_at TNF (ligand) superfamily, 7292 -2.146064062 1.83E-07 -2.34971 8558 -3,490304298 member 4 31540_at NF-receptor superfanily, 3604 14.14497071 1.95E-09 31.32294502 .13544291 member 9 34916_s-at TNF receptor superfamily, 7293 7.281386913 0.00000036 17.13316176 14.8856408 member 4 Histocompati ability subni,_et 40370 f3at HLA-G histocompatibility 3135 2.224416431 1.84E-09 2.315139184 1.850745369 antigen, class 1, G _____ 3 fat HLA-B 3107 2.81351868 1.31E-11 3.293656671 1.69656681 41237_at HLA-A 3105 2.59243429 1.07E-09 2.056585976 1.66805547 WO 2005/068655 PCT/GB2005/000057 48 Probe et Descriptions LocusLink HUVECFC(n=7)Bayes.p HCAECFC(n1)MVECF (n=1) 37421 f at HLA-F 3134 2.42786464 4.91 E-10 3.447090363 2.384322116 32321 at HLA-E 3133 2.208821209 1.1E-08 1.743423717 1.899995194 35017 f at HLA-J (pseuodogene) 2.662234099 5.97E-10 3.747711512 2.904008691 Miscellaneousuin HV FC(7Bys 35320 at NRAMP2 (divalent metal 4891 3.804011587 1.44E-12 3.429131292 3.883439443 ion transport) 40215_at UDP-glucose ceramide 7357 4.497679713 0 3.893723735 4.931113889 giucosyltransferase 31697_s3at ferritin, heavy polypeptide 2.105668901 0 1.337516978 1.511895019 33943at ferritin, heavy polypeptide 2495 3.122808312 2.78E-10 2.663086781 2.529725749 38970_s-at Nef-associated factor 1 10318 7.45565403 0 10.89386893 7.958276569 38971 r at Nef-associated factor 1 10318 9.653298205 5.55E-16 14.75346332 3.797994507 32610_at LIM domain protein (RIL, 8572 3.406069789 1.89E-14 4.37768025 3.218415014 tumour supressor) _______ 33331_at BENE protein (raft- 7851 -7.359188939 5.55E-16 -46.5789075 -18.3751842 mediated trafficking in ECs) 39119_s_at natural killer cell transcript 9235 10.49680235 0 4.836079548 3.470433531 4 36065 -at LIM domain binding 2 9079 -7.075099306 6.46E-12 -11.70672404 -11.6004516 38332_at purinergic receptor P2X, 5025 3.527832595 1.79E-12 6.839982825 3.28582556 ligand-gated ion channel, 4 41446fat RNA helicase-related --- 2.049868207 9.011E-09 2.57850892 3.69227503 protein 38631_at TNF- alpha-induced 7127 15.5435756 6.02E-13 25.32299307 20.24401 protein 2 40236_at cationic amino acid 6542 4.903862742 3.67E-14 3.663619476 5.136877139 transporter 2 41635_at Wilmas'tumour 1- 9589 5.790617037 3.86E-13 5.777745597 7.816513232 associating protein 36550 at RAB5 interacting protein 54453 4.287401682 1.33E-15 2.893396126 4.240726454 33791.at deleted in lymphocytic 10301 -2.154987417 4.84E-07 -2,474972561 -3.124760447 leukemia, 1 _______ 39253 s at ras-like protein , 5898 2.361506735 7,94E-1 1 2.022311156 3.104448716 3996_at chondroitin sulfate 10675 2.079781386 0.00034796 1.723347734 2.787442584 proteoglycan 5 39119__a ntneurol Ilcan C) transcrpt923 35261_at glia maturation factor, 9535 4.535854994 3.76E-12 3.146314731 1.355411967 g_____ amma _______ 40051at TRAM-like protein 9697 -2.023145895 1.16E-09 -2.064329419 -2.568060873 (translocation of secretary proteins) 41191_at palladin (predicted 23022 2.402476155 3.82E-11 -1.092945296 2.895126951 prmunoglobulin) 38169_s at cationic amino acid 6542 12.6862715 0 18.10015779 9.03591152 transporter-2A 36175_s at HIlV typeenhancer- 3097 4.702789112 4.64E-12 5.779921347 .668812125 binding protein 2 33731_at solute carrier family 7 9056 6.830303999 5.23E-12 2.785124946 3.44886334 cationicc amino acid transporter), member 7 38617 at LIM domain kinase 2 3985 2.398434304 2.8E-1 1 3.05797248 3.089108758 1876_at Guanine Nucleotide- --- 2.740128058 4.06E-1 1 3.184919976 4.783089817 Binding Protein Ra, Ras Onogene Related 33371_s at RAB3I, member RAS 11031 2.67768839 9 95E 2 2.885116722 oncogene family WO 2005/068655 PCT/GB2005/000057 49 Probe set Descriptions LocusLink HUVEC FC 0n7) Bayes.p HCAEC FC (n=1) MVEC FC (n1) 39959_at diubiquitin 10537 154.5481774 2.13E-13 83.39051649 60.80792672 38268_at solute carrier family 1 6505 -3.494052945 2.36E-08 -2.323709091 -1.880436681 member 1 34678_at myoferlin (Type II mebrane 26509 -2.461785987 8.1E-11 -2.34118743 -4.428257826 protein) 37423_at sodium/potassium/chloride 6558 5.863341383 8.58E-09 10.30897586 3.262676301 transporter 41048 at PMA-induced protein 1 5366 4.124831328 5.88E-11 5,374932281 2.751035089 1877_g-at Guanine Nucleotide- -- 2.263857729 3.19E-10 1.36624261 2.95732027 Binding Protein Ral, Ras Oncogene Related 37749_at mesoderm specific 4232 -8.563686441 3.39E-12 -3.738761532 -1.890221954 transcript (mouse) homolog 36711_at MAFF (binds to oxytocin 23764 2.330148548 2.1 E-10 3.660794234 3.509266911 receptor gene) 35367_at lectin, galactoside-binding, 3958 2.847428796 2.49E-09 2,186535805 1.966123786 soluble, 3 (galectin 3) 37393_at hairy homolog (Drosophila)|3280 -2.104729557 0.0000105 -3.227167705 -2.968404609 41362_at macrophage lipid 9619 3.698756129 1.87E-08 3.126761474 2.360268513 transporter (ATP-binding) 40434_at podocalyxin-like protein 5420 2.479801376 2.27E-10 2.872125804 4.127017341 41554_at chromosome 8 open 734 4.401795539 2E-10 6.312497146 6.214246908 reading frame 1 38430_at fatty acid binding protein 4, 2167 11.71004306 1.76E-08 -2.470683976 2.325955927 adipocyte 40427_at COX17 (cytochrome c 10063 2.3179959 6.44E-09 3.564946719 2.403583185 oxidase assembly) 41168_at Tapasin (antigen 6892 2.919975741 1.33E-09 4.008077667 3.002345356 processing) 38268_at solute carrier family 1( 6505 -3.494052946 2.36E-08 -2,323709091 -1.880436681 member 1 33900_at follistatin-like 3 (secreted 10272 2,357044965 5.76E-08 2.168463959 1,891151792 glycoprotein) 32606_at brain abundant, membrane 10409 2.154773549 1.85E-07 1.676450671 2.705410717 attached signal protein 1 37168_at similar to lysosome- 27074 2.18129371 0.00000117 5.66836506 3.858733053 associated membrane glycoprotein 1798_at LIV-1 protein, estrogen 25800 3.806942042 2.54E-07 5.605645413 2.523928805 regulated 40153 at ATP-binding cassette, B2 6890 2.658243189 9.77E-10 6.565992214 2.011052241 39327 at Melanoma associated 7837 3.281662101 3.74E-13 1.840301616 2.456998383 gene 38787_at promyelocytic leukemia 5371 3.246279259 5,42E-09 5.014441081 1.86657737 33235_at neuron navigator 3 89795 2.126455294 8.42E-07 7.147716124 3.178133882 40391_at solute carrier family 22 6583 3.503572137 1.28E-08 5.751930923 2.915071673 (organic cation transporter), member 4 _ 39805_at ATP-binding cassette, B6 10058 3.134810592 0.000062 -3.950118144 -7.557051796 (mitochondrial function) 38062_at guanine nucleotide 9771 .385667595 0.00000123 3.284445082 2.129584571 exchange factor for Rap1; M-Ras-regulated GEF 36700_at Drosophila Kelch like 56062 -2.210141615 0.00000889 -2.058838894 -3.814327142 protein 543_g_at cellular retinoic acid 1381 2.37806162 0.00058519 12.12054759 3.960310682 binding protein 1 40171_at frequently rearranged in 23401 2.042289921 0.00045387 -1.102930154 -3.45484887 advanced T-cell lymphomas 2

_______

WO 2005/068655 PCT/GB2005/000057 50 Probe set Descriptions LocusLink HUVEC FC (n=7) Bayes.p HCAEC FC (n=1)MVEC FC (n1) 38152_at loss of heterozygosity, 11 4013 2.090463365 5.18E-07 1,10772429 1.474509395 _ (tumour suppressor) 41419_at CED-6 protein (?involved 51454 2.160266818 0.0000141 2.79D711625 2.280229173 in phagocytosis of apoptotic cells) 40177_at BRCA2 - 3.632767036 0.0000751 4.837141134 2.266454194 36156_at aquaporin 1 (channel- 358 -7.543457532 7.36E-08 -24.72084587 -2.81472244 forming integral protein, 28kDa) 1451_s_at osteoblast specific factor 2 10631 -2.716285201 0.00096058 -3.058214965 -6.172371916 (fasciclin I-like) 32052_at hemoglobin, beta 3043 -2.82310622 0.00061531 -1.063359691 -1.063732475 38267_at solute carrier family 1 6505 -2.372362221 0.0001239 -1.854384932 -4.202930496 member I 34232_at natural killer-tumor 4820 2.060240283 0.00081253 3.524334866 2.678630512 recognition sequence 33533_at DnaJ (Hsp40) homolog, 11080 -3.248997846 1.27E-09 -3.405109343 -4.88373502 subfamily B, member 4 31803 at B7-like protein 23308 8.62168092 6.66E-16 7.351063706 7.831573616 39517_at HTGN29 protein 56951 2.513008231 8.67E-12 3.043956898 3.301473663 32215iat Rho-related BTB domain 22836 4.025081573 2.65E-11 1.546933689 3.717203105 containing 3 31974 at claudin 14 23562 5.268948019 7.62E-10 16.58450042 14.62230502 38234_at transducin-like enhancer of 7090 3.190483556 1.01 E-08 5.862031912 2.662349924 split 3 (E(spl) homolog, Drosophila) 717 at GS3955 protein 28951 -5.936942813 .IE-08 -3.058213083 -3.442126415 34759 at Human hbc647 mRNA --- -2.062062602 2.12E-07 -1.090273524 -1.859178255 sequence 40314 at synaptogyrin 3 9143 2.59238833 5.12E-07 3.4U394603 2.628868732 1562_g._at dual specificity 1850 3.469723923 6.1 9E-07 2.160285876 1.814944895 phosphatase 8 34075_at ring finger protein 3 10336 2.474945089 6.84E-07 1.570008537 1.324684407 158_at DnaJ (Hsp40) homolog, 11080 -3.069096975 9.69E-07 -5.612414258 -4.225543684 subfamily B, member 4 35628_at transmembrane 7 7108 -2.262624361 0.00000127 -7.138287918 -7.896982242 superfamily member 2 39532_at Ras and Rab interactor 1 9610 -2.446039394 0.00000369 -2.423287325 -4.576385229 32464 at defensin, beta 4 1673 5.73206473 0.00000396 9.471069184 5.787182569 40398_sat mesenchyme homeo box 2 4223 -2.929695911 0.00000406 -3.319848792 -1.032947415 (growth arrest-specific homeo box) 36691_at cysteine conjugate-beta 883 -2.592484271 0.00000419 -4.781646333 -4.268473905 lyase; cytoplasmic 32285_g_at T-box 1 6899 -3.404797802 0.00000657 -4.474254059 -1.100865777 35281_at Human laminin gamma2 --- 7.305157538 0.0000141 1.253227767 3.632687454 chain gene 36852_at Putative prostate cancer 7991 2.0126302 0.000015 1.834058874 1.163775279 tumor suppressor 35350_at B cell RAG associated 51363 -2.378507434 0.0000163 -2.826314014 -2.971591523 protein 38223_at vascular Rab-GAPITBC- 11138 -2.237040168 0.0000198 -2.17332853 -6.419950691 containing 1778 _gat Ras and Rab interactor 1 9610 -2.039906548 0.0000265 -2.354421127 -2.277558206 34748_at guanine nucleotide 25780 4.876306368 0.0000375 1.998297818 1.431030207 exchange factor for Rap1 38177_at receptor (calcitonin) 10266 -2.669452927 0.0000544 -1.504408342 -1.725233883 activity modifying protein 2 36767_at cytochrome P450, 1543 -3.25254729 0.0000617 -2.335422922 -2.35009616 subfamily I (aromatic comound-inducible), WO 2005/068655 PCT/GB2005/000057 51 Probe set Descriptions LocusLink HUVEC FC (n=7) Bayes-p HCAEC FC (n1)MVEC FC (n=l) polypeptide 1 36103-at LD78 alpha precursor 4.751320817 0.0000661 7.445011283 16.10643497 38916_at chromosome X open 10046 -2.03566901 0.0000766 -2.600257104 -1.605985898 reading frame 6 37695_at likely ortholog of mouse 9781 -2.301917036 0.00012133 -1.323110698 1.160790171 ubiquitin conjugating enzyme 7 interacting protein 4 37452_at uromodulin (uromucoid, 7369 -2.459571854 0.00013772 1.432388832 -2.496391159 Tamm-Horsfall qlycoprotein) 38298_at potassium large 3779 2.267192754 0.00014094 1.805996602 2,016570577 conductance calcium activated channel, subfamily M, beta member 1 34265_at secretory granule, 6447 2.136706898 0.00020271 2.37154058 6.59160987 neuroendocrine protein 1 (7B2 protein) 37420__at major histocompatibility --- 6.418888272 0.00020626 12.57659136 4.328385052 complex, class I, F ( 1024_at cytochrome P450, 1543 -2.278885393 0.00021089 -4.433899159 -5.141649045 subfamily I (aromatic compound-inducible), polypeptide 1 40604_at dual-specificity tyrosine- 8445 4.160877249 0.00021373 -1.00374691 -1.088223843 (Y)-phosphorylation regulated kinase 2 37830 at transmembrane 4 10867 2.717292959 0.0002566 1,697194729 2.682188088 superfamily member tetraspan NET-5 39579_at claudin 10 9071 -2.657823461 0.00029297 -1.222678519 -2.151570787 39826 f at HIF-1 responsive RTP801 54541 2.730193575 .00029395 2.196725544 -1.095320201 34432 at SH2 domain protein 2A 9047 3.310710864 0.00030924 7.989570792 23.07377029 37241_at paraneoplastic antigen 10687 -2.442605109 0.00032556 -1.856943883 -2.613966323 MA2 40606_at ELL-related RNA 22936 2,424019485 0.00037794 3.31621885 2.346164265 polymerase 11, elongation factor 1561_at dual specificity 1850 3.434679205 0.00038896 1,001924133 1.383633366 phosphatase 8 39300_at calmodulin-like 3 810 -3.091045664 0.00042474 1.486878275 -1.021019291 36965_at ankyrin 3, node of Ranvier 288 -2.723182368 0.00044183 -1.044035474 -2.023634007 (ankyrin G) 37514_s_at mannan-binding lectin 10747 2,200703073 0.00058878 2.16677628 1.730660832 serine protease 2 40626 at metaxin 1 4580 -2.054132333 0.00078486 -1062883007 -1.186917557 32216 r-at Rho-related BTB domain 22836 2,64711066 0.00085998 1.556636149 3.676801387 _____containing 3 _____ 39580-at statherin 6779 3.677272808 0.00091313 3.76121132 1.183111878 32944_a roundabout, axon 6091 2.375016818 0.00093376 1.799248044 1.615217662 guidance receptor, 1homolog 1 (Drosophila) ____________________ WO 2005/068655 PCT/GB2005/000057 52 Table 1b. Genes and ESTs of unknown function, regulated by inflammatory mediators Probe set Descriptions LocusLink HUVEC FC Bayes.p HCAEC FC MVEC FC (n=7) (n=1) (n=1) 34800_at AL039458:DKFZp434NO910_s1 26018 3.40078204 2.85E-13 2.765010993 6.664710547 Homo sapiens cDNA, 3 end 38393_at KIAA0247 gene product 9766 2.29784077 1.67E-09 6.02008351 4.413369148 34678_at AL096713:Homo sapiens mRNA; 26509 -2.461785987 8.1E-11 -2.34118743 -4.428257826 cD NA DKFZp564E1616 ______00 0 2 - 3 1 5 -0 4 7 5 39602_at AL050090:Homo sapiens mRNA; 25924 -4.577280769 0.0000172 -4.30119521 -10.40709155 cDNA DKFZp586FI018 38717_at AL050159:Homo sapiens mRNA; 25840 -4.689298781 1.28E-08 -7.74893638 -11.28080814 cDNA DKFZp586A0522 40542_at cDNA DKFZp564HI916 (from --- -2.496243538 1.49E-09 -3.8269357 -4.459353442 clone DKFZp564H1916) 36336 s at KIAA0963 22904 2.332740057 5.13E-09 8.689197154 4.182729484 38510_at AL049435:Homo sapiens mRNA; --- 5.396432597 9.74E-11 6.475495162 2.715475488 cDNA DKFZp586B0220 41690_at AL049471:Homo sapiens mRNA; --- 3.796753878 2.31E-07 3.480379946 4.086635283 cDNA DKFZp586NO12 37786_at Homo sapiens clone 24707 mRNA --- 2.683364137 0.0001284 2.585161023 1.833430515 sequence 41837_at hypothetical protein 56967 -2.367358274 0.0000417 -2.170427473 -2.218598517 DKFZp761 F2014 35959_at KIAA0844 protein 22891 3.512525058 0.0000819 1.000129624 1.57103734 36250_at Homo sapiens clone 24488 mRNA --- 2.099339801 0.0000777 2.646927476 -1.069488008 sequence 38749 at hypothetical protein MGC29643 116372 -6.715917049 0.0000192 -5.323536941 -5.128912423 31849_at KIAA0564 protein 23078 2.224449383 8.58E-07 -1.476396381 -1.27776956 39827_at hypothetical protein (HIF-1 54541 2.094989151 5.69E-09 -1.05607484 1.073522919 responsive) 35763_at KIAA0540 protein 23218 -4,219436032 1.45E-10 -2.077617899 -6.313755213 34176 at hypothetical protein from clone 643 57228 -2.112126935 1.23E-08 -1.597169536 -1.875122258 41229_at Homo sapiens mRNA; cDNA --- -2.2358848 9.58E-09 -2.83431221 -3.1640925 DKFZp564H1916 36497 at hypothetical protein BC011859 113146 -3.616464046 2.82E-11 -4.334097766 -8.757335062 32110_at KIAA0523 protein 23302 -2.745882047 2.07E-08 -2.214350233 -2.866714311 33325_at Homo sapiens, clone --- 2.176427217 6.55E-08 3.266179064 2.671921634 IMAGE:4151609, mRNA, mRNA sequence 36014_at hypothetical protein 57211 -5.760412704 3.71E-12 -8.607279686 -9,578098002 DKFZp564D0462 40855_at KIAA1053 protein 23034 2.816692342 2.05E-11 2.161737313 2.608672841 37216 at KIAA0963 protein 22904 6.46210333 3.22E-13 8.253255749 4.410973232 40472_at PISC domain containing 254531 -2.478023126 0.00000857 -1.900414388 -7.223997137 hypothetical protein 41735 at KIAA0870 protein 22898 2.356691777 0.0000579 3.836683893 1.946020466 32385_at Homo sapiens mRNA; cDNA --- -3.217722448 0.00028948 -1.690512627 -1,478976553 DKFZp566F1224 41710_at hypothetical protein LOC54103 54103 6.540656908 0.0002523 6.153505937 6.999868011 35484_at Unknown (protein for - -2.144224745 0.00082522 -3.214996363 -1.249999657 IMAGE:5177668) [Homo sapiens], mRNA sequence 39582_at Homo sapiens mRNA; cDNA --- 2.047922256 0.00075152 4.318196752 2.0788606 DKFZp586D122 34857_at Hypothetical protein (?cation- 79572 4.947142933 7.33E-15 6.560037706 9.528191509 transporting ATPase) 39597_at KIAA0843 protein 22885 2.251002894 3.31E-09 1,463446202 1.540119179 38972_at Hypothetical protein (?mucin 115207 -3.47649954 2.91 E-1 3 -7.807767943 -11.3252609 2367p009 .633o19tein)46020466 WO 2005/068655 PCT/GB2005/000057 53 Probe set Descriptions LocusLink HUVEC FC Bayes.p HCAEC FC MVEC FC (n=7 (n1l) (n=1) 33924_at KIAA1091 protein (function 23258 2.032421884 3.58E-08 2.704538654 2.417232497 unknown) 40239 _gat hypothetical protein MGC35048 124152 2.19014209 0.00000228 1.613513848 3.423127335 34303 at hypothetical protein FLJ90798 219654 -4.704828617 0.00000675 -2.511409176 -5.24800397 37030_at expressed in T-cells and 23197 2.060834569 9.18E-07 1.188459581 1.046205726 eosinophils in atopic dermatitis 32791 at MAC30 (hypothetical protein) 27346 -2.011357014 6.47E-07 -2.174949259 -1.604404811 1529 at hypothetical protein CGO03 10129 -2.488539403 2.91E-08 -3.553893245 -4.186928468 37788_at Homo sapiens clone 23688 mRNA --- -2.047017635 0.00028466 -3.046721831 -2.16341444 sequence 39837_s_at Homo sapiens PAC clone -- 3.16875435 3.43E-07 -6.848331513 -1.485922984 DJ0751 Hi 3 from 7q35-qter 35861_at cDNA, 3 end /clone=lMAGE- --- 2.102166336 0.00032601 6,510939455 6.95613937 362388 ____________

______

WO 2005/068655 PCT/GB2005/000057 54 Table 2a: Probe sequences for identification of transcripts of Table la >1736 at HG-U95Av2 agtaaaccccaagcaggcactgcccgcccacaggatgtgaaccgcagagaccaacagagg aatccaggcacctctaccacgccctcccagcccaattctgcgggtgtccaagacactgag atgggcccatgccgtagacatctggactcagtgctgcagcaactccagactgaggtctac cgaggggctcaaacactctacgtgcccaattgtgaccatcgaggcttctaccggaagcgg cagtgcc >34021_at HG-U95Av2 caagaatcccaaactcaccaggatgctcacatttaagttttacatgcccaagaaggccac agaactgaaacatcttcagtgtctagannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnagggatctgaaacaacattcatgtgtgaatatgctgatgagac agcaaccattgtagaatttctgaacagatggattacnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncttctatttatttaaa tatttaaattttatatttattgttgaatgtatggtttgctacctattgtaac >35061 at HG-U95Av2 ggagtcaagcccttataagtcaaaagcatctatgtgtcgtaaagcattcctcaaacattt tttcatgcaaatacacanttctttccccaaatatcatgtagcacatcaatatgtagggaa acattcttatgcatcatttggtttgttttataaccaattcattaaatgtaattcataaaa tgtactatgaaaaaaattatacgctatgggatactggcaacagtgcacatatttcataac caaattagcagcaccggtcttaatttgatgtttttcaacttttattcattgagatgtttt gaagcaattaggatatgtgtgtttactgtactttttgttttgatccgtttgtataaatga tagcaatatcttgqacacatttga >36444 s at HG-U95Av2 ttccatgctactagtgctgactgctgcatctcctacaccccacgaagcatcccgtgttca ctcctggagagttactttgaaacgaacagcgagtgctccaagccgggtgtcatcttcctc accaagaaggggcgacgtttctgtgccaaccccagtgataagcaagttcaggtttgcatg agaatgctgaagctggacacacggatcaagaccaggaagaattgaacttgtcaaggtgaa gggacacaagttgccagccaccaactttcttgcctcaactaccttcctgaattatttttt taagaagcatttattcttgtgttctggatttagagcaattcatc >36782 s at HG-U95Av2 ttcttccaatatgacacctggaagcagtccacccagcgcctgcgcaggggcctgcctgcc ctcctgcgtgcccgccggggtcacgtgctcgccaaggagctcgaggcgttcagggaggcc aaacgtcaccgtcccctgattgctctacccacccaagaccccgcccacgggggcgccccc ccagagatggccagcaatcggaagtgagcaaaactgccgcaagtctgcagcccggcgcca ccatcctgcagcctcctcctgaccacggannnnnnnnnnnnnnnnnnnnncgaaaatctc tcggttccacgtccccctggggcttctcctgacccagtccccgtgccccgcctccccgaa acaggctactctcctcggccccctccatcgggctgaggaagcacagcagcatcttcaaac atgtacaaaatcgattggctttaaaca >37319 at HG-U95Av2 cccaagaaggtctggcaaagtcaggctcagggagactctgccctgctgcagacctcggtg tggacacacgctgcatagagctctccttgaaaacagaggggtctcaagacattctgccta cc >431 at HG-U95Av2 actctaagtggcattcaaggagtacctctctctagaaccgtacgctgtacctgcatcagc attagtaatcaacctgttaatccaaggtetttagaaaaacttgaaattattcctgcaagc caattttgtccacgtgttgagatcattgctacaatgaaaaagaagggtgagaagagatgt ctgaatccagaatcgaaggccatcaagaatttactgaaagcagttagcaaggaaa WO 2005/068655 PCT/GB2005/000057 55 >1006 at HG-U95Av2 ctgaggaacccctggtgcccacaaaatctgttccttcgggatctgagatgccagccaagt gtgatcctgctttgtccttcgatgccatcagcactctgaggggagaatatctgttcttta aagacagatatttttggcgaagatcccactggaaccctgaacctgaatttcatttgattt ctgcattttggccctctcttccatcatatttggatgctgcatatgaagttaacagcaggg acaccgtttttatttttaaaggaaatgagttctgggccatcagaggaaatgaggtacaag caggttatccaagaggcatccataccctgggttttcctccaaccataaggaaaattgatg cagctgtttctgacaaggaaaagaagaaaacatacttctttgcagcggacaaatactgga gatttgatgaaaatagccagtccatggagcaaggcttccctagactaatagctgatgact ttccaggagttgagcctaaggttgatgctgtattacaggcatttggatttttctacttct tcagtggatcatcacagtttgagtttgaccccaatgccaggatggtgacacacatattaa agagtaa >1024 at HG-U95Av2 aagctctgaagaactctctggaagcccctgggcccagtacctagctggctctgtgagggt gctgactggcttcagcaagttagaactagccaaaccaggaccctgtcca >1052_s at HG-U95Av2 agaacgagaagctgcaccagcgcgtggagcagctcacgcgggacctggccggcctccggc agttcttcaagcagctgcccagcccgcccttcctgccggccgccgggacagcagactgcc ggtaacgcgcggccggggcgggagagactcagcaacgacccatacctcagacccgacggc ccggagcggacgccctgctgccgacgccagagccgccgcgtgcccgctgcagtttcttgg acatagaccaaagaagctacagcctggacttaccaccactaaactgcgagagaagctaaa cgtgtttattttcccttaaattatttttgtaatggtagctttttctacatttactcctg ttgatgcagctaaggtacatttgtaaaaagaaaaaaaaccagacttttcagacaaaccct ttgtattgtagataagagg >1058 at HG-U95Av2 ctaagcttttctctcatagcgtagacctagggaagggatgggaagattgcccagtccccg atggctgcgcacacaggaggcggcggacgacaaggcaagtgagtttgcactgtcagcccc agaccgtaagcttggctacactgatgtttttctttactaaggatactattcaaaaattaa cattttcatctcagtaagtttttagaacatcaaaatgttttctgagctccaagtggctag gttgtaaaagttttataataatttgcaattaaaatacatgatacatattaatccattaaa gactagtgggaatgtatcagccagagtagcaagtaatttttgttttataaatcatagtat ctgtcatcttgcagtattaccaatgctgttgtaaattgaatttaaagtggtattaaaaaa aactgttaaacaatttttatctgtttgtatatcttactataga >1061 at HG-U95Av2 tcatgccaagacagtatcagacacagccccagaagggggcattatgggccctgcctcccc ataggccatttggactctgccttcaaacaaaggcagttcagtccacaggcatggaagctg tgaggggacaggcctgtgcgtgccatccagagtcatctcagccctgcctttctctggagc attctgaaaacagatattctggcccagggaatccagccatgacccccacccctctgccaa agtactcttaggtgccagtctggtaactgaactccctctggaggcaggcttgagg >1069 at HG-U95Av2 ggttgaatgtttgtccttaggataggcctatgtgctagcccacaaagaatattgtctcat tagcctgaatgtgccataagactgaccttttaaaatgttttgagggatctgtggatgctt cgttaatttgttcagccacaatttattgagaaaatattctgtgtcaagcactgtgggttt taatatttttaaatcaaacgctgattacagataatagtatttatataaataattgaaaaa aattttcttttgggaagagggagaaaatgaaataaatatcattaaagataactcaggaga atcttctttacaa >1086 at HG-U95Av2 agatgtgtccccaacatccccacagcccgagggcctccttgtcctgcagcaagtgggcga ctattgcttcctccccggcctggggcccggccctcttcgctccggagtaaaccttcttc cccgggacccggtcctgagatcaagaacctagaccaggcttttcaagtcaagaagccccc aggccaggctgtgccccaggtgcccgtcattcagctcttcaaagccctgaagcagcagga ctacctgtctctgcccccttgggaggtcaacaagcctggggaggtgtgttgagaccccca ggcctagacaggcaaggggatggagagggcttgccttccctcccgcctgaccttcctcag tcatttctgcaaagccaaggggcagcctcctgtcaaggtagctagaggcctgggaaagga gatagccttgctccggcccccttgaccttcagcaaatcacttctctccctgcgctcacac WO 2005/068655 PCT/GB2005/000057 56 agacacacacacacacacgtacatgcacacatttttcctgtcaggttaa >1102_s at HG-U95Av2 gtgaaggitgctgaggctctgacccagtgagattacagaggaagttatcctctgcctccc attctgaccacccttctcattccaacagtgagtetgtcagcgcaggtttagtttactcaa tctccccttgcactaaagtatgtaaagtatgtaaacaggagacaggaaggtggtgcttac atecttaaaggcaccatctaatagcgggttactttcacatacagccctcccccagcagtt gaatgacaacagaagcttcagaagtttggcaatagtttgcatagaggtaccagcaatatg taaatagtgcagaatctcataggttgccaataatacactaattcctttctatcctacaac aagagttta >1105 s at HG-U95Av2 ctagctccaaaaccatcccaggtcattcttcatcctcacccaggattctcctgtacctgc tcccaatctgtgttcctaaaagtgattctcactctgcttctcatctcctacttacatgaa tacttctctctt >1113_at HG-U95Av2 aagatgaacacagctggtcacagataaggccattgctagtaacttttggccatgatggaa aagggcatcctctccacaaaagagaaaaacgtcaagccaaacacaaacagcggaaacgcc ttaagtcagctgtaagagacacc'ctttgtacgtggacttcagtgacgtggggtggaatg actggattgtggctcccccggggtatcacgccttttactgccacggagaatgcccttttc ctctggetgatcatctgaactccactaatcatgccattgttcagacgttggtcaactctg ttaactctaagattcctaaggcatgctgtgtcccgacagaactcagtgctatctcgatgc tgtaccttgacgagaatgaaaaggttgtattaaagaactatcaggacatggttgtggagg gttgtgggtgtcgctagtacagcaaaattaa >1114_at HG-U95Av2 caggattagccgatcgttacctcaagggagtgggaattgggcccagctccggcccctcct ggtcacctttggccatgatggccggggccatgccttgacccgacgccggagggccaagcg tagccctaagcatcactcacagcgggccaggaagaagaataagaactgccggcgccactc gotctatgtggacttcagcgatgtgggctggaatgactggattgtggccccaccaggcta ccaggccttctactgccatggggactgcccctttccactggctgaccacctcaactcaac caaccatgccattgtgcagaccctggtcaattctgtcaattccagtatccccaaagcctg ttgtgtgcccactgaactgagtgccatctccatgctgtacctggatgagtatgataaggt ggtactgaaaaattatcaggagatggtagtagagggatgtgggtgccgctgagatcaggc agtccttgaggatagacagatatac >1126_s at HG-U95Av2 aaagotagtgatcaacagtggcaatggagctgtggaggacagaaagccaagtggactcaa cggagaggccagcaagtetcaggaaatggtgcatttggtgaacaaggagtcgtcagaaac tccagaccagtttatgacagctgatgagacaaggaacctgcagaatgt >1173_g at HG-U95Av2 TIGRSequence >1184_at HG-U95Av2 tcagctcttgcaagaggactccctcaatgtggetgacttgacttccctccgggccccact ggacatccccatcccagaccctccacccaaggatgatgagatggaaacagataagcagga gaagaaagaagtccctaagtgtggatttctccctgggaatgagaaagtcctgtccctgct tgccctggttaagccagaagtctggactctcaaagagaaatgcattctggtgattacatg gatccaacacctgatccccaagattgaagatggaaatgattttggggtagcaatccagga gaaggtgctggagagggtgaatgccgtcaagaccaaagtggaagctttccagacaaccat ttccaagtacttctcagaacgtggggatgctgtggccaaggcctccaaggagactcatgt aatggattaccgggccttggtgcatgagcgagatgaggcagcctatggggagctcagggc catggtgctggacctgagggccttctatgctgagctttatcatatcatcagcagcaacct ggagaaa >1207 at HG-U95Av2 ttctccgaggtctggactttcttcattcacaccgagtagtgcatcgcgatctaaaaccac agaacattctggtgaccagcagoggacaaataaaactcgctgactteggccttgcccgca tctatagtttccagatggctctaacctcagtggtcgtcacgctgtggtacagagcacccg WO 2005/068655 PCT/GB2005/000057 57 aagtcttgctccagtccagctacgccacccccgtggatctctggagtgttggctgcatat ttgcagaaatgtttcgtagaaagcctctttttcgtggaagttcagatgttgatcaactag gaaaaatcttggacgtgattggactcccaggagaagaagactggcctagagatgttgccc ttcccaggcaggcttttcattcaaaatctgcccaacc >120_at HG-U95Av2 tgacatcaaatggttaccctgtgctgtacccaactggattgtcatcttctgagaatgcaa actgcagaccccatatctttgaggatcctttcagtatcaactctggaaagaaaatgacta catcaactgaccatctcaaadgaggcacaattctggactgcaatacatgtaaatttgcta ccatcacatgtaatctcacttcttctgacatcagccaagtcaatgtttogettatcttgt ggaaaccaacttttataaaatcatatttttccagcttaaatcttactataaggggagaac ttcggagtgaaaatgcatctctggttttaagtagcagcaatcaaaaaagagagcttgcta ttcaaatatccaaagatgggctaccgggcagagtgccattatgggtcatcctgctgagtg cttttgccggattgttgctgttaatgctgctcattttagcactgtggaagattggattct t >1212 at HG-U95Av2 gccctggagcagatcctacagagcacagcgggcatatactgtgtaggagacgaggtgacc atggetgatctgtgcttggtgcctcaggtggcaaatgctgaaagattcaaggtggatetc accccctaccctaccatcagctccatcaacaagaggctgctggtcttggaggccttccag gtgtctcacccctgccggcagccagatacacccactgagctgagggcctagctcccaaat cctgccccgttggcacagggccacaggagcagaagctgggtgggctgaagaggcctggaa acgagagtcttaattgaggagatgggagactogaactctagccctggatctgccttcctg ctgaaacttgttccacctcagtcccctcatctgtcacacgcatgtggggtggagtaggga gatgcggggagcagggtgggcaggaatactgttatctatgtgacggggcagtcgtgaggc tgagatgagaatgcggattaaaatgcctggcgtgctcaccgtaacaccacggggaaggct gtgtgccttttctcatccgcttttgttgtgtgtgactccaaagaatgcccgcgct >1223 at HG-U95Av2 gcgtgaccgccttctctgagttccgcacctacagcttcccctgctacctcccgcagccgc tcatcaaccacgcgcccaggttggatacggatggcatccacctcctgagcagcctgetcg tgtatgaatccaagagtcgcatgtcagcagaggetgccctgagtcactcctacttccggt ctctgggagagcgtgtgcaccagcttgaagacactgcctccatcttctccctgaaggaga tccagctccagaaggacccaggctaccgaggettggccttccagcagccaggacgaggga >1226 at HG-U95Av2 ttatattgataacagcactgactagggaaatgatcagttttttttttatacactgtaatg aaccgctgaatatgaggcatttggc >1227 g at HG-U95Av2 aactggaccaccagagaatggacaccatccaggaagaccccagcacagactcacatatgg acgaggatgggtttgagaaggaccccttcccaaatagcagcacagctgccaagtcatttg aggatctcacggaccatccggtcaccagaagtgaaaaggctgcctcctttaaactgcagc gtcagaatcgtgttgacagcaaagaaacagagtgctaatttagttctcagctcttctgac ttaagtgtgcaaaatatttttatagatttgacctacaatcaatcacagcttatattttgt gaagactgggaagtgacttagcagatgctggtcatgt >1237 at HG-U95Av2 agaccgaggcgcatagagaccgagcacagcccagctgggctaggccoggtgggaaggaga gcgtcgttaatttatttcttattgctcctaattaatatttatatgtatttatgtacgtcc tcctaggtgatgagatgtgtacgtaatatttattttaacttatgcaagggtgtgagatgt tccccctgctgtaaatgcaggtctcttggtatttattgagctttgtgggactggtggaag caggacacctggaactgcggcaaagtaggagaagaaatggggaggactcgggtgggggag gacgtcccggctgggatgaagtctggtggtgggtcgtaagtttaggaggtgactgcatcc tccagcattctcaactccgtctgtctactgtgtgagacttcggcggaccattaggaatga gatccgtgagatccttccatcttcttgaagtcgcctttagggtggctgcgaggtagaggg ttgggggttggtgggctgtcacggagogactgtcgagatcgcctagtatgttctgtgaac acaaata >1278 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 58 TIGRSequence >128 at HG-U95Av2 ccta~ccatatgtgggacaggaagagagttgtatgtacaacccaacaggcaaggcagcta aatgcagagggtacagagagatccccgaggggaatgagaaagccctgaagagggcagtgg cccgagtgggacctgtctctgtggccattgatgcaagcctgacctccttccagttttaca gcaaaggtgtgtattatgatgaaagctgcaatagcgataatctgaaccatgcggttttgg cagtgggatatggaatccagaagggaaacaagcactggataattaaaaacagctggggag aaaactggggaaacaaaggatatatcctcatggctcgaaataagaacaacgcctgtggca ttgccaacctggc >129g at HG-U95Av2 agactctgtcgactatcgaaagaaaggatatgttactcctgtcaaaaatcagggtcagtg tggttcctgttgggcttttagctctgtgggtgccctggagggccaactcaagaagaaaac tggcaaactcttaaatctgagtccccagaacctagtggattgtgtgtctgagaatgatgg ctgtggagggggctacatgaccaatgccttccaatatgtgcagaagaa >1334 s at HG-U95Av2 atttattactatgactgctccccagccctggctctgcaatgggcactgggatgagccgct gtgagcccctggtcctgagggtccccacctgggacccttgagagtatcaggtctcccacg tgggaqacaagaaatccctgtttaatatttaaacagcagtgttccccatctgggtccttg cacccctcactctggcctcagccgactgcacagcggcccctgcatccccttggctgtgag gcccctggacaagcagaggtggccagagctgggaggcatggccctggggtcccacgaatt tgctggggaatctcgtttttcttcttaagacttttgggacatggtttgactcccgaacat caccgacgtgtctcctgtttttctgggtggcctcgggacacctgccctgcccccacgagg gtcaggactgtgactctttttagggccaggcaggtgcctggacatttgccttgctggatg gggactggggatgtgggagggagcagacaggaggaatcatgtcaggcctgtgtgtgaaag gaagctccactgtcaccctc >1369 s at HG-U95Av2 ttttcctagatattgcacgggagaatatacaaatagcaaaattgggccaagggccaagag aatatccgaactttaatttcaggaattgaatgggtttgctagaatgtgatatttgaagca tcacataaaaatgatgggacaataaattttgccataaagtcaaatttagctggaaatcct ggatttttttctgttaaatctggcaaccctagtctgctagccaggatccacaagtccttg ttccactgtgccttggtttctcctttatttctaagtggaaaaagtattagccaccatctt acctcacagtgatgttgtgaggacatgtggaagcactttaagttttttcatcataacata a >1370 at HG-U95Av2 cccatctgaggatgtagtcgtcactccagaaagctttggaagagattcatccctcacatg cctggctgggaatgtcagtgcatgtgacgcccctattctctcctcttccaggtccctaga ctgcagggagagtggcaagaatgggcctcatgtgtaccaggacctcctgcttagccttgg gactacaaacagcacgctgccccctccattttctctccaatctggaatcctgacattgaa cccagttgctcagggtcagcccattcttacttccctgggatcaaatcaagaagaagcata tgtcaccatgtccagcttctaccaaaaccagtgaagtgtaagaaacccagactgaactta ccgtgagcgacaaagatgatttaaaagggaagtctagagttcctagtctccctcacagca cagagaagacaaaattagcaaaaccccactacacagtctgcaagattctgaaacattgct ttgaccactcttcctgagttcagtggcactcaacatgagtcaagagcatcctgcttctac catgtggatttgg >1372 at HG-U95Av2 atcttttggaactcctttgatctcactgttattattaacatttatttattatttttctaa atgtgaaagaaatacataatttagggaaaattggaaaatataggaaactttaaacgagaa aatgaaacctctcataatcccactgcatagaaataacaagcgttaacattttcatatttt tttctttcagtcatttttgtatttgtggtatatgtatatatgtacctatatgtatttgca tttgaaattttggaatcctgctctatgtacagttttgtattatactttttaaatcttgaa ctttatgaacattttctgaaatcattgattatttacaaaaacatgattttaaacagctg taaaatattctatgatatgaatgttttatgcattatttaagcctgtctctattgttggaa tttcaggtcattt >1377_at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 59 gtccacaagacagaagctgaagtgcatccaaaggtgctcagagagccggcccgcctgaat cattctcgatttaactcgagaccttttcaacttggcttcctttcttggttcataaatgaa ttttagtttggttcacttacagatagtatctagcaatcacaacactggtgagcggatgc atctggggatgaggttgcttactaagctttgccagCtgctgctggatcacagctgctttc tgttgtc >1378_g_at HG-U95Av2 agcccagtgaagaccacctctcaggcccactcgctgcctctctcgcctgcctccacaagg cagcaaatagacgagctccgagacagtgacagtgtctggacacgggcgtggagacatcc ttccgcaaactcagctttaccgagtctctgaccagtggtgcctcactgctaactctcaac aaaatgccccatgattatgggcaggaaggacctctagaaggcaaaatttagcctgctgac aatt >1385 at HG-U95Av2 tgaagcactacaggaggaatgcaccacggcagtctccgccaatttctctcagatttcca cagagactgtttgaatgttttcaaaaccaagtatcacactttaatgtacatgggccgcac cataatgagatgtgagecttgtgcatgtgggggaggagggagagagatgtactttttaaa tcatgttccccctaaacatggctgttaacccactgcatgcagaaacttggatgtcactgc ctgacattcacttccagagaggacctatcccaaatgtggaattgactgcctatgccaagt ccctggaaaaggagcttcagtattgtggggctcataaaacatgaatcaagcaatccagcc tcatgggaagtcctggcacagtttttgtaaagcccttgcacagctggagaaatggcatca ttataagctatgagttgaaatgttctgtcaaatgtgtctcacatctacacgtggcttgga ggcttttatggggccctgtccaggtagaaaagaaatggtatgtagagcttagatttccct attgtgacagagccatggtgtgtttgtaata >1400 at HG-U95Av2 tctccTgaacctgagtagagacactgctgctgagatgaatgaaacagtagaagtcatctc agaaatgtttgacctccaggagccgacctgcctacagacccgcctggagctgtacaagca gggcctgcggggcagcctcaccaagctcaagggccccttgaccatgatggccagccacta caagcagcactgccctccaaccccggaaacttcctgtgcaacccagattatcacctttga aagtttcaaagagaacctgaaggactttctgcttgtc >1401_g_at HG-U95Av2 cctgaaggactttctgcttgtcatccccttgactgctgggagccagtccaggagtgaga ccggccagatgaggctggccaagccggggagctgctctctcatgaaacaagagctagaaa ctcaggatggtcatcttggagggaccaaggggtgggccacagccatggtgggagtggcct ggacctgccctgggccacactgaccctgatacaggcatggcagaagaatgggaatatttt atactgacagaaatcagtaatatttatatatttatatttttaaaatatttatttatttat ttatttaagttcatattccatatttattcaagatgttttaccgtaata >1402_at HG-U95Av2 ttgcacttatgatttcatgtgcggggatcatctgccgtgcctggatcctgaaatagaggc taaattactcaggaagaacaccctctaaatgggaaagtattctgtactcttagatggatt ctccactcagttgcaacttggacttgtcctcagcagctggtaatcttgctctgcttgaca acatctgagtgcagccgtttgagaagaaaacatctattctctccaaaaatgcacccaact agctctatgtttacaaatggacataggactcaaagtttcagagaccattgcaatgaatcc ccaataattgcagaactaaactcatttataa >1403s at HG-U95Av2 gagcttctgaggcgctgctttgtcaaaaggaagtctctaggttctgagctctggctttgc cttg >1405 i at HG-U95Av2 agcttccccaactaaagcctagaagagcttctgaggcgctgctttg >1433 gat HG-U95Av2 cctctcagaacatactgattgggaggtgcgtgttcagcagaacctgcacacaggacagcg ggaaaaatcgatgagcgccacctctttaaaaactcacttacgttgtcctttttcactttg ~aaaagttggaaggactgctgaggcccagtgcatatgcaatgtatagtgtctattatcaca ttaatctcaaagagattcgaatgacggtaagtgttctcatgaagcaggaggcccttgtcg tgggatggcatttggtctcaggcagcaccacactgggtgcgtctccagtcatctgtaaga WO 2005/068655 PCT/GB2005/000057 60 gcttgctccagattctgatgcatacggctatattggtttatgtagtcagttgcattcatt a >1451_s at HG-U95Av2 gttgacttcaggaactgaaacatcagcacaaagaagcaatcatcaaataattctgaacac aaatttaatatttttttttctgaatgagaaacatgagggaaattgtggagttagcctcct gtggtaaaggaattgaagaaaatataacaccttacaccctttttcatcttgacattaaaa gttctggctaactttggaatccattagagaaaaatccttgtcaccagattcattacaatt caaatcgaagagttgtgaactgttatcccattgaaaagaccgagccttgtatgtatgtta tggatacataaaatgcacgcaagccattatctctccatgggaagctaagttataaaaata ggtgcttggtgtacaaaactttttatatcaaaaggctttgcacatttctatatgagtggg tttactggtaaattatgttattttttacaactaattttgtactctcagaatgtttgtcat atgcttcttgcaatgcata >1457_at HG-U95Av2 caaacagcagctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcg gcaatacgttcaccgggacttggcagcaagaaatgtccttgttgagagtgaacaccaagt gaaaattggagacttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgt caaggatgaccgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaa attttatattgcctctgacgtctggtcttttggagtcactctgcatgagctgctgactta ctgtgattcagattctagtcccatggctttgttcctgaaaatgataggcccaacccatgg ccagatgacagtcacaagacttgtgaatacgttaaaagaaggaaaacgcctgccgtgccc acctaactgtccagatgaggtttatcagcttatgagaaaatgctgggaattccaaccatc caatcggacaagtttcagaaccttattgaaggatttgaagca >1461_at HG-095Av2 tcagatgctgccagagagtgaggatgaggagagctatgacacagagtcagagttcacgga gttcacagaggacgagctgccctatgatgactgtgtgtttggaggccagcgtctgacgtt atgagtgcaaaggggctgaaagaacatggacttgtatatttgtacaaaaaaaaagtttta tttttctaaaaaaagaaaaaagaagaaaaaatttaaagggtgtacttatatccacactgc acactgcctagcccaaaacgtcttattgtggtaggatcagccctcattttgttgcttttg tgaactttttgtaggggacgagaaagatcattgaaattctgagaaaacttcttttaaacc tcacctttgtggggtttttggagaaggttatcaaaaatttcatggaaggaccacatttta tatttattgtgcttcgagtgactgaccccagtggtatcctgtgacatgtaacagccagga gtgttaagcgttcagtgatgtggggtgaaaagttactacctgtcaaggtttgtgttaccc tcctgtaaatggtgtacataatgtattgttggtaatt >1520 s at HG-U95Av2 acttcaccatgcaatttgtgtcttcctaaagagagctgtacccagagagtcctgtgctga atgtggactcaatccctagggctggcagaaagggaacagaaaggtttttgagtacggcta tagcctggactttcctgttgtctacaccaatgcccaactgcctgcttagggtagtgcta agaggatctcctgtccatcagccaggacagtcagctctctcctttcagggccaatcccca gcccttttgttgagccaggcctctctcacctctcctactcacttaaagcccgcctgacag aaaccacggccacatttggttctaagaaaccctctgtcattcgctcccacattctgatga gcaaccgcttccctatttatttatttatttgtttgtttgttttgattcattggtctaatt tattcaaagggggcaagaagtagcagtgtctgtaaaagagcetagtttttaatagctatg gaatcaattcaatttggactggtgtgctctctttaaatcaagtcctttaattaagactga aaatatataagctcagattatttaaatgggaatatttataaatgagcaaatatcatactg ttcaatggttc >1561_at HG-U95Av2 gtgctgtttgcgcccttcggccgggcgggcgccccgggaccaggcggcggcagcgacctg cggcggcgggaggcagcgagggctgagccccgggacgcgcggaccggctggcccgaggag ccggccccggagacgcagttcaagcgccgcagctgccagatggagttcgaggagggcatg gtggaggggcqcgcgcgcggcgaggagctggccgcctgggcaagcaggcgagcttctcg ggcagcgtggaggtcatcgaggtgtcctgacccctccgctgccctcggccccgccgcccg cagccaggcccgttataaatgtatatta >1562 g at HG-U95Av2 tatttaagctgttcattctggcaatgatttggcaacagtgcgggtggtcctcgagctcta tttttactgtctggtatttaaactgaaacatacgtttctaagcaatacgaggccaccttc WO 2005/068655 PCTGB2005OOOO57 61 agccacgggcgctggccccgtccgccgaaat ctgacctttgcaaaggctgCCgagctttcgtg >1573_at HG-u95Av2 ggqaggagactgtggtaggggcagggaggcaacactgctgtccacatgacctccatttcc caaagt cct ctgct ccagcaactgcccttccaggtgggtgtgggacacctgggagaaggt gaatgqgggagaqaagggaaaagatccccaagaccccctggggtgggatctgagctccca t >1577_at HG-U95Av2 catggaattctatttgctgqgcttttttttiuctctttctctcctttctttttcttcttcc ctctttactcagccttaattctcattgtcatct gtgftttgaatggtgttgtatgcctttaaatctgtgatgatcctcatatggcccagtgtc aagttgtgcttqtttacagcactactctgtgccagccacacaaacgtttacttatcttat gccacgg >158_at HG-U95Av2 gccaatattcaggaggagaaacatgatcgaa attgtttttatcattaaagacaaagatcatccaaaatttaaaagggatggatcaaatata atttactgctaaaattagtttacgagaggagattgtgtggcgqctcaattaatgtacca acactggatggaagaacatacctatgtcagtaaatgatattgtgaacccggaatgaggag aagaattattgqatatgggCtgccatttccaaaaaatcctgaccaacgtggtgaccttct aataqaatttqaggtgtccttcccagatactatatcttcttcatggaaagaagtactaga catctccgcctcatagaatgagacttgtaga >1591_s at I-G-U95Av2 a >159_at H-G-U95Av2 gtcgttcgtacattttttgaatttgccgaac gtctgtgaacagagagacccttgtgggtccatgctaacaaagacaaaagtctgtctttcc aacaacaattggtaaaactcactgtgatcaa >1633 g at HG-U95Av2 tgttcaggttattgggagactatctatggag atgaagaaccgaaccagcaagtgagagtttg gggatgggctaggggaaataaggcttgctqtttgttttcctggggcgctccctccaattt tgaattgactcctacggattcatcaattata cacqtattgtggggaggggagttccaagtgtgCCctcctttttttt cctgcctggattat ttaaaaagccatgtgtggaaacccactatttaa >1637_at HG-U95Av2 tgcaacactctccgaccttcccaaccgcgaa cccccgtagcggcacttgttctttaatgtgt gggagagctaagtggCttcccattaacctgaggtctctttctttactctgggtcagac ctagtggaggcggctctaatttgctgtggcg gtagggcagagagggcctttcatggctgatcagagctt accagccccaccccaccatggt agctgggtatctaatccgcatctaagactgt ctctgccccccgcggaactgcagcgtgaacc WO 2005/068655 PCT/GB2005/000057 62 gctgggttttacatccagatagtaa >1652_at HG-U95Av2 caccacacaaacttagttcatatgcttttacttgggcaagggtgctttccttccaatacc ccagtagcttttattttagtaaagggaccctttcccctagcctagggtcccatattgggt caagctgcttacctgcctcagcccaggattttttattttgggggaggtaatgccctgttg ttaccccaaggcttct >1664 at HG-U95Av2 TIGRSequence >1669_at HG-U95Av2 tcagcccactacatagatagctttttttttttttttttttttttaataaggacacctctt tccaaacaggccatcaaatatgttcttatctcagacttacgttgttttaaaagtttggaa agatacacatcttttcatacccccccttaggaggttgggctttcatatcacctcagccaa ctgtggctcttaatttattgcataatgatatccacatcagccaactgtggctctttaatt tattgcataatgatattcacatcccctcagttgcagtgaattgtgagcaaaagatcttga aagcaaaaagcactaattagtttaaaatgtcacttttttggtttttattatacaaaaacc atgaagtactttttttatttgtaaatcagattgttcctttttagtgactcatgtttatg aagagagttgagtttaacaatcctagcttttaaaagaaactatttaatgtaaaatattct acatgtcattcagatattatgtatatcttctagcctttattctgtacttttaatgtacat atttctgtcttgcgtgatt >1674_at HG-U95Av2 gaagatggacttcatgcaagttggcagtggtttggtactaaaaattgtggttgtttttt ctgtttacgtaacctgcttagtattgacactctctaccaagagggtcttcctaagaagag tgctgtcattatttcctctt atcaacaacttgtgacatgagattttttaagggctttatg tgaactatgatattgtaatttttctaagcatattcaaaagggtgacaaaattacgtttat gtactaaatctaatcaggaaagtaaggcaggaaaagttgatggtattcattaggttttaa ctgaatggagcagttccttatataataacaattgtatagtagggataaaacactaacaat gtgtattcattttaaattgttctgtatttttaaattgccaagaaaaacaactttgtaaat ttggagatattttccaacagcttttcgtcttcagtgtcttaatgtggaagttaac >1717 s at HG-U95Av2 atatatgtatctaaaccatatgaacatatattttttagaaactaagagaatgataggctt ttgttcttatgaacgaaaaagaggtagcactacaaacacaatattcaatccaaatttcag cattattgaaattgtaagtgaagtaaaacttaagatatttgagttaactttaagaattt taaatattttggcattgtactaataccgggaacatgaagccaggtgtggtggtatgtacc tgtagtcccaggctgaggcaagagaattacttgagcccaggagtttgaatccatcctggg cagcatactgagaccctgcctttaaaaacnaacagnaccaaanccaaacaccagggacac atttctctgtcttttttgatcagtgtcctatacatcgaaggtgtgcatatatgttg >1737s at HG-U95Av2 aagagacatgtaccttgaccatcgtccttcctctcaagctagccagagggtgggagccta aggaagcgtggggtagcagatggagtaatggtcacgaggtccagacccactcccaaagct cagacttgccaggctccctttctcttcttccccaggtccttcctttaggtctggttgttg caccatctgcttggttggctggcagctgagagccctgctgtgggagagcgaagggggtca aaggaagacttgaagcacagagggctagggaggtggggtacatttctctgagcagtcagg gtgggaagaaagaatgcaagagtggactgaatgtgcctaatggagaagacccacgtgcta ggggatgaggggcttcctgggtcctgttccctaccccatttgtggtcacagccatgaagt caccgggatgaacctatccttccagtggctcgtccctgtagtctgcctccctctccat atctccttcccctacacctccctccccacacctccctactcccctgggcatcttctggct tgactggatggaagga >1761_at HG-U95Av2 gaggttgatccacagaggactgggacacaccacgagaatctcccagagtgtcattacagt ggaagactt cgagacgattgatgcaggatattacatttgcactgctcagaatctt caagg acagaccacagtagctaccactgttgagttttcctgacttggaaaaggaaatgtaatgaa cttatggaaagcccatttgtgtacacagtcagctttggggttccttttattagtgctttg ccagaggctgatgtcaagcaccacaccccaaccccagcgtctcgtgagtccgacccagac atccaaactaaaaggaagtcatccagtctattcacagaagtgttaacttttctaacagaa WO 2005/068655 PCT/GB2005/000057 63 agcatgattttgattgcttacctac >1778 g at HG-U95Av2 cagtgggcagtcagaggcaagaagcagaggggaggagcaagggtgccagggagatgggga tgctggggtcaaagccagccccagggacattcgggaacagtctgagacaactgctgaagg gggccagggtcaagcccaggaaggccctgctcagccaggggaaccagaggcagagggaag ccgggcagcagaggagtagcttgaagtggccagaagggtcattcggggcgggagaccctg agcctgctgagaaatccttttagcgccagcaagccccacccagggccctgtcctgtgtct gccaccacctttgtctgatacttgtttccagggaagctgggggaactgccacatctgagg aactggaataa >1788_s at HG-U95Av2 agtgatgaaacccacagatcctagcaaatgtgcccaaccagctttactaaaqggggagga agggagggcaaagggatgagaagacaagtttcccagaagtgcctggttctgtgtacttgt ccctttgttgtcgtcgttgtagttaaaggaatttcattttttaaaagaaatcttcgaagg tgtggttttcatttctcagtcaccaacagatgaataattatgcttaataataaagtattt attaagactttcttcagagtatgaaagtacaaaaagtctagttacagtggatttagaata tatttatgttgatgtcaaacagctgagcaccgtagcatgcagatgtcaaggcagttagga agtaaatcggtgtcttgtagatatgtgcaaggtagcatgatgagcaacttgagtttgttg ccactgagaagcaggcg >1798_at HG-U95Av2, tagtttatgtatcaccagactgggttattgccaagttatatatcaccaaaagctgtatga ctggatgttctggttacctggtttacaaaattatcagagtagtaaaactttgatatatat gaggatattaaaactacactaagtatcatttgattcgattcagaaagtactttgatatct ctcagtgcttcagtgctatcattgtgagcaattgtctttatatacggtactgtagccata ctaggcctgtctgtggcattctctagatgtttcttttttacacaataaattccttatatc agcttga >1845_at HG-U95Av2 agacattgctctatgtctgccttcgaccacagcaagccatcatcctccattgctcccggg gactcaagaggaatctgtttctctgctgtcaacttcccatctggctcagcatagggtcac tttgccattatgcaaatggagataaaagcaattctggctgtccaggagctaatctgaccg ttctattgtgtggatgaccacataagaaggcaattttagtgtattaatcatagattatta taaactataaacttaagggcaaggagtttattacaatgtatctttattaaaacaaaaggg tgtatagtgttcacaaactgtgaaaatagtg >186'7 at HG-U95Av2 taacaccctatgcccattgtcctgatctgaaaattcttggaaattgttccatgtgattaa catggaactgcctctacttaatcattctgaatgattaaatcgtttcattttctaaatgtg ttataatgtgtttagccctttcttgttgctgtatgtttagatgctttccaatcttttgtt actactaataatg >1868 -g at HG-U95Av2 atttgacctgctcaaacgtatcttgaagatggacagaaaagctgtggagacccacctgct caggaaccctcaccttgtttcggactatagagtgctgatggcagagattggtgaggattt ggataaatctgatgtgtcctcattaattttcctcatgaaggattacatgggccgaggcaa gataagcaaggagaagatttcttgggaccttgtggttgagttggagaaactaaatctggt tgccccagatcaactggatttattagaaaaatgcctaaagaacatccacagaatagacct gaagacaaaaatccagaagtacaagcagtctgttcaaggagcagggacaagttacaggaa tgttctccaagcagcaatccaaaagagtctcaaggatccttcaaataa >1876 at HG-U95Av2 TIGRSequence >1877 -g at HG-U95Av2 TIGRSequence >1897 at HG-U95Av2 ggaaccacagatttgtgcccattcctaatattttgttctgcaaattaatgtataatttga ggtgaaattcagttataaagtcaaggacgaatttgcacagtgatatatttctatgtgtat WO 2005/068655 PCT/GB2005/000057 64 gcaagtacaagtatataatatgtcacctggcacattcattttctcagttgaagaagagaa aatttgaaaatgtccttatgcttttagagttgcaacttaagtatatttggtagggtgagt gtttccactcaaaatatgtcaacttaaaaaaaaataggccctttcataaaaaccaaactg tagcaagatgcaaatgcatggcaaatctgtcggtctccagttggttatctgaatagtgtc accaattccaccaagacagtgctgagattggaaagggcactcatttggattgccttactt ctcttgccttaaatatatcccatatatttaatatgtcaaaaagggcttgaggtgaatttc attaaatggaataatatgatgccactttgcagctaaaataagc >1951 at HG-U95Av2 tcaaggccacaaccatgatgatccgaccagcagatttctaaacatcccagtccacctgag gaactgtctcgaactattttcaaagacttaagcccagtgcactgaaagtcacggctgcgc actgtgtcctcttccaccacagagqgcgtgtgctcggtgctgacgggacccacatgctcc agattagagcctgtaaactttatcacttaaacttgcatcacttaacggaccaaagcaaga ccctaaacatccataattgtgattagacagaacacctatgcaaagatgaacccgaggctg agaatcagactgacagtttacagacgctgctgtcacaaccaagaatgttatgtgcaagtt tatcagtaaataactggaaaacagaacacttatgttatacaatacagatcatcttggaac tgcattcttctgagcactgtttatacactgt >1968_g_at HG-U95Av2 ctatggattaagccggtcccaacctgtcatgaaagttgcagtgaagatgctaaaacccac ggccagatccagtgaaaaacaagctctcatgtctgaactgaagataatgactcacctggg gccacatttgaacattgtaaacttgctgggagcctgcaccaagtcaggccccatttacat catcacagagtattgcttctatggagatttggtcaactatttgcataagaatagggatag cttcctgagccaccacccagagaagccaaagaaagagtggatatctttggattgaaccc tgctgatgaaagcacacggagctatgttattttatcttttgaaaacaatggtgactacat ggacatgaagcaggctgatactacacagtatgtccccatgctagaaaggaaagaggtttc taaatattccgacatccagagatcactctatgatcgtccag >1987_at HG-U95Av2 agaggaacctgagtcatgctcaggcccaagccctgttggcaggcagaccactgctttctg gccttccgtgactatctgaaaaaaatogtgaatggctagagctactcttcacttgctgaa cattttcaaaaagaattgacacttgctgaacatttcttttcaattcagaacttctgatgg attaaattgccttcttcctcgaaaaccctgggacccttccagatgggactaactggggaa agtggacaagttacaaacaaagaaactcaaaggaaagtcattggcactgatctctaagat gctatcacatgtgattggtggttga >2002s at HG-U95Av2 ctacagataccacaacctggatcaggtccaagcaaaacgtccagagtgctacaaaatgtt gcgttctcagtccaaaaagaagtggaaaagaatctgaagtcatgcttggacaatgttaat gttgtgtccgtagacactgccagaacactattcaaccaagtgatggaaaaggagtttgaa gacggcatcattaactggggaagaattgtaaccatatttgcatttgaaggtattctcatc aagaaacttctacgacagcaaattgccccggatgtggatacctataaggagatttcatat tttgttgcggagttcataatgaa >2014 s at HG-U95Av2 ccatccttcgatttccctatgattcatggggaactccatttcagcagctcaaacaggtgg tagaggagccatcgccacaactcccagcagacaagttctctgcagagtttgttgacttta cctcacagtgcttaaagaagaattccaaagaacggcctacatacccagagctaatgcaac atccatttttcaccctacatgaatccaaaggaacagatgtggcatcttttgtaaaactga ttcttggagactaaaaagcagtggacttaatcggttgaccctactgtggattggtgggtt tcggggtgaagcaagttcactacagcatcaatagaaagtcatctttgagataatttaacc ctgcctctcagagggttttctctcccaattttctttttactccccctcttaagggggcct tggaatctatagtata >2018_at HG-U95Av2 tcagcttgagtgctgtttacacttgcaaaagagatccctgcccacatcaggtggactgtt tcctctctcgccccacggagaaaaccatcttcatcatcttcatgctggtggtgtccttgg tgtccctggccttgaatatcattgaactcttctatgttttcttcaagggcgttaaggatc gggttaagggaaagagcgacccttaccatgcgaccagtggtgcgctgagccctgccaaag actgtgggtctcaaaaatatgcttatttcaatggctgctcctcaccaaccgctcccctct cgcctatgtctcctcctgggtacaagctggttactggcgacagaaacaattcttcttgcc WO 2005/068655 PCT/GB2005/000057 65 gcaattacaacaagcaagcaagtgagcaaaactgggctaattacagtgcagaacaaaatc gaatggggcaggcgggaagcaccatctctaactcccatgcacagccttttgatttccccg atgataaccagaattctaaaaaactagctgctggacatgaattacagccactagccattg tggaccagcgaccttcaagcagagccagcagtcgtgccagcagcagacctcggcc >2024 s at HG-U95Av2 agtttgctggatttcctgaagagcgatgaaggtggcaaagtgctgcttccaaagctcatt gacttttctgctcagattgcagagggaatggcatacategagcggaagaactacattcac cgggacctgcgagcagctaatgttctggtetccgagtcactaatgtgcaaaattgcagat tttggccttgctagagtaattgaagataatgagtacacageqaagggaaggtgctaagttc cctattaagtggacggctccagaagcaatcaactttggatgtttcactattaagtctgat gtgtggtcctttggaatcctcctatacgaaattgtcacctatgggaaaattccctaccca gggagaactaatgccgacgtgatgaccgccctgtcccagggctacaggatgcccogtgtg gagaactgcccagatgagotctatgacattatgaaaatgtgctggaaagaaaaggcagaa gagagaccaacgtttgactacttacagagogtcctggatgatttctacacagccacggaa gggcaatacc >2036 s at HG-U95Av2 gagctgggacacttaacagatgcaatgtgctactgattgtttcattgcgaatctttttta gcat aaaattt tct act ct ttt tgtttttt gt gtt tt gtt ctttaaagt caggtcca at t tgtaaaaacagcattgctttgtaaattagggcccaattaataatcagcaagaatttgatc gttcagtt ccact tggaggcctt cat cctcgggt gt gct at ggat ggctt ct >2049 s at HG-U95Av2 aagccctggacgatctgcacaagatgaaccacgtgacaccccccaacgtgtocctgggcg ctaccggggggcccccggctgggcccgggggcgtctacgccggcccggagccacct cccg tttacaccaacctcagcagctactccccagcctctgcgtcctcgggaggcgccggggctg ccgtcgggaccgggagctogtacccgacgaccaccatcagctacctcccacacgcgccgc ccttogccggtggccacccggcgcagctgggcttgggccgcggcgcctccaccttcaagg aggaaccgcagaccgtgccggaggcgcgcagccgggacgccacgccgccggtgtccccca tcaacatggaagaccaagagcgcatcaaagtggagcgcaagcggctgcggaaccggetgg cggccaccaagtgccggaagcggaagctggagcgcatogcgcgcctggaggacaaggtga agacgctcaaggccgagaacgcggggctgtcgagtaccgccggcctcctccgggagcagg tggcccagctcaaacagaaggtcatgacccacgtcagcaacggctgtcagctgctgcttg gg >204 at HG-U95Av2 agatcttaaccagtttctatcccttacctgcttttctcttctcttctcctgctccgttcc tcatccacccctccccatctggaccataatagggacaccaaaacaaacccaaattggtaa aa agaat aatcaa aaagaagacat tat ccggtt aagagt ctgt gctggt tgccacnnaag agagaacagttgtccaggatgctggctggtggaacaacctgctggcccgaaacaaggctg ccaggtgtggaacagcccatgc >205 g at HG-U95Av2 acagcccatgetgactggggacatacacttgcatctttgttgaaagcagaagaagacaga ccctttccccaccttccttacctcctcttcccccattaaggcagotcatccaagcttgta tttaactgaataaatgagtagacattgtggacctcacaagattatttaattcttaagatg tgtagaccttgatggtaggtgtgacatgttagtttttcttacttgcatttatttaagaca cactgttacagagatactgttgtcaccttctggggcacggtctttggggagaggggagtg catttagacttatgtggaacctgtacaaattgtgatgtggctacatagaaa >2073 s at HG-U95Av2 ccacagctgtgctggaccgtgagtccccatttgtcgacaacagcgtgtacactgctctct tcctggcaattgacagtggcaaccctcccgctacgggcactgggactttgctgataaccc tggaggacgtgaatgacaatgccccgttcatttaccccacagtagctgaagtctgtgatg atgccaaaaacctcagtgtagtcattttgggagcatcagataaggatcttcacccgaata cagatcctttcaaatttgaaatccacaaacaagctgttcctgataaagtctggaagatct ccaagatcaacaatacacacgccctggtaagccttcttcaaaatctgaacaaagcaaact acaacctgcccatcatggtgacagattcagggaaaccacccatgacgaatatcacagatc tcagggtacaagtgtgctcctgcaggaattccaaagtggactgcaacgcggcgggggccc tgcgctt cagcct gccct cagt cct gct cct cagcct cttcagctt agct tgt ctgt gag WO 2005/068655 PCT/GB2005/000057 66 aactcctgacgtctgaagct >215 g at HG-U95Av2 ggcgccgtgggactctacacggcccatgtgggctacagcatgtaccacctgacatagag ggtcccaggtccccacctgtgggccagccgattcctccagccctggtgctgtacccccga cgtgctcccctgctcggcaccgccagccgccttccctttaaccctcacactgctccagtt tcacctctttgctccctgagttcactctccgaagtctgatccctgccaaaaagtggctgg aagagtcccttagtactcttctagcatt >231 at HG-U95Av2 acctcaccattgtgaagcacctactatgtgctgggtgcctcccacacttgctggggetca cggggcctccaacccatttaatcaccatgggaaactgttgtgggcgctgcttccaggata aggagactgaggcttagagagaggaggcagccccctccacaccagtggcctcgtggttat aagcaaggctgggtaatgtgaaggcccaagagcagagtctgggcctctgactctgagtcc actgctccatttataaccccagcctgacctgagactgtcgcagaggctgtctggggcctt tatcaaaaaaagactcagccaagacaaggaggtagagaggggactgggggactgggagtc agagccctggctgggttcaggtcccacgtctggccagcgactgccttctcctctctgggc ctttgtttccttgttggtcagaggagtgattgaacctgctcatctccaaggatcctctcc a >257 at HG-U95Av2 tagcaacagtcatttctgaaaatatgttggatagaaagtcactctttggcaaaagtgtta gaatttgcttttgtgccatctattccttttatggcatctatcttgaaagtaatcttgtat tggagattgaaagatgctgtaatttagaaattaacatgatatcttaaattacctttatga aatatagttttgtataatagcatagattttccttcaaaaaatgaacatttatatatctac aaaaatatggagaagagcaatttgaaagcctactttctgaagaaaatggtgggatttttt tttatcatgattaaatatcaaaaaattgccctatgaaaactttaaatctctaaaacattt gaaatactaccatatttgtgatttattgagaataaaaatccattttgaaatgtaaaattt ttatgatctgattcagttttaagaa >265s at HG-U95Av2 atgtctaatagttattccctatttgttttcttctgtatgttagggtgctctggaagagag gaatgcctgtgtgagcaagcatttatgtttatttataagcagatttaacaattccaaagg aatctccagttttcagttgatcactggcaatgaaaaattctcagtcagtaattgccaaag ctgctctagccttgaggagtgtgagaatcaaaactctcctacacttccattaacttagca tgtgttgaaaaaaaaagtttcagagaagttctggctgaacactggcaacgacaaagccaa cagtcaaaacagagatgtgataaggatcagaacagcagaggttcttttaaaggggcagaa aaactctgggaaataagagagaacaactactgtgatcaggtatgtatggaatacagtgt tattttctttgaaattgtttaagtgttgtaaatatttatgtaaactgcattagaaattag ctgtgtgaaataccagtgtggtttgtgtttgagttttattgagaattttaaattataact taaaatattttataatttttaaagtatatatttatttaagcttatgtcagacctatttga cataacactataaa >286 at HG-U95Av2 tcgccaggcaggagtttctctcggtgactactatcgctgtcatgtctggtcgtggcaagc aaggaggcaaggcccgcgccaaggccaagtcgcgctcgtcccgcgctggccttcagttcc cggtagggcgagtgcatcgcttgctgcgcaaaggcaactacgcggagcgagtgggggccg gcgcgcccgtctacatggctgcggtcctcgagtatctgaccgccgagatcctggagctgg cgggcaacgcggctcgggacaacaagaagacgcgcatcatccctcgtcacctccagctgg ccatccgcaacgacgaggaactgaacaagctgctgggcaaagtcaccatcgcccagggcg gcgtcttgcctaacatccaggccgtactgctccctaagaagacggagagtcaccacaagg caaagggcaagtgaggtgacgtccggcccaagtgggcccagcccggcccgcgtctcgaa ggggcacctgtgaactcaaaaggctctt >287_at HG-U95Av2 gttaacacaaaatccatgggcagcatgatggcaggtcctctgttgcaaactcagttccaa agtcacaggaagaaagcagaaagttcaacttccaaagggttaggactctccactcaatgt cttaggtcaggagttgtgtctaggctggaagagccaaagaaatattccattttcctttcc ttgtggttgaaaccacagtcagtggagagatgtttggaacacagtcagtggagctggtgg taccaggtttagcattattggatgtcaaaagcattttttttgtcatgtagctgttttaag aaatctggcccagggtgtttgcagctgtgagaagtcactcacactggccacaaggacgct WO 2005/068655 PCT/GB2005/000057 67 ggctactgtctattaaaattctgatgtttctgtgaaattctcagagtgtttaatt >31472 s at HG-U95Av2 gacaagttt tggtggcacgcagcctggggactctgcctcgtgcogctgagcctggcgcag atcgatttgaatatnnnnnnnnnnnnnnnnnnnnnattccacgtggagaaaaatggtcgc tacagcatctctcggacggaggccgctgacctctgcaaggctttcaatagcaccttgccc acaatggcccagatggagaaagctctgagcatcggatttgagacctgcagtttgcattgc agtcaacagtcgaagaaggtgtgggcagaagaaaaagctagtgatcaacagtggcaatgg agctgtggaggacagaaagccaagtggactcaacggagaggccagcaagtctcaggaaat ggtgcatttggtgaacaaggagtcgtcagaaactccagaccagtttatgacagctgatga gacaaggaacc >31540_at HG-U95Av2 atgagaccagtacaaactactcaagaggaagatggctgtagctnnnnnnnnnnnnnnnaa gaagaaggaggatgtgaactgtgaaatggaagtcaatagggctgttgggactttcttgaa aagaagcaaggaaatatgagtcatccgctatcacagctttcaaaagcaagaacaccatcc tacataatacccaggattcccccaacacacgttcttttctaaatgccaatgagttggcct ttaaaaatgcaccacnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntgccaggcccg gccaaaataatgcaccacttttaacagaacagacag >31622_f at HG-U95Av2 gtgtctcctgcacctgcgtggttcctgcaagtgcaaagagtgcaaatgcacctcctgca agaagagotgctgctcctgctgccccgtgggctgtagcaagtgtgcccagggctgtgttt gcaaag >31697 s at HG-U95Av2 caaactggccactgacaaaaatgaccccnnnnnnnnnnnnnnnnnnnnnnnacattacct gaatgagcaggtgaaagccatcaaagaattgggtgaacgtgaccaannnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagctgtggggtgacttccctggtca ccaaggcagtgcatgcatgttggggtttcctttacctt >31803 at HG-U95Av2 aagtgggctgtggtgcccatttgcagtgactgtgaagtgactccaggacggacctgcggg ggcaccnagaggtcctaagccccaggactgagggtcgtgcatcaccactcgggtgtcccg ggaggtgccctgggcccggggacctcacaggcaggacggcgacactaatgcagggagagg gagtctggccccagottttcctatcagaggcgattttccttcaccaggggatgggcagga aagaggcaggggccccagaagcttctgtccctcatgcctgagggcacgggggacacttgg annnnnnnnnnnnnnnngtgcgtccaaggccatgctctctgcgggtcagtgcctgagtct cgcctccctgctggtccctgaagccccctcannnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnlccctctcagcccaacatcagcttcctctttctccctt gctgtagacaggctggat >31825 at HG-U95Av2 gaaacgaccaagaagagaggcttgttggaatcaattctnnnnnnnnnnnnnnnnnnnnnn nnnntagaagtcantgtaactgtagtgtgtctgctngttacctagagggtctnacctncc cnactcttcacagcaaacctgnagcagegcgtncctaagcancctncccgctccnggtga nocccatccttgcanancctgactctgtcactcaagcctttctnccanccaggcccctca totgaatanccaagcacagaaatgagtggtgtgactaattccttacctctcccaaggagg gtacacaactagcaccattcttgatgtnccagggaagaagccacctcaagacatatgagg ggtgccctgggctaatgttagggcttaattttctcaaagcctgacctttcaaatccannn nnnnnnnnnnnnnnccctcctgctgttgcctccctgtgacctggaggacagtgtgtgcca tgtctcccatactagagataaataaatgtagccacatttactgtnaaaaaaaaaaaaaaa aaactcgaggggggccggtacccaattcgccctatagctgagtcgt >31862 at HG-U95Av2 acatcccctcagttgcagtgaattgtgagcaaaagatcttgaaagcaaaaagcactaatt WO 2005/068655 PCT/GB2005/000057 68 agtttaaaatgtcacttttttggtttttattatacaaaaaccatgaagtactttttttat ttgctaaatcagattgttcctttttagtgactcatgtttatgaagagagttgagtttaac aatcctagcttttaaaagaaactatttaatgtaaaatattctacatgtcattcagatatt atgtatatcttctagcctttattctgtacttttaatgtacatatttctgtcttgcgtgat ttgtatatttcactggtttaaaaacaaacatcgaaaggcttatgccaaatggaagatag aatataaaataaaacgttacttgtatannnnnaannnnnnnnaannnnnnnncagataat tcatgtggagatttttggagaaaccatgacggatagtttaggatgactacatgtcaaagt aataaaagagtggtgaattttaccaaaaccaagctatttggaagc >31895_at HG-U95Av2 agtcttggttctccatctgtaattttttttaacagtttgctatagcttactgcttaacta attttaaataaggaaataagtatgttagatgcagtagacgatacaggttgcatgtggaca ctcagtcacattaacaacttgggaaaaaaatggcaatgttacggtgaattctcaggtgaa cttttttcagtta >31974_at HG-U95Av2 cagcggcatgaagtttgagattggccaggccctgtacctgggcttcatctcctncgtccc tctcgctcattggtggcaccctgctttgcctgtcctgccaggacgaggcaccctacnngc cctannccaggccccgcccagggccaccacgaccactgcaaacaccgcacctgcctacca gccaccagctgcctacaaagacaatcgggccccctnagtgacctcggccanncacagcgg gtacaggctgaacgactacgtgtgagtccccacagcctgcttctcccctgggctgctgtg ggctggttcccggcgggactgtcaatggaggcaggggtnnnnnnnnnnnnnnnnnnnnnn nncaatttttgtatccaaggaaataatgtgaatgcgaggaaatgtetttagagcacaggg aca >32034 at HG-U95Av2 cctgttcacaagctgagccatatgtacataatctagattttgttttcatagttttgcact tttatagcctatttttgaagattaacacatttgcaagatgattgactcaatctttgccta atccaatgagtgttacagagagcttgctgtgactagaaccataaatcttaaagggggtat gtgataatagagggctggaatttaaacctgtatttaaaaaaaagaatcaccaaatctatt tgaaaacaagtcgatttgtattatgtggaattttttgggtttcagatttctcttttta accacatttctgaatgtataaaaataccaattattttcctacagccctttgtacttcaaa atatgtttttgtgtccatcagtattaactattg >32052 at HG-U95Av2 getcgctttcttgctgtccaatttctattaaaggttcctttgttccctaagtccaactac taaactgggggatattatgaagggccttgagcatctggattctgcctaataaaa >32114 s at HG-U95Av2 agcttggacagcagactggcctggccctgagactggggagtggctncnacagncctcc tgccacccacacaccactctccctagactctncctagggttcaggagctgctgggcccag aggtgacatttgacnttttttccaggaaaaatgtaagtgtgaggaaaccctttttatttt attacctttcactctctggctgctgggtctgccgtcggtcctgctnnnnnnnnnnnnnnn ngagcctctgcccqgggagcctcaggcagtcctctcctgctgtcacagctgccatccact tctcagtcccagggccatctcttggagtgacaaagctgggatcaaggacagggagttgta acagagcagtgccagagcatgggcccaggtcccaggggagaggttggggctggcaggcca ctggcatgtgctgagtagcgcagagctacccagtgagaggccttgtctaactgcctttc >32115 r at HG-U95Av2 ggtctgccgtcggtcctgctgctaacctggcagcagagcctctgcccggggagcc >32168 s at HG-U95Av2 aaccta~ctgtgaatcatatgttgtaggaaaagctgttcccatgtctaacaggacttgaa ttcaaagcatgtcaagtggatagtagatctgtggcgatatgagagggatgcagtgccttt ccccnattcattcctgatggaattgttatactaggttaacatttgtaatttttttctagt tgtaatgtgtatgtctggtaaataggtattatattttggccttacaataccgtaacaatg tttgtcattttgaaatacttaatgccaagtaacaatgcatgctttggaaatttggaagat ggttttattctttgagaagcaaatatgtttgcattaaatgctttgattgttcatatcaag aaattgattgaacgttctcaaaccctgtttacggtacttggtaagagggagccggtttgg gagagaccattgcatcgctgtccaagtgtttcttgttaagtgcttttaaactggagagge taacctcaaaatattttttttaactgcattctataataaatgggcacagtatgctcctta WO 2005/068655 PCT/GB2005/000057 69 c >32215 i at HG-U95Av2 aacagattactgtctattgtcagcatcattttcatctgtaagtcactactggaatatatt >32216 r at HG-U95Av2 aaatggactgggatagaggacagactgatagtttctttctttcatatcacatgtatagag aaataattatatcagaanctcacaaacctagacatggaaaaacagattactgtctattgt cagcatcatttcatctgtaagtcactactggaatatatttttcttttaatttccagtga ctttagaatacacacagttttt >32285 g at HG-U95Av2 ctatgtggacccacgcaaagatagcgagaaatatgccgaggagaacttcaaaacctttgt gttcgaggagacacgattcaccgcggtcactgcctaccagaaccatcggatcacgcagct caagattgccagcaatcccttcgcgaaaggcttccgggactgtgaccctga >32319_at HG-U95Av2 gtctatgttcttgttgctatgagtcaaggagtgtaaccttctcctttactatgttgaatg tatttttttctggacaagcttacatcttcctcagccatctttgtgagtccttcaagagca gttatcaattgttagttagatattttctatttagagaatgttaagggattccaatcccg atccaaatcataatttgttcttaagtatactgggcaggtcccctattttaagtcataatt ttgtatttagtgctttcctggctctcagagagtattaat >32321_at HG-U95Av2 ccacagagagcctccactagagtgatgctaagtggaaatgtgaggtgcagctgccacaga gggcccccaccagggaaatgtctagtgtctagtggatccaggccacaggagagagtgnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntccc acagataccttttctctcccatgaccctttaacagcatctgcttcattcccctcaccttc ccaggctgatctgaggtaa >323 at HG-U95Av2 TIGRSequence >32464 at HG-U95Av2 gagggtcttgtatctcctcttctcgttcctcttcatattcctgatgcctcttccaggtgt ttttggtggtataggcgatcctgttacctgccttaagagtggagccatatgtcatccagt cttttgccctagaaggtataaacaaattggcacctgtggtctccctnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntgcggattcagaaagggetcc ctcatcagagacgtgcgacatgtaaaccaa >32531 at HG-U95Av2 tagtactgtaaacaggctttagtcattaatgtgagagacttagaaaaaatgcttagagtg gactattaaatgtgcctaaatgaattttgcagtaactggtattcttgggttttcctactt aatacacagtaattcagaacttgtattctattatgagtttagcagtcttttggagtgacc agcaactttgatgtttgcactaagattttatttggaatgcaagagaggttgaaagaggat tcagtagtacacatacaactaatttatttgaactatatgttgaagacatctaccagtttc tccaaatgccttttttaaaactcatcacagaagattggtgaaaatgctgagtatgacact tttcttcttgcatgcatgtcagctacataaacagttttgtacaatgaaaattactaattt gtttgacattccatgttaaactacg >32551 at HG-U95Av2 attttcatatccagcctaaaggtggttgtttattatatagtaataaatcattgctgtaca atannnnnnnnnnnnnannnnannnnnnnttttgtcaganantttagattgtgaatattt tgtaaaaaacagtaagcaaaattttccagaattcccaaaatgaaccagatatcccctaga aaattatactattgagaaatctatggggaggatatgagaaaataaattccttctaaacca cattggaactgacctgaagaagcaaactcggaaaatataataacatccctgaattcagga cttccacaagatgcagaacaaaatggataaaaggtatttcactggagaagttttaatttc taagtaaaatttaaatcctaacacttcactaatttataactaaaatttctcatcttcgta WO 2005/068655 PCT/GB2005/000057 70 cttgatgctcacagaggaagaaaatgatgatggtttttattcctggcatccagagtgaca >32588 s at HG-U95Av2 catctccgicgactgaggcaagagggcgccagtgaggaggaagggaaggcggttcagaga tgttggaggacacccctcgccatctcgcccttgctgggggcacgggagtggggggggtga catgggccctaggcagactgcaagcccgaccgagcacttggactogaactctgtgcc >32606_at HG-U95Av2 acagaactacaggtgcacccaaccacggacatgcattaactcgtcatgagaaatctaggt aggctaagtaggatgagagaatgtttgtcactcccaaaaatatctggagaggaagaatgg aggattggcattgagatccatgtggacaagctaagtgggctctgtctgaaagctggcatt catccacaacattaaaaaaatatcaaaataagaaaggetgtaaattaaaaagaaaacaca gaaaatactgctctcataaagatctgattgccttgnnacaggccctgtgngannnnntca aacgcatcactcccaactcccattgcagaagaaaagctattcaactctcagcggtggagg agtgcatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncagacgcggatctt ggaaatccaggacttcttggnnaagttgactgaaggtatattagatatttccccacaaaa atactatttggattctcccaccccctccctcccttgatgggacaacatectgta >32609_at HG-U95Av2 gcccgcgtctcgaaggggcacctgtgaactcaaaaggctcttttc >32610 at HG-U95Av2 acctgggctccgaggtgtacaggatgctgcggganccagccgagcccgtggccgcggagc ccaagcagtcaggctccttccgctacttgnagggcatgctanaggccggcgagggcgggg attggcccgnncctggcggccccoggaacctcaagcccacggccagcaagotgggcgctc cgctgancggcctgcaggggctgcccgagtgcacgcgctgcggccacggcatcgtgggca coatcgtcaaggcacgggacaagotctaccatccogagtgcttcatgtgcagtgactgcg gcctgaacctcaagcagcgtggttacttctttctggacgagcggctctactgtgagagcc acgccaaggcgcgcgtgaanccncccgagggctacgacgtggtggcggtgtaccccaatg ccaaggtggaactcgtntgagctgggaccctgctcccacgcctgcttcttaaggtccctg ctcggccggtgtaaatatgtttcac >32616 at HG-U95Av2 aataccagcagcagccttagagcacagggagacccgtccatttggcaggggtggetgcct catttagagaggaaaagtaaccatcactggttgcacttatgatttcatgtgcggggatca tctgccgtgcctggatcctgaaatagaggctaaattactcaggaagaacaccetctaaat gggaaagtattctgtactcttagatggattctccactcagttgcaacttggacttgtcct cagcagctggtaatcttgotctgcttgacaacatctgagtgcagccgtttgagaagaaaa catctattctctccaaaaatgcacccaactagctctatgtttacaaatgg >32640 at HG-U95Av2 gtgatttttctatcggcacaaaagcactatatggactggtaatggttacaggttcagaga ttacccagtgaggccttattcctcccttccccccaaaactgacacctttgttagccacct ccccacccacatacatttctgccagtgttcacaatgacactcagcggtcatgtctggaca tgagtgcccagggaatatgcccaagctatgccttgtcctcttgtcctgtttgcatttcac tgggagcttgcactannnnnnnnnnnnnnnnnngcagtgatcagggtcctgcaagcagt >32668 at HG-U95Av2 tcccctcttttgtgaagaaagcgggtccaaatgtgattcaaacaactgtacggagtggca tattagaattgccctaaactgaactgcaaataattatgtgtgtatgtatatgtgtgggaa agagaatgtactgtatatgtgtatgttatacagacatatacacatacatacattgaccca caggacattgtaaaatattatcacatgacatettaagtagaaataagtagggacttttat tccatcctttttttcacgtttacattttaattattacaagttgctcctgccccctccctg aactattttgtgotgtgtatatcactgctttatataagttattttttaaggtgaactcag atgttatggttttgtaaatgtctgcaatcatggataggaataaaatcgcttatttgagag ctttcattaaa >32700 at HG-U95Av2 agtactaccaggtgccaaggaaggggatncaggccaaagaggtgctgaaaaaatatttgg agtcnnaggagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncactctcagaaaagg aaaaagcgattgaagtggaacgtataaaggctgaatctgcagaagotgcaaagaaaatgt WO 2005/068655 PCT/GB2005/000057 71 tggaggaaatacaaaagaagaatgaggagatgatggaacagaaagagaannnnnnnnnnn nnnnngtgaaacaattgactgagaagatggagagggacagggcccagttaatggcagagc aagagaagaccctcgctcttaaacttcaggaacaggaacgccttctcaaggagggattcg agaatgagagcaagagacttcaaaaagacatatgggatatccagatgagaagcaaatcan nnnnnnnnnnnnnnaacatactctaaaagtccaaggagcaaaatttgcctgtccagctcc ct >32718 at HG-U95Av2 cagactgagcaagtggagtagcagaaccaggagcctcttcnnnncnnnaggaaagatnnn nnnnnnnnnnnnnnaagggaaattcctaggattggctgtcccctgccaagcttggtggag cgtctgcaccttggctgcgccgcctgtgcatttgccagtttcctcccactgagaggatgg aggtgtccgcacagctttgggcctcgtgagggatctgncctcctgagcaaagagctcttg atcccgatttcatgcacagccctgcagtaaggagcccagaaggaacatgtgtttoctgtt aaaactcctcttgttctcttttcttacattatgacgtttgttttcaaggagagggtttaa aaatgggatcctgtaagcagacttgggcagtctccttttgaaataggttgtctgtacatg ttctaatgttttgtagaacac >32736 at HG-U95Av2 tcctgccttcctgagggccagaggggagccccaggacccattaagccacccccgtgttcc tgccgtcagtgccaacnnnnnnnnnnnnnnncatctacccgttcactccagtcccacccc acgcctgactcccctctggaaactgcaggccagatggttgotgccacaacttgtgtacct tcagggatggggctcttactccctcctgaggccagctnnncnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnaaatgagtgtctcagaagtgtgctcctctggc ctcagttctcctcttttggaacaacataaaacaaatttaattttctacgcctctggggat atctgctcagccaatggaaaatctgggttcaaccagcccctgccatttcttaagacttto tgctncactcacaggatcctgagctgcacttacctgtgagagtcttcaaacttttaaacc ttgccagtcaggactttt >32737 at HG-U95Av2 acagacggacgtcttcctcatctgcttctccctcgtcagcccagcctcttatgagaacgt ccgcgccaagtggttcccagaagtgcggcaccactgccccagcacacccatcatcctggt gggcaccaagctggacctgcgggacgacaaggacaccatcgagaaactgaaggagaagaa gctggetcccatcacctacccgcaggncnnnnggcactggccaaggagattgactcggtg aaatacctggagtgctcagcnctnacccnagagaggcctgaaaaccgtgttcgacgangc catccgggcngtgctgtgccctcagcccacgcggcannnnnnnnnnnnnnnnnnnnnnct cctctaggggttngcanccnnnnnnnncnnnntagatnggtntgntncnncnnnnnnnna ggnncncgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggagcccttcacgggacg ctacagcctgtgcc >32772 s at HG-U95Av2 ggagacactatattcaatcgtgctaagctcctcaatgttggctttcaagaagccttgaag gactatgactacacctgctttgtgtttagtgacgtggacctcatnccaatgaatgaccat aatgcgtacaggtgtttttcacagccacggcacatttccgttgcaatggataagtttgga ttcagcctaccttatgttcagtattttggaggtgtctctgctctaagtaaacaacagttt ctaacnnnnnnnnnnnnnnntaataattattggggctgnggaggngnagatgatgacatt nttaacagattagtttttagaggcatgtctatatctc >32786 at HG-U95Av2 cgottggacggctgggcacacgcctcccactggggtccagggagcaggcggtgggcaccc accctgggacctaggggcgccgcaaaccacactggactccggccctcctaccctgcgccc agtccttccacctcgacgtttacaagcccccccttccacttttttttgtatgtttttttt ctgctggaaacagactogattcatattgaatataatatatttgtgtatttaacagggagg ggaagagggggcgantcnnnggcggagctggccccgccgcctggtactcaagcccgcggg gacattgggaaggggacccccgccccctgccctcccctctntgcaccgtactgtggaaaa gaaacacgcacttagtctctaaagagtttatt >32794_g at HG-U95Av2 gactccagatactgcctgagcagccgcctgagggtctcggnnnnnnnnnnnnnnnnnncc cgcaaccacttccgctgtcaagtccagttctacgggctctcggagaatgacgagtggacc caggatagggccaaacccgtcacccagatcgtcagcgccgaggcctggggtagagcagac tgtggcttnacctcngngtcntaccagcaaggggtcctgtctgccaccatcctctatgag WO 2005/068655 PCT/GB2005/000057 72 at >32818 at HG-U95Av2 tagaaccagccgtattttacatgaagctgtataattaattgtcattatttttgttagcaa agattaaatgtgtcattggaagccatccctttttttacatttcatacaacagaaaccaga aaagcaatactgtttccattttaaggatatgattaatattattaatataataatgatgat gatgatgatgaaaactaaggatttttcaagagatctttctttccaaaacatttctggaca gtacctgattg >32847 at HG-U95Av2 tccaaggaccggatgaagaagtacatggcaagaaggaantggcagaaaacgggcaatgct gtgagagccattngnagactgtcctctnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnagggtcanccaaccagcccgctcaatgcagaaaaactagaatctnnngaag atgtgtcccaagctttccttgaggctgttgctgaggaaaagcctcatgtaaaaccctatt tctctaagaccattcgcgatttagaagttgtggagggaagtgctgctagatttgactgca agattgaannnnnnnnnnnnnnnnaggttgtctggttcaaagatgaccagtcaatcaggg agtcccgccacttccagatagactacgatgaggnnnnnnnnnnnnnnnnaattattagtg atgtttgcggggatgacgatgccaagtacacctgcaaggctgtcaacagtettggagaag ccacctgca >32944_at HG-U95Av2 accagaccagccaagaaactgaaacnnnnnnnnnnnnnnnnnnnnngagaaacctacaca gatgatcttccaccacctcctgtgccgccacctgctataaagtcacctactgcccaatcc aagacacagctggaagtacgnnnnnnnnnnnnnnnaaaactcccttctatggatgcaaga acagacagannnnnnnnnnnnnnnngaagcagttacaaggggagagaagtgttggatgga agacaggttgttgacatgcgaacaaatccaggtgatcccagagaagcacaggaacagcaa aatgacgggaaaggacgtggaaacaaggcagcaaaacgagaccttccaccagcaaagact cat ct cat ccaagaggat at tcta cctt at tgtaga cct actttt ccaa cat ca aat aat cccagagatcccagttoctcaagctcaatgtcatcaagaggatcaggaagcagacaaaga gaacaagcaaatgtaggtcgaagaaatattgcagaaatgcaggtacttggaggatatgaa agaggagaagataataatgaagaattagaggaaactgaaagotgaagacaaccaagaggc tt >33102 at HG-U95Av2 atatttttggagtcccattgtttcagtgggcattaacagaatgctttaaaaacttctaag acaagaatctatagcattagtatacactggcacataattttttaaaaagttttaagaaaa gattcatttggaattttattcacagtataaaatttcctcacctgaagtaactttgtttgc caa >33103 s at HG-U95Av2 totcacagaaggagaacttgaagagtataagaggacaatcgaacgtaaacaacaaggcct agaagaaaaccat gagctgtttt ccaagagctt catct ccat ggaagt gcct gt cat ggt agtaaatggcaaggatgatatgcatgatgttgaagatgagcttgotaagogagtgagtag gttaagcacaagtacaaccatagaaaacatcgagattactattaagtctccagagaaaat cgaagaagtcctgtcacctgaaggctccccttcaaaatcgccatccaagaaaaagaagaa attccgcactccttcttttctgaaaaagaacaaaaaaaaggagaaagttgaggcctaaat aaagtctttttataattattattataacaatgtgacattgcacatctaaataccacattt aagtt gat cat taat at gcaat ggt agat cagattgggggatgtagcaaactgga cttt a agaac >33113 at HG-U95Av2 tttctccagtgctcaactgttagatattaatcttggcaaactgcttaatcttgtggattt nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagtgaaaggaaaaattgca ttagttggttgcatgaacttcngangggcagatattactgcacaaactgccatctcgctt catttttttaactatgncatttgagtancaganctaatttttaaaatatgctaaactgga anngattannnnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnntggctgt cccccccgccgccccccccacccccat at gtacagat gat aat agggtgtggaatgtcgtcagtggcaaacatttcacagannnttattttgtttctgtcttc aacatttttgacactgtgctaatagttatattc >33130 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 73 cttgtaagccacttgtttggttatgatttgtgtcttatcagggaaaaggtgcccagctgc cagcccagctccgctgCntatctttgcctcacttagtcatgtgcaattcgcgttgcagag tggcagaccattagttgotgagnnnnnnnnnnnnnnnnntgtgctcagaagagcacctgc ccaaagtttttctggttttaatttaaaggacaaggctacatatattcagctttttgagat gaccaaagctagttagggtctccttgatgtagctaagctgcttcagtgatcttcacattt gcactccagttttttttnnnnnnnnnnnnnnnnnnttctacctctctatgtgcctgagtgat gatacaatcgctgtttagttactagatgaacaaatccacagaatgggtaaagagtagaat ctgaactatatcttgacaaatattattcaaacttgaatgtaaatatatacagtatgtata ttttttaaaaagatttgcttgcaatgaccttata >33235_at HG-U95Av2 gtgtcacaaagtcaataggtccttannnnnnnnnnnnnnctaagggaaatccgaactga atttatgcacatagaattgtcaccctgactttgaagcctcaaacatggatcaaatctgtt gtgaaacatcaatatatgtagctggatgagtgactagtttcccttgtataatatgtgatc taagaaaattgctaatctttccctgccattttgagaaacacagtccaaacatgagcataa acagaatttcctgcaatacatncccagtaggtnccacctagtttacaacttaaactagtt tgtgaaacatttgtctgtatacattttatattttgtacattttgatgtaacatatcatgt aaataggcagaaacagtgaaataaatcatctgaaaagttttgtagtctttgtaaagcccc aacaataagtacttggtgtcaatggacttaactggatgatgtattttctattggtttatt gttcctctagcttgtaaaccagcttgcatatatttttttgcaaatgtgcaccctgtatct gtctaaatt >33236 at HG-U95Av2 tgagcaacagtgcagaggtgaaacgggagcnnnnnnnnnnnnnnnngggaggetgttgot atcgggtcaacaacagcttggaccatgagtaccaaccacggcccgtggaggtgatcatca gttctgcgaaggagatggtnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntggaaa aggccaaggttgaagtcggtgtggccacggcgcttggaatcctggttgttgctggatgct cttttgcgattaggagataccaaaaaaaagcgacagcctgaagcagccacaaaatcctgt gttagaagcagctgtgggggtcccagtggagatgagcctcccccatgcctccagcagcct gaccctcgtgccctgtctcaggcgttctctagatcctttcctctgtttccctctctcgct ggcaaaagtatgatctaattgaaacaagactgaaggatcaataaacagccatctgcccc >33243 at HG-U95Av2 tgcttctggaattgagttctccttttaagtaccaatgatacttaaatttctcagaaatgt aatggtgtgtcattgccttgaaatgcttgcttagggottcttttatgttatcttaaaaag tgnnnnnnnnnnnnnnnttttttacatccatttcacatgtaagagacaaaaaagtctaga ttggtcttgatattgagataataaaaagtaagtagcattaagaaaggtaacaatncttca ttcnnnnnnnnnnnnnnnnntgaaacaatttaggggaatgaggggcaaaaggggagaaat actgctaaagaacatgagcataaaaatgcgtgcgtttcagtgtttaagaaggcttgataa agaatgtcacttttttatttaactgataagatttttgttattttttactttgataagtaa accaaagaatatttgtatttcaancagtttgtgtggtgtttctatataattttctgtgta taaataannnnnnnnnnnnnnnnnnnnnnnntaaaaaagnnnnnnnnnnnnnnnnnccag ctatgtcctctaggaaatgacag >33249 at HG-U95Av2 cacagcatgcagactgggagttgctagcaaacaaatggcttacntacnnaangcagottt tagttcagacttagtttttataaaatgggaattnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnncagctttttgtattaacaaagttactggctctttgtgtgtetcca ggtaactnnnnnnnnnnnnnnnncaaagccatattctaaattcactgttgaatgcctgtc ccagtccaaattgtctgtctgctcttatttttgtaccatattgctcttaaaaatcttggt ttggtacagttcataattcaccaaaagttcatataatttaaanaaacactaaattagttt aaaatgaagcaatttatatctttatgcaaaaacatatgtctgtctttgcaaaggactgta agcagatt >33281 at HG-U95Av2 acccaciggaaagagtgtggcagcaactgcntggctgacotttctatcttctctaggctc aggtactgctcctccatgcccatggntgggncgtggggagaagaagctntcnnacgcctt cccactccctctggtttataggacttcactccctagccaacaggagaggaggcctcctng gggtttccccagggcagtaggtcaaacgacctcatcacagtcttccttcctcttcaagcg tnncatgttnaacacagntntnnccnntcccntgtgatttnnganggnnnnonnnnnnnn WO 2005/068655 PCT/GB2005/000057 74 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnctatgcttggtctgactgagcctaaagt tgagaaaatgggtngccaaggccagtgccagtgtcttggggcccctttggctctccctca ctctctgaggctccagctggtcctgggacat >33295_at HG-U95Av2 cagactgggtgcaggccaggtcccaggcctcaccctggggetcactgtgggaatttgggg agtggetgccctactgacactgcctgtcaccctggccagtggtgcttntggtggactctg caccctgatatacagcacggagctgaaggctttgcagnccacacacactgtagcctgtct tgccatctttgtcttgttgccattgggtttgtttggagccaaggggetnaagaaggcatt gggtatngggccaggcccctggatgaatatcctgtgggcctggtttattttctggtggcc tcatggggtggttctaggactggatttoctggtgaggtccaagctgttnnnnnnnnnnnn nnntctggcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntctgccaccaggccacccgcaccct cttgccctctctgcccctccctgaaggatggtettctcatctggacacccttggaagcaa atcctagttctcttcccacctgtcaacctgaattaaagtctacactgcctttg >33304 at HG-U95Av2 gttcatccggcctgagggagagatcaccgattacagaaccngggtcagcggggtcacccc tcagcacatggtgggggccacaccntttngccgtgnccaggctagagatcctgcagctcc tgaaaggcaagctggtggtgggtcatgacctgaagcacgacttnnnnnnnnnnnnnnnnn acatgagcggctacacaatctacgacacgtccactnnnnnnnnnnnnnnnngtgaggcca agctggaccactgcaggcgtgtetccctgcgggtgctgagtgagcgcctcctgcacaaga gcatccagaacagcctgcttggacacagcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nctatcaaatctcccagagaatccgagcccgccgagggctgccccgcctggctgtgtcag actgaagccccatccagcccgttccgcagggactagaggctttcggetttttgggacagc aactaccttgcttttgga >33331 at HG-U95Av2 gaaggacccatgtcccaggaaccgcgntgcgccacctgcactcacccccctcacattctc ttaagcacccggtngccctccgaggcctggcggaatggtggtgcccacggggttgggcaa gggctcaccaggacctcaacgggcaaagttgtgcacactaaaatatcaaatcaaggtget tggttttaaagtaaatgtttttctaaagaaagctgtgntcttctgttgacccagacgaat anngcacagccctgtaactgcacgtgccttctgtcattgggaatgaaataaattattacg agaaaggganttgtcctaannngtttgaggccttacagttttgtatctacatttttcccc tcctggggtttgcggggacagggacagaactacaggagtcatgggaaagaaaattctggc ttcactactgctcactgctcactttctgatcactctganacnnntttttttttttttttt ttgcaacctgataccttgaaaag >333'71 s at HG-U95Av2 cgacctctcagatattagggaggttcccctgaaggatgctaaggaatacgctgaatccat acjgtgccatcgtggttgagacaagtgcaaaaaatgctattaatategaagagctctttca aggaatcagccgccagatcccacccttggacccccatgaaaatggaaacaatggaacaat caaagttgagaagccaaccatgcaanccagccgccggtgctgttgacccaagggcngtgg tccacgntacttgaagaagccagagcccacatcctgtgcactgotgaaggaccctacget cggtggcctggcacctcactttgagaagagtgagcacactggctttgcatcctggaagnc ctgcaggggnnngggcaggaaatgtacctgaaaaggattttagaaaaccctggnaaaccc accacaccaconnnacaaaatggcctttagtgtatgaaatgcac >33410 at HG-U95Av2 agtgactgtgtttccctcaaagactgtagotcagtattcgggagtaccttggtggatcat cctagtggc >33411_g at HG-U95Av2 ctgtagcgtgaacgtgaactgtgtgaacatcagatgcccgctgcgggggctggacagcaa ggcgtetcttattttgcgctcgaggttatggaacagcacatttctagaggaatattccaa actgaactacttg >33439 at HG-U95Av2 gaccaggtgccttgccgcagagaaaancnaccaaagtctcctgttegctcataaagaagt ttttgggatgggagagannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntt tttacagaggnnnnnnnnnnnnnnnnncaacacaaaacnncttcccctttttaaaatgat WO 2005/068655 PCT/GB2005/000057 75 ttctgttctaatgccatagatcaaaggcctcagaaaccattgtgtgtttcctctttgaag caatgacaagcactttacttt cacggtggtttttgttttttcttattgctgtggaacctc ttttggaggacgttaaaggcgtgttttacttgtttttttaagagtgtgtgatgtgtgttt tgtagatttcttgacagtnnnnnnnnnnnnnnnnnnnnnnnnnngcctatttaaagacnc tacgtgatctgattgagatgtaca >33533 at HG-U95Av2 aatagtattccagcagacattgtttttatcattaaagacaaagatcatccaaaatttaaa agggatggatcaaatataatttactgctaaaattagtttacgagaggagattgtgtggcg t gctcaattaat gt acca acactggatggaagaacat acct at gtcagt aaat gat attg tgaancccggaatgaggagaagaattattggatatgggctgccatttccaaaaaatnnnn nnnnnnnnnnnnnnnnnnnnnnnnnntttgaggtgtccttcccagatactatatcttctt catnnaaagaagtactnnnnnnnnnnnnnnnnnnnnnnnagaatgannnacttnnntana nat atttt gat aaggcact ga aaat at aaaaggant ggtagttt actgat gt agat gt ga attctgtataaagatgtgtaaattnttttgagggttcattaaattgcatgaatagagaca ggtcaaataaataggcaaaagggatttttacagttagagatagaagagaaaaccattcac tgtattt >33707 at HG-U95Av2 cgtggcegggctctactacccgaagnatagtgcccgaagttgctgcttggcatagatgag cctcagcttccagggcactgtgggcntgttggtctactagggccctgangtccacctggc ct toct gtt ctt cact ccctt cagccacacgctt cat ggcctt gagtnnnnnnnnnnnnn nnnnnnnnnnccaatcaccagtgaccagctagactgtgattttgatagcgtcattcagaa gaaggcgtccaaggagctgaaggtggtgaaatttgtcctgcaggtccctcgggagatcct ggaget ggagcatgagtgt ctgacaat cagaagcat cat gt ccaatgtccagat ggccag aatgaatgtgatagttcagaccaatgccttccactgctcctttatgactgcacttctagc cagtagotctgcacaagttagctctgtaga >33731 at HG-U95Av2 ctgtgtatgtcagttgctgcagaaatggatttggaagatggaggagagatgcccaagcaa cgggatcccaantctaacnaaacaccatctggaatcctgatgtggaaagcaggggtttet ggtctactggetagagctaaggaagttgaaaaggaaagctcacttctttggaggcacctg tccagaagcctggcctaggcagcttcaacctttgaacttactttttgaaatgaaaagtaa tttatttgttttgctacatactgttccagacttttaaaggggacaatgaaggtgactgtg gggaggagcatgtcaggtttgggcttggttgttttagaagcacctgggtgtgcctaccta ctcctcttttcttttaaaagggcccacaatgotccaatttcctgtctcctttagagagac atgaaact >33764 at HG-U95Av2 gtgtattaccagtatttacttgctttcttgatttcaccaaaaccaaatttaatttaaagg accacattaatttttcaaagggaaagagacaattaattgtacataatgtatacacacaca naaaaaaaaatacctgtagaaatattattccagcatagcnggaaaacaaacaaaagtatt ggactgtcggaggtgagcctgtgcgtctgtaaccctttgtgactcctgagcgtgcgctgt cttnctaggttaactcacgaagtacattctctgtcttactgatactgtaggttcacccat ttttttttaatttcctcgcaaataacaagaccnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnttcttttatatgcagcaaacacaccgtccatttctgaagaggcttcggcntgaag gcattttccaatgatgttagtgcacaaaacgctttaaattagactggaactgccagaatc aaatgtaaatgaggaatttctcgtacccctactgcatggtatcgattttta >33772 at HG-U95Av2 ttgcttccaggtgtgcctggcatgggcctggcccaggaagacaccacctcactgaggact ttgcgaatatcagagacctcagactcttcacagggtcaggactcagagagtgtcttactg gt .ggatgaggctggtgggagcggcagggctgggcctgcccntaaggggagctccctgcaa gtcacatttcccagtgaaacactgaacttatcagaaaaatgtatataataggcaaggaaa gaaatacagtactgtttctggacccttataaaatcctgtgcaatagacacatacatgtca cattt agct gt gct cagaagggct at cat catecct acaact cacatt agagaacat cct g g >33790 at HG-U95Av2 cccacagcatgaagatctccgtggctgccattcccttcttcctcctcatcaccatcgccc tagggaccaagactgaatcctcctcacggggaccttaccacccctcagagtgctgcttca WO 2005/068655 PCT/GB2005/000057 76 cctacactacctacaagatcccgcnnnnnnnnnnnnnnnnnnntactatgagannnnnnn nnnnnnnnnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagaatgagtgacc cagaaggggtggcgaaggcacagotcagagacataaagagaagatgccaaggccccctcc tccacccaccgctaactctcagccccagtcaccctcttggagcttccctgctttgaatta aagacc >33791 at HG-U95Av2 agaatatctagcatgtaaggcctttcaatattaatataagcccaatatcagctctttctc tttgtatttcatctctttctactctcctatttgtattttgtgttcctatcaaagtgtcgt atctgggag >33802 at HG-U95Av2 ttctttctagagagggaattctcttggctggnttccttaconnnnnnnnnnnnnnnnntn nngggcctccagccetctcactgtgtccctctctctggaaaggaggaaggagcctatggc atettccccaacgaaaagcacatccaggcaatggcctaaacttcagagggggcgaaggga tcagccctgcccttcagcatcctcagttcctgcagcagagcctggaagacaccctaatgt ggcagatgtctcaaacctccaaaagccctgagtttcaagtatccttgttgacacggccat gaccactttccccgtgggccatggcaatttttacacaaacctgaaaagatgttgtgtctt gtgtttttgtcttatttttgttggagccactctgttcctngetcagcctcaaatgcagta tttttgttgtgttctgttgtttttatagcagggttggggtggtttttgagccatgcgtgg gtggggagggaggtgtttaacggcactgtggccttgg >33803 at HG-U95Av2 tttctaccatttcagagaggccttttggaatgtggcccctgaacaagaattggaagctgc cctgcccatgggagotggttagaaatgcagaatcctaggctccaccccatccagttcatg agaatctatatttaacaagatctgcagggggtgtgtctgctcagtaatttgaggacaacc attccnagactgcttccaattttctggaatacatgaaatatagatcagttataagtagca ggccaagtcaggcccttattttcaagaaactgaggaattttctttgtgtagotttgotct ttggtagaaaaggctaggtacacagctctagacactgccacacagggtctgcaaggtctt tggttcagctaagctaggaatgaaatcctgottcagtgtatggaaataaatgta-tcatag aaatgtaacttttgtaagacaaaggttttcctcttctattttgtaaactcaaaatatttg tacatagttatttatttattggagataatctagaacacaggcaaaatc >33849 at HG-U95Av2 tcttactggaatgtctaggcactgtacagttattatatatcttggttgttgtattgtacc agtgaaatgccaaatttgaaaggcctgtactgcaattttatatgtcagagattgcctgtg gctctaatatgcacctcaagattttaaggagataatgtttttagagagaatttctgcttc cactatagaatatatacataaatgtaaaatacttacaaaagtggaagtagtgtattttaa agtaattacacttctgaatttatttttcatattctatagttggtatgacttaaatgaatt actggagtgggtagtgagtgtacttaaatgtttcaattctgttatattttttattaagtt tttaaaaaattaaattggatattaaattgtannnanannannnantaattttaaactgaa tgccctcaataagtaatactgaagnnnnttcttaaatgaagataaattatctccaatgaa aagcatgacatgtgtttcaatagaagaatcttaagttggotaaattcaaagtgcttgaca tcaaaatgttctngagtgattagctactagattctgaatcatacatcacatctgactaga gaccag >33862 at HG-U95Av2 tcacttggcgaggagcccgcctgctccggcccctcctgcagttcaccttgatcatgatgg ccttctacacgggactgtctogcgtatcagaccacaagcaccatcccagtgatgttctgg caggatttgctcaaggagccctggtggcctgctgcatagttttcttcgtgtctgacctct tcaagactaagacgacgctctccctgcctgcccctgctatccggaaggaaatcctttcac ctgtggacattattgacaggaacaatcaccacaacatgatgtaggtgccacccacctcct gagctgtttttgtaaaatgactgctgacagcaagttcttgctgctctccaatctcatcag acagtagaatgtagggaaaaacttttgcccgactgatttttaaaaannaaaaaaaaaatg ttttactatgtggccttcca >33900 at HG-U95Av2 tgtgacatccggagtcctggagccgggtgtnccagtggnancactaggtnnntgctgnct ncnnnnnnngnnnnnnncncannnnnnnntnnttngtcccccacaacctgccccggnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn WO 2005/068655 PCT/GB2005/000057 77 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnttctcccacgacggctcaccctcccctccat ctgcgttgatgctcagaatcgcctacctgtgcctgcgtgtaaaccacagcctcagaccag ctatggggagaggacaacnnnnnnnnnnnnnnnnnnnnncggtctggggtgaggagtgtg gggagcttgggcatcctcctccagcctcctccagcccnnnnnnnnnnnnnnncctgtggt gcccagaaaagtgcccctaggttggtgggtctacaggagcctcagccaggcagcccaccc caccctggggccctgcCtcaccaaggaaataaagactc >33925 at HG-U95Av2 ttggtttcggacgacccttgctctgaccggaagagaagtccctatcccacacctgcctgt cacgttccctcccctttccccagcgcactgttgagggcagcctctccagctctcttgttt atgcaaacgccgagcgcctgggaggctcggtaggaggagtcttccacggccccgccccgn ccctgtcggtcccgccctnccccccgccgggctcctggggotgtggccgaaaggtttctg atctccgtgtgtgcatgtgactgtgctgggttggaatgtgaacaataaagaggaatgtcc aagtgnnnaaaaaaaaaaaaannagggagtttgggtgcacaaggcctccgc >33943 at HG-U95Av2 gtgaccacgtgaccaacttgcgcaagatgggannnnnnnnnnnnnnnnnnnnnnnnnnnn nnnttgacaagcacaccctgggagacagtgataatgaaagctaagcctcgggctaatttc ccnatagccgtggggtgacttccntggtcaccaaggcagtgcatgcatgttggggtttcc tttaccttttctataagttgtaccaaaacatccacttaagttctttgatttgtaccattc ttcaaataaagaaatttggtacccaggtgttgtctttgaggtettggatgaatcagaaat ctatccaggctatcttccagattccttaag >34022_at HG-U95Av2 gtatcattgacacttcctgcagggtggtccctngccctnacnaganctgaaantgaaaan gagancagcagctttctagggacagctggaaanggacttaatgtgtttgactatttctta cgagggttctacttatttatgtatttatttttgaaagcttgtattttaatattttacatg ctgttatttaaagatgtgagtgtgtttcatcaaacatagctcagtcctgattatttaatt ggaatatgatgggttttaaatgtgtcattaaactaatatttagtgggagaccataatgtg tcagccaccttgataaatgacagggtggggaactggagggtggggggattgaaatgcaag caattagtggatcactgttagggtaagggaatgtatgtacacatctattttttatacttt ttttttaaaaaaagaatgtcagttgttatttattcaaattatctcacattatgtgttcaa catttttatgctgaagtttcccttagacattttatgtcttgcttgtagggcataatgcct tgtttaatgtccattctqcagcgtttctc >34075 at HG-U95Av2 aggacaacgactaccaccgcagcgacgagcaggtgagcannnnnnnnnnnnnnnnnnnnn nnnnnnnnnncgggetgaagcggaagtggatccgctgctcagcccaggcgaccgtcttgc atctgaagaagttcatcgccaaaaaactcaacctttcatcctttaacgagctggacattt tatgcaacgaggagatcctgggcaaggaccacacactcaagttcgtggttgtcactaggt ggagattcaagaaggcgccgctcctgctgcactacagacccaagatggacttgctgtgaa tggtgccacacagcgcccacagactgggcnntcgcacccttggntnntcccggccgncgc gettaagaacattgcctctgggtgtcatgtggaccagacttctgaataga >34082 at HG-U95Av2 actctgtgcccgaatggtggtgcaggcgccctgtcctggttgtgttgttacgtgtttgac cagcacaggggtccggtggggaaaatgtatgggttnntntcagttgttgotantnctgan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnat gattgtgtttaggtttgaaattgctcaagtgtctggctcaggtggtggttctgagacnnn nnnnnnnnnnnngagcccagatgcttaggtccactagggcccatctagggaagggaaagg agatttcagcggnttccccgaaaggaacaggactgtcgggatgcttccoggatgtctaca gttgccccttcctgcagtgagattactgcttcctgtttccctccagotcttcccagcagc agtgagggagtattaagagggatcttgtagtcgctgcctggctcttgtgggcggcccttt aagactcaggttgagctcagccaagtcccgcttgcgccaggntttgattcaaggtngtca gnaagttagattgtcaaaacatttcgagagagaggcag >34209 at HG-U95Av2 agatacggcatcaggacttacacctcctgcctgacccccaggettctctctcctttctcc cagcaaactgcagtggcagaaaggaggttcagaggctgggaaagtgggcctccccttgca actcagagctgctgcactcaggagggccccatccaatcccgggcccctgcagggaaaagc gctgggtgtgtgtcanaggcgcagggtgggtggggctgccagccaggaccctggcctgca WO 2005/068655 PCT/GB2005/000057 78 gcctgatccaaaccaaagactgtagaaccctggggtgtggetaacggcccctccagcacc catagccaggtcttcctggcccttgaggctgggctggcggacaggcacctacc >34232 at HG-U95AV2 atatggcaacggaacatectcaagcagaggtagtaaaacaggnnnnnnnnnnnnnnnaaa gtaaagtgttgggtgaagtggggaaacaggacagcagctctgctagttggctagnnnnn nnnnnnnnnncgggaagaaggaggtggctgagaagagccagatcaacctcattgataaga aatggaagcccctgcaaggtgtggggaacctggcagnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaatgaaaccacaaggcttgagaatag aaattaaaagcaaaaataaagttcggcctgggtctctctttgatgaagtaagaaagacag cacgcttaaaccgtagaccaagaaatcaggagagttcaagtgatgagcagacgcctagtc gggatgatgatagccagtccaggagtccaagtagatctcgaagtaaatctgaaaccaaat caagacacagaacaaggtctgtctcctatagtcactcaagaagtcgatc >34261 at HG-U95Av2 ctctaactggcctggctctggaagggctggtgaggactctgcctccttgcctgcctacaa ggtgcctggtttgcagcaggctctccgetctttccagcaaagctgctcagagagggtgtc cagcadagtggagaggccggaagtgagacgggcagacggcacctgcagcctgaaacgcac cgctcctgcgtgcgcccccacctggtcccoggatgcccccaccacctggacagaggccac actgactgcccacccagctgtggcgggaggtgcagagcagagggctttagggagcagtga ctgcggtcacccctttagttctctgggtgtagaccacaccacctcccactgggcaccccc caacacggtgtcctgccacccagcgcctggctccaggaaaacacgcttgccttccttccc ggcannntegccactctccttatggactctgttctgtttgtacatggctgacggaaatct ctttggt >34265 at HG-U95Av2 gatgctigacgaaaacccacattacctgttaggcctcagcatggcttatgtgcacgtgta aatggagtccctgtgaatgacagcatgtttcttacatagataattatggatacaaagcag ctgtatgtagatagtgtattgtcttcacaccgatgattctgctttttgctaaattagaat aagagcttttttgtttcttgggtttttaaaatgtgaatctgcaatgatcataaaaattaa aatgtgaatgtcaacaataaaaagcaagactatgaaaggctcagatttcttgcagtttaa aatggtgtctgaggttgtactattttggccaagtctgtagaaagctgtcatnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnntgggcattgttatacaccagtaaagaaggctgtac tcaagaggaggagctgacacatttcacttggetgcgtcttaataaacatgaatgc >34272 at HG-U95Av2 tgaattcatctcagtccaggcaaccaaagaggtgaacctggattcnnnnnnnnnnnnnnn nncaagccggaacatgctagagcctacaataacctgctttgatgaggcccagaagaagat tttcaacctgatggagaaggattcctaccgccgcttcctcaagtctcgattctatcttga tttggtca cccgtccagetgtggggcagaaaagcagaaaggagccaagagttcagcaga ctgtgcttccctggtccctcagtgtgcctaattctcacctgaaggcagagggatgaaatg ccaagactctatgctctggaaaacctgaggnnnnnnnnnnnnnnnnatnnnnnnnnnnnn nnnnnnnnnnattgtagnctaatattcatgctgcctgccatgt >34273 at HG-U95Av2 tgatttgaccactgacagcctccaccttgagcactattctaaggagcaaataccttagct cccttgagctggttttctctgatggcacttttgagctcctaagctgccagccttcccttc ttttcctgggtgctcagggcatgottattagcagctgggttggtatggagttggcagaca ggatgttcaacttaatgaagaaatacagctaaggccttgccagcaacacctgccgtaagt tactggetgagtgagggcatagaagttaaaggttactgtttttatcetctatcctttttt cctttcctgatcaaggtgctcttctcattttttcctgagaaccttagccatcagatgagg ctccttagtttattgtggttggttgttttttctttataatggctctgggctatatgccca tatttataaaccagcagcaggggaaagattatattttataagagggaacaaattttcaca atttgaaaagcccacataagttttctcttttnnnnnnnnnnnnnnnnnnnnnnnnninnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnctttttaggctctgagactaaatga >34288 at HG-U95Av2 tttgcaacaggcagagctgtgtcgcacagcagtgctgtncnnnanagccagctgaggaca ggcttgcctggacttctgtaagataggattttctgtgtttcctgaattttttatatggtg atttgtatttaaattttaagactttattttctcactattggtgtaccttataaatgtatt tgaaagttaaatatattttaaatattgtttgggaggcatagtgctgacatatattcagag WO 2005/068655 PCT/GB2005/000057 79 tgttgtagttttaaggttagcgtgacttcagttttgactaaggatgacactaattgttag ctgttttgaaattatatatatataaatatatataaatatataaatatatgccagtcttgg ctgaaatgttttatttaccatagttttatatctnnnnnnnnnnnnnnnnnnnnnnnnnat atggaacnnnnnnnnnnnnnnnntgcagtttgtgacattaatagtattgtaaagttacat tttaaaataaacnnnnnnnnnnnnnnnnnnnnaaatctgcacacacaacgaacagttgca tttcagagagttctctcaatttgtaagt >34304 s at HG-U95Av2 agtacttgctaaaaatggcaacagaggagtgaggagtgctgctgtagatgacaacctcca ttctattttagaataaattcccaacttctcttgctttctatgctgtttgtagtgaaataa tagaatgagcacccattcnnnnnnnnnnnnnnnnnnnnnnnnnnnncatgtttgaaatga ggtctgtttaaagtggcaatctcagatgcagtttggagagtcagatctttctccttgaat atctttcgataaacaacaaggtggtgtgatcttaatatatttgaaaaaaacttcattcto gtgagtcatttaaatgtgtacaatgtacacactggtacttagagtttctgttt >34375 at HG-U95Av2 ccagatgcaatcaatgccccagtcacctgctgntataacttcaccaataggaagatctca gtgcagaggctcgcgagctatagaagaatcaccagcagcaagtgtoccaaagaagctgtg atcttoaagaccattgtggccaaggagatctgtgctgaccccaagcagaagtgggttcag gattccatnggaccacctnggacaagcaaacccaaactccgaagacttgaacactcactc cacaacccaagaatctgcagctaacttattttaccctagetttccccagacaccctgttt tattttattataatgaattttgtttgttgatgtgaaacattatgccttaagtaatgttaa ttcttatttaagttattgatgttttaagtttatctttcatggtactagtgttttttagat acagagacttggggaaattgcttttcctcttgaaccacagttctacccctgggatgtttt gagggtctttgcaagaatcattaataca >34390 at HG-U95Av2 gtacagotgtgttctggtacaacctcttgcggancgggnnaagntgactaccgaacaaga catgctgcctgccctgtgcttgtgggctgcaagtgggtctccaataagtggttccatgaa cgaggacaggagttcttgagaccttgtggatcaacagaagttgactgacatccttttctg tccttccccttcctggtccttcagcccatgtcaacgtgacagacacctttgtatgttcct ttgtatgttcctatcaggctgatttttggagaaatgaatgtttgtctggagcagagggag accatactagggcgactcctgtgtgactgaagtcccagccettccattcagcctgtgcca tccctggccccaaggctaggatcaaagtggetgcagcagagttagctgtctagcgcctag caaggtgcctttgtacctcaggtgttttaggtgtgagatgtttnnnnnnnnnnnnnnnct gataccttgtttacatgtttgtttttatggcatttctatctattgtggct >34432 at HG-U95Av2 caggtggctcccagctgcattctgagaactctgtgattgggcaaggccctcccctgcccc accagcccccacccgcotggagacacaccctcccccacaatctttctagacaggtgcttc aggacagaggacaggcatggcttccccttgggcctcctcagtaggcggtctggcctgacc cccaacaaagaagcctggaggtcagagaagcaaatgcngagcctgctccctcctaagaag atcccaagaatccaatggctcagtccttggtgatctaagacagcaaagaagtgtgcaagg agggccctgttagetcccactgtcctggtttctcctcctggagtctaatttccttggccc tctgagccttttgagtetgggccctggtccaatgctgctgttgt >34636 at HG-U95Av2 tagaggggcaccttttcatggtetctgcacccagtgaacacattttactctagaggcatc acctgggaccttactc >34666 at HG-U95Av2 tgctctattgtagcatttcttgatgttgcttagtcacttatttcataaacaacttaatgt tctgaataatttcttactaaacattttgttattgggcaagtgattgaaaatagtaaatgc tttgtgtgnattgannctgnanttggncnattttcttcagagagctaaattacaattgtc atttataaaaccatcaaaaatattccatccatatactttggggacttgtagggatgcctt tctagtcctattctattgcagttatagaaaatetagtcttttgccccagttacttaaaaa taaaatattaaciLctttcccaagggaaacactcggctttctatagaaaattgcacttttt gtcgagtaatcctctgcagtgatacttctggtagatgtcacccagtggtttttgttaggt caaatgttcctgtatagtttttgc >34678 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 80 ccgaactatttgtcaatgaagattgtaaagccaaatgtgtaacaaaggcaaaggcttcat ttcaagagtcatccagcaatgagagaatcctgcctctgtagaccaacatccagtgtgatt ttgtgtctgagaccacaccccagtagcaggttacgccntgnnnncnnnnnncnnnnntnn nnnnnngnnnntnnnnnncnnnnnnnnnnnnnnnaacnnnnnnnnnnnnnnnnntgttat ctcttaagtattaaaagttttattttctaaagtttaaatcatgtttttcaaaatattttt caaggtggctggttccatttaaaaatcatctttttatatgtgtcttcggttctagacttc agottttggaaattgctaaatagaattcaaaaatctctgcatcctgaggtgatatacttc atatttgtaatnnnnnnnnnnnnnnnnnnnnnnnaannnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngcccacaaccattgctatattttgtatgga >34690_at HG-U95Av2 ttaaaaagccacattggagctcccttctacccactaaaaaataaccaatttttacatttt ttgagggggagtgagttttaggaaaggggaattaagattccagggagagctctggggatn nnnnnnnnnnnnnnnnnnntctctccccaagcccctttttagtgactaagtcaaggcccc aactcccctcccccaccctacgctgagcttattcgagttcattcgtactaataatccctc ctgcggcttcctcattgttgctgttttaggccaccccagctcagccaatgattcctttcc ctctgaatgtcagttttgtttttaaaagtcacttgcttannnnannnnagcgtatgtgta tttggnggggaaaancctaatttcnggggatttctgtggtaggtaatanggagaagaaan gggcactngggggctgttctccttccttccctggg >34720 at HG-U95Av2 tctcaccaacgaaggctaggaggcggcgtcagagntgnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnncactctgatttctaaaagttaaaaaaaatatatgaaatctctgtnnn nnnnnnnnnnnnnnnnnnnnttattaaatttcggcccttaacccagccttttccagtgtg taacccagtttgaaatcttaaaaaaagaaaaaatgaaaaaaaaaggaaaaaaagaaaaaa ggaaaaaaacagtttgaacacaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnctctgcatgcaacagtaaaaattaatataatattttccccacaaaagaaacactt aacagaggcaagtgcaatttataaatttatatctaaaggggaatcatgattataagtcct tcagcccttggactctaaattgaggggattaaaaagantttaaaataattttgaannnnn ttntnttnnncncnnnnnntnnnngnnnnnnnannncattaattcaagacaaatccatgt ggcttgagg >34748 at HG-U95Av2 tgctcagcaaaattgttgagtacctgttctgggcaggtcccacgctatatgcacaaagtt aagaaaaacttggtettagcccttngnnnnnnnnnnnnnnnnnngggcattaaggcaaag tagttccagtgatttaaaatacggttccaaatacgctaannnnnnnnnnnnnnnaccaga tttacagattggaaatactgcagatgatgtgaagttatcagttggaggagctgtgatta a gctggataataagagaacgtgccatctgtaaagcactcagaaggcagccatccctagatg ttggtttcatgtatattacactatctactactatccataaatgcaatnatatgcatgtta acaacattaaaaacagcaaacagcaatctaagtacagaaaagctttttgtgtgtttaaaa aaattgaagaaaattcaggaagaaacgtgttaataaacattgtactgttcttttgcttct caaaggaantattcacttgccactttggttatttttgagttttcgtacataggaagtttt atattgccagccttcctgtgataaagatattaa >34759 at HG-U95Av2 caaattgccatgttatggttctgccttgaaacagcacaatgaagtgtatcagtatattct gtgattatgaaacttatatgttgtgttgttttgtgtcttctgttgcctgtcctttgggcc agatgtgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnttacctaactttttgtatgttttcatgactgtgtgttattttc caaagctgttcctacctcaccatgaggctttatggattgtt >34760 at HG-U95Av2 cttgtagtgagcagtgtatggtctcttttgttcagaatttaaaactgataaccaatgaaa gccttttctcttattcctctaccgtcatttacatgataatctgaagctaatatgacaata tttaaatactaagtggtactagggaactacaagaatactgtaaagcttaagccattgtta tcactgtcatttagcatttaataacaaaactatacagaattatgtgcataccaatgaatg ttttgtaccatctagttaaattttttaaataaagttttatgggttaagcagaananaann nnnatactgaattttattaaaagtatatatacttcaaattcaaagcatcccttaggaccc acagaatatattaaaactaccacccttaaattttatatttttgctttaagacagacaatg caaaggtaactggcaagaggtgagcaaatgttttagaacatttatattattgcttaaaat gagatttgaaattgtaataaaattcttgnntatgaagtctgatgtcttctctgagcac WO 2005/068655 PCT/GB2005/000057 81 >34876 at HG-U95Av2 tgaggtgcccaacacccattcatctcaagtgcttcagtctttggtttatttcatgcactg tgccttcaaaatgaaatttttaaaagggactttaaatgaagttgaatagtagtttttaaa agtcaatttgtaatttatgtgaaatctaactgtaatgaggtcctttctgttttttatatg taaacagatctactaatcctgtataaaagttattttacgaanaaaaanaaaaaaaaaaaa nnnnctcataatcttttttcagatgnnnnnnnnnnnnnnnnnnnlffffllllfff nnntatttagtttttctgcctatgctagtggaaaaatagtaccaggatcagaatacaggg tatcacctatggaatgtttctgtatttatgaattgactcaaaagaaagotttgtttctga aatcgcat >34886_at HG-U95Av2 atcatacagatcaggcagtgtttaaaatgatggtaggtagcacagtggacagtctttgat catcatgtagaatatggctatgaatcaggaaagagattagaacatttaataatgtatgta cagctggtgcttagtttttttttaatctaaatttaattaccttattggatatttgatatt tggttatttaatcacannnnnnnnnnnnnnnnnnnnctgattggtgttttatctcctgtg atcctttgatggctttttttgcctaccatttcacagaggtttagacagcagtagtagotc cctaggagagtttactgatgaaacagcctctgcaaga >34887_at HG-U95Av2 gcactaccatagctacatcagtttgatacagtattgaaaaattatcagttatattttgct gtttatgatctatttgtagattaggattaaaatggatttaatccatttttaaggctgtgt gaatttttctaaacaagaaccatttgcaatatggatttcttagagattaaaccaattata acttattagcagtcgcgagcacatgttcatatagtcaatgtaaaaatacactaatgagta tttggtaaatcccagtaggcttttaccattagcataattttgtgttgtacaattaagtta caattacatctctaattttggataatattcattggttaacaataaagtgacaaaagctca nnnnnnnaaannnnanngnnnnnannnaacatggattttttgtatgtttcttgaaaatta caatctttatcacagccatgaatcaccacaacttaaaagtaagaagtagataggaaataa ttttaaatcctcatagatntactctttccccgatacctcttttggtatg >34916 s at HG-U95Av2 ccaactgcaccttggetgggaagcacaccctgcagccggccagcaatagotcggacgcaa totgtgaggacagggaccccccagccacgcagccccaggagacccagggccccccggcca ggcccatcactgtccagcccactgaagcctggcccagaacctcacagggaccctccaccc ggcccgtggaggtccccgggggncnnncggtnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncggagggaccaga ggctgccccccgatgcccnacaagncccctgggggaggcagtttccggacccccatccaa gaggagcaggccgacg >34975 at HG-U95Av2 cagatctgtcatgtatccctaaaaggagggagctggccactggctnttgggaaagccatg agtatatagttagcaaatactgaactttctcagatatggcattagatgcaagacaacctc ctagggattgatgcctaactgatggattctctttgagactatttagatattatgtgagca atttaaagaccagatctaagcaaattttgaaatagatgtttgttttttgtatttctcagt atggaaactaatgctgccactctcatccccgtcccaaccatctctgtcaaaaatatacct ttttcatatgatattctgagctaatctgataaaatctatgccaatatatactattgcttg tgt >35017 f at HG-U95Av2 tacctggagggcacctgcatggagtggctccgcagacacctggagaacgggaaggagacg ctgcagcgcgcggacccccccnaagacacacgtgacccaccnccctnnctctgaacatga ggcataacgaggtnctgggttctgggcttctaccctgcggagatcacattgacctggcag cgggatggggaggaccagacccaggacatggagctgtggagaccaggcccacaggggat ggaaccttccagaagtgggcggttgtggtagtgccttctggagaggaacagagatacaca tgccatgtgcagcacaaggggcntgcccaagcccctcatcctgagatgggagccctctcc ccagcccaccatccccattgtgggtatcattgctggcctggttctccttgg >35025 at HG-U95Av2 tttctggaggtctctgaacccagggaagacaagaaggaaagattttgttgttgtttgttt atttggtttccccagtagttagctttcttccctggattcctcacttttgaagagtgtgag gaaaacctatgtttggcgcttaagctttcagctcagcttaatgaagtgtttagcatagta WO 2005/068655 PCT/GB2005/000057 82 cctctgctatttgctgttattttatctgctatgctattgaagtttnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnntaatcttacaaagtgtcttggaattgtaggtgact attatttttccaagaaatatcccttaagatattaactgagaaggctgggggtttaatgtg gaaatgatgtttcaaaaggaatcctgtgatggaaatacaactggtatcttcactttttta ggaattgggaaatattttaatgtttcttggggaatatgttagagaattcccttactcttg attgtgggatactatttaattatttcactttagaaagctgagtgtttcacaccttatcta tgtag >35153 at HG-U95Av2 tacattctagatgcaagtctcttgtcggatatangtattgagatattacacctagtctgt ggcttgactgttttctttatgtcttttgatgaatagaagttttaaattttgacaaggtca aatttatttttttcttttgtttgatattttttctctccaatttaaccccaagatttcaga tattctgctctattatataaactttatatttttatatttgtgatctaccttgaattgata tgtatgttgtgaattatggatcagggttctttttttcccccatacaagtatccagtcatt gtaacactgtttattg >35168 f at HG-U95Av2 taaatggccaaagcttataggactctgtgacaggttgt >35261_at HG-U95Av2 cgcctagaagacagcggaactaagaaaagaagaggcctgtggacannnnnnnnnnnnnnn nnnnnnnnnnnnnnnncgaggtagacccagagctaacagaaaagctgaggaaattccgct tccgaaaagagacagacaatgcagccatcataatgaaggtggacaaagaccggcagatgg tggtgctgqgaggaagaatttcagaacatttccccagaggagctcaaaatggagttgccgg agagacagcccaggttcgtggtttacagctacaagtacgtgcatgacgatggccgagtgt cctaccctttgtgtttcatcttctncnncccttgggctgcaagccggnaacaacagatg atgtatgcaggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncaaaggtgttcgaa atccgcaccactgatgacctcactgaggcctggctccaagaaaagttgtctttctttcgt tgatctctgggctggggannnnnnnnnnnnnnnctgagtcctcaaggtgactggggact >35280 at HG-U95Av2 gatgcgcatcaatgtattttatcttattttctcaatctcctctctctttcctccacccat aataagagaatgttcctactcacacttcagctgggtcacatccatccctccattcatcct tccatccatctttccatccattaccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntaaatttaaacttacaaacnnnqnt tgncacaagtggtgtttattgcaataaccgcttggtttgcaacctctttgctcaacagaa catatgttgcaagaccctcccatgggggcacttgagttttggcaaggctgacagagctct gggttgtgcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnntaacaccagtgggaattgctggaggaaccagaggcacttc caccttggctgggaagactatggtgctgccttgcttct >35281 at HG-U95Av2 ataagcaacttcacagaacacgagacagcttgggaatcnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnngacagttttaagcagaggaataacatcaccactgtatatttcag aaagatcactagggcagcc >35320 at HG-U95Av2 gttcttgttcttcttaaatgtgacatgaaataattgtgctgctacattatactggaaatt aacaggggaaaagggaagagctcttggctcccttgaggtttgtagtggtgttaggagt ggttacaactgagcttttagtaaccatttaaccgtatgtaaacttggtttctaattaaaa aaaaatttctttttccaaaaaannaannnnnnnnnnnnnttaannnnnaantnntttntn nanannnntacaacaactttgatacaaaaatactgaaacagcaactaccacctggaatgg cacactaagtccacactgttaggattttctccttagaaag >35350 at HG-U95Av2 taatgaggctcctccgctctggacacaacccttttatagattaatttctctgccaattaa cttgtcattttcagtacatattttactattccacaccaaccataattacaacaagggatt tttcttatgcactcctatgcatgtgaataacatgtggtgtaattctgcttcttacagaag tattactgaaggtattatttccaatattatttggtttattatgcggatcttttttatata tgcagtcccatcccttctgtgccactcaatgccatccagacatggtttttccctccaggg WO 2005/068655 PCT/GB2005/000057 83 gcctnnnntctccagagggcacttcggctgcctctgcttcctctcattcgaggcccggct cttgctgacagaataggttccgttctgggcggtggttctcgagcctgccattcaaaacca aagcaaattggagcatttctcacaacatggtattgaagttcctttttgttctcaaaagtt gtgaccgtgttaaattgtactcccttagtcctgtaag >35366 at HG-U95Av2 aatggtacattttgccaaagaccacttatacttgagaacatggaagaatttgcctgatac tctctttggggaaaagagtctctcctcttttcctcaaaccccagtacactcagcctctct gnccccaccttctccntgactttngtcctcacttngcttctgcagtancattggaacctn gaattngaaagaaagtcttccttngaataattnggagtttgtcttgagaggcaaatatag ccccaagaatcacaagattcgaggaccatgtaggtcttttacgtagcccaaatccataaa ttagtctcactttttgtatttatcgtttcatattaaaccctctatatcaaatgttcatca tgattttgtatgatttttataactattttattcattttattagatttattctaaaatttt ttaatggtaaattcttaaactgtggaaaccactgaaggtgcttattaactgttctcccag atttgtacaagtattggatgattccttgagtttacagc >35367 at HG-U95Av2 acaattctgggcacggtgaagcccaatgcaaacagaattgctttagatttccaaagaggg aatgatgttgccttccactttaancccacgcttcaatgagaacaacaggagagtcattgt ttgcaatacanaangctggataataacntggggaagggaagaaagacagtcggttttccc atttgaaagtgggaaanccattcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaa atcagcaaactgggaatttctggtgacatagacctcaccagtgcttcatataccatgata taatctgaaaggggcagattaaaaaaaaaaaaagaatctaaaccttacatgtgtaaaggt ttcatg >35372 r at H-U95Av2 tatttqtgcaagaatttggaaaaatagaagatgaatcattgattgaatagttataaagat gttatagtaantttattttattttagatattaaatgatgttttattagataaatttcaat cagggtttttagattaaacaaacaaacaattgggtacccagttaaattttcatttcagat anacaacaaataattttttagtataagtacattattgtttatctgaaattttaattgaac taacaatcctagtttgatactcccagtcttnnnnnnnnnnnnnnngttggtagtgctgtg ttgaattacggaataatgagttagaactattaaaacagccaaaactccacagtcaatatt agtaatttcttgctggttgaaacttg >35396 at HG-U95Av2 aaatcctgcccaaaatgtgaagcttggttgactgatgttcatgatagaaagaataaaatg tttctctctctctannnnnnaaaannnaanagtttatttctgtgaaagaagtatttaaac tttcaatattttaactttttgtttttatttcttttagaaaaggccaatatacctatcncn ctttggaagtaaaaatacacactttcgtgtgtacctaaaaaaaaaatcgttgaaaatcaa ggccaaaggtagtgcaattttttcattaagatttaaaaaaaagggaatgatagtctttga aagaaaacagtaggcatccagcactggacaaaacatgggtatcaaagatgaataatcttt ggagattctggcagtgttttcccagaacaagtcaag >35410 at HG-U95Av2 ccctaggatgctatttaagttgtactgtattagaacactgggtgtgtcataccgttatct gtgcagaatatatttccttattcagaatttctaaaaatttaagttctgtaagggctaata tattctcttcctatggttttnnnnnnnnnnnnnnnnnittagtatggcataatgtcatgat ttactcattaaactttgattttgtatgctattttttcactataggatgactannnnnnnn nnnnnnnnntatacactttagatagatgaagaagcccaaaaacagataaattcctgattg ctaatttacatagaaatgtattctcttggttttttaaataaaagcaaaattaacaatgat ctgtgctctgaaagttttgaaaatatatttgaacaatttgaatataaattcatcatttag tcctcaaaatatatacagcattgctaagattttcagatatc >35414 s at HG-U95Av2 gccttctactggtgcctgcggaagcggcggaagccgggcagccacacacactcagcctct gaggacaacaccancaacaacgtgcgggannnnntgaannnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnncaacacggtccccannnagnantangngaacaagttgagctatgactta acatagccaaaatgtgagtggttgaatatgattaaaaatatcaaattaattgtgtgaact tggaagcacaccaatcttactttgtaaattctgatttcttttcaccattcgtacataata ctgaaccacttgtagatttgatttttttttttaatctactgcatttagggagtattctaa WO 2005/068655 PCT/GB2005/000057 84 taagctagttgaatacttgaaccataaaatgtccagtaagatcactgtttagatttgcca tagagtacactgcctgccttaagtgaggaaatnnnnnnnnnnnnnnnaagttcnnnnnnn nnnnnnnnnataaaacagagtaatcttgttggttcaccattgagaccgtgaagatacttt gtattgtcctattagtgttatatgaacatacaaatgcatctttgatg >35628 at HG-U95Av2 gcctctgtcatctgcctcatcaatgctantggttactacatctnccgtggggncgaattc cnagaaaaacacttnccgaaagaatccttctgaccccagagtggctgggcttgagaccat ctctacagccacagggcggaaactgctggtgtctgggtggtggggtatggtccgccatcc caactatcttggagacetcatcatggctctggettggtccttgccntgcggggtgtcaca cctgctgccctacttctacctcctctacttcaccgcgctgctggtgcaccgtgaggcccg ggatgagnnnnnnnnnnnnnnnnnnnnnnnnnnggcctggcaggagtactgccggcgtgt gccttaccgcatcatgccctacatctactgaagcggctccaccaccccaggtggggncat gtgcccactcatccaccagcacacccaggaccaggagcctcgacacacttgggactcaag ggcttgcaccccacccagccctgaggatgaacaacctcag >35638 at HG-U95Av2 tcacttttgcaagttccacagagtaagacattgggtctattccagctcattcattttata ttgaaaaaaataattttaaaaatggtggcttcagctccagcccctttccaaaatttttca accccaccctgtttggatttttaattaaaaactagtagttctcttggtgttaaaacactt ctgtcctgtgaggtttcccaatggtgtttttcttgtaaatgtgttggacaaatgtgaaga tgcattgtagtttaaccatatgcccacatttagtctctttattcctagttggtgagaaac ctgt >35664_at HG-U95Av2 gtacactcaagtctaagaatatatgagtggatcatttaccgccccccgccccacnnnnnn nnnnnnnnnnnnnnngtcnttttnnnnaataangtattcttctatggtagtannnnccta cagatctgnnncccttcttcttctaangggtaagtcataatctgtgtaatactacaattt atgggatgctcactatgccctgtttctcttctaaacaatttacatgtaatgtctcattcc tcacaataacccttgtaaagtgggcatgattanccatgatttttatagttgaagaaccta agacacagagaccaaggcccatgagctcatagggctgaggcaggatttggaatcaggcca tgtettctccagagcccacatccatcctttctctatattgcctcccacagatgtgctaaa atttatttaactaatcctttatcctctatttgtgttgtctcccattttttattattacaa tattactgtggtgaacatgc >35666_at HG-U95Av2 gaagaaggggccatcacaggatgccacccctgncntgggttgggnnnnnnnnnncacgac cagccccttcctgggtatttattctctatttattggggataggagaagaggcatcctgcc tgggtgggacagccccttcagccccttctcccctccccgcctggccanggcagggccacc ccactctacctccttagctttcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnagagctgacgggaggccccagctctgaggggagggggtccgtg gtanangcctggggccggtagaggctccccagggctcccttatgtccnnnnnnnnnnnnn nngggtgtggatgtaattagctctggggggcagttgggtagatgggtgggggctcctggt ggccttntgctgcccaggccacagccgcctttgggttccatcttgctaataaacactggc tctgggactagaaa >35702 at HG-U95Av2 aggaatgtgccctggagatcatcaaagggggagctctgcgccaagaagaagtgtattatg acagctcactctggaccactcttctgatcagaaatccatgcaggaagatcctggaatttc tctactcaacgagctataatatggacagattcataaacaagtaggaactccctgagggct gggcatgctgagggattttgggactgttctgtctcatgtttatctgagctcttatctatg aagacatcttcccagagtgtccccagagacatgcaagtcatgggtcacacctgacaaatg gaaggagttcctctaacatttgcaaaatggaaatgtaataataatgaatgtcatgcaccg ctgcagccagcagttgtaaaattgt >35724 at HG-U95Av2 acttcaaattggacccaggagccaaacattcccaacctatccctaaagggtggacaagct tcatttacacgatatctgnagatgtgtatattgggcccgatgatgcacaacaaaaaatag aacctcatcacacagcagtgcttggagaaggtgacagtgtccangtggagaacaaggatc ccaagagaagccactttgtcttaattgctggggagccattaagagaaccagttatccaac atggtccatttgtgatgaacaccaatgaagagatttctcaagctattcttgatttcagaa WO 2005/068655 PCT/GB2005/000057 85 acgcaaaaaatgggtttgaaagggccaaaacctggaaatcaaagattgggaactagtgga aagcggaagagcaggtcttgatgtgtcctagaattttgccatttnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnaaccttatttagccggtgcttctaaagaattccacactaacg tgataacatggtttttgtaacaataaatgtaggatatttcctggcacatgcaaa >35735 at HG-U95Av2 acacggtctatgagcaataatgtgatttctggacatngcccatgtataatcctcactgat gatttcaagctaangcaaaccacctnatacagagatctagaatctctttatgttctccag aggaaggtggaagaaaccatgggcaggagtaggaattgagtgataaacaattgggctaat gaagaaaacttctcttatnnnnnnnnnnnnnnnnattataacttcaatgggacactttag accattagacaattgacactggattaaacaaattcacataatgccaaatacacaatgtat ttatagcaacgtataatttgcaaagatggactttaaaagatgctgtgtaactaaactgaa ataattcaattacttattatttagaatgttaaagcttatgatagtcttttctaattctta acactcatacttgaaatctttctgagtttccccagaagagaatatgggattttttttgac atttttgacncatttaataatgctcttgtgtttacctagtatatgtagactttgtcttat gtgtcaaaagtcc >35766 at HG-U95Av2 tgaggagagcaccacagtggtcaccnacacagtctgctgaggttggagctgctgagacga cgctcacagagctgagacgtacagtccagtccttggagatcgacctggactccatgagaa atctgaaggccagcttggagaacagcctgagggaggtggaggcccnnntacgccctacag atggagcagctcaacgggatcctgctgcaccttgagtcagagctggcacagacccgggca gagggacagcgccaggcccaggagtatgaggccctgctgaacatcaaggtcaagctggan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggcgaggactttaatcttggtgat gccttggacagcagcaactccatgcaaaccatccaaaagaccaccacccgccggatagtg gatggcaaagtggtgtctgagaccaatgacaccaaagttctgaggc >35803_at HG-U95Av2 gtgtcattgctaaaacctcactgaacaganngcagccaaggtctgtgttcagcacttggt ctctgttgttacgtaaaataataagcatttaaaatagtttacagannnnntnnnnnngnn cnnttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnftnnnnnnnnnn nnnnnnnnnnnnnnnctttcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnntggcaggagagattaaggtaattacaacactcagttctatgtct tacaagcactttgtcttgtctctgcaagaaaattcgattccagtcatttcccataaaata cagacattttaccaacataatatgctttgattgatgcagcattatgctttgggcagtatt acaannnnnnnnnnnnnnnnnttctgtatttaaatattgtaaaaagaaaataagttataa ctgttataaagcagaacttttgttgcattttttaaactgttgaagtcactgtgtatgttt gtttggtcaatgtttccgc >35822_at HG-U95Av2 ggccagactatcaggcccatttgttccccntgcaccgagggaacaactcgagcntttga ggcttncctccnaactaccacttgccagcaacaaaangnaagagctgctccctgcacagg atatcaaagctctgtttgtgtctgaggaggagaaaaagctgactcggaaggaggtnctac atcaagaatggggataagaaaggcagotgtgagagagatgctcaatatngccccaggeta tgacaaagtcaaggacatctcagaggtggtcancccctcggttccntttgtactggangg agtgagtnccctatgctgacccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnttcaagttggtgtaatcagctggggagtagtgga tgtetgcaaaaaccagaagcggcaaaagcaggtacctnntcacgcccgagactttcacat caacctctttcaagtgctgccctggctgaaggagaaactccaagatgaggatttgggttt tc >35824 at HG-U95Av2 tgaaaatggccttggagcattatctttagttacttgaagagtttctagtttttttaaaat acagtttatgttaaaataatttttattaatttagagaagacaatcaatgtctgtgagaaa acggactttcttttggattttctttttgtggtcattgtgagtgattgctttttccttttc ttagtttcacattcttcctttgttctaaaacttagactgacatctagctttgacaatcat agtatgttttattttcctgagggggaataacttataatgctgtttagttttgtactattg gtgtgttggtgaatttttaaactgtgtgctaactgcaataaatt >35844 at HG-U95Av2 tacagtaaccacatgcggctgtttaaagttaagccaattaaaatcacataagattaaaaa WO 2005/068655 PCT/GB2005/000057 86 ttnnnnnnnnnnnnnnnntaaccacgtttctagaggcgtcactgtatgtagttcatggct actgtactgacagcgagagcatgtccatctgttggacagcactattctagagaactaaac tggcttaacgagtcacagcctcagctgtgctgggacgacccttgtctccctgggtaggnn ngggggggaatgggggagggctnnatnngnccccagctggggcctgttgtctgggaccct ccatctcctgagaggggaggcctggtggettagcctgggcaggtcgtgtctcctcctgac cccagtggctgeggtgaggggaaccaccctcccttgotgcaccagtggccattagctccc gtcaccactgcaacccagggtcccagctggctgggtcctcttctgcccccagtgcccttc cccttgggctgtgttggagtgagcacctcctctgtaggcacctatcacactgttgtc >35938_at HG-U95Av2 aggcagtttgcaatcccatgacaactggatttaaaagtacagtacagatagtcgtactga tcatgagagactggctgatacncaaagttgcagttacttagctgcatgagaataatacta ttataagttaggttgacaaatgatgttgattatgtaaggatatacttagctacattttca gtcagtatgaaettcctgatacaaatgtagggatatatactgtatttttaaacatttctc accaactttcttatgtgtgttctttttaaaaattttttttcttttaaaatatttaacagt tcaatctcaataagacctogcattatgtatgaatgtta >35966 at HG-U95Av2 ccatttttaagaagaggtgttccagttctgcatctgataccgtctcctttccctgaagtc tggcacaccatggatgacaatgaagaaaatttggatgaatcaaccattgacaatctaaac aaaatcctacaagtctttgtgttggaatatcttcatttgtaatactctgatttagtttag gataattggttctagaattgaattcaaaagtcaaggcatcatttaaaataatctgatttc agacaaatgctgtgtggaaacatctatcctatagatcatcctattcttatgtgtctttgg ttatcagatcaattacagaataattgtgttgtganannnnnnnnnaaattgctcattaat ttttatttacagattgaaaaagaggcaccgtgtaaagaaaatggcaaaataaatatcttt ccannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggaannangtagcc ttnnnnattttatgattttttcatatgtggaaatctattacatgtaatacaaaacaaaca tgtagtttgaaggcggtcagatttctttgagaaatc >35992 at HG-U95Av2 tggagacacacttcccagatcaccgcanngnnnnnnnnnnnnnnnnngntctnggncgtt cnggentncctgccgggtggettcttcaatcccgtetcottcccaagctcccggcttttt ctaatcaggcaggcgtctgtcaaccctctcnncnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnntgcgccaacctgtgtggggtcttcttegggcctccctctccgconcgctcctgctc ctacctgcagcacccccagctccgactccagactctctgcatcaggtctccccactccac gctccgggcgccccaactccaacaccacgtcctgncgcgcaggttctnncccnngcggag gagcgcgcagggtgggcggcttaccatagcaagtgatcctgegatagggaacgcgccctt gcccogaggctgcactaccacaggaaataac >36057 at HG-U95Av2 aaattctgattggttatgtaccgtcaaaagacttgaagaaatttcatgattttgcagtgt ggaagogttgaaaattgaaagttactgcttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnaatgtatcatccagagtgatgttatctgtgacagtcacca gctttaagctgaaccattttatgaataccaaataaatagacctcttgtactgaaaacata tttgtgactttaatcgtgotgcttggatagaaatatttttactggttcttctgaattgac agtaaacctgtccattatgaatggcctactgttctattattt >36059 at HG-U95Av2 gaaggatcttattgcacttgggctgttcagaatgtagaaaggacatatttgaggaagtat ctatttgagcactgatttactctgtaaaannnnnnnnnnnnnnnnnntaaactannnnnn nnnnnnnnnnnnnnnnnnnntgtaatggttttaacgttactcactggagagattggactt tctggagttatttaaccactatgttcagtattttaggactttatgataatttaatataaa tttagcttttcttaatcannnnnnnnnnnnnnnannnatgactaatcctgcacctgctct gtctggcagacccatgctgtggaaaacctgcttacagacatcacttttaagtcctttgtg gatgtgggcacagtgaagagcaataaanantgtgaggttcctgntggagttttcagctca totggagaagacaggtegaaggccagagttccttgactgatgaaacctttatttoctctg gaagaaggaatgggtagatggggtttcctctttgagttgc >36065 at HG-U95Av2 ggcccagcaaggtaatttatggttgagctgatgtcaattggttctngtcttgagtcgact caatttagcccaagtgctgaaacaagaaatgtcatttttttcatcaaagacaccagggca WO 2005/068655 PCT/GB2005/000057 87 gatttttaagtaaagaaagacaattggacccttaagaatttatgcatttgtaaagttgct gttgatccaaatattttcaagccatgtaatccattggttttgtgggcagtttaataaacc tgaacctttgtgtgttttctaattgtacctgagttgaccatcctttctttttatagtata tttcttgtatgatattttgtaaagctctcacctggttcttttatggggacttttcgtttt tgggcaactccagtgtatttatgtgaaactttataagagaattaatttttccatttgcat attaatatgttcctccacacatgtaaaggcacagtggctccgtgtg >36103 at HG-U95Av2 agcaggagcctgagccttgggaacatgcgtgtgacctccacagctacctcttctatggac tggtnnnnnnnnnnnnnnnncactgtgggactcttcttaacttaaattttaatttattta tactatttagtttttgtaatttattttcgatttcacagtgtgtttgtgattgtttgctct gagagttcccctgtcccctccncnttccctcacanngngtctggtgacnnnnnnnnnnnn nnnnnnnnnnnnngtaggcagtcatggcaccaaagccaccagactgacaaatgtgtatcg gatgcttttgttcagggctgtgatcggcctggggaaataata >36149 at HG-U95Av2 tgggcagccagcattcattgtaagttccctctttgaaaactggtgtgtgggtgttcagtt ctgtgtctggtgggtatggacagacagtaatctcctgtgatctgtgctagctgtgaggca gctctggaannnnnnnnnnnnnnnggtttgaaccgtgaacaaaactgtgttttgagttta gctgacattaaagaaaaaagttcatcacgtgactgttaatgtaaacctggttattaaaat aactatgaaattannaaaaaaaaaaaaaaaaannnaaaannnnnnnnnatttaaaacagg agaaatctggtaagttgttaggnttctaaattccttttagtctgttcactgagatattaa atttcagtagacagaacccaaaaagagatttcatttctttctaatcactttggcttctnt ctnttttnttaagtaggtaaaaaccttccttggtgggcacctaagcaggatgcagccaat tagttcatgaacccagctgcgga >36156_at HG-U95Av2 taagtcctttcaattccaccagggccagagcagctccaccactgtgcacttagccatgat ggcaacagaaaccaagagacacaattacgcaggtatttagaagcagagggacaaccagaa ggcccttaactatcaccagtgcatcacatctgcacactctcttctccattccctagcagg aacttctagctcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnntttcagctagacaatg atttggccaggcctagtaaccaaggccctgtctctggctactccctggaccacgaggctg attcctctcatttccagcttctcagtttctgcctgggcaatgnccaggggccaggagtgg ggagagttgtgatggaggggagaggggtcacacccaccccctgcctggttnntaggctgc tgcacaccaaggccctgcatctgtctgctctgcat >36175_s at HG-U95Av2 tagagcttggttatcggccggcccggtggnttggcaggcagtgctgtgcgctnntcnatg gagaagacctgggcttagcaatctccttagttcttgctacacaggatggtgactggaact aaggctacacagagggtcgcacttggactctganggttgggtgtggaagggggaaaaggg gatggagacctgctnccccagctcttcctgtcagccggtttancatgggaancagggtta ancatctgtgttnaggggaggtncaccttaccctttttcataggggaagagtgtcacact cctggctatctcagggggaatggggaaaagaatctttcaagggcaaagaactcgtgggag gatgtctgttgtatgtaatactcacaatggcttttggttagtgttgaaggtgggaagagc atttgtaggtccagaagagtgaaagagagggaggggtgcagcaacatgtgcacaggcacg cacanntntgcacgcacacatacaatctgggttatctttgtgctat >36215 at HG-U95Av2 gtctgatcgatcatgcagatacaatgttggtatttgagaggttagtttttttncctacac ttttttttgccaactgacttaacaacattgctgtcaggtggaaatttcaagcacttntgc acatttagttcagtgtttgttgagaatccatggcttaacccacttgttttgctatttttt tctttgettttaattttccccatctgattttatctctgcgtttcagtgacctaccttaaa acaacacacgagaagagttaaactgggttcattttaatgatcaatttacctgcatataaa atttatttttaatcaagctgatcttaatgtatataatcattctatttgctttnnnnnnnn nnnnnnnnnnnnnnnaacaccacttcttttcatctgtaccacaccctggtgaaacctttg aagacataaaaaaaacctgtctgagatgttctttctaccaatctatatgtctttcggttn nnnnnnnnnnnnnnnnnnnnnnnnnnngtaaatgctgatattgatttcactggtccatct atatttaaaacgtgcaagaaaaaaataaaatactctgctctagcaagttttgtg >36227 at HG-U95Av2 taccaaaaccagtgaagtgtaagaaacccagactgaacttaccgtgagcgacaaagatga WO 2005/068655 PCT/GB2005/000057 88 tttaaaagggaagtctagagttcctagtctccctcacagcacagagaagacaaaattagc aaaaccccactacacagtctgcaagattctgaaacattgctttgaccactcttcctgagt tcagtggcactcaacatgagtcaagagcatcctgottctnnnnnnnnnnnnnnnnnnnnn ngtttaaggtgacccaatgattcagcta >36233 at HG-U95Av2 ctgaaaccaagaaggatctgtatgaacccactcatgggggcaaggtcttgagcatggccc ctgnnctcacctctgtggaaatcattccattccgagtggctgcctacaacaaagccaaaa aagccatggacttctatgatccagcaaggcacaatgagtttgacttcatctcaggaactc gaatgaggaagctcgcccgggaaggnnnnnnnnnnnnnnnnnnnnnnnnnnnccccaaag catggaaggtcctgacagattattacaggtccctggagaagaactaagcctttggnncca gagtttctttctgaagtgctct >36314 at HG-U95Av2 aacttctcccggtgcctggagctgcagtgtcagcccgactcotcaaccntgccaccccca tggagtecccggcccctggaggccacagccccgacagccccgcagccccctctgctcctc ctactgctgctgcccgtgggcctcctgctgctggcngotgcnnnnnnnnnnnnnnnncag aggacgcggcggaggacaccccgccctggggagcaggtgccccccgtccccagtccccag gacctgotgcttgtggagcactgacctggccaaggcctcatcctnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnncccttccttgggcccctctcattccctccccagaatggaggcaacgccaga atccagcaccggccccanttacccaactctgtacaaagcccttgtccccatgaaattgta ta >36344 at HG-U95Av2 tttgcctgagcagctcttggtgggagacatgttcaattacttoctctctctggccattgg ggtctttctgttcccagccttcctcacagcctcnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnncttctgccatggatgaaaactcagagaagaaaaggaagagggccatcaaactcat tgtcactgtcctggccatgtacctgatctgcttcactcctagtaaccttctgcttgtggt gcattattttctgattaanagccagggccagagccatgtctatgccctgtacattgtagc cctctgcctctctacccttaacagctgcatcgacccctttgtetattnnnnnnnnnnnnn nnnnnnnnnnnnnnnngcaaagaacgctctcctttgccgaagtgtccgcactgtaaagca gatgcaagtatccctcacctcaaagaaacactccaggaaatccagotcttactcttcaag ttcaaccactgttaagacctcctattgag >36345 g at HG-U95Av2 tgttaagacctcctattgagttttccaggtoctcagatgggaattgcacagtaggatgtg gaacctgtttaatgttatgaggacgtgtctgttatttcctaatcaaaaagg >36377 at HG-U95Av2 ggcgaaagatatctctccattgtgcatctgcctcttttgacgttggaagacacatgtctt actccccaaagggagcccagcactgggagccttcttgatgatctcaaaaataatagctat tcaagaaaatcaccaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntg ggagcaacatgaatgttctacaaaagtttaaagcagagattgtttcaaatgggtgtagta gatattactgaaaaccaaaaaagagtgagattgtcagtgtaagaatgtgatttaatgttt gtagtgcttacaattttgtgtaccaactggatgactaaaaagagtaaaataatttaatta atagctcatattttatgtgtgaaaacatgttagtgaacatatataatcaaaatagatttc attgctattgcatagtc >36445 at HG-U95Av2 cagtactttggacatgctctggaggagaaagattggtcctcagatgaccctttctcatg ctgcaggattocatgctactag >36543 at HG-U95Av2 gggtgcatttctaggacttttctaacatatgtctataatatagtgtttaggttctttttt ttttcaggaatacatttggaaattcaaaacaattggcaaactttgtattaatgtgttaag tgcaggagacattnnnnnnnnnnnnnnnnnnctaatatgctttacaatctgcactttaac tgacttaagtggcattaaacatttgagagctaactatatttttataagactactatacaa actacagagtttatgatttaaggtacttaaagcttctatggttgacattg >36550 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 89 ggaaccacctatgcttaaaatactgtaaatatgcantgaggtttggcaaaatctattcca tgtgtgatttgcttgtagaaacaattttgaaagccccttgaggaaaataaaaatcaagaa gaacacttttctcccttttccatacaaattaaaacttaacagcatcaaattattgggacc agaaaccaagtaatgtataatgtggcttttgttgagttaaataagatgctatataatgga gaagaatttgaaaatgcacaaaaaaatcaatctacattatcagnnnnnnnnnnnnnnnnn nnnntatgttaaatannnnnnnnnnnnnnnnnnnnnaactatgagggtcttgtatccacg taacacaggtagttacaaaaacatgttattgtactgtgtaaagatgcatagtcatctcat ttggttggctttgtaccttgtaccttttttagccttggcttttgttgaactagaaccctc agca >36564_at HG-U95Av2 gcaccgagcccaagtgcccatatgaacctctctgccctagccgagggacaaactgtnnnn nnnnnnnnnnnnnnnnnnnnnnagagtatgaagtggaatgaatgctcctgttctgagaag cacacttgtaactgcatcttttgga >36578 at HG-U95Av2 tatgccaggaatgtgccccttctctaagaaaatgccctatttgcaggggtataatcaagg gtactgttcgtacatttctctcttaaagaaaaatagtctatattttaacctgcataaaaa ggtctttaaaatattgttgaacacttgaagccatctaaagtaaaaagggaattatgagtt tttcaattagtaacattcatgttctagtctgctttggtactaataatctnnnnnnnnnnn nnnnnnnntcatatatttaatcttaatctgtttatttacaagggaagatttatgtttggt gaactatattagtatgtatgtqtacctaagggagtagtnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnactggatttgttgttctttcagaaagctttgaatactaaattatagtgt agaaaagaactggaaaccaggaactctggagttcatcagagttatggtgccgaattgtct ttggtgcttttcacttgtgttttaaaataaggatttttctcttatttctccccctagttt gtgagaaacatctcaataaagtgctt >36600 at HG-U95Av2 cagatacctoggattgaggatggtaacaattttnggagtggctgtccaggagaaggtgtt tgagctgatgaccagcctccacaccaagnctagaaggcttccacactcaaatctctaagt atttctctgagcgtggtgatgcagtgactaaagcagccaagcagccccatgtnnnnnnnn nnnnnnngctggtgcacgagctggatgaggcagagtaccgggacatccggctgatggtca tggagatccgcaatgcttatgctgtgttatatgacatcatcctgaagaacttcgagaagc tcaagaagcccaggggagaaacaaagggaatgatctattgagagccctctctcccannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntggnnnnnnnnnnnnnnnnncaaac ttgcttctgttgagatttttccctcac >36658 at HG-U95Av2 gaccttatccacaacccggggcttggaaaggaaggtattttggaatcacaccctccggtt atgttgctccagtaaaatctnnnnnnnnnnnnnnnnnnnnttcttagcatggtgagctga gttcatggcttttttttgtagccagtcctgtccctggnccatccatgtgatggttttgga tggagttaaacttgnatgccagtgggcagtgcatgtggaaagtatcagagtaagnonnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnanggttttctttagaatcagaattgta gccagtttctttggccagaaggatgaatacttggatattactgaaagggaggggtggaga tgggtgtggcagtgtatggtgtgtgatttttattttettctttggtcatgggggccaagg agaaaggcatgaatcttccctgtcaggctcttacanccacaggcactgtgtctactgtct g >36659 at HG-U95Av2 acagacgagacaacagcacacaggcagccagcegtnggccagaggntcgaggggnnctca ggggcntcaggenaccogtnccccacacganngggccccgtngggtgggcctnggccctn gctttnctacngnccaatgttatgnccagctnccatgttctncccaaataccngttgnat gtgaattattttaaaggcaaaacngtgctctttannttttanaaaacactgataatcaca ctgcggtaggtcattcttttgccacatccctatagaccactgggtttggcaaaactcagg cagaagtggagaccnttctagacatcantgtcagccttgctacttgaaggtacaccccat agggtcggaggtgctgtccccactgccccacnttgtccctgagatttaacccctccactg ctgggggtgagotgtactcttctgactgc >36690 at HG-U95Av2 gactattttcaagcaacctggtecacccaggattagtgaccaggttttcaggaaaggatt tgcttctctctagaaaatgtctgaaaggattttattttnnnnnnnnnnnnnnnnngaaaa WO 2005/068655 PCT/GB2005/000057 90 taccctcctcaaataacttgcttaactacatatagattcaagtgtgtcaatattctattt tgtatattaaatgctatataatggggacaaatctatattatactgtgtatggcattatta agaagctttttcattattttttatcacagtaattttaaaatgtgtaaaaattaaaaccag tgactcctgtttaaaaataaaagntgtagttttttattcatgctgaataataatctgtag ttaaaaaaaaagtgtnnnnnnnnnnnnnnnntgaaatgtcagactgtaaaaccttgtgtg gaaatgtttaacttttattttttcatttaaatttgctgttctggtattacc >36691_at HG-U95Av2 cttcagcgccactggctggaaggtgggctgggtcctgggtccagatcacatcatgaagca cctgcggaccgtgcaccagaactccgtcttccactgccccacgcagagccaggctgcagt agccgagagctttgaacgggagcagctgctcttccgccaacccagcagctactttgtgca gttcccgcaggccatgcagcgctgccgtgaccacatgatacgtagcctacagtcagtggg cctgaagcccatcatccctcagggcagctacttcctcatcacagacatctcagacttcaa gaggaagatgcctgacttgcctggagctgtggatgagccctatgacagacgcttcg >36700 at HG-U95Av2 tacaaactgtgacctcagcttcagagtgtcagggcctcacttgtatagaatgtaatgtto tcotcaaacatttatgttaactctataaacaaatatcgttaagttaaacaagttttcaaa aacaaaacaatttttaaagtaccttaaaattgaggatgttactcagtgttaacacatggg aacaccaaaatattcaataagcctggtcaattctatagtta >36711_at HG-U95Av2 ttgcacggatctaagttattctccccagccagagcccgngctnnctgctcccngggaaaa gntggcgtantggncctgagctgggntttatattttatatctgcaaataaatnacatttt atcntanatttagggaaagccngagagnaacaacaaaaaatgtttaagccnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnfnnnnnnnnnnnnnnnnnnnnntattgcccggctcct agaatttatttatttcctgacttacagcaagcgagttatcgtcttctgtattttg >36767_at HG-U95Av2 cagaggtagtctcactgcttgaactanlgctgagcaatctgaccctatqggtctaggacac agttcctgggaacatcacattcctctgcccttcctgcaggcaggaacaaacagggctgcc ttctggccttgtaagacccttattgotgtcctggaggggctggggacttgtgtctgcggg gatcagagcgcacagggagtgcacatatccaggcaccaggactagggctggagtgagggg ggggtatttcaattaccttctattggtctcccttctctacactcttgtaataaaatgtct atttttaatgtttgtacacaacaatccttctattctagcctgcattgagcttgcatgctt gcataagagcttaagaaccattgatttaatgtaatagggaaaattctaacccaggtatcc aaaaatgtgtaagaacaactacctgagctaaa >36790_at HG-U95Av2 gagaagttccattcaaagtgccaatgatagagtcaacanggaaggttaatgttggaaaca caatcaggtgtggattggtgctactttgaacaaaaggtccccCtgtggtcttttgttcaa cattgtacaat >36791_g_at HG-U95Av2 ctgagtttgcggagaggtcagtaactaaattggagaaaagcattgatgacttagaagaga aagtggctcatgccaaagaagaaaaccttagtatgcatcagatgctggatcagactttac tggagttaaacaacatgtgaaaacctccttagctgcgaccacattctttcattttgtttt gttttgttttgttttnnnnntaaacacctgcttaccccttaaatgcaatttatttacttt taccactgtcacagaaacatccacaagataccagctaggtcagggggtggggaaaacaca tacaaaaagncaagcccatgtcagggcgatcctggttcaaatgtgccatttcccgggttg atgctgccacactttgtagagagtttagcaacacagtgtgctta >36792 at HG-U95Av2 gaagaagttccattcctttctgattggcacacgtgcagctcatgacaatctgtaggataa caatcagtgtggatttccactcttttcagtccttcatgttaaagatttagacaccacata caactggt WO 2005/068655 PCT/GB2005/000057 91 >36825 at HG-U95Av2 cttggtttcactagtagtaaacattattattttttttatatttgcaaaggaaacatatct aatccttcctatangaangaacagtattgctgtaattccttttcttttcttcctcatttc ctctgccccttaaaagattgaagaaagagaaacttgtcaactcatatccacgttatctag caaagtacataagaatctatcactaagtaatgtatccttcagaatgtgttggtttaccag tgacaccccatattcatcacaaaattaaagcaagaagtccatagtaatttatttgctaat agtggatttttaatgctcagagtttctgaggtcaaattttatcttttcacttacaagctc tatgatcttaaataatttacttaatgtattttggtgtattttcctcaaattaatattggt gttcaagactatatctaattcctctgatcactnnnnnnnnnnnnnnnntattaaatgtaa ggcacttttctatgaattttaaatataaaaataaatattgttctgattattactgaaaan annnnagccatttcaatgtcttgggaa-acaa >36852_at HG-U95Av2 ccacggctatccttatagtgatctggactttgagtgagaagatgtgatttggaccatggc acttaaaaactctat >36879_at HG-U95Av2 cgagccctgtgctcgggaagtcccgcagaacgccggcagctgctgcctcgcgcccgggag caggaggagctgctggcgcccgcagatggcaccgtggagctggtccgggcgctgccgctg gcgctggtgctgcacgagctcggggccgggcgcanccgcgctgggganccgctccgcctg ggggtgggcgcanagctgctggtcgacgtgggtcagaggctgcgccgtgggaccccctgg ctccgcgtgcaccgggacggccccgcgctcagcggcccgcagagccgcgccctgcaggag gcgctngtactctccgaccgcgcgccattcgccgccccctcgcccttcgcagagctcgtt ctgccgccgcagcaataaagctcctttgccgegaaaa >36929 at HG-U95Av2 gtgcccggatccagagtgtgaagacagaggcagaggagctgtttggggagaccatggaga tgatggacaggatgaaagacatggagttggagctgctgcggggcanccnaggccatcatg ctgcgctcagcggacctgacaggactggagaagcgtgtggagcannnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngcong ttnccnnnnnnatctgccgcctttgcttttggttgggggcagattgggttggaatgcttt ccatctccaggagactttcatgnagcctaaagtacagcctggaccacccctggtgtgtag ctagtaagattaccctgagctgcagctgagcctgagccaatgggacagttacacttgaca gacaaagatggtggagattggcatgccattgaaactaagagctctcaagtcaaggaagct gggctgggcagtatcccccgcctttagttctccactggggag >36965_at HG-U95Av2 aatgcttgccgctttagaggtggatggtgctcataaaaggccccagtcgggggtatttaa aaaggactgaacagaaatccttagctagtagaatggnnnnfnnnnnnnnnnnnnnnnnnt gtattgtgtactggctataagatgtagacacctttcagtaagccaatcatttgtaaccat tctagcagtgtcatattaggttaataaggctgctgtgttttaaagggcatttttatttgg gttttggtgaaattctttaatttgttgattatattcacataaaatcagcattcattgaca catagctctaatgacatatgtatgaaaaaccatacactggatgacctagtcgattatt >37015 at HG-U95Av2 gtgaaaatctctcagaagaactcataaangaaaatacaagagtggagagaagctcttcaa tagctaangcatctccttacagtcactaatatagtagattttnaaagacaaaatttttct tttcttgantttttttaaacataagctaaatcatattagtattaatactacccatagaaa acttgacatgtagcttcttctgaaagaattatttgccttctgaaatgtgacccccaagtc ctatcctaaataaaaaaagacaaatteggatgtatgatctctctagctttgtcatagtta tgtgattttcctttgtagctacttttgcaggataataattttatagaaaaggaacagttg catttagcttctttcccttagtgactcttgaagtacttaacatacacgttaactgcagag taaattgctctgttcccagtagttataaagtccttg >37027 at HG-U95Av2 gttgcagacggaggtcaggtcttccnnnnnnnnnnnnnnnnnnnnnnnnnnnnagcaaac gcccacagatggcccagaggtggtggtagtcagggtgtgtgggtgtttttagggttcttt agtgttgtttcttnnnnnnnnnnnnnnnnnnnnnnnnnngtttggtgtgacggtgagag gaaattagaatctgtttgcaaattgtccaacccaccccctcaacatgaggggcttccatt ttctgtgttttgtaagggaactgtttccttcatgccgccatgttcctgatattagttctg atttctttttaacaaatgttannnnnnnnnnnnnnnnnnnnnnnnnnntaatggccaatt WO 2005/068655 PCT/GB2005/000057 92 aactgagaatgtaagaaaattgatgctgtacaaggcaaataaagctgtttattaaccttn aaaaaaaaaaaaaaaaaaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnan ncngccatgttcctgatattagttctgat >37168at HG-U95Av2 cagttgctcatttttatgggattgcttagctgggctgtaaagatgaaggcatcaaataaa ctcaa agt attttt aaattttttt gat aat agagaaacttcget aaccaact gtt cttt c ttgagtgtatagccccatcttgtggtaacttgctgcttctgcacttcatatccatatttc ctattgttcactttattctgtagagcagcctgccaagaattttatttctgctgttttttt tgctgctaaagaaaggaactaagtcaggatgttaacagaaaagtccacataaccctagaa ttcttagtcaaggaataattcaagtcagcctagagaccatgttgactttcctcatgtgtt tccttatgactcagtaagttggcaaggtcctgactttagtctta >37185 at HG-U95Av2 ctcaccctaaaactaagcgtgctgcttctgcaaaagatttttgtagatgagctgtgtgcc tcagaattgctatttcaaattgccaaaantttannnnnnnnnnnnnnnnnnnnctgctct tetgaacaacttctgctacccactaaataaaaacacagaaataattagacaattgtctat tataacatgacaaccctattaatcatttggtcttctaaaatgggatcatgcccatttaga ttttccttactatcagtttatttttataacattaacttttactttgttatttattatttt atataatggtgagtttttaaattattgctcactgcctatttaatgtagctaataaagtta tagaagcagatgatctgttaatttcctatctaataaatgcctttaattgttctcataatg aagaataagtaggtatccctccatgcccttct >37187_at HG-U95Av2 cgcctaatgtgtttgagcatcacttaggagaagtcntctatttatttatttattnattna tttgttngttttagaagnttctatgttaatattttatgtgtaaaataaggttatgantga atctacttgcacactcncccattatatttattgtttattttaggtcaaacccaagttagt tcaatcctgattcatatttaatttgaagatagaaggtttgcagatattctctagtcattt gttaatatttcttcgtgatgacatatcacatgtcagccactgtgatagaggctgaggaat ccaagaaaatggccagtnagatcaatgtgannnnnnnnnnnnnnnnnnnngtctattttg taactgtaaagatgaatgtcagttgttatttattgaaatgatttcacagtgtgtggtcaa catttctcatgttgaagctttaag >37218 at HG-U95Av2 gtgtaccagatttcagaacttatatttccacctcttccaatgtggcaccctttngcccag aaaaaagnccaggaatgtantcgagggaatggccatcagaatcactatcctcctcctgtt ccatttggttatccaaatcagggaagaaaaaataaaccatatcgcccaattocagtgaca tgggtacctcctcctggaatgcattgtgaccggaatcactggattaatcctcacatgtta gcacctcactaacttcgtttttgattgtgttggtgtcatgttgagaaaaaggtagaataa accttactacacattaaaagttaaaagttcttactaatagtagtgaagttagatgggcca aaccatcaaacttatttttatagaagttattgagaataatctttcttaaaaaatatatgc actttagatattgatatagtttgagaaattttattaaagttagtcaagtgccgaagtttt taatattggacttgagtatttatatattgtgcatcaactctgttggatacgagaacactg tagaagtggacgatttgttctagcacctttga >37221 at HG-U95Av2 tttatggtcccacttgtatatgaaaatgtggttagaatgttaattggataatgtatatat aagaagttaaagtatgtaaagtataacttcagccacatttttagaacactgtttaacatt tttgcaaaaccttcttgtaggaaaagagagctctctacatgaagatgacttgttttatat ttcagattttattttaaaagccatgtetgttaaacaagaaaaaacacaaaagaactccag attcctggttcatcattctgtattcttactcactttttcaagttatctattttgttgcat aaactaattgttaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagaactttgacca aggctataaannnnacnnacattattttcagtattgttggttatatttaaattttcctta caataaagcacacttttataatnaaaannngaattattgtttttcatacttttttgcttg tttcttaaagttttctgacgtgc >37241 at HG-U95Av2 catgacatctggaacacagaaagccctcaatacattgaagctcttaggattttcacgatg ttcctgtctgctcaatgcatgctttctttattgttctgacagttgtgtggtaacaagcta atatgcttccagttgacttccagtctaccctggtgttagaaaccgtttcatctcttattg taaatttgagtgcttgttgttttttatatttgtgatgannnnnnnnnnnnnnnttgacaa WO 2005/068655 PCT/GB2005/000057 93 ttgttagaggtttgacttttaaataattacttattttttctgattgtggttcagtttaac. tgaagaatatcctgagattgtaagaaaagcattttttaaaaggtatcacttgtgatcatt tatct >37255_at HG-U95Av2 gcttggacagccagtgccctcgtggnttcgggaagannnnnnnnnnnnnnnnnnnnnnnnn ntgtcccagcctcccataccagcaaaatgccccctgcttccctaagggtcaggtccagag cagggcccacaagggggattagagtggcctggnccctccccctctacctcagtagccccc aggcctgagatggctgagaagggaagggtatccttttcccacagttctgggacaaataaa ggggcttcctttggtaccccacataatagtgctaggtacctttgacccatcatcttggga ggtggggaggaatgagagggtccaggcagggtgtaggggaatgtattagtccaatgagat ttccctcttcatccgcagcagtgtatctattctatacctggctatgggagagaccccttg catgggagggaccccttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnccc ggcctccctaatgtcattcacattgaatggggatgaggtcggacagnngctcatagagcc gagtatgagccctagctgtgggctag >37286 at HG-U95Av2 caccttttttgctgtgaaactgaaatagtgaacttttctacgtattgacagcagattttt cgatgaaatcttcagagctttgcctatggggcacagtaggcctagtaacctggcatgttt gatatatgtaggtaaagcataatttaaagtaatcccaggtaaagatggccctaaatactt tcatgtctctatattcatttttcacagatccacctgtctcttgaaaatataaaaagacaa aacaggtttgccttggcatcagagagcacaaagattaaaagttactttaaatttgccaat attttgggagaacaataaaactacattttttcctcttccatactggtagatgcgaaattt atctgtgcatgaaagggtcacttctgtaatagtgcaacagatttggtattaaaaattaaa tgtggttttaaaagttcctctctcttttgtaatttatgttcccaattgagtgtgaatgtc caagtaatggtgtatgtaatggtacaggcaaatgtgactggatttc >37287 at HG-U95Av2 tgtaaatggttctcggagcttctttgggttaaagggtctaatgccaggaacagcatacaa agttcgagttggtgctgtgggggactctggttttgtgagttcagaggatgtgtttgagac aggcccagcgatggcaagccggc >37288_g at HG-U95Av2 ctcagggctggttcattggtctgatgtgtgctgttgctctccttatcttaattttgctga ttgtttgcttcatcagaagaaacaagggtggtaaatatccagttaaagaaaannnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnagaagaccacaagcctttgaaaaaaggaagtcgaactccttcagacaggactg tgaaaaaagaagatagtgacgacagcctagttgactatggagaaggggttaatggccagt tcaatgaggatggctcctttattggacaatacagtggtaagaaagagaaagagccggctg aaggaaacgaa >37352 at HG-U95Av2 gatgccaagacttggcctgcagaatgtcaggaatgtgaattaaaagctgctgtttccaga cgctttttattctgagcaccttcactaccttgtatccagttcatctgggaactccttttt gcattttagaaaatggaaagaggcaggaaattatgataaactcatgtttaacagaaagag tttcactgactaaatgtatgtaattatattttgttgttgtagaagaaataaatagcaaat ttgtggtattcttttttttaaacctgctctcattcctattaacactaagatcttagattt ttatagtgataaatgggttgacatcattgtcatttgtaattgtaaagcctcaaaagacaa ctgttcctactatgtaattatagacag >37353_g at HG-U95Av2 aagcaagcatggtgagaaggctcctatgacttctagaagtacatctacttggagaatacc cagcaggaagagacgtttcagcagtagtgacttttcagacctgagtaatggagaagagct tcaggaaacctgcagctcatccctaagaagagggtc >37354 at HG-U95Av2 ttctactttggaaaaacacagtgggaaaagaagaaaaaagagaaggcatagatctaaagt aaatggtctccaaagagggagaaagaaagacagacctagaaaacatttaactctgaataa caaagtccaaaagaaaagatggcaacaaagaggaagaaaagccaacactagacctttgaa aagaagaagaaaaagaggtccaagnatncccnaagntgaaaatattaattttaaacaatc tgaacttcctgtnacctgtggtgaggtganggncactctatntaaggagcgattcaaaca WO 2005/068655 PCT/GB2005/000057 94 aggaacctcaaagaagtgtntacagngtgaggataaaaagtggttcactcccagggaatt tgaaattgaaggagaccgcggagcatccaagaactggaagctaagtatacgctgcggtgg atataccctgaaagtcctgatggagaacaaatttctgccagaaccaccaagcacaagaaa aaaggtgatnnnnnnnnnnnnnnnnnnnaatgtctcgtctattatgttgttgattttcta tctctgtggacttac >37377 i at HG-U95Av2 ctctgtgcagtcactggaggttgaagccaagtggggtgctgggaggagggagagggaggt cactggaaaggggagagcctgctggcacccaccgtggaggaggaaggcaagagggggtgg aggggtgtggcagtggttttggcaaacgctaaagagcccttgcctc >37383f at HG-U95Av2 cctttgtgacttcaagagcctctggcatctctttctgcaaaggcanctgaatgtgtctgc gtncctgttagcataatgtgaggaggtggagagacagcccacccnngtgtccacngtgac ccctgtncccannctgacctgtgttncctccccnntcatctttcntgttccagagangtg ggnctggatgtctccatctctgtctcaa >37388 at HG-U95Av2 ttgacaaatgtatatgcctgagaactttgaatgatgctgaaagctagaagcaaaccaggt actcttcagtcagggactggttgaagattttatggatgaggagttagcaaaatatctata tatgcatatcttctgactcccagggatacataagaaacacagggcctagaacagtatgaa taaacacacatatacacaaacatcacagaagatactaaaggtat >37393_at HG-U95Av2 toccgatggccagtttgctttcctcattcccaacggggccttcgcncacagcggccntgt catccccgtctacaccagcaacagcggcacctccgtgggccccaacgcagtgtcaccttc cagcggcccctcgcttacggcggactccatgtggaggccgtggcggaactgaggggnnnt caggccnacccctcctcctaaactccccaacccacctctcttccctccggactctaaaca ggaacttgaatactgggagagaagaggacttttttgattaagtggttactttgtgttttt ttaatttctaagaagttactttttgtagagagagctgtattaagtgactgaccatgcact atatttgtatatattttatatgttcatattggattgcgcctttgtattataaaagctcag atgacatttcgttttttacacgagat >37402_at HG-U95Av2 aaaggtcacctgcaagaacgggcagggcaactgctacaagagcaactccagcatgcacat cacagactgccgcctgacaaacggctccanggtanccccaactgtgcataccggaccagc ccgaaggagagacacatcattgtggcctgtgaagggagcccatatgtgccagtccacttt gatgcttctgtggaggactctacctaaggtcagagcagcgagataccccacctccctcaa cctcatcotctccacagctgcctcttccctcttocttacctgctgtgaaagaagtaacta cagttagggctcctat >37417_at HG-U95Av2 ccgctcttcttgaatcatgctgggctgcccctgctcagcaccccgcctggtgtgggcctg gtctcagcagcggctgcggctgtggcagcctccatctccagcaagtctcctggcctctcc tcctcatcctcttcatcctcatcctcctcctcctccacttgcagcgagacggcagcacag acccctggaggtccaggggggcccgaggcagggtccaaacctgagtgagggccagccatg cctcccctcccattcctctggtccctgccttggtcccttgcctgggaagagggcgaggag gccagtggtggggacncagagggtcctcagagcaggagtgacaagggaggaaagaccaaa aaaacaaccaaccaaaaaaaaaaaaaaaaaaggaaagaaactaaccaacaaaagagaaaa ocaaaaataatcacaacagaaaccagctgccccaaaggaaccagaggtga >37419_g_at HG-U95Av2 gagaaacgcatcaacccctgcagtgcggcccccatgctgcccagcccagggaagccggcc agctacagcccccatatggtcacaccccaagggggcgcggggaccttaccgttgtcccaa gcttccagcagtctgagcacaacagttactaccttatcctcagctgtggggacgctccac cccagccggacagctggagggggtgggggcgggggcggggctgcgccccccctcaattcc atcccctctgtcactcccccacccccggccaccaccaacagcacaaaccccagccctcaa ggcagccactcggctatcggcttgtcaggcctga >37420 i at HG-U95Av2 cgcagatcctccaaaggcacacgttgcccaccaccccatctctgaccatgaggccaccct WO 2005/068655 PCT/GB2005/000057 95 gaggtgctgggccctgggcttctaccctgcggagatcacgctgacctggcagcgggatgg ggaggaacagacccaggacacagagttgtggagaccaggcctgcaggggatggaacctt ccagaagtgggccgctgtggtggtgccttctggagaggaacagagatacacatgccatgt gcagcacgaggggctgcconagccncnnatcctgagatgggagcagtctccccagcccac cannnnnnnnnnnnnnnntcgttgctggccttgttgtccttggagctgtggtcactggag ctgtggtcgctgctgtgatgtggaggaagaagagctcagatagaaacagagggagcnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggtgtctctcacagctaataaag tgtgagacagcttccttgtgtgggactgagaagcaagatatcaatgtagcagaattgcac ttgtgcctcacgaacatacat >37421_f at HG-U95Av2 ccgcagatacttggagaatgggaaggagacgCtacagcncgcagatcctccaaaggcaca cgttgcccaccaccccatctctgaccatgaggccaccctgaggtgctgggccctgggctt ctaccctgcggagatcacgctgacctggcagcgggatggggaggaacagacccaggacac agagcttgtggagaccaggcctgcaggggatggaaccttccagaagtgggccgctgtggt ggtgccttctggagaggaacagagatacacatgccatgtgcagcacgaggggctgcccna gccncnnatcctgagatgggcagtctccccagcccaccannnnnnnnnnnnnnnntcg ttgctggccttgttgtccttggagctgtggtcactggagctgtggtcgctgctgtgatgt ggaggaagaagagctcagataga.aacagagggagcnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnggtgtctctcacagctaataaagtg >37423 at HG-U95Av2 ttcataaatgttctatacagtggacagccctccagaatggtacttcagtgcctagtgtag taactgaaatcttcaatgacacattaacatcacaatggcgaatggtgacttttctttcac gatttcattaatttgaaagcacacaggaaagttgctccattgataacgtgtatggagact tcggttttagtcaattccatatctcaatcttaatggtgattcttctntgttgaactgaag tttgtqagagtagttttcctttgctacttgaatagcaataaaagCgtgttaactttttga ttgatgaaagaagtacaaaaagcctttagccttgaggtgccttctgaaattaaccaaat >37452_at HG-U95Av2 tagagactcaactatccaagtggtggagaatggggagtcctccnagggcegattttcegt ccagatgttccggtttgctggaaactatgadctagtctacctgnactgtgaagtctatct ctgtgacaccnnnnnnnnnnnnnnnnnntacctgctctgggaccagattccgaagtgg gagtgtcatagatcaatcccgtgtcctgaacttgqgtcccatcacacggaaaggtgtcca ggccacagtctcaagggcttttagcagcttgnnnnnnnnnnnnnnntggctgcctctgct tctctcggccaccttgaccctgacttttcagtgactgacagcggaaagccctgtgctcca tggctgccatctcacctcctgctgggcagggggcatgatgcgggccagtgctccagccac agaaaagaaagttcatgctttgttcagcctgccttct >37459 at HG-U95Av2 gagaccgggtgttcctccagatgccctcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnntccactcctcnnnttcnnnntanntattgtatcccatgtaanannnnnnnnannnna aanaaanaaannannnnnannntatagaagaaaatgacacaccaaaaaatccaaatgaaa aacataattgcttcaaaacacttacacagttggaaagttatatgtaagtgaaaatttgga ccattgtgtacaaataaaaactaagatgcatgtttaatactccananannngnnnngnaa nnncgaatgantgggatagagttatgtatcaagtactgacacttggttgtacccactgga atcatattagctgttttatgttatatgcttccacagtaacctgcttattcagatcagtca aaatatatcagtatgaaagatcatagctaatgaaaggcactcactcatattgtttacttt aaaatatttataaatangccttaaagaaatacaaatgatancaattananannnnannna nnnnnntaatttcctctgtatttgtgtagatactttg >37461 at HG-U95Av2 cgctcaaggccacaaccatgatgatncgaccagcagatttctaaacatcccagtccacct gaggaactgtctcgaactattttcaaagacttaagcccagtgcactgaaagtcacggctg cgcactgtgtcctcttccaccacagagggcgtgtgctcggtgctgacgggacccacatgc tccagattagagcctgtaaactttatcacttaaacttgcatcacttaacggaccaaagca agaccctaaacatccataattgtgattagacagaacacctatgcaaagatgaacccgagg ctgagaatcagactgacagtttacannnnnnnnnnnnnnnnnnaagaatgttatgtgcaa gtttatcagtaaataactggaaaacagaacacttatgttatacaatacagatcatcttgg aactgcattcttctgagcactgtttatacactgtgtaaatacccatatgtcctgaat WO 2005/068655 PCTGB2005OOOO57 96 >37484_at H-G-U95Av2 tcttttcgctattataaggaa Ctnnlfllfllfllflfflfflfflf nnnnnnnnnnnnnnnnnnnnnfl nnnnnnnnnnnnnnnnnlffnlrfffffat at ccaaagatggg ntcannnnnnnnfllfllflfflflftgtgaaagaaatgtataattcatgacaagtcatgtaact attacacggtctatgaataagctctaca >37493_at H-G-U95Av2 gattttgtaaatCatt~attataqcaatttggaatggtagaatttg gtagaatcctctgttcataatg >37494_at HG-U95Av2 gcccccttgggaggtcaacaacctgggaggtgttgagacccccaggcctagacagg agccaagggcagcctcctgtcaaggtagctagalflfnnnnnnnnnnnnnnnnnnnnnnn nngqcccccttgaccttcagcaaatcactt ctctccctgnnnllflfflfllfllflfflfllnn nnnnnnnnnnnnnnfffffflllttttt cctgtcaqgttaacttatttgtaggtt ctgcattat tgagctgagccttat >37514_s at HG-U95Av2 aggagcggcgctggaccctgactgcaccccccggctaccgcctgcgcctctacttcaccc acttcgacctgqagctct c 0 cacctctgcgagtacgacttcgtcaagctgagctcgqggq ccaaggtgctggccacgctgtgcgggcaggagagcacagacacggagcgggcccctggca acqagaagccgttcnnnnnnnnnnnnacgggctgcatc tctactgctcctgccgcgcagg >37534_at I-G-U95Av2 ttgagatcgtggtgt cttfflfflfllfllfllflfflfffgat caaggatgtagtatct cat ttatagattgaaatttcct aattt att ct aaannnnnnnnnnnnnflflfflflfflflfflnnn tcaaat acannnnnnnnnnnfllffllfflffllfflfnflnt tnnnnnnnnnllfllflfflfflf nnnnntgtgtg tgtcacttc tg tat cga >37565 at HG-U95Av2 gttctagaaqqgtatcCatgataacaaCaaccactttatflfflfllflffl gtggattcatttaaggtctactcaaaagtaacactgtca WO 2005/068655 PCT/GB2005/000057 97 >37608 g at HG-U95Av2 ttccagtcagcagaggaagccttgaggggcttgtatggtcgtgtgaggaaaggggctgtg cttgtctgtgcctgggctgaggagggcgccgacgccctgggccctgatggcaaattgctc cactcggatgetttaccgccaccccgcgtggtggatacactgnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnncggcaagaagtgtggcctgcagggctttgatggcatcgtgtgagag caggtgccggctcctcacacaccatggagactaccattgcggctgcatcgccttctcccc tccatccagcctggcgtccaggttgccctgttcaggggacagat >37611_at HG-U95Av2 ggatcgttatctactgactatattttcccttattactgcttgcagtaattcaactggaaa ttaaaaaaaaaaaactagactccattgtgccttactaaatatgggaatgtctaacttaaa tagctttgagatttcagctatgctagaggcttttattagnnnnnnnnnnnnnnnnnnnnn nnangttactaatatatctgtaacactattacagtattgctatttatattcattca,gata taagatttgtacatatttcatcctataaagaaacggtatgacttaattttagaaagaaa attatattctgtttattatgacaaatgaaagagaaaatatatatttttaatggaaagttt gtagcatttttctaataggtactgccatatttttctgtgtgg >37637 at HG-U95Av2 tccttaaagaactggctgatggggcaggaggtccaggcctgggctctnnnggncctccta gagggccattggagettgcagctcagacccccnactttgagttttatttatttaaatagt agttggatgottggacttgtctgaCCCfgaaacccttgcctcatcagttttcctga tttacaagtgcaatattttagccaatgccttgggagaagetgccatgcaaaggtggacac cattctccagcttcaggggatatgctcgtcccgggcaccggtggcaggcagctggccttc tggactaaggcagcctggggggacactgcagtctggctacacacagagatcntggcaccc cctgggtggagtgtccctcgggggctttgggaaagcatggcaccctcagaccacacagta gccaagttctggagcaa >37645 at HG-U95Av2 catttgcactactggaaggagttagatgttggtactagatactgaatgtaaacaaaggaa ttatggctggtaacataggtttttagtctaattgaatcccttaaactcagggagcattta taaatggacaaatgcttatgaaattaagatttgtaatatttctctctttttagagaaatt tgccaatttactttgttatttttccccaaaaagaatgggatgatcgtgtatttatttttt tacttcctcagctgtagacaggtccttttcgatggtacatatttctttgcctttataatc ttttatacagtgtcttacagagaaaagacataagcaaagactatgaggaatatttgcaag acatagaatagtgttggaaaatgtgcaatatgtgatnnnnnnnnnnnnnnntaggaaata ttctgtaatcttcagacctagaataatactagtcttataataggtttgtgactttoctaa atcaat >37695 at HG-U95Av2 gggcotgcgttaaaacctaattgctaatgcttcacaactaggagagcatgccgtcttgat gtttaaaaaacccagggtctccacccttcctttgatttgtgcaattctgtcttccacagt tccggagccttcagtgaggggtagctacatgccccatgcctgccctttctttccttcttt getcactttactatgggtgtattttaatcttgtataaaaatatnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaacagatttgat ttgtgtttttgaaatgtcagtacattttgtgccactaacactgtgatgtataaaagagct gtttgaatgccttttaatgttgtgttttgtactctggaatcatatggaaaaagtttgatt tgtaatttcaatacatattttaaatgtannnnnnnnnacgtagtttgtccccccctttag cagggattcctttttaaagct >37701 at HG-U95Av2 cataaagactgaccttgaattcagcctnnnnnnnnnnnnnnnatcactcagaactattga ttcaaagttgggtagtgaatcaggaagccagtaactgactaggagaagctggtatcagaa cagottccctcactgtgtacagaancgcaagaagggaataggtggtctgaacgtggtgtc tcactctgaaaagncaggaatgtaagatgatgaaagagancaatgtaatactgttggtnc caaaagcatttaaaatcaatagatctgggattatgtggccttaggtagctggttgtacat nctttnccctaaatcgatnccatngttanccacatagtagttttagtttagnnnnnnnnn nnnnnnnngtgtttactatgtgcaanggtattgaagttcttatgaccacagatcatcagt actgttgtctcatgtaatgctaaaacnnnnnnnnnnnnnnnntgcattgttaaaaatgat gtgtgaaatagaatgagtgctatggtgttgaaaactgcagtgtccgttatgagtgccaaa WO 2005/068655 PCT/GB2005/000057 98 aatctgtcttgaaggcagctacactttgaagtggtct >37712_g_at HG-U95Av2 gaggatatccatcagccatttcaacaacatatggtaccgagtactctctgagtagtgcag acctgtcatctctgtctgggtttaacaccgccagnnnnnncaccnnnnnnnnnnnnnnn nnnnnnnnnnnnnnacacctacataacatgccaccatctgccctcagtcagttgggagct tgcactagcactcatttatctcagagttcaaattctccctgccttctactcaaagcctc aacatcaagtcagaacctgtttctcctcctagagaccgtaccaccaccccttcgagatac coacaacacacgcgccacgaggcggggagatctctgttgacagttgagcagctgtagc agttcgtacgacgggagcgaccgagaggatcaccggaacgaattccactcccccattgga ctcaccagaccttcgccggacgaaagggaaagtcctcagtcaagcgcatgcgactttct gaaggatgggc >37745 s at HG-U95Av2 ctgctgtaagtttcttaactgttttttgtaacaagcaaagagaatatggcaaatatttg tatattcccaanggggccgggtgctttnnnnnnnnnnnnnnnatggatgaagtttcgct gggtgctcgtgactggccnagttttgtgcagctgactgtctcagccaaaccactgatctt ccctggaggccttnnnnnnnnncnnncnngentnnncctgaggtccccnntnnccagtcn nnnnnnnnnnnnnnnnnnnnnnnnnntgttatgtacaggaggaccttttaaaaaaatcaa gtttctattttttgctggtagtccgcatacccataccctctgtttttgaaaggcaaaggc caatcagtccccatttgtagcatggcaccagggtcttaggcctagtcctctcattcctcc caccctccgagatggtcagtgtgtcatgggaagcccacccccagctctgccagtgctctc tgggcctggctcccagtcagtggtggccacgatgcggtacagggcatccctccttcccat ctacgggtgttctcaataaacaatgtacagttgtttgggcccaga >37749 at HG-U95Av2 ctctgccagagtagtgaagctaattaaacacntttggtttctgaataaattgaactaaat ccaaactatttcctaaaatcacaggacattaaggaccaatagcatctgnnnnnnnnnnnn nnngttattagctgggaagaccaattctaacagcaaataacagtctgagactcctcatac ctcagtggttagaagcatgtctctcttgagctacagtagaggggaagggattgttgtgta gtcaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnt gcctgtcccagagaggctttccaatgtagctcagtaattcctgttactttacagacagga aagttccagaaactttaagaacaaactctgaaagacctatgagcaaatggtgctgaatac tttttttttaaagccacatttcattgtcttagtcaaagcaggattattaagtgattattt aaaattcgtttttttaaattagcaacttcaagtataacaactttgaaactgg >37785_at HG-U95Av2 ttgggggcctacagcagcctcaccttcagcttcatgcctcttccacacagcgtttccatg caggtcaggggatgggaggggtccctgagcccttcccttcccctctaaggaggcagcaac ggcagagtggggaantgganngnnnnnnnnnctnnntngnntnnnnnnnnccnngnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncagagccnaatgagaaggaaacctcatc tttgcatagcccatgccntcatggagaggtgacatcatacattcacatgttctcaccta agtccccagggt >37823 at HG-U95Av2 cccaggtgcagtgtgacattattttattataacanccncaaagagattatttttaaataa tttaaagcataatatttcttaaaaagtatttaattatatttaagttgttgatgttttaac tctatctgtcatacatcctagtgaatgtaaaatgcaaaatcctggtgatgtgttttttgt ttttgttttcctgtgagctcaactaagttcacggcaaaatgtcattgttctccctcctac ctgtctgtagtgttgtggggtcctcccatggatcatcaaggtgaaacactttggtattct ttggcaatcagtgctcctgtaagtcaaatgtgtgctttgtactgc >37830 at HG-U95Av2 acctgcctgcgctctccagatatganccctgcanccaccccccacagcntgccctacccc acctacnntgentcagentnggacttctcagtgggtggagtgccagggaggaggaggcac acggagacctggggctcggggcccctggattcctgcatctgcatatgcgtatttgccaaa gacgacagggtgggctggggtgcgctccggaggaacccccggcactgatgggcttctgcc cctgcccttcctcacactgacactttgtccccacaggaggtggtggggagcagagtgcccgcc ccgtggagatacnnccccagcgggggctgcgacatccatggccaccatggggcacctggc ggggcgggggtctgccggcctctgggcaaggcccctggagcatctogcccaggcttttta taccttacaatgtaacttttttattttattttactctatgattattcaggaatattatct WO 2005/068655 PCT/GB2005/000057 99 ctcagataagt >37841 at HG-U95Av2 gaaagcaggattccatcgctggaacaattacatgatggactggaaaaatcaatttaacga ttacactagcaagaaagaaagttgtgtgggtctctaattaatagatttaccctttataga acatattttcctttagatcaaggcaaaaatatcaggagcttttttacacacctactaaaa aagttattatgtagctgaaacaaaaatgccagaaggataatattgattcctcacatcttt aacttagtattttacctagcatttcaaaacccaaatggctagaacntgtttaattaaatt tcacaatataaagttctacagttaattatgtgcatattnnnnnnnnnnnnnnnnnnnnnt tctttctttccttaataaatttaagttttttccccccaaaattatcagtgctctgctttt agtcacgtgtattttca >37944 at HG-U95Av2 ccacttt gat gct atttgggtt at gat ggggcaagatggcagaggt att gggtt tttt tg tttttttccattcctctctacttctgtttcctagctttttctttctggagtttaagtaca gtgatggttggcttgagnnccttttnaaatctngcccagtataaacattagcctgcttaa tatttagacatttataggtagaattctgagcactcaactcatgtttggcattttaaagta aaaacaagtgtgacttcgaggaccaaagaaattgtcagctatacatttatctttatgaac tcatttatattcctttttaatgactcgttgttctaacatttcctagaagtgttcttataa aggtctaatgtatccacaggctgttgtttattagtaaatgcaaagtaatgactttgtct gttttactctagtctttagtacttcaaaattaccttttcatatccatgatcttgagtcca tttgggggatttttaagaatttgatgtatttcaatacactgttcaaaattaaattgttta attttatgtatgagtatgtatgttcctgaagttggtcctatt >38022s at HG-U95Av2 tcaacaagggcctggtggacaagatcatggtggaccgcnnnnnnnnnnnnnnnnnnnnnn nnnnnggcttcgaggacccacgcaccaagaccaagatgtcggccgcccaggccetgaaga agggctgctctactacgaggccggccagcgcttcctggaggtgcagtacctgaccggcg gottgatcgagcccgacacgccgggccgcgtgcccctggacgaggccctgcagnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngctggaccgcagcatggtgg aggagggcacggggctnnnnnnnnnnnnnnnnnnnnnnnnnnccaccaagggctactaca gcccctacagcg >38062 at HG-U95Av2 aaatcagtgacctgaagcaagaaatcttgccttttaatgtatcattaattagggctgctg tgatattgtcagcttgcattaacaattagaagatagagaacccgccatcagggtgnnnnn nnnnnnnnnnnnngactacacttggtagttttccaccatttaaagaactggtaaatatga aacatttgttgagttaccagaattgccattaacagtgttttctttcccatattccatgct ttctgcctctgtgtatatatataatatatatgtatatgactgtgctgtgtatttatcgaa gctagtaagcaataatttatatgtaaaaatggccaagcaatataaggttaaaacttatat aagtaacccttaccttatcttgtattttcaattttttttnaaaactgcttttccaaatat gagactatg >38066 at HG-U95Av2 ctgatctatacaaattttcagaaggttattttctttatcattgctaaactgatgacttac catgggatggggtccagtcccatgaccttnggggtancaattgtaaacctagagttttat caa ctttggtgaacagttttggcataatagtcaatttctacttctggaagtcatctcatt ccactgttggtattatataattcaaggagaatatgataaaacactgccctcttgtggtgc attgaaagaagagatgagaaatgatgaaaaggttgcctgaaaaatgggagacagcctctt acttgccaagaaaatgaagggattggaccgagctggaaaacctcctttaccagatgctga ctggcactggtggtttttgctctcg >38129 at HG-U95Av2 atctccagaaagtggtattccataaaacctaccaactcatggattcccaagatgtgagct ttttacataatgaaagaacccagcaattctgtctcttaatgcaatgacactattcataga ctttgattttatttataagccacttgctgcatgaccctccaagtagacctgtggcttaaa ataaagaaaatgcagcaaaaagaannnnanagaaatatttggtggttttttttttttnnn naaacatccacagttaaggttgggccagctacctttgggnntgacccconccattgccat aacatcctgctccattccctctaagatgtaggaagaattcggatccttaccattggnaat cttccatcgaacatactcaaacacttttggnccaggatttgagtetctgcatgacatata WO 2005/068655 PCT/GB2005/000057 100 cttgattaaaaggttattactaacctgttaaaaatnnnnnnnnnnnnnnntttaacagac accctaaaagtctccttttcnacatagttgaagacagcaacatcttcactgaatgttttg >38130_s at HG-U95Av2 catattgcttttgctgcattagaagctgtttgtttccaaactcgagagattttggatgcc atgaatcgagactgtggaattccactcagtcatttgcaggttgatggaggaatgaccagc aacaaaattcttatgcagctacaagcagacattctgtatattccagtnnnnnnnnnnnnn nnnnccgaaaccactgcactgggtgctgccatggaggcaggggctgcagaaggagtcgac gtatggagtcttgaacctgaggatttgtccgccgtcacgatggagcggtttgaacctcag a >38152_at HG-U95Av2 agtgctacatgatgccggtgttgaccttccttcaagaggaccaaatgatttcagaattta gttttagcagctgaaaatttatttctccctgtaaacgttaaaaacagttttccaaataac atcaacaacnnnnnnnnnnnnnnnnttcttattctttctaaactacaacgaacacaagaa ttgaatagtaagatgttaattttttttactataaacatttttagagaagtaaaacatgct gaaaactacacaaattataagcatacaactggactcattatcacagtgaatgcactgtgt gat c gccacataggtaaaaactggaatggtcgtaggcctctccatctgtacccttttcca tcatgtcctattccctgtcactacacactaaaactttcctgacttacaataccatgggtt atttatgcttg >38169_s at HG-U95Av2 ggatcgtctcccagggtaacctcgaagagtgagtnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnctcttctgcccctcccttctgccaacacagcagtcagcttct ctcgtgagctttctggtaggannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngctg tttcttgttctcttcgttgccatcgttctcaccnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngcatcttggtgaac atttacttgatggtccagttaagtgcagacacttgggtcagattcagcatttggatggca attggcttcctgatttacttttcttatggcattagacacagcctggagggtcatctgaga gatgaaaacaatgaagaagatgcttatccagacaacgttcatgcagcannnnnnnnnnnn nnnnnnnttcaagcaaatgaccatcacccaagaaatctcagttcacctttcatattccat gaaaagacaagtgaattc >38177 at HG-U95Av2 ggcgctgtcctgaatccccacgaggccctggctcagcctcttcccaccacaggcacacca gggtcagaaggggggacggtgaagaactatgagacagctgtccaattttnctggaannnn nnnaannannannnnnnnncnannnnnaaggattggtgcgactgggccatgattagcagg ccttatagcaccctgcgagattgcctggagcactttgnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnatctttgagactcaccagatccactttgccaactgc tccctggntgcagcccaccttctctgaccccccagaggatgtactcctggccatgatcat agcccccatctgcctcatccccttcctcatcactcttgtagtatggaggagtaaagacag tgaggcccaggcntagggggcnacgagcttctcaacaaccatgttactccacttccccac ccccaccaggcctccctcctcccctcctactcccttttctcactctcatccccaccacag nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggtcatggcacaagttctgtaatcttc a >38222 at HG-U95Av2 cacccagaagaagttccgccggcgaccacatgagctcctacagaaactcacagccaaatg gcagaggcagggtcgctgagtcctccaggtcctgggcagccttcatatttgccattgtgt ccggggcaccaggagccccaccaaccccaaaccatgcggagaattagagttcagctcagc tgggcatggagttaagatccctcacaggacccagaagctcaccaaaaactatttcttcag ccccttctctggcccagaccctgtgggcatggagatggacagacctgggcctggctcttg agaggtcccagtcagccatggagagctggggaaaccacattaaggtgctcacaaaaatac agtgtgacgtgtactgtcaa >38223 at HG-U95Av2 gcaagacagcagctgctatgcacacntggagtccaccataccaaagcacgaaccagactg tttcttnggggtcagccctanaccgngatttcagtctnnnnnnnnnnnnnnncatctggc taaacaacctgacaaactgtggccaggggaaccgacacaaccctcaagcatttctatgta ttgagaattgtcagtgccctaaggtatccattggttcccttgatgccaacttacaatttt WO 2005/068655 PCT/GB2005/000057 101 taccggatttgctgaaatgggcacnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ngaacacaatgtctcatactaaccaagaagcaagaaaagccccatgctttcatttttcac ttggagtgacaatgggagaggtcaggaatcaagttcactttcaagatctaagggagtcca ctatctgtgcaattgtatttggcttttttttgcactgtttcaatgctggtaattgaaacc attttaatatatttggttgtattcactttatatgtccttccaaaaatgttgttgtgtaca naccatgctttcaatgttggcttcca >38234_at HG-U95Av2 cagccgagcgttcagggctgcgctccggccggctgagagggcacgtgccccgtcacagtc tggactcctgggcctggattgatgtgtctcacagactcggaagggttctgctcctcctcc tccccctgaacaatgctggcagttgctacaaatagatttattggaggcttatggctccgg ttcccccacanacccgctcatgagtctctgtttgttcttcccttttcttttgccctgtcc ctcaccttgggtcgggggtgctggagtggaccacaatgttgtgetgggggatgggggggt ctctctttgccgattgtgcagtgcacaagatttgtgaaaaatgtaaataacagactccta ttgcg >38247_at HG-U95Av2 cagactgggaacagggcccaggaatctgtgtggtacaaacctgcatggtgtttatgcaca cagagatttgagaaccattgttctgaatgctgcttccatttgacaaagtgccgtgataat ttttgaaaagagaagcaaacaatggtgtctcttttatgttcagcttataatgaaatctgt ttgttgacttattaggactttgaattatttctttattaaccctctgagtttttgtatgta ttattattaaagaaaaatgcaatcaggattttaaacatgtaaatacaaattttgtataac ttttgatgacttcagtgaaattttcaggtagtctgagtaatagattgttttgccacttag aatagcatttgccacttagtattttaaaaaataattgttggagtatttattgtcagtttt gttcacttgttatctaatacaaaattataaannnnnnnnnnnnnnnngaccacatatctt tggaaaatagtttgcaacatatttaagagatacttgatgccaaaatgactttatacaacg >38267_at HG-U95Av2 gttctaactagtaatcttggccctattcattacatcctctgcttgtcattctgctaattt atgaagatagtttattatagtctgtacttcagttctcatcttgtaaataatgcttaacat aaacttgtacttacactgaaatccaaaatagtcatgtttctgcagtattctgtagccaac ttaaacctgtgctttcatgtttaagaaatgagaaattgtgccaaagatagcagaagagta gataagtgctcagtattgacgacctacatctgaaatctacancataatgatactgaattg ttatgtaaacatcataaatagtaaataatgattcaatgtgaattttaaaatgcaaatatt gctattgtttataggaaataaatctaaatataaatgaaannnaannnannaantttatct tgggctaaatggttctaccccttactaggttgccccaattagtggcactagttggcaag ctgttcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnac tgctgttaactcataaaagagaagagtgttccatttcagtctcaataa >38268 at HG-U95Av2 ctcatgcatagacaagtgttttgggtttttaaaaaaaatattctgtcattggttacaaat ttttactcaggctttctattggcatggatttcctttgacctctcannnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnccccagttaatgtgccaaaatgtcaatttttaacttatc tccagccaatttcaaagaaaacagaccagcatagnttctgncnatnacngtttnagntg ggcatagggnttggaagaaagggagaaggattcttttttcaatgtactgtattgggacgc tggtaactgttaacccagtgttcagcatagagctatatatatatatatatnngtatatat ttattattttcatatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaatgtgaaataa agagttctccttgtacttgaataataaccacgnttccaacccaggtctgctttngggctt atcagaactcctttctaag >38276 at HG-U95Av2 ccggagccataactgctgcagtttgggcccaggctatgtgctcttctggtgccctaggga ctgctgtggccagagcctggggccagccagtacagtcctgagccgaggaggagggactgc aagtggaagagagccagtctggaaggaagagctttccaggtggacagggcttcttggaag acccccaaagccccaggtatcctgggtgaagcctgtttgcctctcttgaaaatggcaggt gctcttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagtaggaagcatggact ctcctgagtgagaagagactgaaataggagcaagcagaaccctgagaggtgtcccatett attgctgttgaggaccctgaaacaccgttgtttaaagacttcacacagaaggctctgaac tgagccactggggaa >38278 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 102 gtaggccagcccatggtgttgtgtacactgtggagtcgacaggggcctacnnnnnnnnnn nnnnnctgccagggggctctgaactagtgcctgctacccaggacacccgggccatncccc tggctgggcagcctggcacaagtgaagaaaaggcagtgggaaaactgggtttatctcaa ggcagcagcctgagcccaggagcagaggacccagttgttataaggcgctgggagaggatn ggcagctcccactgccccagagcggagctcgaagcacccaggttgcccacggaa >38287_at HG-U95Av2 actggaggaacctccacttgtttggctgctgcaaatgtggtgagaaatatcagctataa atatcgagaggacttgtctgcacatctcatggtagctggctgggaccaacgtgaaggagg tcaggtatatggaaccctgggaggaatgctgactcgacagccttttgccattggtggctc cggcagcacctttatctatggttatgtggatgcagcatataagccaggcatgtctcccga ggagtgcaggcgcttcaccacagacgctattgctctggccatgagccgggatggetcaag cgggggtgtcatctacctggtcactannnnnnnnnnnnnnnnggaccatcgagtcatctt gnnnnnnnnnnnnnnnnnnctatgatgagtgaaccttccccagacttctctttcttat tttgtaataaactctctagggcca >38298_at HG-U95Av2 ataccacttgtcagggcacaggggactggetgggccccnagggntgctccccacttgcag cacaatgccttctccacctgccctcccactcttccagtccaatccacgctgtcttctgtt gcaggactaacctttgagaaatccttttgtgaagtcattgcctgctcaagaatgtacagt ggctccccaatgccttggaggccataaggccagccagttctagctctctattacctgtcc ccactcaactgactcatacctgtnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncgat gatcgtcacctctgtgcctgagttctccctgttgtctcaaagcggtacccatcctccccc agaagctgtccccagcgagcctcccttctttgtttgaattctctaataagagcaacnnnn nnnnnnnnnnntagaacacatttacagtattactattttctaggatataaagtgccatat atatttttaattccaatattaataaatgtatgccaaacaacaannaaaaaaaaaaannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnncagetgcaaggaaacacatgagaac >38299 at HG-U95Av2 tgggcacctcagattgttgttgttaatgggcattccttcttctggtcagaaacctgtcca ctgggcacagaacttatgttgttctctatggagaactaaaagtatgagcgttaggacact attttaattatttttaatttattaatatttaaatatgtgaagctgagttaatttatgtaa gtcatatttatatttttaagannnnnnnnnnnnnnnnnnnnntgtattagttttgaaata ataatggaaagtggctatgcagtttgaatatcctttgtttcagagccagatcatttcttg gaaagtgtaggcttacctcaaataa >38315 at HG-U95Av2 agcttgcagggagtaaagcaggcccgcctccctttcttcccatccacatactcctcttet gctttccagtgactccaccagtttgatgtgggaagtgttagcttcctttccttcttocat cccttcttccatctttccagctgtcaaatccaatccagtctctaacctanatgcagatca tttatttaaaagtaccaaacataacccagagtntgtggaatatgggcaacatatatatag ccttctgtatttaacgatcttctgcttcttaaccgtaccagttttctatttataactctt atctatccatgatgttttaaagtctccacttgctgttatttacaaacgacagtgcattca gcagcccagtgccgtgagccctgacagatgccgtatttctgagtgcttccatgtgannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttacctttgga ctgcaacaaaaaatgtgaaaatgaagatttatttcttttaatttacttaaaaagaaacct ctgtgctagcaataaagcatttat >38326 at HG-U95Av2 gacaggctctccagaagcaagccctgcaggagaaaggcaagcagcaggacacggtcctcg gcggccgggccctgtccaaccggcagcacgcctcctaggaactgtgggagaccagcggag tgggagggagacgcagtagacagagacagaccgagaaggaagggagagacagagggggcg cgcgcacaggagcctgactccgctgggagagtgcaggagcacgtgctgttttttatttgg acttaacttcagagaaaccgctgacatctagaactgacctaccacaagcatccaccaaag gagtttgggattgagttttnctgctgtgcagcactgcattgtcatgacatttccaacact gtgtgaattatctaaatgcgtctaccattttgcactagg >38332 at HG-U95Av2 cagggtcttgctagtgagctggaccagtgaggcctaccccacacctgggctctccacagc cccatcaaagaacagagaggaggaggagggagaaatggccaccacatcaccccagagaaa tttctggaatctgattgagtctccactccacaagcactcagggttccccagcagotcctg WO 2005/068655 PCT/GB2005/000057 103 tgtgttgtgtgcaggatctgtttgcccactcggcccaggaggtcagcagtctgttcttgg ctgggtcaactctgcttttcccgcaacctggggttgtcgggggagcgctggcccgnacgc agtggcactgctgtggtttcagggctggnnnnnnnnnnnnnnngaagcctcctgtctcc agctctctccaggacaggcccagtcctctgaggcacggcggctctgttcaagcactttat gcggcaggggaggccgccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngcatttctcctcagagaagcg ctgtgctaaggtgatcgaggaccagacatt >38430_at HG-U95Av2 gatgcttttgtaggtacctggaaacttgtctccannnnnnnnnnnnnnnnnnnnnnnnaa gaagtaggagtnggcttnnncnncnaggaaagtggtggcatggccaaacctaacatgat catcagtgtgaatggggatgtgat canccattaaatctgaaagtacctttaaaaatactg agatttccttcatactgggccaggaatttgacgaagtncactgncagatgacaggaaagt caagagcaccataaccttagatgggggtgtcctggtacatgtgcagaaatgggatggaaa atcaaccaccataaagagaaaacgagaggatgataaactggtggtggaatgcgtcatgaa aggcgtcacttccacgagagtttatgagagagcataagccaagggacgttgacctggact gaagttcgcattgaactctacaa >38433_at HG-U95Av2 tgtttcaaggcactctagattccattggtccaagattccggatcctaagcatctaagtta taagactctcacactcagttgtgactaactagacaccaaagttctaataatttctnaatg ttggacacctttnaggttctttgctgcattctgcctctctaggaccatggttaagagtnc caagaatccacatttctaaaatcttatagttctaggcactgtagttctaagactncaaat gttctnaagtttctaagattctaaaggtccacaggtctagactattaggtgcaatttcaa ggttctaaccctatactgtagtattctttggggtgcccctctccttcttagctatcattg cttcctcctccccnaactgtgggggtgtgcccccttcaagcctgtgcaatgcattaggga tgcctcctttcccgcaggggatggacgatctcccacctttcgggccatgttgcccccgtg agccaatccctcaccttctgagtacagagtgtggactc >38438_at HG-U95Av2 aggtgctcagagagccggcccgcctgaatcattctcgatttaactcgagaccttttcaac ttggcttcctttcttggttcataaatgaattttagtttggttnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntngcttactaannnnn nnnnnnnnnnnnnnnnnnnnnnntgctttctgttgtcattgctgttgtccctctgctacg ttcctattgtcattaaaggtatcacggtcgccacctggcattccttctgaccacagcatc attttgcattcaaattaagggttaagaaaagagatattttaaaatgagagtcacttgatg tgccat >38439 at HG-U95Av2 acacttgggatttttctcctctgtcccgaggtcgtcgtctgctttcttttttgggtttct ttctagaagattgagaagtgcatatgacaggctgagagcacctccccaaacacacaagct ctcagccacaggcagottctccacagnccccagcttcgcacaggctcctggagggctgcc tgggggaggcagacatgggagtgccaaggtggccagatggttccaggactacaatgtctt tatttttaactgtttgccactgctgccctcacccctgcccggctctggagtaccgt ctgc cccagacaagtgggagtgaa >38453 at HG-U95Av2 cgtggcaatgagactctgcactatgagaccttcgggaaggcnagcccctnctccgcagga nnnnnnnnnnnnnnnnnnacagcacggctgacagagaggatggccaccgcaacttctcct gcctggctgtgctggacttgatgtctcgcggtggcaacatctttcacnaaacactcagcc ccngaagatgttggagatct atgannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnagcggatgggcacctacggggtgcgagcggct tggaggaggctgccccnngnnttccggccatagcaaccatgantngcatggnccnncacc acggtggtcactggaactcagtgtgactcctcagggttgaggtccagccctggctgaagg actgtgacaggcagcagagacttgggacattgccttttctagcccgaatacaaacacctg gactt >38454_g_at HG-U95Av2 cactggaactcagtgtgactcctcagggttgaggtccagccctggctgaaggactgtgac aggcagcagagacttgggacattgccttttctagcccgaatacaaacacctgg WO 2005/068655 PCT/GB2005/000057 104 >38463 s at HG-U95Av2 tgtcaaagtgactgcgttcatcagttttacactggggctgctacataatattttcatttg aacgaagaacttcaaaaagcacaggactagatgatctctgttccttttggctctaatatg. ctacaactgtaggccaattatcactttaccaattaagagttaggccagataagtgaaatt tnnnnnnnnnnnnnnnnnnnnnnnnnnnataggcctaaactggatttccttattccaaat cctgtcttttccccactattccattagaccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnflnnnnaaaatttctcccttatcta ctgtgatgacttcagaagatacaatggtcccaggggccaagtagaaagcatt >38466_at HG-U95Av2 tcactgtggccatcaggactttccctgacagctgtgtactcttaggctaagagatgtgac tacagcctgcccctgactgtgttgtcccagggetgatgctgtacaggtacaggetggaga ttttcacataggttagattetcattcacgggactagttagctttaagcaccctagaggac tagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaggtagaaatgtc tatgttttctactccaattcataaatctattcataagtctttggtacaag >38488_s at HG-U95Av2 tgtgctgtcaaaacaagtttttctgtcaagaagatgatcagaccttggatcagatgaact cttagaaatgaaggcagaaaaatgtcattgagtaatatagtgactatgaacttctctcag acttactttactcatttttttaatttattattgaaattgtacatatttgtggaataatgt aaaatgttgaataaaaatatgtacaagtgttgttttttaagttgcactgatattttacct cttattgcaaaatagcatttgtttaagggtgatagtcaaattatgtattggtggggctgg gtaccaatgctgcaggtca >384_at HG-U95Av2 acgccgagatgaccacacggatggtggcgtccaagatggagctacacgcgttatctacgg gccgcgagccccgcgtggccacggtcactcgcatcctgcgccagacgctcttcaggtacc agggccacgtgggtgcatcgctgatcgtgggcggcgtagacctgactggaccgcagctct acggtgtgcatccccatggctcctacagccgtctgcccttcacagc'cctgggctctggtc aggacgcggccctggcggtgctagaagaccggttccagccgaacatgacgctggaggctg etcaggggctgctggtggaagccgtcaccgccgggatcttgggtgacctgggctccgggg gcaatgtggacgcatgtgtgatcacaaagactggcgccaagctgctgcggacactgaget cacccacagagcccgtgaagaggtctggccgctaccactttgtgcctggaaccacagctg tcctgacccagacagtgaagccact >38584 at HG-U95Av2 tattttcctgtcagcatctgagcttgaggatggtagtgagnaaatgggccagggcgcagt cagctccagtcccagagagotcctctctaactcagagcaactgaactgagacagaggagg aaaacagagcatcagaagcctgcagtggtggttgtgacgggtaggaggataggaagacag ggggccccaacctgggattgetgagcagggaagctttgcatgttgctctaaggtacattt tt >38617 at HG-U95Av2 gagatagctccctgagctgggccatctgacttctacctcccatgtttgctctcccaactc attagctcctgggcagcatcctcctgagccacatgtncnggnnnngnaaancctnnnnnn nnnnnnnnnnnnnnnnnnnnactcttcatcacaactagatttgcctcttctaagtgtcta tgagcttgcaccatatttaataaattgggaatgggtttggggtattaatgcaatgtgtgg tggttgtattggagcagggggaattgataaaggagagtggttgctgttaatattatetta tctattgggtggtatgtgaaatattgtacatagacctgatgagttgtgggaccagatgtc atctctggtcagagtttacttgctatatagactgtacttatgtgtgaagtttgcaagctt gctttnaggnctgagccctggactcccagcagcagcacagttcagcattgtgtggctggt tg >38631 at HG-U95Av2 gctctaccccaggaaaatgtgagctogttttcctgctcggcatgtgctccccctaagget ctgctccnnnnnnnnnnnnnnnngttccttctcagcctgagagggggcccttcgnnctca ggcatgactcagcccnnnnnnnnnnnnnnnngnnnnnnnnnnnnnnnnnnnnnnnnnnnn cttgggtongtccccttttcccaggtactgccttacaaagctgtggccaggaagtggccg gtataaaggatgcccaaggtctttgtacgtgtgtaggagttagcgtgtttgatattgtta atataataataattattttttagagtactgcttttgtatgtatgttgaacaggatccagg WO 2005/068655 PCT/GB2005/000057 105 tttttatagct >38787 at HG-U95Av2 tgccgaaaactcgtcctcccgagagctggatgacagcagcagtgagtccagtgacctcca gctggaaggccccagcaccctcagggtcctggacgagaaccttgctgacccccaagcaga agacagacctctggttttctttgacctcaagattgacaatgaaagtgggttctcctgggg ctacccccacccctttctaatttagtctctgagtcccaaaaag >38880_at HG-U95Av2 gcacccacgggtgtgotggatactggagtttgagaggagggaggtgctggggccaaagga gacactanaaaagtggtagatgggacaggtaagtggcagaggtgaggggntaagttanaa tgtanaagggcagtaattaggggtgagggaaaggagataggggaccctaggaggtagagt gggnccatgtcgtgaggcagttgaagagttgaggaaaggttttnctgggccctactgctc ccctctgctgcaggtaagtcagagcagtttaccacagcttcaggccacgagag >38916_at HG-U95Av2 gaacctttcagtctccgctagctctttcctnnnnnnnnnnnnnnnnnnnnnngtttttatc gttaagtgccccacagagacactttaccaggaggtgggagagttctccagatttgggag aggcgcagagacagtgtgtgagccgagccctgtctcagcaatccacctggaggagctaga gtatcctcctccctttaccattcagaccgagagaaaaagcccagcttgtgtgcaccctcg tggggttaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntttgttttgatgtaaggc tctgtggtttgggggggaacatctgtaaacattattagttgatttggggtttgtctttga tggtttctatctgcaattatcgtcatgtatatttaagtgtctgttatagaaaacccacac ccactgtcctgtaaacttttctcagtgtnnnnnnnnnnnnnnntcacattttaattgcca cctcgtatttcacctctacatttgaaatctggcgtctgtttcaagccagtgtgtt >38944 at HG-U95Av2 ctctcagaacatactgattgggaggtgcgtgttcagcagaacctgcacacaggacagcgg gaaaaatcgatgagcgccacctctttaaaaactcacttacgtttgtcctttttcactttg aaaagttggaaggatctgctgaggcccagtgcatatgcaatgtatagtgtctattatcac attaatctcaaagagattcgaatgacggtaagtgttctcatgaagcaggaggcccttgtc gtgggatggcatttggtctcaggcagcaccacactgggtgcgtctccagtcatctgtaag agcttgctccagattctgatgcatacgg >38970 s at HG-U95Av2 accatccgttgcagaagcctccaggagcagcaatcctaagagtgggaggcagconaagac ccccttccttcaaaanncntcccggaagtggtttcaggccctctagttgccatgaccaat ttgtgtgtgtgtttaatttttgcttcaagotctgtagcaggacctgccccacgcacaccc ctacccctctgtgaggagctgtgggaagtgtgggtttgtctccagaacagaagagaatga tggatattctggctctggggccctctccaccaccactcacagtagccttgctgaagccat cacagatgggagaaggccatgccagccacgtccgccgaggggcgccagcctgaagctgcc aggccctgaggttcagaccctggaccccatagctggaggcctgtggtgccagaagcccag attagggtggctgtccatccctggatagctatttgcacgaatcatggacataa >38971 r at HG-U95Av2 gcaatcctaagagtgggaggcagccnaagacccccttccttcaaaanncntcccggaagt ggtttcaggccctctagttgccatgaccaatttgtgtgtgtgtttaatttttgcttcaag ctctgtagcaggacctgccccacgcacacccctacccctctgtgaggagctgtgggaagt gtgggtttgtctccagaacagaagagaatgatggatattctggctctggggccctctcca ccaccactcacagtagccttgctga >39032 at HG-U95Av2 atgacacaaaactatgagagtgacaaaatggtgannnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntgtagtgtaactattttg tancaatagaggactgtaactactatttaggttgtacagattgaaatttagttgtttcat tggctgtctgaggaggtgtggacttttatatatagatctacataaaaactgctacatgac aaaaaccacacctaaagaaattttaangannnnnnnnnnnnnnnnnntcactttngtngt aatctngaaatcntnnnnnnnnnnnnnnnnnnnnnnnnaatccttgttcactgaagtett tcaattgagctggttgaatactttgaaaaatgctcagttctaactaatgaaatggattto ccagtagggnnnnnnnnnnnnnnnntgtatagtagttatatgcatatgtttctgtgcatg ttctctacacaattgtaaggtgtcactgtatttaactgttgcacttg WO 2005/068655 PCT/GB2005/000057 106 >39070_at HG-U95Av2 ggggccgtcttcctcctgtctctttcctttcaccctagcctgactggaagcagaaaatga ccaaatcagtattttttttaatgaaatattattgctggaggcgtcccaggcaagcctggc tgtagtagcgagtgatctggcggggggcgtctcagcaccctccccagggggtgcatctca gccccctctttccgtccttcccgtccagccccagccctgggcctgggctgccgaca'cctg ggccagagcccctgctgtgattggtgctccctgggcctcccgggtggatgaagccaggcg tcgccccctccgggagccctggggtgagccgccggggcccccctgctgccagcctccccc gtccccaacatgcatctcactctgggtgtcttggtcttttattttttgtaagtgtcattt gtataactctaaacgcccatgatagtagcttcaaactggaaatagcgaa >39071_at HG-U95Av2 actcagtgttttggagagtattccttttagtttgttggttggctggtttgaacgatagna aatatgcagcatgcaatatatgcttatatttcattttaatttctgatatataatgaactt cttgggagaggtactgaatctttgatgttttttgtcattgttctcaagtgcaatataaca atgtaaccaaatctagataatttcaaagttgtcattaatttagtaagcctaatataaaca aatatttgtattatttttnnnnnnnnnnnnnnnnnnttaagtgaggttatttacccctaa atggtccattctgcattgtatttcaggctggaaatgaattattctttaccagttttgaaa cactttgaaatatcctaaggtaacttggaagctgtgtagtatatcaaattaatttgotac ctaataacatagaaagtaaatatCtttgtggtcacccacattgggtgagacagaaaat >39081_at HG-U95Av2 gtgatccttatcagggagagcaggaatccttattcccggtgtcgctagtactcatctctg ccgcctcctgtctgcccccagnnnnnnnnnnnnnnnnnnncnncgaacccgcgnnnnanc ntgtcccgactctagccgcctnttcagnnnncnnngnnnccnannnnnncnnnnncnnc ngnnnnnnonfffffffffffffffffffffffllllnnnnnnnaaatgcacctcctg caagaaaagctgctgctcctgctgccctgtgggetgtgccaagtgtgcccagggctgcat ctgcaaagggcgtcggacaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnccccgctcc cagatgtaaagaacgcgacttccacaaacctggatttt >39107 at HG-U95Av2 acttcagtgtcagtatccctgccttcagtcttctttagaaatcacatctgtgttcaatcc attgtttagagggagtgtatttttcctgttccnnnnnnnnnnnnnnnngttcacaattgg atcacaatgcagaggagtctgttcctcccccgtcggcttctcggtgctgggagggtgacc tgtcccagatgactcatcaccctgacatgctcttgacaaaggacaccaccaagaggagat ggcagctgtaccggtgcagcctctgtctgagggggatatttgcctcagtgtgattaaaaa tcagtcatgaaagatttttgaattcagattatttttatcaggaacagattttgaacatcc tgaaatcttttccctggcatcatattaggttttctttgttcactatgatgtaaagtttca gactcttgatatttttaatatcaacatagacggtaggacaaggaacggtaccagaaatga gtaaagagacaataatgataagatcgatttatcaagacataacaaccccaaatgtatatg cactaaataacagcttcaaaatacatgaagcaaaatgg >39119s at HG-U95Av2 gtcccggatgttgaggatcccgcaanccgaggagcctggggagagcttttntnacaaggt catgagannnnnnnnnnnnnnnnncntgcagcggctgcagacctggtggcacggggttct ggcctgggtgaaggagaaggtggtggccctggtccatgcagtgcaggccctctggaaaca gttccagagtttctgctgctctctgtcagagctcttcatgtcctctttccagtcctacgg agncccacgggggacaaggaggagtgacaccccagaagtgctctgaaccccaatcctc aaaatgaagatactgacaccacctttgc >39120 at HG-U95Av2 tgtcccgctgcgtgttttcctcttgatcngggaactcctgcttctccttgcctcgaaatg gaccccaactgctcctgctcgcctgttggctcctnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnaaatgcacctcctgcaagaagagctgctgctcctgctgccctgtgggctgt gccaagtgtgcccagggctgcatctgcaaagggacgtcagacaagtgcagctgctgtgcc tgatgccaggacagctgtgctctcagatgtaaatagagcaacctatataaacctgga >39253 s at HG-U95Av2 aagcagacagctatcggaagaaggtagtgctagatggggaggaagtccagatcgatatct tagatacagctgggcaggaggactacgctgcaattagagacaactacttccgaagtgggg aggggttcctctgtgttttctctattacagaaatggaatcctttgcagctacagctgact WO 2005/068655 PCT/GB2005/000057 107 tcagggagcagattttaagagtaaaagaagatgagaatgttccatttctactggttggta acaaatcagatttagaagataaaagacaggtttctgtagaagaggcaaaaaacagagctg agcagtggaatgttaactacgtggaaacatctgctaaaacacgagctaatgt >39267_at HG-U95Av2 tgcacatgaagtgagcttggcagtatttcagctggctggaggaattggagaaaggcccca accaggtttctgaannnnnnnnnnnnnnnnnnnagaaactggactttttacaagtcttta caaaactgtcaataataatggcagtactaagagatttataatcataatgtttacaatgca gcctactggattgtctctagatctgtttttcttaaacactaacagaataattctttataa ataggtaagccttacacttgttaaagaaatttacctctaatttcagtctcactaatgtaa aatactgggacttaagtatacaattcagtcactaactgtacagttttatgtggggaacaa ttcatgcaggctactggaaaattaaatcttattaccaannnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnncaagatgatgttttgcagcattcnnnnnnnnnnnnnnnaatggaga gggcagagaagactttatacaaccagtttttccattgcagagtcttaagaaagattatta gat gact ta cctatatggact aat gccat ccaggaa ct cagaggtat g >39300 at HG-U95Av2 gaggcaggaatctccatttttgtgctttttgaaaatgcaatgaattcctatacgggggag cgggaaaggtgcctcagagagagacaagtctggatgagggaaatattgaatattctcaat caaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngacttgaaagacctgag tccattacgttgagaagggacctgctgattgotttgattccccctggcaagtgctccctg gttgtgaatgccaggcactagagatggtgaggggttggggggcagttgggcacacacagt gtaagagcaattcagagccgttagtcctgcactagccctcaagctgctggcaacacctag agaaggtcgaagggecctgccagagatccc >39310 at HG-U95Av2 gcaaagagcccataaatcctgaccaatccaactctgaattttaanncaaaagcgtnaaaa aaaagattccctccttacccccaacccactcttttttcccaccacccactctcctctgcc tcagtaagtatctggaggaagaaaacaggtgaaagaagaagtaaaaaccatttagtatta gtattagaatgaagtcaaactgtgccacacatggtgaatgnnaaaaaaaaaaaagaggct gtgttttgtcacacagggcagtcattcagcaccagagcacgtgatggtctgagactctct taggagcagagnnnnnnnnnnnnnnnnnngtgggnnnnnnnnnnnnnnnnnnggggcaac tgagtctgcgggagaagagcggccctatgcatggtgta >39327 at HG-U95Av2 ggttccatcacaagctatgtttaaaaagaaaattggtgtttggcaaacggaacagaacct ttgatgagagcgnttcacagggacactgtctgggggtgcagtgcaagcccccggcctctt ccctgggaacctctgaactcctccttcctctgggctctctgtaacatttcaccacacgtc agcatctaatcccaagacaaacattcccncntgctcgaagcagctgtatagcctgtgact ctccgtgtgtcagctccttccacacctgattagaacattcataagccacatttagaaaca gntttnntttcagctgtcacttgcacacatactgcctagttgtgaaccaaatgtgaaaaa acctccttcatcccattgtgtatctgatacctnccgagggccaagggtgtgtgttgacaa cgccgetcccagccggccctggttgcgtccacgtcctgaacaagagccgcttccggatgg ctcttcccaagggaggaggagctcaagtgtcgggaactgtctaacttcaggttgtgtgag tgcgt >39333 at HG-U95Av2 gaatgacttgacttcaaaagcaacaaccttaaaggccgtcatttcattagtattcctcat tctgcatcctggcttgaaaaacagctctgttgaatcacagtatcagtattttcacacgta agcacattcgggccatttccgtggtttctcatgagctgtgttcacagacctcagcagggc atcgcatggaccgcaggagggcagattcggaccactaggcctgaaatgacatttcactaa aagtctccaaaacatttctaagannnnnnnnnnnnnnnatgtaatttctttaaatgtgta tttcttaagaattcaaatttgtaataaaactatttgtataaaaannaagcttttattaat ttgttgctagtattgccacagacgcattaaaagaaacttactgcacaagctgotaat >39397 at HG-U95Av2 atttttaggtgaagtcgagcactctaattagagaactggaggaaccacatataacactta acttcccctaccctgcccctccccaaaagaaaccatgacaaacctagcttttaaaaaata ttttaagaaagagaatgaactnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnngtgaacttttgtaatttgaattgggtcccgcttagttc ttgaattgttatgaaaatcctatatctgtttgtatatttgcaaaccctttgtattataat WO 2005/068655 PCT/GB2005/000057 108 tgttgatattttccctttttaaaaaataccattgaaatcagcatgacaaaaataacactg ttggcacttataggtaacgtga >393 s at HG-U95Av2 atacctgtttctttgggacattccgtcctgatgattttttattggttggtttttattttt ggggggaatgacatgtttgggtcttttatacatgaaaatttgtttgacaataatctcaca caacatattttacatctgagcacaatgcctttttgtttaccgtagcgtatacatttgttt tgggatttttgtgtgtttgttgggaattttgtttttagccaggtcagtattgat >39402 at HG-U95Av2 aatgtggactcaatccctagggctggcagaaagggaacagaaaggtttttnagtacggct atagcctggactttcctgttgtctacaccaatgcccaactgcctgccttagggtagtgct aannnnnnnnnnnnnnnnncagccaggacagtcagctctctcctttcagggccaatcccc agcccttttgttgagccaggcctctctcacctctcctactcacttaaagcccgcctgaca gaaaccacggccacatttggttctaagaaacnnncctctgtcattcgctcccacattctg nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnaagggggcaagaagtagcagtgtctgtaaaagagcctagtttttaatagct atggaatcaattcaatttggactggtgtgctctCtttaaatcaagtcctttaattaagac tgaaaatatataagctcagattatttaaatgggaatatttataaatgagcaaatatcata ctgttcaatg >39409 at HG-U95Av2 ctggacacccatctctaaagcaggacgcctgccagggggatagtgggggcgtttttgcag taagggacccgaacactgatcgctgggtggccacgggcatcgtgtcctggggcatcgggt gcagcaggggctatggcttctacaccaaagtgctcaactacgtggactggatcaagaaag agatggaggaggaggactgagcccagaattcactaggttcgaatccagagagcagtgtgg aaaaaaaaaaacaaaaaacaannnnnnnnnnnnnnnnnnnnnnnnagagtctctnnnaaa antnnnnnnnnanannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttgatgtact ttacctgaaacaacccaaagggcccctttctttcttctgaggattgcagaggatatagtt atcaatctctagttgtcactttcctcttccactttgataccattgggtcattgaatataa c >39421 at HG-U95Av2 gacggtataacacatctactgaaaaagcaannnnnnnnnnnnnnnnatttaagccagccc ccacctagggtctatttgtgtggcagttattgggtttggtcacaaaacatcctgaaaatt cgtgcgtgggcttctttctccctggtacaaacgtatggaatgcttcttaaaggggaactg tcaagctggtgtcttcagccagatgacatgagagaatatcccagaaccctctctccaagg tgtttctagatagcacaggagannnnnnnnnnnnnnntccacagtccacggtacacagtc gggtgggccgcctcccctctcctgggagcattcgtcgtgcccagcctgagcagggcagct ggactgctgctgttcaggagccaccagagccttcctctctttgtaccacag >39517 at HG-U95Av2 tcttaggggtcattatcacttaaataatactgtacctaggtctttcaaattaaaattata cctgaatgaagttgtttgtatacataaaggatatttgtgtacaattaccttttttccccc acacttgttttctttgtttttgttnnnnnnnnnnnnnnnnnnnnnnntnnactatgggat tcatttatgtctgtctttctatcataaagaattgatcaatatgtaaatatgtgatttgaa ccatggttgacttacaagtgtcactacagctttttagaaaacatagccctaatatatgtt aagcaggacccgggtgagccagtggnnttgcgctttatgtagagctggaagaaggccgtc catcctgtctcttgggcggacagtgtactttcctaatagggaagggaagcacaatggaaa tacccctgaaccg >39532 at HG-U95Av2 attgccaccctgaaccagctctgtgccaccaagttccgagnnnnnnnnnnnnnnnnnnnn nncctcttcctgtacaaggagnnnggctaccnccgcctgccccctgggnccntggccnac aggctgcccaccactggctacctcgtctaccgccgggcagagtggcctgagacccagggg gctgtgacagaggaggagggcagtgggcagtcagaggcaagaagcagaggggaggagcaa gggtgccagggagatggggatgctggggtcaaagccagccccagggacattcgggaacag tctgagacaactgctgaagggggccagggtcaagcccaggaaggccctgctcagccaggg gaaccagaggcagagggaagccgggcagcagaggagnnnnnnnnnnnnnnnagaagggtc attcggggcgggagaccctgagcctgctgagaaatccttttagcgccagcaagccccacc cagggccctgtcctgtgtctgccaccacctttgtctgatacttgtttccagggaagctgg WO 2005/068655 PCT/GB2005/000057 109 gggaactgccacatctgaggaactggaataa >39579 at HG-U95Av2 attcatactgtcagggctgtgctcaatgactggatgttccctatatgcaaacaaaatcac aacggaattctttgatcctctctttgttgagcaaaagtatgaattaggagccgctctgtt tattggatgggcaggagcctcactgtgcataattggtggtgtcatattttgcttttcaat atctgacaacaacaaaacacccaqatacacatacaacggggccacatctgtcatgtcttc tcggacaaagtatcatggtggagaagattttaaaacaacaaacccnnnnnnnnnnnnnnn naaaaatgcttatgtctaaaagagctcgctggcaagctgcctcttgagtttgttataaaa gcgaactgttcacaaaatgatcccatcaaggccctcccataattaacactcaaaactatt tttaaaatatgcatttgaagcatctgttgattgtatggatgtaagtgttcttacatagtt agttatatactaatcattttctgttgtggct >39633_at HG-U95Av2 gacaaatacaagtctgccaggcggngntnnnnnnnnnnnnnnngaaggagctggccacn tggaccccgactgagtttcgggaatgtgactacaacaaattcatgagtgttctggacacc aacaaggactgcgaggtggactttgtggagtatgtgcgctcacttgcctgcctctgtctc tactgccacgagtacttcaanggactgcccctncagagcccccctgctnccnagtagcct ctgctccagggggtgcgctggctgtcgggggnctgggcatgtctcccacaccccctccta ccctctctcctgtacccctttcaatctggacttgcccaggtcttctgcgatcagttaacc cattttacctaggaggcccagagatgtgagggctccttcctcaggatgcccagcgaatga ggggtagagccactctgggncccagcctgcctgccgcacccctgtggcctcccttgtgga tgggaggaggcgggatctgctctgaggccctcgaggctcagcagagcgtgcaccaatgag accacgatgggaaagg >39640_at HG-U95Av2 atacagctctcttcagagtaactgtnaaccttttataaccaacactagagttnnntttnn aaaagacaagatatttataatgacgactngtatagcttttaagttatttttctagtatgt ggctttctntagccgtgntaacgnncaaactgttcatcnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagcacaaggcattggccctct ggactcctttctccttttctttcctctctaggctgctcctgaatcctgttctctgacatc cgtggagcccctcctgcatccacctatgcctcctataagtccanttgaaatctcagcctc cttcaacattttcttctcgtgtgtggcccacatccctccacttctccaacttctgtttaa tctgatcacggctctttttaagccctggcagcattttggtccctgctccttgcccatagt aaannnnnnnnnnnnnnnnnnnnnnnnnnnnnagtttcaagtgggcaactctgctctcta tt >39663_at HG-U95Av2 ggtcagttatccttctctccttagccacataacttcttctctcatgaatcatccagtcat tccaatggcaaataagttctcctcacctacccttgagctgcaaggtgaattcnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaggt gggcaatgggcactccaatgaggcagccttgatcctccacagaaaagggtttgattgtcg gttctctagcaaaggcacagggctgttttgttctactactcagggaaagatattggtaca gaaacttttaaacaagtttattgtcgaaagtctcacaccttcatcactatccttgatgca ttcacctcccggcactcagaatataagtgagatcaacttgagtccaatggaaatcagcac attccgaatccagttgaggtgaacctgactttcacatttggattgagaatcattggcttt tatacctttcttggtttgacgtgcaataaagaagcacattattttagcttctggctactg tgag >39680 at HG-U95Av2 gtctcatcttgagtaaaagaacccagccaactatgaagttccttgtctttgccttcat cttggctctcatggtttccatgattggagctgattcatctgaagagaaatttttgcgtag aattggaagattcggttatgggtatggcccnnnnnnnnnnnnnnnagaacaaccactata cccacaaccataccaaccacaataccaacaatataccttttaatatcatcagtaactgca ggacatgattattgaggcttgattggcaaatacgacttctacatccatattctcatcttt cataccatatcacactactaccactttttgnangaatcatcaaagagcaatgcaaatgna aaacactataatttactgtatactctttgtttcaggatacttgcc >39681 at HG-U95Av2 tgcagcagcacatggaggtccacgcgggcgtgcgcagctacatctgcagtgagtgcaacc gcnccttccccagccacacggctctcaaacgccacctgcgctcacatacaggcgaccacc WO 2005/068655 PCT/GB2005/000057 110 cctannnnnnnnnnnnnnnnggcagctgcttccgggnnnnnnnnnnnnnnnagagccaca aacgcatccacacgggtgagaaaccctacgagtgcaatggctgtggcaagaagttcagcc tcaagcatcagctggagacgcactatagggtgcacacaggtgagaagccctttgagtgta agctctgccaccagcgctcccgggactactcggccatgatcaagcacctgagaacgcaca acggcgcctcgccctaccagtgcaccatctgcacagagtactgccccagcctctcctcca tgcagaagcacatgaagggccacaagcccgaggagatccogcccgactggaggatagaga agacgtacctctacctgtgctatgtgtgaag >39728_at HG-U95Av2 tgtgccctgggtcaccgtcaatgggaaaccCttggaagatcagacccagctccttaccct tgtctgccagttgtaccagggcaagaagccggatgtctgcccttcctcaaccagctccct caggagtgtttgcttcaagtgatggccggtgagctgcggagagctcatggaaggcgagtg ggaacccggctgcctgcctttttttctgatccagaccctcggcacctgctacttaccaac tqgaaaattttatgcatcccatgaagcccagatacacaaaattccaccccatgatcaaga atcctgctccactaagaatggtgctaaagta >39742_at HG-U95Av2 ggaaaatctagtttcacagctatttgaatttttttctggatttactatataactcttatt ttttaaaagatcattctgttctttcaaggagaaataagcctaaaagaagaaaaacaaaaa aaattctgtataaaactgtaatncctttgtattcatgtttacagtgctattactataatt caaaattatgtatgtgacttagagttatataatcataatttatgtttatttcaaatatct aagtttattgcttggatttctagtgagagctgttgaatttggtgatgtcaaatgtttcta gggtttttttagtttgtttttattgaaaaatttaattatttatgctataggtgatattct ctttgaataaacctataatagaaaatagcagacaacataaacatctttgtaaatatcaaa cctaatacatttcttgtccagtgataaaacaactgg >39781 at HG-U95Av2 actcccctgggcatcttctggcttgactggatggaaggagacttaggaacctaccagttg gccatgatgtcttttcttctttttcttttttttaacaaaacagaacaaaaccaaaaaatg tccanaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaanaaaaaaanaannnnnnnnnnate cagtcaagccatgatgtcttttcttct >39791_at HG-U95Av2 gtaacagacattgttttgccaacattgcctatttcagtggcacgtcatctagttttaaaa aaataaaacattttaaatggacaganaaaaaaaanannnnnnnntttaactcgtaagtgn nnnnnnnnnnnnnnnnngacatgtccnnctttctctccagttcnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnagttgtactctgcttgaggggaagaaggctcctgctctgctgtgta ggtagtcataggaattgtattcttaatgtacaggcactaattgtcatctgtgatgtacat tttatgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntatgtgtgtg tatgtgtgtgttttgtaaaatctgtaaatagcacatgaccaaatgaacatattg >39805 at HG-U95Av2 aggcatccatgatgccattatggctttccctgaagggtacaggacacannnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntcnaatganag ggccatccaggcttctctggccaaagtctgtgccaaccgcnnccaccntngtagtggcac acaggctctcaactgtggtcaatgctgaccagatcctogtcatcaaggatggctgcatcg tggagaggggacgacacgaggctctgttgtcccgaggtggggtgtatgctgacatgtggc agctgcagcagggacaggaagaaacctctgaagacactaagcctcagaccatggaacggt gacaaaagtttg >39826 f at HG-U95Av2 cttaaacgcagctgccaggtgtaatttttcaagtgtcaaagatcccaagtgatccctgac acccaccccttcctactcttacattcatgcgtctnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnntgctccgatcagaanaannanannnaaaanaacnnncanncacafnnggnccn tnnanancagnaananacacaanccacctccacgacctccgacctcccccctccctccgg ntngctctgaggnagcacgtgcctcttccttcaccctgggccnggctggggcgggagcag ccnagctgctctctggatgtcacaccactgttaactgtca >39878 at HG-U95Av2 atggatgtcaatgacaccagcccagttgtcatttctccaccgtctaatacttcctttaag WO 2005/068655 PCT/GB2005/000057 111 ttggtgcccctctcagccattcctgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnctggaatgaacgctgaactaaagnnnnctatagtnagtgnaancnntaannncnna tnnnnnnnngnnnnnnnnacaggtaacattactnnnnaanaaaaaccancncctactgat gtgggattgcatcgtttgqtqgtcaacataagtgancctggggtanccctaagtctttgc acacgcttgtgcttgtattcctttatgttnnnnnnnnnnnnnnnnnngcctcctatatct atgacttgatccgcaggactatggagaccccgttggacaggaacataggggatagtagcc aaccctatcaaaatgaggactatctaaccatcatgattgccatcatcgccggtnnnnnnn nnnnnnfnnnnnnnnnnnnnnnnnnnnnnnnnggtnnnntgtcgccatgcatcaaggttca aagcagctcagaggagcaagcaaggtgccgaatggatgtcccc >39959_at HG-U95Av2 cttatggcattgacaaagagaagaccatccaccttaccctgaaagtggtgaagcccagtg atgaggagctgcccttgtttcttgtggagtcaggtgatgaggcaaagaggcacctcctcc aggtgcgaaggtccagctcagtggcacaagtgaaagcaatgatcgagactaagacgggta taatccctgagacccagattgtgacttgcaatggaaagagactggaagatgggaagatga tggcagattacggcatcagaaagggcaa >39966_at HG-U95Av2 caggctgacttggatgtgaactgtettcagaataatttaacctaaagcagagcaagaaga gaggaagcgggggtagtgggtggggggtaggggaagaannattatctcctcttgtacaga gtctatttcttgtaaccatttgttaaactcttttctttttctgatctcatggcatgcttt tatgtattttgtacaggaggcaaaaaaaatacttaaaataagcaaagaaactgaacagaa ttgcatacattgggttgttttttctgtgctgtctgtacattgcttctgctgctgtgattt ctaaacctgtgctgttattcaactgactttt >40049 at HG-U95Av2 cctccagggtgattttatgatcagtgttgttgctctaggaagacatttttccgtttgctt ttgttccaatgtcaatgtgaacgtccacatgaaacctacacactgtcatgcttcatcatt ccctctcatctcaggtagaanggttgacacagttgtagggttacagagacctatgtaaga attcagaagacccctgactcatcatttgtggcagtncccttataattggtgcannnnnnn nnnnnnnnnnnnnttagatcctggtttcataacttcctgtacttgaagtctaaaagcaga aaataaaggaagcaagttttcttccatgattttaaattgtgatcgagttttaaattgata ggagggaacatgtcctaattcttctgt >40051 at HG-U95Av2 tcattgtccaggaataagattggcgtggtgcccatgacatcaccgtcactctgcctaaaa gcactctagagctacttgttcacgtggagaggaaggatattttgcgaancaacagnccgc aggtggagagccctgttcacctgatagggtctagctgtgacagtaaatataataccgctg tttccttgggtacagatttgagtgttcatgtgatgagactgtaaacctcatttttcggtt cctctgtttaaaaaaacatctgaaggatgaactaaggctgctggtgccctgagcaactga taatgcaaatgtggacaaagtgtctgttttctactctagcctgttcatatggaccaaatt tcaacaaggaactcaaggaaaatttgtacctgccgtatttatgctttcatgtaaaa >40069 at HG-U95Av2 ctgccttcttgttccagctaggcaatgcntttttttttttttttgaagcagttctcttta taaagtgttattttgatagtttgtggattctaaaatatatatatatttatataaacacca tataagtcaaatatgtatttaacaaagcaatatgtattcattcactttcaagatttgttt tggtgtcaaaataacatgaaaaggtagatggagttgttctgttgaattagctctgccac caatatgtatcttcatacacgtttggaaatgtttcctgcagcattaggtatgacttgtto tgagtactgcttccggtgctaaaatgaacaaagaatttgtacttaatggcatggactctg gagaatctatgcgaatcaacctttctaccttaatatctccccaaaaatgtatagtgcctt gtttttatgtacagtttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnatgatggtttnnn nnnnnnnnnnnnnttttactctcaaatagtcaaaataaaaacatctcaatttctaatanc ngttgtaaacannnngtacacatgtcattttgtgatataggactcccaaataaa >40088 at HG-U95Av2 atgtatacagttgcaagtctggacaaatgtatagaataaaccttttatttaagttgtnnn nnnnnnnnnnnnnnnaanngnnnnngggnnncnntgnnnnnnnnnnnnnnnnnnnnnnnn tnnnnacaaatcagatcagatgttcatcctnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttgattcgaagggtcttaaagaattt ttttaatcgtcaaccacttttaaacataaagaattcacacaactactttcatgaattttt WO 2005/068655 PCT/GB2005/000057 112 taatcccattgcaaacattattccaagagtatcccagtattagcaatactggaatatagg cacattaccattcatagtaagaattctggtgtttacacaaccaaatttgatgcgatctgc tcagtaatataatttgccatttttattagaaatttaatttcttcatgtgatgtcatgaaa ctgtacatactgcagtgtgaatttttttgttttgttttttaatcttttagtgtttacttc ctgcagtgaatttg >40091 at HG-U95Av2 aaaggctcgattttgtatctgcaggcagacacggatctgagaatctttattgagaaagag cacttaagagaatattttaagtattgcatctgtataagtaagaaaatattttgtctaaaa tgcctcagtgtatttgtatttttttgcaagtgaaggtttacaatttacaaagtgtgtatt aaaaaaaacaaaaagaacaaaaaaatctgcagaaggaaaaatgtgtaattttgttctagt tttcagtttgtatatacccgtacaacgtgtcctcnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnngcgagcgtgcaccatccctttttgaagtgtaggcagacacagggacttgaa gttgttactaactaaactctctttgggaatgtttgtctcatcc >40126 at HG-U95Av2 ttaattagggatcttgctgcttttctttttctacacgaagttttcattaaagccacagan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn l f ttaaatgaa ttagaaactatttgaggctataaaaatgtccttgagtttggagcctgagotctggnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagagtaagnnnnnnnnnnnn nnnnnntatccgttcttcacttagcaggaatatgaaagaaaggcacatgtttaagaggaa tacctaaaggtttttctaaattccaacatttaaaaggcaattgtgggetatttttatttt ttaatattttgaaataaagtttagtgtetagggctgggagccaggactgatcttocattt ctt >40153_at HG-U95Av2 ggtactcccgctcagtgcttctcatcacccagcacctcagcctggtggagcaggctgacc acatcctctttctggaaggaggcgctatccgggaggggggaacccaccagcagctcatgg agaaaaaggggtgctactgggccatggtgcaggctcctgcagatgctccagaatgaaagc cttctcagacctgcgcactccatctccctcccttttcttctctctgtggtggagaaccac agctgcagagtaggcagctgcctccaggatgagttacttgaaatttgccttgagtgtgtt acctcctttccaagctcctcgtgataatgcagacttcctggagtacaaacacaggatttg taattccttactgtaacggagtttagagccagggctgatgotttggtgtggccagcactc tgaaactgagaaatgttcagaatgtacggaaagatgatcagctattttcaacataactga agg >40171 at HG-U95Av2 aatgtatgcgccagggtgcttccgtggggcannnnnnnnnnnnnnnccatccaagcccaa ggacctgggataaactgggagaactatggcagctacttgcatcgacttgtacctcactta gcccttggg >40177 at HG-U95Av2 atattatactttagggcaaccctagttggcagctttgagagaagttcttcattacagaag aattocattaaacatggaaggaataactaaactaaaaatcatcactttgcaattctgaat gaaatnnnnnnnnnnnnnnnnnatttattattggataaaaccatcagatataaggttaat agggaacttgacagcagacagagggaagag >40199 at HG-U95Av2 gtttcacctctttgctccctgagttcactctccgaagtctgatccctgccaaaaagtggc tggaagagtcccttagtactcttctagcatttagatctacactctcgagnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaagaa aagcgcagagaaatcggtgtctgacgattttggaaatgagaacaatctcaaaaaaaaaaa aaaaaaaaaaaaaaaaannnnnnngaaaagagaaaaaaaagactagccagccaggaagat gaatcctagcttcttccattggaaaatttaagacaagttcaacaacaaaacatttgctct ggggggcagggaaaacacagatgtgttgcaaaggtaggttgaagggacctctctcttacc >40214 at HG-U95Av2 gctacgtaaggcagcccgtgaaccaagcctactttttctgtcatntgattcaccatgtca gtaagcgtatctggaattactcttattccactatcacaaatccatataagatcatacttt WO 2005/068655 PCT/GB2005/000057 113 gcaacttcatatcctggcattaaattattaattttaggattaatgccaacttttttgcca cctataaacaatctagcatcaacatttggatattttccannnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnntcatgatcttgtacacaaaggagcacttcatatttgggataatccaat tcaaagaatgtttccaggttgttgattaagttaggatctacccctttcagtggtttcaga agagagacacctgggagcttgctataaggctgtttgtcagttgccttcttgttgaggt >40215 at HG-U95Av2 caatgtccactcaagttgcaatgcaaaactctggctcatattcaatttctcagtttcaat ccagaatgatcaggtggaccaaactacgaattaacatgttcctgctacaataatttgtg agccaatttcagaatgctttgttgccagtttaattattggatgggcagcccaccatgtgt tcagatgggatattatggtatttttcatgtgtcattgcctggcatggtttatatttgact acattcaactcaggggtgtccagggtggcacactgtgtttttcaaaacttgattatgcag tcgcctggttcatccgcgaatccatgacaatatacatttttttgtctgcattatgggacc caactataagctggagaactggtcgctacagattacgctgtgggggtacagcagaggaaa tnnnnnnnnnnnnnnnnnnnnnnnntgactgtatataaaggaaaaaagagaagtattata aattatgtttatataaatgcttttaaaaatctaccttctgtagttttatcacatgtatg >40236 at HG-U95Av2 ctttcctcgtgttgggcctgagtgtcttgaccacttacggagttcatgccatcnncaggc tggaggcctggagcctcgctctcctCgcgctgtttcttgttctcttcgttgccatcgttc tcaccatctggaggcagccccagaatcaacgaaaagtagccttcatggttccattct >40240_at HG-U95Av2 tctcgctgcctcacaagcagtgacacctcgggtcctttccgttgctatggtgaaaattcc tggatggaatggatcacatgagggtttcttgttgcttttggagggtgtgggggatatttt gttttggtttttctgcaggttccatgaaaacagcccttttccaagcccattgtttctgtc atggtttccatctgtcctgagcaagtcattcctttgttatttagcatttcgannnnnnnn nnnnnnnnnnnnnnfnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacctctagcatcgann nnnnnnnnnnnnntnanctgacggcatggaatgtataaatgagggtgggtccttctgcag atactctaatcactacattgctttttctataaaactacccataagcctttaacctttaaa gaaaaatgaaaaaggttagtgtttgggggccgggggaggactgaccgcttcataagccag tacg >40290_f at HG-U95Av2 agacaggacagtttcccaggaagatgggcagagacttgagtgngnnnnnncnnnnncac agagacgtgccangcggtgttggcgctcggggcgagatgctgcccttctttngcacgann cntggcctcttgcttggcgtgataaccctgtcatcttcccaaagctcatttatgagccac cagaggctcct >40310 at HG-U95Av2 tttccgtctttttgatgagaacaatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaagacct acctggagtggcccatggacgaggetcagcgggaaggattttgggtaaatctgagagctg cgataaagtcctaggttcccatatttaagaccagtctttgtetagttgggatcttnnnnn nnnnnnnnnnnnnnnnnnnnattcagacataattatataaaaactacgtggatgtaccgt catttgaggacttgettactaaaactacaaaacttcaaattttgtctggggtgctgtttt ataaacatatgccagatttaaaaattggtttttggtttttcttttttctatgagataacc atgatcataagtct >40314 at HG-U95Av2 ctgtgggccaagacaccagccctgtcctagcccttcagtaannnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnngnnaagacaagcccctcagcaggagagaggcccagaggctc cagctggccaccgtgccccacaagatggcccctgtgtggttccctttaccttggcttcct ggcccagtccctgcctctccacctgcaccctgcttcctnggcccagtcccaggttggagt ccctctgcatagctgactactcatgcattgcnnnnnnnnnnnnnnnnnnnnnnnnnnnnc aacaccaaacgtggttgccacatttcatcagacagacacctccctctggagatgcagttg agtgacaaccttgttacattgtagcctagaccaattctgtgtggatatttaagtgaacat gtttacaatttttgtatatatcactctctccctctcctgaaagaccagagattgtgtatt ttcagtgtcccatgttccgactgc >40322 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 114 ttgctgtctgatctttgtagactgttcctgtttgctgggagcttctctgctgcttaaatt gttcgtcctcccccactccctcctatcgttggtttgtctagaacactcagctgcttcttt ggtcatcettgttttctaactttatgaactccctctgtgtcactgtatgtga >40333_at HG-U95Av2 agcatcactcacagcgggccaggaagaagaanaagnactgccggcgcnactcgctctatg tggactnnnnnnnnnnnnnnnnnnnnnnnnctnggattntnggccccaccaggctaccag gccttctactgccatggggactqcccctttccactggctgaccacctcaactcaaccaac catgccattgtgcagaccctggtcaattctgtcaattccagtatccccaaagcctgttgt nnn nnnnnnnnnnnnnnnnnncatctccatgctgtacctggatgagtatgataaggtggta ctgaaaaattatcaggagatggtagtagagggatgtgggtgccgctgagatcaggcagtc cttgaggatagacagatatacacaccacacacacacaccacatacaccacacacacacgt toccatccactcacccacacactacacagactgcttccttatagctggacttttatttna aaaaaaaaaaaaaaaanggaaaaaatccctaaacattcaccttgaccttatttatgactt tacgtgc >40362 at HG-U95Av2 tgtcacttggtgatacagotctgcagaacctggagcagctgctagacgggccagaagccc agggcagctgggcagagctggcagagcgtetggggctgcgcagcctggtagacacgtacc gacagacaacctcacccagtggcagcctcctgcgcagctacgagctggctggcggggacc tggcaggtctactggaggccctgtctgacatgggcctagaggagggagtgaggctgctga ggggtccagaaacccgagacaagctgcccagcacagaggtgaaggaagacagtgcgtacg ggagccagtcagtggagcaggaggcagagaagctgggcccaccccctgagccaccaggag ggctctcgcacgggcacccccagcctcaggtgactgacctgctgcctgcccccagccccc ttcccggaccccctgtacagcgtccccacctatttcaaatcttatttaacaccccacacc cacccctcagttgggacaaataaaggat >40367 at HG-U95Av2 gtgtctccaagagacatgttaggataagcaggtctttgcaccaagatgaacacagctggt cacagataaggccattgctagtaacttttggccatgatggaaaagggcatcctctccaca aaagagaaaaacgtcaagccaaacacaaacagoggnaacngnnttaagtccagctgtaag agacaccctttgtacgtggacttcagtgacgtggggtggaatgactggattgtggctccc ccggggt at cacgcctttt actgccacggagaatgccctttt cct ct ggct gat cat ct g aactccactaatcatgccattgttcagacgttggtcaactctgttaactctaagattoct aaggcatgctgtgtcccgacagnnnnnnnnnnnnnnnnnnnnnnntaccttgacgagaat gaaaaggttgtattaaagaactatcaggacatggttgtggagggttgtgggtgtcgotag tacagcaaaattaa >40370 f at HG-U95Av2 atcatactgacctggcagcgggatggggaggaccagacccaggacgtggagctcgtggag accaggcctgcaggggatggaaccttccagaagtgggcagctgtggtggtgccttctgga gaggagcagagatacacgtgccatgtgcagcatgaggggctgccggagcccctcatgctg agatggaagcagtcttccctgcccaccatccccatcatgggtatcgttgctggcctggtt gtccttgcagctgtagtcactggagctgcggtcgctgctgtgetgtggagnaagaagagc tcagattgaaaaggagggagcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnngtggcaagtccctttgtgacttcaagaaccctgacttctctttctgcagagacc agcccacccctgtgcccaccatgaccctcttcctcatgctgaactgcattccttccccaa tcacctttcctgttccagaaaaggggctgggatgtctccgtctctgtctcaaa >40385 at HG-U95Av2 aggctgtgacatcaatgctatcatctttcacacaaagaaaaagttgtctgtgtgcgcaaa tccaaaacagacttgggtgaaatatattgtgcgtctcctcagtaaaaaagtcaagaacat gtaaaaactgtggcttttctggaatggaattggacatagcccaagaacagaaagaacctt gctggggttggaggtttcacttgcacatcatggagggtttagtgcttatctaatttgtgc ctcactggacttgtccaattaatgaagttgattcatattgcatcatagtttgctttgttt aagcatcacattaaagttaaactgtattttatgttatttatagctgtaggttttctgtgt ttagctatttaatactaattttccataagctattttggtttagtgcaaagtataaaatta tatttgggggggaataagattatatggactttcttgcaagcaacaagctattttttaaaa aaaactatttaacattcttttgtttatattgttttgtctcctaaattgttgtaattgc >40391 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 115 tactttgtttacctcggtgcttacaacagaatgetgccctacatcgtcatgggtagtctg act gt cctgattggaat cctcaccctttttt tccctgaaagtttgggaat gactct nnnn nnnnnnnnnnnnnagatgcagaaagtgaaatggttnannnnnnnnnannnnnnaaaaaaa caagagactcaatgnagnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnntgaaaaacagaaaaataagaccctgtggagaaattcgt tgttcccactgaaatggactgactgtaacgattgacaccaaaatgaacottgctatcaag aaatgetcgt cat acagtaaact ct ggat gatt ctt ccagat >40393 at HG-U95Av2 gtgtggatacctgagaaggactacttggtatcaaatacttttgagatggctacagtcagc tagetggacagcccatgctgactggggacatacacttgcatctttgttgaaagcagaaga agacagaccctttccccaccttccttacctcctcttcccccattaaggcagctcatccaa gottgtatttaactgaataaatgagtagacattgtggacotcacaagattattt >40398 s at HG-U95Av2 atttcttcctgattgacaacagtgttagacaaggtgcaaagcgaaactggttgctcaagt tgatagaaaac >40399 r at HG-U95Av2 acaatcagtatgtgcttacctgtgttcaagtagagaaaaatacagtagagtctgatagga catattcttgtaccacagacaaaacaaatcttatgttgcatttactatcaactgctgcta atacgttattataaaacttacctagctcctgaattcttcctatcttatagcttaaa >40427 at HG-U95Av2 catagctgcttttggcgcgaaagatgccgggtctggttgactcaaaccctgccccgcctg agtctcaggagannnnnnnnnnnnnnnnnnnnnnnnnttgcccggagaccaagaaggcgc ncgatgcgt gtat cat cgag aaaggagaagaacact gt ggacat ct aatt gaggcc caca aggaatgcatgagagccct >40434 at HG-U95Av2 agaat tgct act cgaaggt gccaga at gacacaaaggacagaatt ccttt ccca gt tgtt accctagcaaggetagggagggcatgaacacaaacatannnannnnnnnnnnnnct acac tntctntnaatnanttnngnnnnnnangtnannnaannnttnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnggaacttactccaacaggactgagggaccaagg aaacat gat gggggaggcagagagggcaa gagt aaaact gt agcatagcttttgt cacgg tcactagctgatccctcaggtctgctgcaaacacagcatggaggacacagatgactcttt ggtgttggtetttttgtctgcagtgaatgttcaacagtttgcccaggaactgggggatca tatatgtettagtggacaggggtetgaagtacact >40493 at HG-U95Av2 agagaccctgagttcccactcagacccactcagccaaanntctcatggaagaccnaggan gggcagcactgnntttttgnnttttttgtttttngttttttttttttnngnacactgtcc aaaggttttccatcctgtcctggaatcagagttggaagctgaggagettcagcctctttt atggtttaatggccacctgttctctcctgtgaaaggetttgcaaagtcacattaagtttg cat gacctgtt at ccct ggggccct at ttcat agaggct ggccct attagt gatttccaa aaacaatatggaagtgccttttgatgtcttacaataagaataacatggtccattcacctt tatgttatagatatgtctttgtgtaaatcatttgttttgagttttcaaagaatagcccat tgttcattcttgtg >40496 at HG-U95Av2 tacaggatcccaatgacaagaccaanttctacgcagctggcctggtgtcctgggggcccc agtgtgggacctatgggctctacacacgggtaaagaactatgttgactggataatgaaga ctatgcaggaaaatagcaccccccgtgaggactaatccagatacatcccaccagcctctc caagggtggtgaccaatgcattaccttctgttccttatgatattctcattatttcatcat gactgaaagaagacacgagcgaatgatttaaatagaacttgattgttgagacgccttgct agaggtagagtttgatcatagaattgtgotggtcatacatttgtggtctgactccttggg gtcctttccccggagtacctattgtagataacactatgggtggggcactcctttcttgca ctattccacagggataccttaattctttgtttcctctttacctgttcaaaattccattta cttgatcattctcagtatccactgtctatgtacaataaagg >40505 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 116 tocccctagggctcaggcactgaggngcctggggacagtggagcatatgggtgggagaca gatggagggtaccctatttacaactgagtcagccaagccactgatgggaatatacagatt taggtgctaaaccntttattttccacggatgagtcacaatctgaagaatcaaacttccat cctgaaaatctatatgtttcaaaaccacttgccatcctgttagattgccagttcctgggn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnafllllaaaaaaaaaaaaaann nnnnnnnnannnannannanattgagggcctccaggacttggcaagtcttggtnnnnnnn nnnnnnnnnnnnnnnnnnnngatgggcaggcaaatctgtccgttctc >40511_at HG-U95Av2 ccgttcaccagttgccattgagggtttcagagaqcctttttctaggcctacatgctttgt gaacaagtccctgtaattgttgtttgtatgtataattcaaagcaccaaaataagaaaaga tgtagatttatttcatcatattatacagaccgaactgttgtataaatttatttactgcta gtcttaagaactgctttctttcgtttgtttgtttcaatattttccttctctctcaatttt tggttgaataaactagattacnattcagttggcctaaggtggttgtgctcggagggtttc ttgtttcttttccattttgtttttggatgatatttattaaatagcttctaagagtccggc ggcatctgtcttgtccctattcctgcagcctgtgctgagggtagcagtgtatgagctnnn nnnnnnnnnnnnnnnnnnnnnnnnncgacaggccacgtcctgcaatcggcccggctgcot cttcgccctgtcgtgttctgt >40568 at HG-U95Av2 cacatgattacaattgccagtagagttgttgtttggggtacaagatgagaagaaagaaaa acctacagcctttctacattctgacatgctaacagtggtttaagtttctaaagtgttnnn nnnnnnnnnnnngncaaggggagggagcagaagcacttatgtttacggatattttaaact ctgttagagagcagcctttgaaaatccccaatttggttctgctttttgacctctctctac cttttcagggtaattttgtggnnnnnnnnnnnnnnnnnnnnangctttnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnngnccctgagcgatcttctatgcagttctgccatgcg tcctgttggtctctctgtgttctttgttacttgggtgcaatagcaacttccctaccccgt gcattccatctttcatgttgtgtaaagttcttca >40604 at HG-U95Av2 atggtttgacttattcttcgtatcattagaagaaccccagagatagcattcctctatttt attttactttcttttggattgcactgattgtttttgtgggaatgacactttatctggcaa agtaactgagagtttggtaaaagaatattttcttctctgaataataattattttcacagt gaaaatttcagtattttatcactaatgtatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnctgcctgtttggaca ataggttttgggtagtacagattaggataagtaagcttatatatgcacagagattattgt attacctgtaaattgatttacaagtacttaaaagcgtggtccccagtgaggccaaga >40606 at HG-U95Av2 tcgtctcctatgagcaacgccagaattataaggatgacttcaatgcagagtatgatgagt acagagctttgcatgccaggatggagactgtagctagaagatttatcaaactagatgcac aaagaaannnnnnnnnnnnnnnntcaaaagagtatcagaatgttcatgaagaagtcttac aagaatatcagaagataaagcagtctagtcccaattaccatgaagaaaaatacagatgtg aatatcttcataacaagctggctcacatcaaaaggctaataggtgaatttgaccaacagc aagcagagtcatggtcctagaactctgcttggaccagaagatgtgaataaacttaagctt atttatttaaaattcnnaannannnnnnnnanantctaaaaaggtgaaactttggctgtt gaaagtttcagtattagtaaacttngagttactttttcttttccattttactttgcttcc ctgcatttcggaag >40626 at HG-U95Av2 ctgtgttccctcttggaacctgaccnnnnatgctagaagaacccttggaaaacatgctgg cccagccctctagttttacaaataagggagtgcacagccctgagaggttacatggcctgc ccaagatcacgcagtcaatggcagagtaaagagcatagcctaggcctccccactcctcta gtaatgctctttcatcttctccaacctggctctaagccttgtccatcctgagccccatat ctagcccaacctagtccctgaaaacaagaagtggcccttagaaatctctctccagtccca ctatcagaggccaactgctgtcttccagtctccttcagcctgtgctcctctccctccctg actgacaggcagaaggtacngtgcctctggatatccccacagtgccctgagctgcatctc ttgcngactgctttaatacatcacagtgacattgtgtgtgtctctgccac >40648_at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 117 atccaattgtacctgatgtttttggtatttgtcttccttaccaagtgaactccatggccc caaagcaccagatgaatgttgttaagtaagctgtcattaaaaatacataatatatattta tttaaagagaaaaaatatgtgtatatcatggaaaaagacaaggatattttaataaaacat tacttatttcatttcacttatcttgcatatcttaaaattaagottcagctgetccttgat attaacatttgtacagagttgaagttgttttttcaagttcttttctttttcatgactatt aaatgtaaaaatatttgtaaaatgaaatgccatatttgacttggcttctggtcttgatgt atttgataagaatgattcattcaatgtttaaagttgtataactgattaattttctgatat ggcttcctaataaaatatgaataaggaannanaaaaanaannnannnnanacttgaaaga cagtggtcggcagcggccttgtggcctttgcaaaggaattcccttaatgcctggtccttg gggcaattgctctgaccattcttggcattgctttatagagatatggaaaaaccacaccag ggtct >40670_at HG-U95Av2 tgctggtgccttcattcatgaaaagcatgcccatacgattaaacctgcgagatcggagtt ctttaattaggaatggaatgcaacagatttggacaagtcaaggacaagnnntttnnnnnn nnnnannnnnttntcnctgntannnnnnncagtatgtagccgagaaccatatggagaaca tcaaatacagtggaacaaatgtaactgctattgatgtcacactttgtgaagtagtctttg ttgcttaaaaagggtgacatctagtggctaaacat >40671_g_at HG-U95Av2 gactcaattgcagtgatcctgttcagtggggtgcatttttacannnnnnnnnnnnnnnnn nnnnnnnnnnnnnnaaaannnggacaagcgaagggttgttatgttggctttgatctagca catgcagttggaaatgttgaactctacttacatgactggggagttgattttgcctgctgg tgttcctacaagta >40672_at HG-U95Av2 cagcaccagatttaagatggataacaaactgcagttaatccctggggtctgtggattccg aatttcaaatcctcccattttgttggtctgttccttgcatgcta >40687 at HG-U95Av2 aaggctctgcagagatgactgggctggggaagcagatgcttgctggccatggannnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnacagacagnntcagcatggaatgotcttggcca agggtactgggggccctctggccttttgcagctgatccagaggaacccagagccaa.ctta ccccaacctcaccctannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn acaggaaaaggcggattgaggctgctgggtcagccttgatngcacagacagagcttgtgc cggatttggccctgtcaaggggactggtgccttgttttcatcactccttcctagttctac tgttcaagottctgaaataaacaggacttgatcacaaanannnnnnnannnannnnnnnn nnnnnnnnnnngggttgggggatagagttattttgcccaggcttcctttacttcttggtc ctgta >40698 at HG-U95Av2 tcaaaacgctgattaaaagaagcacggtatgatgaccaaacataaaaagtgttttataat tgttggtttttaataacaactaatattttactctgatagttaaactaactcgagattc tcagagtttatgcccctatgattgggttttccaaaacaaatgctattatttctctaa agaagaaggagattggaattcaagtaaatacaactgttccactcaacatgccgacctaac tataattgacaacatagaagaaatgaattttcttaggcggtataaatgcagttctgatca ctggattggactgaagatggcaaaaaatcgaacaggacaatgggtagatggagctacatt taccaaatogtttggcatgagagggagtgaaggatgtnnnnnnnnnnnnnnngatggtgc agcaacagctagatgttacaccgaaagaaa >4069at HG-U95Av2 acgtgccctacaagttcaaggtgcaggccaggaccactgagggttcgggccagagcgcg agggcatcatcaccatagagtcccaggatagaggacccttcccgcagctgggcagccgtg ccgggctcttccagcacccgctgcaaagcgagtacagcagcatcaccaccacccacacca gcgccaccgagcccttcctagtggatgggctgaccctgggggcccagcacctggaggcag gcggctccctcacccggcatgtgacccaggagtttgtgagccggacactgaccaccagcg gaacccttagcacccacatggaccaacagttcttccaaacttgaccgcaccctgccccac ccccgccatgtcccactaggcgtcctcccgactcctctcccggagcctcctcagctactc catccttgcacccctgggggcccagcccacccgcatgcacagagcaggggctaggtgtct cctgggaggcatgaagggggcaaggtccgtcctctgtgggcccaaacctatttgtaacca WO 2005/068655 PCT/GB2005/000057 118 aagagctgggagcagcaca >40823_s at HG-U95Av2 gacagcactcaactcaagcacaaagtacgggccaggggggtctttctgcaccttcatcct taatatgtcacagtttgtgtgatnnnnnnnnnnnnnnncctgatggggcaactgtgagca ttaaacctgaaccagaagatcgagagcctaactttgcaaccattggtctgcaggacatca ctttagat >40899_at HG-U95Av2 cacacggagcagctccagatgagcaggtccgaggttacntgacctgcggcgcacccttca gggtcttgagattgagctgcagtcacagctgagcatgaaagctgccttggaagacacact ggcagaaacggaggcgcgctttggagccnnnnnnnggcgcatatccangcgctgatnann nnnnnnnnnnnnnnnnnnggncgatgtgcgagctgatagtgnnnnnnnnnnnnnnnnnnn nnnnnngctcatggacatcaagtcgcggctggagcaggagattgccacctaccgcagcct gctcgagggacaggaagatcactacaacaatttgtctgcctccaaggtcctctgaggcag caggct >408 at HG-U95Av2 attaactctacctgcacactgtcctattatattcattctttttgaaatgtcaaccccaag ttagttcaatctggattcatatttaatttgaaggtagaatgttttcaaatgttctccagt cattatgttaatatttctgaggagcctgcaacatgccagccactgtgatagaggctggcg gatccaagcaaatggccaatgagatcattgtgaaggcaggggaatgtatgtgcacatctg ttttgtaactgtttagatgaatgtcagttgttatttattgaaatgatttcacagtgtgtg gtcaacatttctcatgttgaaactttaagaactaaaatgttctaaatatcccttggacat tttatgtctttcttgtaaggcatactgccttgtttaatggtagttttacagtgtttctgg cttagaacaaaggggctta >41048 at HG-U95Av2 ggaacagttagttctcatctagaatgaaagttccatatatgcattggtgaatatat atgt atacacatacttacatacttatatgggtatctgtatagataatntgtattagagtattat atagcttcttagtagggtctcaagtaagnttcattttttttatctgggctatatacagtc ctcaaataaataatgtcttgattttatttcagcaggaataattttatttattttgcctat ttataattaaagtatttttctttagtttgaaaatgtgtattaaagttacatttttgagtt acaagagtcttataactacttgaatttttagttaaaatgtcttaatgtaggttgtagtca ctttagatggaaaattacctcacatctgttttcttcagtattacttaagattgtttattt agtggtagagagntttttttttcagcctagaggcagctattttaccatctggtatttatg gtctaatttgta tttaaacatatgcacacatataaaagttgatactg >41140 at HG-U95Av2 agctgctagagttctgtctggactttccagagaccagtattcccttttgctgcctctaaa aggcctgtccctgcagacatgagagacaqcaggtctcatgggggtgacaagctttttttt ttttncttaaagaattttcaaaatcaaattccagaatgattttacggagatatcccagga aaattaaggcttctcttaaacactaaaaaggcatgtaattgcttgttagcaaaatggata tgacacatctctgatacttttttcattattggttgggctgagcagtcagaagacctggtc gtcgtcttgactttgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnagggacacngagtggcccttcatgtacatccatggtgtgctggcttaaaat >41168 at HG-U95Av2 gagaacccgtactctagggccaaatccattcttcttgccctggctcacttgtccccccca ccgccccgcgctggagccactgcctagttcttcagccctagatggtgctcgccagacctc ctetcaatgctcatcacacacagggctattcctttcctccaatgaaccaaacgcctcccg cccacctccaggtcccagtcctctgttccctttgcctggtccacccttgccctccctggg tcgcaganganggtcggcctcgtcanttccccgcagaccgccgcgcgtccctcttgtgcg gttcaccacagttgtatttaagtgatcgtgtgagtcgtcgttaaatgcctgtctccccgc ggatcatgggctcctngaggnnnnnnnnnnnnnnnnnnnnnnnnnnnnntaacccgcgc cggcatagggacct aaggcccactggagggcgctcatcaagtagctgctggatgttgacg aaggaagcggcggcgcagctcagggatctccgagtcaggacggtcggccaganccacggg gtaacgggtctaatcgtgtaggaataaagctgtattccagtgcttc >41171 at HG-U95Av2 tagcaatccaggagaaggtgctggagagggtgaatgccgtcaagaccaaagtggaagctt WO 2005/068655 PCT/GB2005/000057 119 tccagacaaccatttccaagtacttctcagaacgtggggatgctgtngccaaggcctcca aggagactcatgtaatggattaccgggccttggtgcatgagcgagatgaggcagcctatg gggagct cagggccatggtgctggacctgagggccttctatgctgagctttatcatatca tcagcagcaacctggagaaaattgtcaacccaaagggtgaagaaaagccatctatgtact gaacccgggactagaaggaaaataaatgatctatatgttgtgtggaaaaaaaaaaaaaaa aaaaannnnanaannnnnnnnnnnnnnnnnnnnnnncctgaagatgaatgtggtgggaag gggtgggtgtcacaaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna agaggggattcaggccctttctcatccagtag >41184 s at HG-U95Av2 ctatgggcagtatgatctgtggctgggataagaagggtccnnnnnnnnnnnnnnnnnnnn nnnnnnngactcggctctcaggaaatatgttctccacgggtagtgggaacacttatgcct acggggtcatggacagtggctatcggcctaatcttagccctgaagaggcctatgaccttg gccgcagggctattgcttatgccactcacagagacagctattctggaggcgttgtcaata tgtaccacatgaaggaagatggttgggtgaaagtagaaagtacagatgtcagtgacctgc tgcaccagtaccgggaagccaatcaataatggtggtggtggcagctgggcaggtctcctc tgggaggtcttggccga >41191_at HG-U95Av2 ggcctctcttagctcagttactcaattcatacgtagtattttttaaaataattttatatc tgtgtaccaccccatatatttcatattactgtttcacatgtacagctttctacttctttg taagaacancaaccaalnnnnggtttaannnnnnnnnnnnnnnnnnnnnnnngggtg gcagatgttctatgcagtgtggttcaagtttctttgaccgcacttatatgcattgctaat atggaatttaagataccatacacagtctctcatggacctatctctattgtagaattatga cttatgtcttacttgncaaatttttctgaatgtgacctttttttgctgatttgctgggtt tgggattaactagcattattttgccacctttatattgtatttataaaaaaaaagtactat caatcaatcatactactttggattgttg >41237 at HG-U95Av2 cctgactttgtttctgcaaaggcacctgcatgtgtctgtgttcntgtaggcataatgtga ggaggtggggagaccaccccacccccatgtccaccatgaccctcttcccacgctgacctg tgctccctccccaatcatctttcctgttccagagaggtggggctgaggtgtctccatctc tgnctcaacttcatggtgcactgagctgtaacttnttccttccctattaaaattagaacc tgagtataaatttactttctcaaattcttgccatgagaggt >41239_r at HG-U95Av2 tttgcaaatctcaggataaagtttgctaagtaaattagtaatgtactatagatataactg tacaaaaattgttcaacctaaaacaatctgtaattgcttattgttttattgtatactctt tgtctttttaagacccctaatagccttttgtaacttgatggcttaaaaatacttaataaa tctgccatttca >41266 at HG-U95Av2 agtctcagtttcttgcttggggaacttgtgtccctaatgtgtttagattgCtagattgct aaggagtgatactttgacagtgtttttagacctgtgttactaaaaaaaagatgaatgtc ctgaaaagggtgttgggagggtggttcaacaaagaaacaaagatgttatggtgtttagat ttatggttgttaaaatgtcatctcaagtcaagtcactggtctgtttgcatttgat acat >41294 at HG-U95Av2 gtgaatatctctgtgatgaattccactggtggcagtagcagtggcggtggcattgggctg accctcgggggaaccatgggcagcaatgccntgagcttctccagcagtgcgggtcnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaggagtncccgcgactga gccgcctcccaccactccactcctccagccaccanccacaatcacannnnnnnnnnnnnc cnttgccgaggctgaggagtgtggggagtggnnnnnaagnatncncgngccnngcagga ggnagctggaagcngccctgcagcgggccaagcaggatatggcacggcagctgcgtgagt accaggaactcatgagcgtgaagctggccctggacatcgagatcgccacctaccgcaagc tgctggagggcgaggagagccggttggctggnagatggnagtgggnagccgtgaatatct ctgtgatgaattc >41352 at HG-U95Av2 gttctgatttgacacactgattttaatcttcgaatcatgacactgagtgcagaggaggtg gcattccgacagcaggacatacatgttggtgtgaagactgggacgacactgggtagaatc WO 2005/068655 PCT/GB2005/000057 120 tagtttttaattattattaatataaaggatcaaattaatttaaatatgattctgaagtct acagaacttttagttctgtgctgtctatgtggacactttggtaaaatgcaaattatgata tggacgttatcattggtctggtgagatgtttcatatttgtgacagttaatttaaaaatta tganttaatgotgcctgtgtctatggggttctgtcttctttgatagccatctattcatct ggatcatgggaccctctctaatccttccaccaatcaaataagctattgctattggtttgg agttgagatatcagtctcggaaactt >41362 at HG-U95Av2 cacaactggggcagaatttaaagctgcaacacagetggtgatgagaggctncctcagtcc agtcgctccttagncnccaggcaccgtgggnccnggatggggaactgcaagcannctctc agctgatggctgcncagtncagatgtctggtggcagagagtccgangcatggagcgattc cattttatgactgttgtttttcacattttcatctttctaaggtgtgtcncttttncnann nnnannnnnttttnnnannccaaaagtcgatcaatcgcattcattttaagaaattatacc tttttagtacttgctgaagaatgatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnatagacagcacttgtgaaggattgaa tgcaggttccaggtggagggaagacgtggannnnnnnnnnnnnnnnncatgcagacattt ttaaaagctatacaaaaaattgtgagaagacattggccaactctttcaaagtc >41384 at HG-U95Av2 ttettgtttataacagtgccttaaggtatgatgtatttctgatggaagccattttcacat tcatgttcttcatggattatttgttacttgtctaagatgcaatttgattttatgaagtat ataccctttacccaccagagacagtacagaatccetnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngttattaatttaaaactccattattaggattacattttaaagttttatt tatgaattccctttaaaaatgatatttcaaaggtaaaacaatacaatataaagaaaaaaa taaatatattaataccggennnnnnnnnccatttttaacctcagccttccctactgtcac caacaaccaagctaaataaagtcaacagcctgatgtg >41419 at HG-U95Av2 ctcattggaattttcttcaagtgttaaaggtacattttcactaggaaaagaaatcaaata tgcttatgcaatatatatttgtgtgtttttccttaatgttatatggtatatatgagcctt, cttgtttagtttcttttatctgctaagttgtaccttaattagagggcaatatatgtttca taaagaagagtctttataantttgtttgtcagatagtatttnggaanttgtataataagg atgtttagaagccatataagtggctttttttaacagatagaatttgtatttttattgtac tttaaaaagatttatgtaataggtatatatttagtggccatttattatcaatggtaacac aatggagtactaagatggtatttgcacatttaagatatgttactttaccaatttttaatg gtaatcaactctgctactggcatgatgaaatagtacataactggtcattaattatgaaca tttanttctccagtgcgtttttatgaagatctggttgaaaattgtatttctatgtaaact caacgatatgtttggttttcctg >41433 at HG-U95Av2 caaagtaaaacttgctgcctgaagancagtanctnccatcangatgagagaactggagga gttccttgatctgtatatacaataacataatttgtacatatgtaaaataaaattatgcca tagcaagattgcttaaaatagcaacactctatatttagattgttaaaataactagtgttg cttggactattataatttaatgcatgttaggaaaatttcacattaatattnnnnnnnnnn nnnnntttgtcatctttcttctattttattccctttcacaaaattttattcctatatagt ttattgacaataatttcaggttttgtaaagatgccgggttttatatttttatagacaaat aataagcaaagggagcactgggttgactttcaggtactaaatacctcaacctatggtata atgg >41439 at HG-U95Av2 ctgtttctggtaaataccatatatgatcctcgaaatgataatatctccannnnnnnnnnn nnnnneaaatttgagtagatattttaaacacctaacaaagtaaagggetaaaagccattc agatagcagtaaaacattctgtatgatgtgcaataaaacatccaagatcttttttgaaag ttttatttataatatacatttttgtatgagaaaggtgattggtacagggtgcctatttta gtcatggatcaaaatttgtgtaacttgcagggctttctttctttttcttcaaatttacaa gggttcattttggaaactacattttaaactttggaatcaaattgtttcttatttgggagg ataatgtatatacattggtattatgttaaataataaaattgttctaatttggtgccannn nnnnaaaaaaaaannnnanntttgnatctcaagctattttcatatgttatgtgtcaatgt atcatctctcagaaaggttttacaatccaaacattatatgttctctgtgtaactgaattt cacttatcttttataaaccagaaacattaattgaaaanannttctggggattttctcttg acttgta WO 2005/068655 PCT/GB2005/000057 121 >41446 f at HG-U95Av2 ctggtgtctcctgcacctgcgctggttcctgcaagtgcaaagagtgcaaatgcacctcct gcaagaagagctgctgctcctgnctnncccgtgggntgtagcaagtgtgcccagggctgt gtttgcaaagggcgtcagagaagtgcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nncagatgtaaacagagagacatgtacaaacctggnnnttttttttttataccaccttga cccatttgctacattccttttcctgtgaaatatgtgag >41475_at HG-U95Av2 ggaccagcccttgctctgactgcggccaagcaccacgcaggaggccactcttgtctctca gcagctgttcccaggnggnagctccctnctnggcacatgggggctggncacaatagccca gagggtcagaactggacagctgcagagacctgtgcccagagaanggtctcgacccactca aggacacacagcaggtccgtggatgggctggatgagtgaccagggccagcctctgtctca ggacattccagaaggacaaggagatgtctctccctctcccaaagcaccagcgtccctgcc tcccgtgggccctgtccgggttgccctggtgaccccagcctctgtccacttcctaaccca gggaccctgcacagccagaactncctttggccctacggatggccactggctctggtctaa agtgcctgggcttggtggccatcaagagggagccagtcaggcctgtgagggccgtagacc ttgtatataccctgcaccagcagtgaccgggcagagcc >41534 at HG-U95Av2 catccatacattactgtgtttggctgaattccactctaatatgatgctccnattatgcac catactgtgatgacctttctactccgaaacctgctggagcctnccnttggccgtggggtg tcagccaatcactgcttgttccacttgttgtacattttatttttgagtctttttctttet catatacagaaaaatagtatgaaaataaaataaatgtatgaaacagtattaatgcagaaa tgtgctactaatggatgtctgagtcaccagaaattccattcttaaagaggcggttagcac ctattagacgtaacagtgatgtcttttaaaaaatccaaaagcatattgcaacaataagtt tgagactttgtgtgaacaaagggaaattcagcctcttatgtctttg >41554_at HG-U95Av2 gtccacagttattcaaacaatggctttttttgtgatgagagtatttgttaaaaaaaaaaa aaagacttcaagaaaaataaaagttcagtggagctgcaaataaatctggtgaataatttc atctttggtaatctcccatttcctgagttcttcctcaatccaagotgtcctgtgtagtat ataacatttgggcattttctctgatatactatactctcatgttctataaatttctgtccc gtaattctaacactttacattttttctttgotatcagctatagctattcatggaagggaa gaatcactaaatacttgtetagttatagnnnnnnnnnnnnnnntcctccttatccctcga tgcctggcttggtgtctggcaaacagtccataattagcagatgttgaaagaccgtttaca aagcagaatttggggatttaaagtgcaatgatacaacaaaaagatttaattacagcttcc agtgttttgactatgtgaaccat >41592 at HG-U95Av2 agotgtgccgccagcgcatcgtggc~caccgtgggccgcgagaacctggctcgcatccccc tcaaccccgtcctccgcgactacctgagntncnnnncnnnncnnnnnnnnnnnnnnnnnn ccgccgtgcacgcagcattaactgggatgccgtgttattttgttattacttgcctggaac catgtgggtaccctccccggcctgggttggagggagcggatgggtgtaggggcgaggcgc ntcccgccctcggctggagacgaggccgcagaccccttctcacctcttgagggggtcctc cccctcctggtgctccctctgggtccccctggttgttgtagcagcttaactgtatctgga gccaggacctgaactcgcacctcctacctcttcatgtttacatatacccagtatctttgc acaaaccaggggtt >41601 at HG-U95Av2 gacccacaagcagatatttgaattacttcttnnnnnnnnnnnnnnnnnnnnnggatgggc tgcatttactgtgtgaaggataaaaatcattagcctggattctgatttctataaattgcc attaaaagctttttttcccctaagaactgaaatgtgctcaccagccaaaacattttaact tgtaaattttgagggcagttaaccaaacctgtgactaatcatatctcctcctacccccca tttccaaggacatttgttactcagatacttgttatactaatacttgaacttgtaccttat ggtatttgctatcttttaactagtcatgatattcttatactttagttacacttttggaat ttgatacaaggttgagtggggtgtgtgggtgtatgtatgagtgaaacagttetcaaaaga atgtaagaaaaaccatttttataaaattgtgactttttaaaaacatagtctttgtcattt atagaattaacaagctgotcagggtatattttatagctgtagcactgatatc >41612 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 122 atcttgttttacactcccatgggtccttcaggetctcatcttttttctttttccagtcta ttttcnnnnnnnnnnnnnnnnnttaatttttattgaccttccatggtcctcactgattgt tttctttgtcanacctaanctgttgnagtttgtgncagtgagttttncattttggttttg tattttnccagttgtttnaatttnccattgggtgggttcttttgtnacaccttctgtttc tttgncttattttttaacgnccaaagaaagactctcagagaatagacaactatattccaa agtcatggttctctggtggtttgtcttgacatttgaatagaaatgttaaactatctgggg gaatagaaagcccacagtcttctgagttgtgctacaccaatatttctatgaacagatctt acaactgagagtgatctgcagatttttcagagtcatgttctcc >41635_at HG-U95Av2 gctctatattacttgcttgagccttaatcaatgtggttttattcaatggtttgttctttg aatggttgcaaaaactgtagataatcttactgaggactgtacaaacatgaaggtgtggta tcaaacttcaggnnnnnattataaacattcatttcacaactagattgt ataaggatattagctgtgatgagactcactgcattattttttttagtgaattttatgaaa tccccgttccattcaacaggcacatgtttaaaagagctttgtcgttggtgttaatggggg aatgtgttccttcattgtatttgggccttttgtattgcactcttgat >41654_at HG-U95Av2 aaaggctgaacatcaatgcggccaaatctagtttcctcccagaagatgaaaagagggagc ttctcgacctgctctataaagcctatgggatgccaccttcagcctctgcagggcagaacc tctgaagacgccactcctccnnnnnnnnnnnnnnnnnnnnnnnnnnnactctgtggggct gagcaacatttttacatttattccttccaagaagaccatgatctcaatagtcagttactg atgctcctgaaccctatgtgtccatttctgcacacacgtatacctcggcatggccgcgtc acttctctgattatgtgccctggccagggaccagcgcccttgcacatgggcatggtt >41656_at HG-U95Av2 tgtacccgcgactaactagacttttctgctgttgtgcaaagttcagtttcttctcagcaa catcaaggatatatgaagaaaaggaaataaaaaactgtaaagtcaaaagagatgcctggt ggaacttattcgtgctatcagggcattgatagtttgaatgtttttattacttatgcaaaa ttgcacatactcctctatnctgattttatcatgaaaactgtcatgtgtcatgctaatgga >41677_at HG-U95Av2 agcaagctcaccaggcctctcagaagtcccagnnnnnnnnnnnnnnnngccgggtcggcg cctcctgcgcgagggagcaggttctccgcattcccatgggcaccacctgcctgcctgtcg tgccttgganncnnnnoccngnnnnnnaggagagaccaaaggcttctgagcaggattttt atttcattacagtgtgagctgcctggaatacatgtggtaatgaaataaaaanccctgnco ccgaatcttccgtnccctcatcctaacttncagttcacagagaaaagtgacatacccaaa getctctgtcaattacaaggcttctcctggcgtgggagacgtctacagggaagacaccag cgtttgggcttctaaccaccctgtctccagctnctctgcacacatggacagggacctggg aaaggtgggagagatgctgagcccagcgaatcctctennnnnnnnnnnnnnngaagaaga aaactcaactcagtgccattttacgaatatatgcg >41711 at HG-U95Av2 catcccagtgttatgtaaagatggtgtgcctgagggagcccccacagctggtgctgggcc tgcatttccttggccccaacgcaggcgaagttactnnnnnnnnnnnnnnnnnnnnnnant gnggggcttcctatgcgcaggtgatgcggaccgtgggtatccatcccacatgctctgagg aggtagtcaanntgcgcatctccaagcgctcaggcctggacnnnnnnnnnnnnnnnnnnn nnnnntaagcgccatccctgcaggconagggcacacggtgcgccogcegccagctcctog gaggccagacccaggatggctgcaggccaggtttggggggcctcaaccctctcctggagc gcctgtgagatggtcagcgtggagcgcaagtgctggacaggtggcccgtgtgccccacag ggatggctcaggggactgtccacctcacccctgcacctctcagcctctgccgccgggcan ccccccccaggctnntggtgconnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnntccgagccccctggcatttctgcaatgcaaata >41742 s at HG-U95Av2 gcagtccttgatggagatgcagagtcgtcatggggcgagaacaagtgactctgaccagca ggcttaccttgttcaaagaggagctgaggacagggactggcggcaacagcggaatattcc gattcattcotgccccaagtgtggagaggttctgcctgacatagacacgttacagattca cgtgatggattgc >41743 i at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 123 actggaactggcagagaaggctctggcttccaaacannnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnngcaggaagaggacctggaaaccatgaccatncnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaattcatgaggaa aaggagcaactgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnaggcaggcagtccttgatggagatgcagagtcgtcatggggcgagaacaagtgactct gaccagcaggcttaccttgttcaaagaggagctgaggacagggactggcggcaacagcgg aatattccgattcattcctgccccaagtgtggagaggttctgcctgacatagacacgtta cagattcacgtgatggattgcatcatttaagtgttgatgtatcacctccccaaaactgtt ggtaaatgtcaga >41816 at HG-U95Av2 tctctcctgtgtaaatgtcacgccccacccctgtttcatgtgggcactaacacgtgtgcg ttcctggcgggcacactcaggaccgtgcctcacagggcccactccctgcctatgcctccc tettggggggccgaggagggcggetgctctgtcatgagaatgtacggcccgtggatgatt aacgggcctttttcacttagaagctg >41831_at HG-U95Av2 cgtccagcacgaaggccacgctgtacccgccgatcctgaacccgccgccctccccggcca cggacccctccctgtacaacatggacatgttctactcttcaaacattccggccactgcga gaccgtacaggccctacatcattcgaggaatggcgcccccgacgacgccetgcagcaccg acgtgtgtgacagogactacagcgccagccgctggaaggccagcaagtactacctggatt tgaactnggactcagacccctatccacccccacccacgccccacagccagtacctgtcgg cggaggacagctgcccgccctcgcccgccaccgagaggagctacttccatctcttcccgc cccctccgtccccctgcacggactcatcctgacctcggccgggccactctggcttctctg tgcccctgtaaatagttttaaat >425_at HG-U95Av2 gctctcacctcatcagcagtgaccagtgtggccaaagtggtcagggtggcctctggctct gccgtagttttgcccctggccaggattgctacagttgtgattggaggagttgtggccatg gcggctgtgcccatggtgctcagtg >463_g at HG-U95Av2 ttgccaaactgcgcaaagatattcgccaggagtatogagaggactttgtgctcaccgtga ctggcaagaagcacccgtgctgtgtcttatccaatcccgaccagaagggtaagattagga gaatcgactgcctgcgacaggcagacaaagtctggcgtetggatctagtcatggtgatcc tgttcaaaggcatccccttggaaagtaccgatggagagcggctcatgaaatccccacatt gcacaaacccagcactttgtgtccagccacatcatatcacagtatcagttaaggagctt >464 s at HG-U95Av2 gggcctagcagtcttcacctctgagtcaggctaggggcctccccttctcatcctccccac ccccccgccaaggttctcacactggcctgggcttgggtgcccatataggaggtctgtatg ttcaccaacagtgcggaggggtcacacattgcaaaacactgcccagaacagtaaaaagag >481 at HG-U95Av2 gaagacttggccaagaagtattttgctcagatagttcatgctatatcttattgccataaa ctccatgtggttcacag >535 s at HG-U95Av2 tgatttcaaattgaactcctccattgtggaacccaaggagccagccccagaaacagctga tggcccctacctggtgatcgtggaacagcctaagcagagaggcttccgatttcgatatgg ctgtgaaggcccctcccatggaggactgcccggtgcctccagtgagaagggccgaaagac ctatcccactgtcaagatctgtaactacgagggaccagccaagatcgaggtggacctggt aacacacagtgacccacctogtgctcatgcccacagtctggtgggcaagcaatgctcgga gctggggatctgcgccgtttctgtggggcccaaggacatgactgcccaatttaacaacct gggtgtcctgcatgtgactaagaagaacatgatggggactatgatacaaaaacttcagag gcagcggctccgetctaggccccagggccttacggaggccgagcagcgggagctggagca agaggccaaagaactgaagaaggtgatggatctgagtatagtgcggetgcgcttctctgc cttccttagagccagtgatggctc >543 g at HG-U95Av2 gaatatgtcatagttctgagctgccagtggaccgcccttttcccctaccaatattaggtg WO 2005/068655 PCT/GB2005/000057 124 atcccgttttccccatgacaatgttgtagtgtcccccacccccacccccctggccttggt gcctcttgtatccctagtgctgcatagcccggcatttgcacggtttcgaagtcattaaac >544_at HG-U95Av2 ggtgaagaccttgctgctaaatgctgctcagaacaccatggagccacccctg-accccgcc cagcccagcagggccgggactgtcacttggtgatacagotctgcagaacctggagcagct gctagacgggccagaagcccagggcagctgggcagagctggcagagcgtctggggctgcg cagcctggtagacacgtaccgacagacaacctcacccagtggcagcctcctgcgcagcta c >545_g at HG-U95Av2 agtggcagcctcctgcgcagctacgagctggctggcggggacctggcaggtctactggag gccctgtctgacatgggcctagaggagggagtgaggetgctgaggggtccagaaacccga gacaagotgcccagcacaacagaggtgaaggaagacagtgcgtacgggagccagtcagtg gagcagaaggcagagaagctgggcccaccccctgagccaccaggagggctctgccacggg cacccccagcctcaggtgcactgacctgctgcctgcccccagcccccttcccggaccccc tgtacagcgtccccacctatttcaaatcttatttaaca >570_at HG-U95Av2 actgicactggactcgtaccaggccccgggccccggggatggaggcaccgccagccttgt gggcagcaacatgttccccaatcattaccgcgaggcggcctttgggggcggcctcctatc cccggggcctgaagccacgtagccccgcgatgccagaggaggggcactgggtggggaggg aggtggaggagccgtgcaatcccaaccaggatgtctagcacccccatccccttggccctt cctcatgcttctgaagtggacatattcagccttggcgagaagotccgttgcacgggtttc cccttgagcccattttacagatgaggaaactgagtccggagaggaaaagggacatggetc ccgtgcactagcttgttacagctgcctctgtccccacatgtgggggcaccttctccagta ggattcggaaaagattgtacatatgggaggagggggcagattcctggccctccctcccca gacttgacttgaaggtggggggtaggttggttgttcagagtcttcccaataaagatgagt ttttgag >574 s at HG-U95Av2 actctgagcaagt cccagat at act acaactcaatgcaat cttt aacat gt tgaat acca agaact gcccaagt tt gaagga caaa ccgaaggt gatcat cat ccaggcct gccgt ggtn ncagccctggtgtggtgtggtttaaagattcagtaggagtttctggaaacctatctttac caactacagaagagtttgaggatgatgctattaagaaagcccacatagagaaggatttta togctttctgotcttccacaccanntaatgtttcttggagacatcccacaatgggctctg tttttattggaagactcattgaacatatgcaagaatatgcctgttcctgtgatgtggagg aaattttccgcaannttcgattttcatttgagcagccagatggtagagcgcagatgccca c >576 at HG-U95Av2 atcggcgtgctgcgggatcagcaacgctaccacgaagacattttcgggctcacgctgcgc acccaggaggtgacaagccgcatacgcacccagagcttttccttgcaggagcgtcagttg cggggcgcagtgccctgggcgttagaccctcccggctcagacaccaacagcccctgagag ccgcctggctttcccttccagttccgggagagcggetgcccgactcaggtccgcccgacc aggatcagccccgctcctcccctcttgaggtggtgccttctcacatctgtccagaggetg caaggattcagcattattcctccaggaaggagcaaaacgcctcttttccctctctaggcc tgttgcctcgggcctgggtccgccttaatctggaaggcccctcccagcagcggtacccca gggcctactgccaccogettcctgtttcttagtccgaatgttagattcctcttgcctctc tcaggagtatcttacctgtaaagtetaatctctaaatcaagtatttattattgaagattt accataagggact gt gccagat gttaggagaact act >583 s at HG-U95Av2 tgcccatctatgtcccttgotgtgagcaagaagtcaaagtaaaacttgctgcctgaagaa cagt aact gccatcaagatgagagaact ggaggagtt cctt gat ctgt at atacaat aa c ataatttgtacatatgtaaaataaaattatgccatagcaagattgcttaaaatagcaaca ctctatatttagattgttaaaataactagtgttgcttggactattataatttaatgcatg tt aggaaaattt cacatt aatattt gct gacagctgacctttgt cat cttt ctt ctattt tattccctttcacaaaattttattcctatatagtttattgacaa >590 at HG-U95Av2 WO 2005/068655 PCT/GB2005/000057 125 tccgtggcaatgagactctgcactatgagaccttcgggaaggcagcccctgctccgcagg aggccacagccacattcaacagcacggctgacagagaggatggccaccgcaacttctcct gcctggctgtgctggacttgatgtctcgcggtggcaacatctttcacaaacactcagccc cgaagatgttggagatctatgagcctgtgtcggacagccagatggtcatcatagtcacgg tggtgtcggtgttgotgtccctgttcgtgacatctgtcctgctctgcttcatcttcggcc agcacttgcgccagcagcggatggg >595 at HG-U95Av2 aaagccagtaaccatgagtatgaggaaatctctttctgttgctggcttacagtttct ctg tgtgcttt gt ggttgot gt cat atttgct ctagaagaaaaaaaaaaaaggaggggaa at g cattttccccagagataaaggetgccattttgggggtctgtacttatggcctgaaaatat t tgt gatccat aact ct aca cagcct tt actcat act at taggcaca cttt cccctt aga gccccctaagtttttcccagacgaatctttataatttcctttccaaagataccaaataaa ctt cagtgtttt cat ct aatt ctctt aaagtt gatatct taat attttgt gtt gat cat t atttccattcttaatgtgaaaaaaagtaattatttatacttattataaaaagtatttgaa atttgcacatttaattgtccctaatagaaagccacctattctttgttggatttcttcaag tttttctaaataaatgtaacttttcacaagagtcaac >626 s at HG-U95Av2 cgggctctgctctgatcacctttgatgaccccaaagtggctgagcaggtgctgcaacaaa aggagcacacgatcaacatggaggagtgccggctgcgggtgcaggtccagcccttggagc tgcccatggtcaccaccatccaggtgtccagccagttgagtggccggagggtgttggtca ctggatttcctgccagcctcaggctgagtgaggaggagctgctggacaagctagagatct t cttt ggcaagactaggaacggaggt ggcgatgtggacgttecgggagct act gccaggga gtgt cat gctggggttt getagggat ggagt ggct cagcgt ctgt gccaaateggccagt tcacagtgccactgggtgggcagcaagtccctctgagagtctctccgtatgtgaatgggg agatccagaaggctgagatcaggtcgcagccagttccccgctcggtactggtgctcaaca ttoctgatatcttggatggcccggagctgcatgacgtcctggagatccacttccagaagc ccacccgcgggggcggggaggtagaggccctgacagtcgtaccccaag >669 s at HG-U95Av2 gaga~cigtgtatcaggtcagggacttggacaggagtcagtgtctggctttttcctctga gcccagctgcctggagagggtctcgctgtcactggctggctcctaggggaacagaccagt gaccccagaaaagcataacaccaatcccagggctggctctgcactaagagaaaattgcac taaatgaatctogttcccaaagaactacccccttttcagctgagccctggggactgttcc aaagccagtgaaatgtgaaggaaagtggggtccttcggggcgatgctccctcagcctcag aggagctctaccctgctccctgctttggetgaggggcttgggaaaaaaacttggcacttt tt cgt gt ggat ctt gcca cattt ct gat cagaggt gtacact aacattt cccccgagct c ttggcctttgcatttatttatacagtgccttgctcggcgcccaccaccccctcaagcccc agcagccctcaacaggcccagggagggaagtgtgagcgccttggtatgacttaaaattgg >706 at HG-U95Av2 TIGRSequence >712 s at HG-U95Av2 TIGRSequence >717 at HG-U95Av2 gttcggatttgactgcctgtatatgttttgtgaaatggtcctgtttttgggtaggtgaca cgtggact ct agtatgtaaat gtt actt gaat ctgt gctt cat aatagt gt gtggcat gt atgtgcagactcttggatgctttatgcctgcgcaccaggagccctgtcctcacgttccca ggagggcggcttcacccttcgtaaccaggagacaaggcggccatggatttgcccttgatt ctattttgctaatggaagatagaaaggagagaaggtttttttttttttttaacattctga agatggtgctgtgtcaagaaggacottttttttcccctctcccctattttttaagtacct tggaggaggagaggttggtgacatgcatggtggggatctatggcctctggtgctt >823 at HG-U95Av2 acctgaggggcctcttatgggctgggttctacccaggtgctaggaacactccttcacaga tgggtgcttggaggaaggaaacccagotctggtccatagagagcaaaacgctgtgctgcc ctgcccaccctggcctctgcactcccctgctgggtgtggcgcagcatattcaggaagctc agggccctggctcaggtggggtcactctggcagotcagagagggtgggagtgggteccaat WO 2005/068655 PCT/GB2005/000057 126 gcactttgttctggtcttccaggctgggagagcctttcaggggtgggacaccctgtgat ggggccctgcctcctttgtgaggaagccgctggggccagttggtcccccttccatggact ttgttagtttctccaagcaggacatggacaaggatgatctaggaagactttggaaagagt aggaagactttggaaagacttttccaaccctcatcaccaacgtctgtgccatttt >848 at HG-U95Av2 tccaggctcgtcattggaggtgaacaagcaaacccagacggctccactaggacttcaaat tgggggttggatttgaagacttttaagtttccttccagcccagaaagtctctcattctag cctcctggcccaggtgagtcctagagctacaggggttctggaaacattcaggagcttcct gtcctcccagctcctcactcaccttcagtaacccccactggactgacctggtccacaggg cacctgccaccctgggcctggcagctcagcttcccaacacgcaggagcacacccagcccc cacatcctgtgcctccatcagctaaacaccacgtcacttcatgcaggtgaaacccagtca ctgtgagctcccaggtgcagccagaggcacctcaaga >849 g at HG-U95Av2 tttggtgctttccagaatcccgtaacacctgattaactgaggcatccacttctttcagca gactgatcaggacctccaagccactgagcaatgtataaccc >873 at HG-U95Av2 atagcgcctgtataagtagatctgctttctgttcatctctttgtcctgaatggctttgtc ttgaaaaaaaatagatgttttaacttatttatatgaagcaagctgtgttacttgaagtaa ctataacaaaaaaagaaagagaaaaaaaaaaacacacaaaaagtcccccttcaatctcgt ttagtgccaatgttgtgtgttgcactcaagttgtttaactgtgcatgtgcgtggaagtgt tcctgtctcaatagctccaagctgttaaagatatttttattcaaactacctatattcctt gtgtaattaatgctgttgtagaggtgacttgatgagacacaacttgttcgacgtgtagtg actagtgactctgtgatgaaaactgtgactccaagcggtgtgtccctgcgtgcctttata ggaccctttgcacgaactctggaagtggctcttataagcgcagcttcagtgatgtatgtt t >874_at HG-U95Av2 gagcagtttgccctgggttccctccttccacctgcgttcctcctctagctcccatggcag ccctttggtgcagaatgggctgcacttctagaccaaaactgcaaaggaacttcatctaac tctgtcctccctccccacagcttacagaccattgtgg >875 g at HG-U95Av2 tgggttcaggattccatggaccacctggacaagcaaacccaaactccgaagacttgaaca ctcactccacaacccaagaatctgcagctaacttatttttccctagctttccccagacac cttgtttattttattataatgaattttgtttgttgatgtgaaacattatgccttaagtaa tgttaattcttatttaagttattgatgttttaagtttatetttcatggtactagtgtttt ttagatacagagacttggggaaattgcttttcctcttgaaccacagttctacccctggga tgttttgagggtctttgcaagaatc >925_at HG-U95Av2 gaggcctgcgtgttggatgaacttgacatggagctagccttcctgaccatgtctggcatg gcatggaagagtttgaggacatggagagaagtctgccactatgcctgcagctctacgccc cagggctgtcgccagaactatcatggagtgtgcaatggggaccgcggcatgcagctcat gcacgccaacgcccagcggacagatgctctccagccaccgcacgagtatgtgccctgggt caccgtcaatgggaaacccttggaagatcagacccagctccttacccttgtctgccagtt gtaccagggcaagaagccggatgtctgcccttcctcaaccagctccctccggagtgtttg cttcgagtgttggccggtgggctgcggagagctcatggaaggcgagtgggaactcggctg cctgcctttttttctgatccagaccctcggcacctgctacttaccaactggaaaatttta tgcatcccatgaagcccagatacacaaaattccacccctagatcaagaatcctgctccac taagaat >943_at HG-U95Av2 gacggtataacacatctactgaaaaagcaacgggaaatgtggtcctatttaagccagccc ccacctagggtctatttgtgtggcagttattgggtttggtcacaaaacatcctgaaaatt cgtgcgtgggcttctttctccctggtacaaacgtatggaatgcttcttaaaggggaactg tcaagctggtgtcttcagccagatgacatgagagaatatcccagaaccctctctccaagg tgtttctagatagcacaggagagcaggcactgcactgtccacagtccacggtacacagtc gggtgggccgcctcccctctcctgggagcattcgtgtgcccagcctgagcagggcagct WO 2005/068655 PCT/GB2005/000057 127 ggactgctgctgttcaggagccaccagagccttcctatctttgtaccacagtttcttctg taaatccagtgttacaatcagtgtgaatggc >962 at HG-U95Av2 cttcccagctcttagaaatgtgctacgatgtctgtgaaggcatggccttcttggagagtc accaattcatacaccgggacttggctgctcgtaactgottggtggacagagatctctgtg tgaaagtatctgactttggaatgacaaggtatgttcttgatgaccagtatgtcagttcag tcggaacaaagtttccagtcaagtggtcagctccagaggtgtttcattacttcaaataca gcagcaagtcagacgtatgggcatttgggatcctgatgtgggaggtgttcagcctgggga agcagccctatgacttgtatgacaactcccaggtggttctgaaggtctcccagggccaca ggctttaccggccccacctggcatcggacaccatctaccagatcatgtacagctgctggc acgagcttccagaaaagcgtcccacatttcagcaactcctgtettccat WO 2005/068655 PCT/GB2005/000057 128 Table 2b: Probe sequences for identification of transcripts of Table lb >1529 at HG-U95Av2 aattactgtatctaaaaggagctgctatgaagtacctttcttatgttgctaggctactgt ttctgaaagccctggatctctttgcaccaaaaatggtccagatagactctttttaaggat cttggctgctttttactagaaggttgcttttatgagcatatttatactgctgaaggatga gtgttaattttaattaactttgccgttttgtagagaaaactattcacaagataaattcca agtcttttcacctgtcaggcatgca >31849 at HG-U95Av2 aaattcacagtactccattttggggtccaaactgtaatgctcaaaataataaatgcttac acgaaaattatttattgagaatattcatataaaaattacctaaagcaaagtaaaaaaagt aaaatcaaggtggtatatttgaagtgaatggtgattggaaatttttagctgtaacaaaaa gaaagaaaacaactttttttaaagcctcattctcttttctttcaaaatgtaccttattcc cacacactcttgggctgacctttattttatcaataagctcaatattactttgtttaaaat aagannnnnnnnnnnnnnncattctctctttaaccatataatttaaaaactcctcttcac gattgatagcaaaatcagaaacgttaggnnnnnnnnnnnnnnnnnnnnnnnnnnntaagt tggaaaaactattattaataatattatcctatccatccatatctattgaaattgtacagg tocataatttcattttaattaattataggaaagaagaaaagataatacccatttgttata tcacccctctccctatcattaactatcaaataaataaataaaagcaatctgatttccaac gtggta >32110 at HG-U95Av2 atgatct gccagagcctctccaggggtggaatacatgnccnggactaagnccaatgacan ccttnccatctttnccagctatggtgactgggttaggtatgatncttgtgagttaagaca atgaagnccagagggaatttcaagacttatgggaatgctgggtagaagctgttttaattc ccctgttgaatgtgaaaaaggtagtagtattcctgggtctttatgatgaccaccttgggc cttgggatcatgaccaggaatcacgtgaagctgacaccactgaagggagagttgagaggc agaaagagatcaagtccttggtgaaattgtttaagtacaggatcaagccttgcttgagat tggccttacct >32385 at HG-U95Av2 gtcatct tgtaattctatgtgtaactttggaggaatttccaaactgttttctgcaatggc tgcaccattttacattcctgtcagcaatgtacaggattccagtttctccatatccctgcc aacacttggtattttcctttttttcagttagttactctagtgggtatgtggtggttgtcc cattgctgtttgttttgattttcattgtccctaatgactaatgatattgagcatctaata tccagttgtcccagcaacatttgtttgaagagactattctttcctgtgtaaetggtettg gcatctttgttgaaaatcgattggcagccaggtgcagtagctcacacctgtaatcccagc actttgggaggetgcgctgggcagatcgcttaagct >32791 at HG-U95Av2 ttgtaaacagatcatcctaggcgaaagttttttttgtttgtttgcttttaaattagttta tttctaaatcttagtcttccacatttctagaggccacctgacacaagtccctgtatctga agtctannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagtggataact taatcttttaatacagttccgtcattcccatcttgttttcagaagagaaggtnnnnnnnn nnnnnnnnaacatatccactgtgtgcatagagggtctcttcacgttgatgcttggcattc catcagctttctctaagtctttgctcaagttcaaccttaaaatgatgttagacaacaggt cccagtcagttccctctattttcacccattttgctcacaagccatattggcccgattagt ggtactgtctgactcacgtgtgtgatccaaataaaggtagctgctgaccannaaanaaaa aaaaaaaaaaaaaannnnanananaanccagggttctctcatgaggagttaa >33325 at HG-U95Av2 cataccaaagtcaaacatgggcaagaggtgannnnnnnnnnnnnnnnnnnnnnnnnnntt tgtctgtgattttaaactaactgtgtatgtattgatgtttggaagattgtttgaatttta aagt gat aatagt actt aatgtt at ccagtatt gttcatt aaat ggt gtt at cct aaagc tgcacttgggatttttacctaacgctttactgattctctcaagcacatggncaaagtttg ant tt gcactccgtt catt tctga cacgttttgct gncct cct accttt ct aagc gt cat gcaaattcgagaatggagaaggacgotgccggtccctgagcggtgtggagagggcggaag gtggactccagcgcagcttgaggggetgaggacggaggctgcagcatctgtgtcgttcta ctgagcacgcttetctgcctcgctcctgacnnnnnnnnnnnnnnnnnnnntcagcagtta WO 2005/068655 PCT/GB2005/000057 129 tgtttacacatcatttttatgttcctgctttgtaattcatgtttgagatgggtggccact gtaca >33924 at HG-U95Av2 gtcgcattaatgaggcccttccacatcatttttaaactaatgtttttctatattaacatt attatggatatttggctttcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncccatgc tccaatcaaagggatttttagtagtgcctctaagcaagcaccgatgagtcagtcccacgt attttcttttttgtcagtattgtttgggaaggagacatgccgggatgtgtcatcgtgcca aataccacatttcctgttggcacagtttcacagaagtaaacataagcatgttttaacagg tttttcttttcttttttcttttttaaaatgttttatttatttaacccgccattgtgtgtt tttaagtattttcttttnnnnnnnnnnnnnnnnnnnnnnnncaatctaactggctatgtt attattattaaatttatgttttgcaacttagaaaccagctacagtatgg >34176 at HG-U95Av2 ggagettattcctggctccatcgctaacacgttgactgcttattatgggaaanttttctc tgaagccagggagaagcattgattgatgtgggcaaatccaagctccagccaggtcgcagt cccaaat gccga cat cact gact ccagggaccagggacat ggagaaaget gttt at gat a tctttaaccaggccctcttnactagagctggtgtttgtgactggnccaacaagatgtggc tatgnccaggggacatctgagtatgtgncccagtcatcttttttcacaggttgaagggag agaaaagatttt gagtt aaggt cat tggctgct ct act ctgt cccctacctggt cacct a gtgatagccccagtggagatactgtccatacaaggtnnnnnnnnnnnnnnnataccacag taaaaggccaggccaggaggggtaggagactatggagatcttacctcctgataaatg >34303 at HG-U95Av2 aatgtcaaccggagcccttacaccagccctccagcatctaatnnacttnnaanntnnnnt naannnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nntggcagoggncttatccttctctgttgccaaccttgccgtccgacctcctccgccccc atgcggtgaccccgtccgtgtctgtgtctgtccatacgtgtgagtccagctaaaaagaca aaacagaaccnnnnnnnnnnnnnnnnnnnnnnnntggagaaggctccgacgtctccgaag tgcagcccttgggatggcattccgttgtgtgccttattcctggagaatctgtatacggct cgcctatagaaatatagcct >34678 at HG-U95Av2 ccgaactatttgt caatgaagatt gt aaagccaaatgt gt aacaa aggcaaagg~ctt cat ttcaagagtcatccagcaatgagagaatcctgcctctgtagaccaacatccagtgtgatt ttgtgtctgagaccacaccccagtagcaggttacgccntgnnnncnnnnnncnnnnntnn nnnnnngnnnntnnnnnncnnnnnnnnnnnnnnnaacnnnnnnnnnnnnnnnnntgttat ctcttaagtattaaaagttttattttctaaagtttaaatcatgtttttcaaaatattttt caaggtggctggttccatttaaaaatcatctttttatatgtgtctteggttctagacttc agcttttggaaattgctaaatagaattcaaaaatctctgcatcctgaggtgatatacttc atatttgtaatnnnnnnnnnnnnnnnnnnnnnnnaannnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngcccacaaccattgctatattttgtatgga >34800 at HG-U95Av2 tggccaaaagotgaagggagttactgagaaaatagttaacaattactgtcaggtgtcatc actgttcaaaaggtaagcacatttagaattttgttcttgacagttaactgactaatctta cttccacaaaatatgtgaatttgotgcttctgagaggcaatgtgaaagagggagtattac ttttatgtacaaagttatttatttatagaaattttggtacagtgtacattgaaaaccatg taaaatattgaagtgtctaacaaatggcattgaagtgtetttaataaaggttcatttata aatgtcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaannnngnonnnaattatc tttcccccaaaaaagaaaaaaaaaataggcgaagcaaaatcacatactgtttgttnnnnn nnnnnnnnnnnnnnntgctagattcctgacattttgttttgaatttttc tacacctggag cttgt >34857 at HG-U95Av2 gaaagetttcccaattgcacttgcatctaaacaaaactgttgcagtttttactctattta ttttgttccccatgtttatgaaagtcctgcacagtttcaaaggcatggtaaataatatat caatgtttatgtagtctgttacagaaacagctatagataacattatccagtgaagagcaa aatt caagcttt agaaaat att catgcatgcaat ttt ga cat at ctaaaaat aggttttt gtatatttatggtgggaggtggttgggaacttttaacaaaatggggtgttaatttttgta WO 2005/068655 PCT/GB2005/000057 130 cagtctgtgggcatttacacatttttaatgtattaaaatttggtaattatgtgtacatta aattaataaaagttacttctagttatgatttgtgaattccctaagaccttggattttttt aagtaactttatatcagaaatgatactgcatctttattttttaaaattgtattgctgct caagaatggtaccctcttgtcaaaaaggcat >35484 at HG-U95Av2 acactgttttgtaatgatcgctttgcatgtcttttccagctgactccgccaccatctcct gcctggatgactgcagcagcatccttgctggcctctctgcttcctgcattgcctcctctg aatcttcaggatgccaagtttgtggaggaacggagannnnnnnnnnnnnnnnnnnnnnnn anngtcatgaacaaagtcatccagatggtccccgagttcgctgccagccccnannangnn nnccnnnnncnnnnnnnngcccttcttcgtgatgggattacaggtcggaatgtacggatt gtttcattttggggtaatgatggatcagccacagccaagccttacccgtgctgacgaatc t >35763 at HG-U95Av2 ttgcccatgaaggtggccatccgcagcgtggccgtgaccaaggagcgcagccacgtgctg gtgggcctggaggatggcaagctcatcgtggtggtcgcggggcagccctctgaggtgcgc agcagccagttcgcgcggaagctgtggcggtcctcgcggcgcatctcccaggtgtcctcg ggagagacggaatacaaccctactgaggcgcgcnnnnnnnnnnnnnnncggctgctcggg ccccgcccccggcaggcctggcccgggaggccccgcccagaagtcggcgggaacaccccg gggtgggcagcccangggggtgagcggggcccaccnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnccctcagggattggcgggeggaagtcccgcccctogcoggctgaggggccg ccctgagggccagcactggcgtctgcggccgctgnnnnnnnnnnnnnnnagtctggggnn gggttccccggcttccaagtcgctg >35861 at HG-U95Av2 gatgctgcccttctttgcacgaaagcctggccctcttgctttggcgtgataaacccctgt ccatcttccccaaagctcatttatgagcccacccagaggctcctacccccaaagattttc acagaaacttgaggcc >35959 at HG-U95Av2 gatcttcagaaagtaccataatgtcatcctactctacatttcacaagacgaattattttg agatttgtttattatattaaaatgtttttttacgttcccactaaattttgaccccatata aagaaatgtgttatgtatgttgtgcctccttagagacataaatttagtgtcaaaacatgg gagatggcttactcagaagcatactccacttaacataccatggcctgagctaagtaccat gtcctgtttgtgtcttatttttaaatattttctttgtccacatgggccgttgaccttaga gttaaggcggttngcttttttgaagaaatcanccaaagtttctgggaaactatgttncaa ggttgaaatggagagtagatttaattttatttgtcttgtagggaagaaatcttcctttga accgcttttcttgotttttccctttttcccaaactaggttacaggttcttatctgcaagg ttcaagttgcttagacattgttttccagtattctgcagggccagtcagttgtacagaagt t >36014 at HG-U95Av2 gttctaagcatgcagttctcacctccatttagtcccccatcagaacagnnnnnnnnnnnn nnnnnnnggagcctaaatttagttcagcttacctttgagaatagcatcaattcagactct cttttcattatgttttcttttctttttccctctttttaaactacattgtgttagagtcat agtctaggatcctgagagattttccattcttgtcaccattcacttgcattgtaaagattt tctttgtctgttgttggcatagattcttttgtacatatttatttatttgtgtttatatat gtcaattggtttcctttcttagcttgatattgcctagctttgttgttttaattaactttc tattagagagactgtatatattttttctaaatactttgtgaaatcatttttggtagcaat atctttgaatatgatgaataaaagtgactgtgagtgcaaatagaattagcagtaagaagc tactctagctaatttgccat >36250 at HG-U95Av2 gccccagacccttgaaggaaggtgctccccttcacacacccaggctggaaannnnnnnnn nnnnnngacggcttgatggtagccaggacctcctctttactgcgggggtgggcgggggcg gaggatgggaactggctagtgagccctgaaata >36336 s at HG-U95Av2 cccggagaggtgctggacctcacctacagccccccggccgaggccttcccgccgcccccg cacttctctttcccggcgccgctgtccctggacgccggccccggcgtcgtgccgctgggc WO 2005/068655 PCT/GB2005/000057 131 acccccgacgcccaggccgaccctgcggccctegcgcaccagggctgcgacatcaacttc aaggaggtgctggaggacatgctgcgctcgctgcacgcgggccgccctccgagggcgcg ctgggggagggcgcgggggcggggggcgcggcgggcggtggtcccgagcggcagagcgtg atccagttcagcccacc >36497 at HG-U95Av2 attcacacggtactcagaggcactgntggggaagtttgttggtctttattagataaattt ccagagacctgtccataatacccaacagaacatgactgtttctttgaggaaagggttata atgtctgtggtgtacaagtcgtttttggtataacttctttcctgctgctgctgcttcccg gcaaacatagttttcctatttcaggcagagtgcggtatattccaggaaacactgtttcct actcacttagettacttctttgttgaatgcctcactaatggcaagtttcaagatgttttg ggtgacaatgcacacatgctgggcaaaagggtgatggccagtggetggcagctgggccag cagaagctaggacatctgtgagttgtcattctcatctatccatgtccactggcctgccag catccgccagtgccttgccagtgtgcacggtcccacactgtggcccctgagtcccctaat gtacacgctgcagccagaatgcagatggagotggcttggetgttccctggatg >37030 at HG-U95Av2 ccacgactgaagttgtagattgagcngaataaccatgggaagtgaccaagncaaagacac tcgattggnagtcagttgaatatttgtacccntcagtggagcccttctggntcttttctn nnnnnnnnnnnnnntttcctctagncaaatacttctttctccttgcttgcctccaccatg atatttgaataagagatggccagaggataacacttgtctcttaaaaactaagctaaaaag aacctagaaccttcaattgagcagttgtgaaaattgctaatggtnccaaggccaagcaaa gagtttcagaaaatgactgagaaggagcgataacccccagaatgcaaaatcaggggcatc attatccggtgcttgaacaangnngntccgctctacaactggtttttttaggacttgtga ggaacacagcaacggaaatccatccacaaaggatgcagtgccccaacttgt >37216 at HG-U95Av2 accactgctcagaggagccctaggccctggccgcagtgccttcagcgcccgacccgggcc cccacctggtcagccnnnnnnnnnnnnnnnnnnnnnnnnnnnnggccggggcgtggcagg gccctctctgtgcctctcctcccaagtaggaaggggctccgggtggctgctctgggactg ggcacccacaagggctcagtgggcccaaacccttnnnnnnnnnnnnnnnnnnnnnnncca agagctagaaactcaggaaaccccaggtgctcagggccccgcgtctcgggggctccgtgg ggcagacccctgctaatatatgcaattctccctcccccagcccttccctgacccataagt tattgcccgctca >37786 at HG-U95Av2 cgtccattactcaaggagacagcataacagatgcagaacaagtcatatttgaagaatgtt ttgtactaaacttcatttaattattcagtttttaaagggaaaaagggcgtganctcacac agtgagctgtttatttaaatatcattaaggagaaaaaaaaatatggtgagaagctcgotc ctttcaacttgtttggtactgacagctgatagaagctattttctaataataaacatccag tgtgtgaaagacaaaaaaaaannantgcaatactctttttttaatgataaaacctgtgaa gtttcccaaagcaggttttaaaaggaaaaaaaggaaaagcaaaaaggttgctgttctcac tcccatctcatttagtgcatgtcttaattcgggattagtaatgaattggaggatcattag acatttctaggaacc >37788 at HG-U95Av2 catgaatcacatagagcagtggagttttanccaagtggtgtgtgtggtttttgtttttta ctatgcaaagatgggaaatgcacaaacttttcaaagactagtgtetgaagaactttacaa acaatacttgaaccctttctttaaagttatcccatcatgttttatagtcattgttgottc cattgttagtttccattttcaagtgctttgtaattttttaagtgcactacctgaaatttt gtttgaaattaataaattcattcgtatcttgttggctgcctatgaatggagattcagtag tcattgtatgcatctttaagtcaaatgtgtattaaaactttcgttaacgtanaaaaaaaa aaannnannnnnnaannnnnnnnnnnnnncnnccttttctgtttcctcttgtagtgctga tta >38393 at HG-U95Av2 cccaaggtgggacttggagaatattttgcnttggcatatgtttggtctgaatggtgtagt tgctggttccctagagaggaaaaggtggcnnggcccnnnnnnnnnnnnnnnnnnnnctta atttccagttgaaaccctagtagaattgtgaatgaaaacctcaaggttgagncccctctg ccaagcagcagagctagtagaaggggatgcaggggcaaagcactcagttgccaagcaagg aggagagatgtacgtgggctgtgtggcagtccccacaccctgccctggcttcttcaggtt WO 2005/068655 PCT/GB2005/000057 132 atcgcaccactatggaatcctttgcagaatggtactcatataatggtttaaaacaacaca ttcataattgactctgtgcaggatgtcactcaatcagtttgggtttgcttt >38510_at HG-U95Av2 gtcctcccatattggcaaagataaagcaattgacaaaaatggaattcttgttcaatactg gcaggagtgaaaattggtagaacctttntagaaggnattnggcnannatgtatgnaaan cntaaatgtngatacncctttacccagcagtttgtttnggaatttatcctaatgaataaa agttgnccnagncntcnaaacangannnnnaannnanatttcnatgatgtttatgatatt aaaacattggnaacaactgaaacatCcntcagtaaaagatggattaaataaattccatgc nagttgtcatttaaaaatatttagatatatgtttattgctatggatatatgttcccaaaa tattattgaatcaaaaagtagactacaggatatatgttgaatatgagctcatttataaca ttgaatattttaagataatgtatgtttcatagagagatcttcaccaaatgttaaggattt >38717 at HG-U95Av2 tacaaggttgccacacctagttctgcccagctttatgtcttttattccagtattccacca aagtttgttttcctgncattccagttctcaagtcttaagnataaagattgtacttgacag tttagtatatccataaaactatttgaggtggttaaggttcttgggttcattttccttaat actttgctgaatattgtagattgtaggcaatgaaaaagtctactaaattaggaaaacctt gaataattaggtatcctaggtaagagcccctaaacatcaagcaatctgtgagtctgtaaa gaaataaatattttttggattattcttatctaattccacccctgttggaagatgatttct ttgttctttgcaactatggaagctg >38749 at HG-U95Av2 ggcggcagcacagcacctgcacgaacacccgccgaaactgctgcgaggacaccgtgtaca ggagcgggttgatgaccgagctgaggtagaaaaacgtctccngagaaggggaggaggatc atgtacgcccggaagtaggacctcgtccagtcgtgcttgggtttgnccgcagccatgatc ctccgaatctggttgggcatccagcatacggccaatgtcacaacaatcagccctgggcag acacgagcaggagggagagacagagaaaagaaaaacacagcatgagaacacagtaaatna ataaaaccataaaatatttagcccctctgttctgtgottactggccaggaaatggtacca atttttcagtgttggacttgacagcttcttttgccacaagcaagagagaatttaacactg tttcaaacccgggggagttggctgtgttaaagaaagaccattaaatgctttagacagtgt aaaaaaaaaaaaanannnnnnnnaannnnaaaaaaannnnnnnattggtgtttgtttgcg tatcengaaagcagntcatgttatccataaatctggttttg >38972 at HG-U95Av2 cgttagtaaccatttagtgacaaaggattaaaacatccatctggatgttaattttgaaga tgtaaattatatgttgtttaaatttttccaggcatctgaaaaccttatctgctagacaat gtaagattcacacagagttatctngggattctgattttttaaatagtacatatcattaaa ccattttctctaaatgtaagaagagcagaaaaaatcttataagattatcagatttttcta atgacacagaaatgtaagaaaaaaatccctttatattgaaaaaagatgcagtcaaagtct tttcagacatgcccaaactttgagaatttcttcaaccatctaatgctataaagatttttg ttcttcctgttcacaaccagttgtataacagaaatactagctactgttttccttcctgtg t >39582 at HG-U95Av2 ggccacaaatggagggattgtcctttcaagcaccacagcttcagataaaattagtacttt caaatattgtccactttaacttaaaaaattctagagggattatattggagactcaactgc ccttnggttttagtttataaaatggcctagtactgtggaattttaattttagaaagtctt agcatcagatcataaacattcattaaaagaaetcacatcccatctgaaacttcccagggg agttgggattcttagtagattggtagaaaggggctcattttctactgcatttcccatttt tggtatcttgttcagcatgttttatttttatttcttgtctgcagaacatcctatatttat gagaacattctttaagaagaccaccacatagaataccccttcctatcagctcgctctgat ttagccttaat >39597 at HG-U95Av2 caaacataacggatgtaaggcagaaagtgatcggagaaggaatgagaaantgtgcgtgat gttaatgaaaagtcatatgcagctagagcagacccaggaaagctttctggaagagattgc atctgaggaaattcaggaaggatctttgtagattggggggagattctaaattgaaggggt gatngggtgaggggccagagggaagtctgctgtgttctcatgtaggatgtcagccctccc tgcaacttctctttttggccaatgtcttttcactttcctgaccctttagaatcatcccca gccagacgcaatcatggaagttgccttattgtcactggttaagaacttggcgaga WO 2005/068655 PCT/GB2005/000057 133 >39602 at HG-U95Av2 gggtctacattaatcttccagtactccttgctgatgctgtgttatgtgtcatctaacaga aatgactcctttgaaataagtaaatctttggtttttgttnnnnnnnnnnnnnnnnaagc aaaacaaacaaacaaaaacaaattttaagaacacaacaaaaaagatttgacttccgaata gaatgttttctttaagaggcatgaaaagcaactattgttgtgttacagtgttaaaaatat tcagttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnntgtggcatctgaacttttataaaggtttccttgtgc caaataagtgcaaagatttaatttactattaaaaaccataagcatatgttatagttccag aagaattattttgtcatcaagtgattttgatctttagtgtcaatatttatatttagatta atttttataaatgaaaatattttaatggtttaagaaaatgaggacaacaggataatatct ttgatgacttctgaaagttatgcttccctt >39827 at HG-U95Av2 acgtgctcctcagagcagccggagggaggggggaggtcggaggtcgtggaggtggtttgt gtatcttactggtctgaagggaccaagtgtgtttgttgtttgttttgtatcttgtttttc tgatcggagcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnannnnnnnnnnnaa nnnnagnnnnggnngggnnnnnngnnnnggatcacttgggatctttgacacttgaaaaat tacacctggcagctgcgtttaagccttcccccatcgtgtactgcagagttgagctggcag gggaggggctgagagggtgggggctggaacccctccccggnnnnnnnnnnnnnnnnnnct tccatctagaactgtttacatgaagataagatactcactgttcatgaatacacttgatgt tcaagta >39837 s at HG-U95Av2 cctagttctcacgaggaccctttcttgcccacagtttcgagaggcccgtgccatgagacc gcctggggtgagcaaggcgacctgnnctgctgccngaaggtttggccgccgcgggacacc tgtttccttcccncagtgtctgcgtccgcacagcatacccagtcggacctcctaggaca gagactcagcgaacccttgtgggaaccgctgagctgaagttcttggaaggctcccaccc aggtgccccgttggaaagcagatat >40239 g at HG-U95Av2 tataagtatgcaacagtcagccgggggaagataaaggtacattataaaacacacattaat gcatttaataaatatatattatctatcaaaagtgagccttagctcttcatcagttaataa aaagcacctgctgagaactcctgtaagctggtatcatcattgcatcattggattataaaa gccacaatgctccctttcaacttggggtttg >40472 at HG-U95Av2 ttgctgaagagcaagcagagggtccnnnncgcctgctgtacaannnnnnnnnnnnnnnca tcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnaggcctctccctctgtcagttccagaacttctccctccatg acccactctatgggaaactcttcagcacctacctgcgccccccacacacctctcgaggca cctcccagacaccaaatgcctcatccccaggcaaccccactgctctggccaatgggactg tgcaagcacccaagcagaagggagactgagtgcctcagcctctcaccccctcctcctcag ggcagcgctaggggcctcccctatgcctcagccccatctctgctcctgtttgaattttg >40642 at HG-U95Av2 taagcccttgatgacttattgcatgatacagtannnnnnnnnnnnnnnnnnntaaataca tgaaaagcagtgtaagctagtgacactaaagccagtcttgtattactgtatttttgacag aatggttttgaaaactgtgctacagggactgatgtggcaaatatatctctttatgcagaa ggaagtctttttttttcntttttttttttttaagaagtatggctttttatgcatccttca tcgagggcattgaagttgcatggactgataaaagttgatgcaaaacaagaaagaaacaaa caaaaaaaaaaaaccagcaaaatgtttaccaaaaaactcaaacaaatgagcagtgcctgt tcaatttcacagtctctgttgagttcagttgtaaatatgtttcaaatgacattttcttgg gaaaaaaaatctctacaacattgtagaatgtgaggggtaactacatcccaggcatag >40855 at HG-U95Av2 ctcatgtatttatgcctaatgtaagctgacttttaaaaagctttcttttgttgcatgccc tgtgcaggcatctgtattgtacatgcatgcctttCgtcctgttttcctgtataaagttag tgaacaaagaaatatttttgcctagttcatgttgccaagcaatgcatattttttaaattt gtcatatatggaaagagcatgtttgttacatgtaaaagctttactgatatacagatatac taatgtttgaagatgctgttctttgcaagtgtacagttttcannnnnnnnnnnnnnnnnn WO 2005/068655 PCT/GB2005/000057 134 ncacccttgtggtttaaacttgctacaatgtatttattattcatttcctcccatgtaact aagaatcatggctat >41229 at HG-U95Av2 caacttttgtaggactgtgtgtttctttagatacatttagtacaactgtaggtgacgagt agtcagttattttgtgCtactacnnnnnnnnnnnnnnnnnnnnnnnnacttttggcatt ttgtcctcatgggccataaatacagaaccttgtattttaattaaanttttttncaaaagg anggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttagcagtaggatgtattatacgaca gttacttaatttctagagttcaggcctctgggatcaaccccagactgggccagaatgtta gtgaaggttttattgtgcccggttggaggataacgttctttgggtactttttgtgggttg caaatgaactcaattgccacaagttttaaactggtgtaaatcaagcttgacttaatgtga ttgttactgttatatccagcctatactgctagcagctgctcatactgcagtcaattactg gaagcggatat >41690 at HG-U95Av2 ttgccctggtgagacccataccattnnnnnnnnnnnnnnnnnnncttaaagtccagtgtt ggctgttagtgtatttgatattctgcctgtctcctcatggttgaaatatgtctgaagaat agcagcataatctcttggctgtttatacttttttaaactttcctgtgttgtaaatattgt atacttttggtgattccagctatgtaacctctatgctctgtaaggtgattatttgtatat agcaacatggcccagtgatattatatagtttcccaatggagaggttattgagtaaccttt gcattagtttaaacactaccagaagaatgctgagccaactataaacactcaattttgtat gttttccaaattgtacttattactgcttttgatactgtattacgtgccaatagtttccca atcacatagcaggcaaga >41710 at HG-U95Av2 ccataattgtttagccatgtgagtttcaggttggtacacgttcagacagaactgctgtat cacattccaattttgaatagccagtgagcaatcaagtgtagagaaatgataaatggccta agaagnnnnnnnnnnnnnnnnnatgctcttcctagtagcttaataggccacaagcta gtttctgttgcactctgaaataaaatatgctttaaaaatgtagggaacagtgcttagaaa agcaaaaactaggtgtgtcattgaaataataggcataaaaattaaatgttacataagaac actatttggaaagagggtcttttaaaaactgaatttgtactaaatcagatttgccatgt ccagtacagaataatttgtacttagtatttgcagcagggtttgtctttgtgaattc >41735 at HG-U95Av2 gctctacactccagggcatcttgacccagccgaaaaagttgaagatgctcaccccaagtt atggtgtgcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnncactgcaaaagtgaactgcatggtgatggccgaccagaa ccaggtgtgggttggctcggaagactccgtcatctacatcatcaacgtccacagcatgtc ctgcaacaagcagctcacagcccactgctccagtgtcacggatttgattgtgcaggacgg acaggaggcacccagcaacgtgtactcgtgcagcatggacggcatggtgctggtgtggaa tgtgagcacactgcaggtgacca >41837at HG-U95Av2 tcaccaatgcatatgaagagtatgcttggggaagagcttaggaatggggtgggcatggga ntgctgggtagncagccnnttnnagcaaatctgcatcnntnctcttatttcnnngacctt tntnccangtnncccagtccnnntnnnnnnnnnnnnnnnnnnnnnnnnnnnntnctttat actatttaatcttttgcagaaaccttactattataacttgctactctccagataccaatt cttcnnnnnnnnnnnnnnnnnnnnnnnnnnntgtcttactgatgttttcatgatcaactt gtaaatgtaagcagttgacttcataaaaggtattttaactattcttggagtcctttgcta cccaagcacctggtttcaccatgcgatcactgacttctctacag >717_at HG-U95Av2 gttcggatttgactgcctgtatatgttttgtgaaatggtcctgtttttgggtaggtgaca cgtggactctagtatgtaaatgttacttgaatctgtgcttcataatagtgtgtggcatgt atgtgcagactcttggatgctttatgcctgcgcaccaggagccctgtcctcacgttccca ggagggcggcttcacccttcgtaaccaggagacaaggcggccatggatttgcccttgatt ctattttgctaatggaagatagaaaggagaaggtttttttttttttttaacattctga agatggtgctgtgtcaagaaggaccttttttttcccctctcccctattttttaagtacct tggaggaggagaggttggtgacatgcatggtggggatctatggcctctggtgctt

Claims (33)

1. A method of assessing a tissue inflammatory response comprising: making a quantitative determination of the level of at least five transcripts shown in Table 1, or proteins encoded thereby, in a sample; and comparing the abundance of said transcripts or proteins so determined with the level of said transcript obtained from a control sample.

2. The method according to claim 1 wherein said sample comprises cells obtained from a site within a patient believed to be affected by a tissue inflammatory response.

3. The method according to claim 2 wherein the cells are endothelial cells or said sample is of patient blood, serum or urine.

4. The method of claim 3 wherein the endothelial cells are human umbilical vein endothelial cells, human coronary artery endothelial cells or human uterine microvascular endothelial cells.

5. The method according to any one of claims 1 to 4, wherein the control sample is obtained from endothelial cells from a tissue of said patient not affected by a tissue inflammatory response.

6. The method of any one of claims 1 to 4, wherein the control sample is obtained from a tissue demonstrating an inflammatory response in said patient at an earlier point in time. WO 2005/068655 PCT/GB2005/000057 136

7. The method of any one of claims 1 to 6 wherein the tissue inflammatory response involves one or more of: the movement of leucocytes across an endothelium, the movement of leucocytes to inflamed tissue, the activation of leucocytes, the activation and angiogenesis of endothelial cells and/or the inhibition of apoptosis of leucocytes or endothelial cells.

8. The method according to claim 1 which is a method of diagnosing a condition with which a tissue inflammatory response is associated or monitoring the progress of a condition with which a tissue inflammatory response is associated and which is already diagnosed or monitoring the effectiveness of treatment of a condition with which a tissue inflammatory response is associated.

9. The method of any one of the preceding claims, wherein said determination is made after a course of treatment of said patient.

10. The method of any one of the preceding claims, wherein the abundance of at least 10 transcripts or proteins encoded thereby shown in Table 1 is determined.

11. The method of claim 10, wherein the abundance of at least 20 transcripts or proteins encoded thereby shown in Table 1 is determined.

12. The method of any one of the preceding claims, wherein the abundance is determined by hybridisation to a gene chip array. WO 2005/068655 PCT/GB2005/000057 137

13. The method of any one of claims 1-11, wherein the abundance is determined by quantitative PCR.

14. A method for the diagnosis of a condition with which a tissue inflammatory response is associated comprising the determination of the abundance of endothelial cell-derived proteins encoded by at least five of the transcripts of Table 1 in a sample from a patient suspected of suffering from such a condition.

15. The method of any of the preceding claims, wherein the tissue inflammatory response is associated with an inflammatory disease, vasculitic syndrome, atherosclerosis or an associated disease, chronic transplant rejection or wherein the condition involves tumour growth.

16. The method of claim 15 wherein the inflammatory disease includes inflammatory bowel disorders, psoriasis, ischemic reperfusion, adult respiratory distress syndrome, asthma, allergic rhinitis, dermatitis, meningitis, encephalitis, uveitis, diseases involving leucocyte diapedesis, central nervous system inflammatory disorders, Alzheimer's, endometriosis, multiple sclerosis, multiple organ injury syndrome, alcoholic hepatitis, bacterial pneumonia, antigen antibody complex mediated diseases; inflammation of the lung (including pleurisy, alveolitis, pneumonia, chronic bronchitis, bronchiectasis, cystic fibrosis and COPD), vasculitis, polyarteritis nodosa, giant cell arteritis, microscopic polyarteritis, pre-eclampsia and autoimmune diseases.

17. The method of any of the preceding claims, wherein said comparison determines an alteration in the pattern of WO 2005/068655 PCT/GB2005/000057 138 transcript levels or transcript abundance between said sample and said control sample.

18. The method of any of the preceding claims wherein the level/abundance determined is of at least one transcript or protein encoded thereby selected from: colony stimulating factor 3 (granulocyte), colony stimulating factor 2 (granulocyte-macrophage), granulocyte chemotactic protein 2, diubiquitin, ELAM-1, TNF-induced protein 6, Exodus 1, IL-l@, VCAM-1, ICAM-1, IAP1, TNF-inducible A20, RIPK2, MMP 10, TRAF1, JAK binding protein, dual specificity phosphatase 4, IL-6, IL 8, Gro-gamma, MCP-1, Gro-beta, Gro-alpha, ENA-78, fractalkine, small inducible cytokine subfamily A14, small inducible cytokine A5, L17 receptor, toll/interleukin 1 receptor-like 4, CCAAT, MAD-3, COX-2, Mn SOD, NO synthase, L-kynurenine hydrolase, tissue factor pathway inhibitor 2, laminin gamma 2, Toll-like receptor 2, natural killer cell transcript 4, TNF alpha induced protein 2, cationic amino acid transporter 2A, fatty acid binding protein 4, TNF receptor superfamily member 11b and TNF superfamily member 9.

19. The method of claim 18, wherein the transcript or protein encoded thereby is selected from: colony stimulating factor 3 (granulocyte), colony stimulating factor 2 (granulocyte macrophage), granulocyte chemotactic protein 2, diubiquitin, ELAM-1, TNF-induced protein 6, Exodus 1 and IL-1p.

20. A gene chip array suitable for use in the method of any one of claims 1 to 19, comprising at least five nucleic acids suitable for detection of at least five transcripts shown in Table 1; optionally a control specific for said transcripts; and optionally at least one control for the gene chip. WO 2005/068655 PCT/GB2005/000057 139

21. A gene chip array for detection of at least five transcripts shown in Table 1 comprising at least five nucleic acids selected from Table 2 capable of detecting the presene of said at least five transcripts; optionally a control specific for said transcripts and optionally at least one control for said gene chip.

22. A protein based assay suitable for use in the method of any one claims 1 to 19, for the assessment of at least five proteins encoded by transcripts including those shown in Table 1, optionally a control specific for said proteins and optionally at least one control for the assay.

23. An assay according to claim 22 which is an ELISA or antibody chip.

24. An assay method for determining a modulator of a tissue inflammatory response or a condition associated therewith comprising: a) providing a protein encoded by transcripts from Table 1; b) bringing the protein into contact with a candidate modulator of its activity; c) determining whether said candidate modulator is capable of modulating the activity of the protein.

25. An assay method according to claim 24, wherein said candidate modulator is an antibody or binding fragment thereof which binds said protein.

26. An assay method according to claim 24, wherein said candidate modulator is a fragment of said protein or a mimetic thereof. WO 2005/068655 PCT/GB2005/000057 140

27. An assay method for a modulator of a tissue inflammatory response or a condition associated therewith, wherein said method comprises a) providing an endothelial cell in culture; b) bringing said cell into contact with a candidate modulator of said condition; and c) determining whether said candidate modulator is capable of modulating the level of at least one transcript of Table 1.

28. An assay method according to claim 27 wherein said candidate modulator is an antisense oligonucleotide or an RNAi.

29. An assay method according to claim 27 wherein said candidate modulator is a sense oligonucleotide.

30. Use of a modulator obtained according to the assay methods of any one of claims 24 to 29, for the treatment of a tissue inflammatory response or condition associated therewith.

31. A vector comprising a sequence encoding a transcript from Table lb operably linked to a promoter for transcription of said sequence.

32. The vector of claim 31 wherein said sequence is linked in frame to a translation initiation region for translation of said sequence.

33. The vector of claim 31 wherein said sequence is in an antisense orientation.